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The map label for this gene is pyrC

Identifier: 41407214

GI number: 41407214

Start: 1168143

End: 1169435

Strand: Direct

Name: pyrC

Synonym: MAP1116

Alternate gene names: 41407214

Gene position: 1168143-1169435 (Clockwise)

Preceding gene: 41407213

Following gene: 41407215

Centisome position: 24.19

GC content: 72.54

Gene sequence:

>1293_bases
ATGAGCGTGTTGCTGCGCGGAGTCCGGTTGTACGGCGAGGGCGACCGGGTCGATGTCCTGGTCGACGACGGGCAGATCGC
CGACATCGGCGCCGGGCTCGACATCCCCGACACCGCCGACGTCATCGACGCCACCGGCCAGGTGCTGCTGCCCGGGTTCG
TCGACCTGCACACCCACCTGCGCGAGCCGGGCCGCGAATACGCCGAGGACATCGAAACCGGTTCGGCCGCTGCGGCTTTG
GGTGGCTACACCGCGGTGTTCGCGATGGCCAACACCAACCCGGTCGCCGACAGCCCGGTGGTCACCGACCACGTGTGGCA
CCGGGGCCAGCAGGTCGGCCTGGTCGACGTGCACCCGGTGGGCGCGGTCACCATGGGTCTAGCCGGCAAGGAGCTCACCG
AGATGGGCATGATGGCGGCGGGGGCCGCACAGGTGCGGATGTTCTCCGACGACGGCGTCTGCGTGCACGACCCGCTGGTG
ATGCGCCGCGCCCTGGAATACGCCACCGGCCTGGGCGTGCTCATCGCCCAGCACGCCGAGGAGCCGCGGCTGACCGTCGG
CGCGGTCGCCCACGAGGGGCCCACCGCCGCCCGGCTGGGACTCGCGGGCTGGCCGCGGGCGGCCGAGGAATCGATCGTCG
CCCGCGACGCGCTGCTGGCCCGCGACGCCGGCGCCCGGGTGCACATCTGCCACGCCTCCACCGCGGGCACCGTCGAGATC
GTGAAATGGGCCAAGCAGCAAGGTATCTCGATCACCGCCGAGGTCACCCCGCACCACCTGATGCTGGACGACTCGCGGCT
GGCCAGTTACGACGGGCGCAACCGGGTCAACCCGCCGCTGCGCGAGGCGGCCGACGCGGCCGCGCTGCGGCGGGCGCTGG
CCGACGGCGTGATCGACTGTGTGGCCACCGATCACGCGCCGCACGCCGAGCACGAGAAGTGCGTGGAGTTCTCCGCGGCC
CGCCCCGGCATGCTGGGGCTGCAGACGGCGCTGTCGATCGTGGTCCACACGATGGTCCGCCCCGGGCTGCTGACCTGGCG
GGACATCGCCAAGGTGATGAGCGAAAACCCCGCGCGCATCGCAAATCTGCCCGATCACGGCCGCCCGCTGGAGGTGGGGG
AGCCGGCCAACCTGACGGTGGTGGACCCCGACGCCAGCTGGACGGTGGCCGGGTCGGACCTGGCCAGCCGGTCGGCCAAC
ACCCCCTACGAGGCGATGACGCTGCCGGCCACCGTGACCGCGACCCTGCTGCGCGGCAAGGTCACCGCCCGCGACGGGAA
GTGCCCGGCATGA

Upstream 100 bases:

>100_bases
ACTCGTCGCAATCGGCTGTGCTGCAACAGGTTTCCAATGGTGTGCACGTGCGGATGGCGGTGCTGTTCCACGTGCTGGTG
GGCGCGGAGGAGATCGCCGC

Downstream 100 bases:

>100_bases
GCCGCGCCGGCGACGATGCGGTGCGCCGCATGAGCGGCGGCACTGAGGAGGAGCGGGGCCAATGAATTCCGGCACGCTGG
TGGGCTCGCTGATCTTCGCG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSVLLRGVRLYGEGDRVDVLVDDGQIADIGAGLDIPDTADVIDATGQVLLPGFVDLHTHLREPGREYAEDIETGSAAAAL
GGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTMGLAGKELTEMGMMAAGAAQVRMFSDDGVCVHDPLV
MRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPTAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEI
VKWAKQQGISITAEVTPHHLMLDDSRLASYDGRNRVNPPLREAADAAALRRALADGVIDCVATDHAPHAEHEKCVEFSAA
RPGMLGLQTALSIVVHTMVRPGLLTWRDIAKVMSENPARIANLPDHGRPLEVGEPANLTVVDPDASWTVAGSDLASRSAN
TPYEAMTLPATVTATLLRGKVTARDGKCPA

Sequences:

