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The map label for this gene is fadE12_1

Identifier: 41406821

GI number: 41406821

Start: 746837

End: 748003

Strand: Direct

Name: fadE12_1

Synonym: MAP0723

Alternate gene names: 41406821

Gene position: 746837-748003 (Clockwise)

Preceding gene: 41406820

Following gene: 41406822

Centisome position: 15.46

GC content: 64.44

Gene sequence:

>1167_bases
ATGGATTTCGCGCTGACCGAGGACCAGGAGCTGATCCGCCGGTCCGTCGCGGAGTTGGCCGGGAAATTCGACGACCAGTA
CTGGATGGAGAAGGACCAGGCGCACGAATTTCCGACCGAGTTCTACAACGCCATCGCCGAGGGCGGCTGGTTGGGGATGA
CCATTCCCACCGAGTACGGCGGTCACGGCCTGGGCATCACCGAAGCCACCATTCTGCTGGAGGAGGTCGCCAAGTCCGGC
GGCGCCATGAACGCGGCCAGCTCGATCCACCTGTCCATCTTCGGCATGCAACCGGTGGTGGTGCACGGCTCCGACGAACT
CAAGGCCCGTACCCTGCCCGCCGTCGCCACCGGTCAGGTGCACGTCTGCTTCGGCGTCACCGAACCCGGTGCCGGACTTG
ACACTTCACGCATCACCACGTTCGCCAAGCGGGATGGGGACCGTTACATCGTCAACGGCCGCAAGGTGTGGATCTCCAAA
GCGATGGAGTCCGACAAGATCCTGTTGCTGACCCGCACCCAGGCCTACGACGAGGTCACCAAGAAGACAGACGGGATGAC
GCTGTTCATCACCGACCTGGACCGCAGCCGGGTCGACATCCGCCCGATCCGCAAGATGGGCCGCAACGCCGTCAGCTCCA
ACGAGTTGTTCATCGACAATCTCGAGGTGCCGGTCGAGGACCGAATCGGCGAGGAGGGCAAGGGATTCCAGTACATCCTC
GACGGCCTGAACCCGGAGCGGATGCTGATCGCGGCCGAGGCGCTGGGCATCGGCCGGGTGGCGCTGGACAAGGCGGTGAA
ATACGGCAACGAGCGTGAGGTCTTCGGCCGTCCCATCGGCATGAACCAGGGCCTGCAGTTCCCGCTCGCCGATTCGCTTG
CCCGCCTCGATGCGGCCGAACTGATGCTGCGCAAGGCCACCTGGCTCTACGACAACGGCAAACCCTGTGGGCGCGAGGCG
AATACGGCCAAATACCTGTGCGCCGACGCCGGCTTCACCGCGGCCGACCGGGCGTTGCAGACGCACGGCGGCATGGGGTA
CGCCGAGGAGTACCACATCACCCGCTACTTCCGCGAGGCCCGGCTGATGAAGATCGCGCCGGTCAGCCAGGAGATGATCT
TGAATTTCCTGGGCGCCAACGTGCTGAAGTTGCCGCGCAGCTACTAG

Upstream 100 bases:

>100_bases
GACTGAGCACCGTACTGTCGCCGAGCAGACGCAAAAGCCCCCGATCCATCGGCGTGTCGGGTGCTTTTGTGTCTGCTCGC
GCTCGAGAAAGGGGCGTGGC

Downstream 100 bases:

>100_bases
GCCCGGCGTCGAACGTGTACTCACGGCTGATTTTTGGCGATTTTTTCGCTACCAGTACACGTTCGGCAATGATGGGACGG
TCGGGCATGAGGAATCGGAG

Product: FadE12_1

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MDFALTEDQELIRRSVAELAGKFDDQYWMEKDQAHEFPTEFYNAIAEGGWLGMTIPTEYGGHGLGITEATILLEEVAKSG
GAMNAASSIHLSIFGMQPVVVHGSDELKARTLPAVATGQVHVCFGVTEPGAGLDTSRITTFAKRDGDRYIVNGRKVWISK
AMESDKILLLTRTQAYDEVTKKTDGMTLFITDLDRSRVDIRPIRKMGRNAVSSNELFIDNLEVPVEDRIGEEGKGFQYIL
DGLNPERMLIAAEALGIGRVALDKAVKYGNEREVFGRPIGMNQGLQFPLADSLARLDAAELMLRKATWLYDNGKPCGREA
NTAKYLCADAGFTAADRALQTHGGMGYAEEYHITRYFREARLMKIAPVSQEMILNFLGANVLKLPRSY