>Translated_430_residues
MSVLLRGVRLYGEGDRVDVLVDDGQIADIGAGLDIPDTADVIDATGQVLLPGFVDLHTHLREPGREYAEDIETGSAAAAL
GGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTMGLAGKELTEMGMMAAGAAQVRMFSDDGVCVHDPLV
MRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPTAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEI
VKWAKQQGISITAEVTPHHLMLDDSRLASYDGRNRVNPPLREAADAAALRRALADGVIDCVATDHAPHAEHEKCVEFSAA
RPGMLGLQTALSIVVHTMVRPGLLTWRDIAKVMSENPARIANLPDHGRPLEVGEPANLTVVDPDASWTVAGSDLASRSAN
TPYEAMTLPATVTATLLRGKVTARDGKCPA
>Mature_429_residues
SVLLRGVRLYGEGDRVDVLVDDGQIADIGAGLDIPDTADVIDATGQVLLPGFVDLHTHLREPGREYAEDIETGSAAAALG
GYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTMGLAGKELTEMGMMAAGAAQVRMFSDDGVCVHDPLVM
RRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPTAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEIV
KWAKQQGISITAEVTPHHLMLDDSRLASYDGRNRVNPPLREAADAAALRRALADGVIDCVATDHAPHAEHEKCVEFSAAR
PGMLGLQTALSIVVHTMVRPGLLTWRDIAKVMSENPARIANLPDHGRPLEVGEPANLTVVDPDASWTVAGSDLASRSANT
PYEAMTLPATVTATLLRGKVTARDGKCPA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=405, Percent_Identity=31.1111111111111, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI19923821, Length=461, Percent_Identity=25.8134490238612, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI4503051, Length=449, Percent_Identity=25.1670378619154, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI62422571, Length=449, Percent_Identity=25.1670378619154, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI4503375, Length=464, Percent_Identity=24.7844827586207, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI4503377, Length=467, Percent_Identity=22.9122055674518, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1786722, Length=428, Percent_Identity=30.607476635514, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI87082175, Length=440, Percent_Identity=25.6818181818182, Blast_Score=112, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI193204318, Length=392, Percent_Identity=31.8877551020408, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI86575075, Length=422, Percent_Identity=24.4075829383886, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17539558, Length=460, Percent_Identity=23.695652173913, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=398, Percent_Identity=26.6331658291457, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24642586, Length=397, Percent_Identity=30.9823677581864, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI17137462, Length=435, Percent_Identity=23.9080459770115, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI18859883, Length=412, Percent_Identity=27.6699029126214, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI221377917, Length=440, Percent_Identity=23.8636363636364, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45272; Mature: 45141

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLLRGVRLYGEGDRVDVLVDDGQIADIGAGLDIPDTADVIDATGQVLLPGFVDLHTHL
CCCEEEEEEEECCCCEEEEEECCCCEEEECCCCCCCCCHHHHHCCCCEECCHHHHHHHHH
REPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPV
HCCHHHHHHHHCCCCHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHCCCEECEEEECCC
GAVTMGLAGKELTEMGMMAAGAAQVRMFSDDGVCVHDPLVMRRALEYATGLGVLIAQHAE
CHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCEEEECHHHHHHHHHHHHCHHHHEECCCC
EPRLTVGAVAHEGPTAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEI
CCCEEEEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
VKWAKQQGISITAEVTPHHLMLDDSRLASYDGRNRVNPPLREAADAAALRRALADGVIDC
HHHHHHCCCEEEEECCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEE
VATDHAPHAEHEKCVEFSAARPGMLGLQTALSIVVHTMVRPGLLTWRDIAKVMSENPARI
HCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEE
ANLPDHGRPLEVGEPANLTVVDPDASWTVAGSDLASRSANTPYEAMTLPATVTATLLRGK
CCCCCCCCCCCCCCCCCEEEECCCCCEEEECCHHHHCCCCCCHHEEECCHHHHHHHHHCE
VTARDGKCPA
EEECCCCCCC
>Mature Secondary Structure 
SVLLRGVRLYGEGDRVDVLVDDGQIADIGAGLDIPDTADVIDATGQVLLPGFVDLHTHL
CCEEEEEEEECCCCEEEEEECCCCEEEECCCCCCCCCHHHHHCCCCEECCHHHHHHHHH
REPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPV
HCCHHHHHHHHCCCCHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHCCCEECEEEECCC
GAVTMGLAGKELTEMGMMAAGAAQVRMFSDDGVCVHDPLVMRRALEYATGLGVLIAQHAE
CHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCEEEECHHHHHHHHHHHHCHHHHEECCCC
EPRLTVGAVAHEGPTAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEI
CCCEEEEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
VKWAKQQGISITAEVTPHHLMLDDSRLASYDGRNRVNPPLREAADAAALRRALADGVIDC
HHHHHHCCCEEEEECCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEE
VATDHAPHAEHEKCVEFSAARPGMLGLQTALSIVVHTMVRPGLLTWRDIAKVMSENPARI
HCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEE
ANLPDHGRPLEVGEPANLTVVDPDASWTVAGSDLASRSANTPYEAMTLPATVTATLLRGK
CCCCCCCCCCCCCCCCCEEEECCCCCEEEECCHHHHCCCCCCHHEEECCHHHHHHHHHCE
VTARDGKCPA
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]