Sequences:

>Translated_388_residues
MDFALTEDQELIRRSVAELAGKFDDQYWMEKDQAHEFPTEFYNAIAEGGWLGMTIPTEYGGHGLGITEATILLEEVAKSG
GAMNAASSIHLSIFGMQPVVVHGSDELKARTLPAVATGQVHVCFGVTEPGAGLDTSRITTFAKRDGDRYIVNGRKVWISK
AMESDKILLLTRTQAYDEVTKKTDGMTLFITDLDRSRVDIRPIRKMGRNAVSSNELFIDNLEVPVEDRIGEEGKGFQYIL
DGLNPERMLIAAEALGIGRVALDKAVKYGNEREVFGRPIGMNQGLQFPLADSLARLDAAELMLRKATWLYDNGKPCGREA
NTAKYLCADAGFTAADRALQTHGGMGYAEEYHITRYFREARLMKIAPVSQEMILNFLGANVLKLPRSY
>Mature_388_residues
MDFALTEDQELIRRSVAELAGKFDDQYWMEKDQAHEFPTEFYNAIAEGGWLGMTIPTEYGGHGLGITEATILLEEVAKSG
GAMNAASSIHLSIFGMQPVVVHGSDELKARTLPAVATGQVHVCFGVTEPGAGLDTSRITTFAKRDGDRYIVNGRKVWISK
AMESDKILLLTRTQAYDEVTKKTDGMTLFITDLDRSRVDIRPIRKMGRNAVSSNELFIDNLEVPVEDRIGEEGKGFQYIL
DGLNPERMLIAAEALGIGRVALDKAVKYGNEREVFGRPIGMNQGLQFPLADSLARLDAAELMLRKATWLYDNGKPCGREA
NTAKYLCADAGFTAADRALQTHGGMGYAEEYHITRYFREARLMKIAPVSQEMILNFLGANVLKLPRSY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=384, Percent_Identity=29.6875, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI7656849, Length=381, Percent_Identity=30.9711286089239, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4501859, Length=378, Percent_Identity=29.3650793650794, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI187960098, Length=366, Percent_Identity=29.2349726775956, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI4557231, Length=366, Percent_Identity=29.2349726775956, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=28.5714285714286, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=29.0322580645161, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI4501857, Length=379, Percent_Identity=28.7598944591029, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI21361497, Length=357, Percent_Identity=27.4509803921569, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI76496475, Length=372, Percent_Identity=28.7634408602151, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4557235, Length=372, Percent_Identity=28.7634408602151, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4503943, Length=357, Percent_Identity=27.1708683473389, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI7669494, Length=357, Percent_Identity=27.1708683473389, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI38505218, Length=329, Percent_Identity=24.3161094224924, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI48976061, Length=336, Percent_Identity=24.4047619047619, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI211971008, Length=336, Percent_Identity=24.4047619047619, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI87081958, Length=389, Percent_Identity=32.6478149100257, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1786223, Length=390, Percent_Identity=30.5128205128205, Blast_Score=174, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17570075, Length=370, Percent_Identity=30.5405405405405, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=28.4182305630027, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17534899, Length=372, Percent_Identity=29.5698924731183, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=27.6139410187668, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17569725, Length=370, Percent_Identity=29.7297297297297, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17538396, Length=373, Percent_Identity=27.8820375335121, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71990804, Length=299, Percent_Identity=31.438127090301, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71985184, Length=361, Percent_Identity=29.9168975069252, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17533517, Length=356, Percent_Identity=28.3707865168539, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17505929, Length=352, Percent_Identity=29.8295454545455, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=25.8855585831063, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=31.8777292576419, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71985192, Length=317, Percent_Identity=28.7066246056782, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17534353, Length=321, Percent_Identity=27.1028037383178, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71982178, Length=228, Percent_Identity=31.5789473684211, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=26.7782426778243, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562446, Length=317, Percent_Identity=25.5520504731861, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=335, Percent_Identity=25.9701492537313, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=335, Percent_Identity=25.9701492537313, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=29.3963254593176, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24666513, Length=380, Percent_Identity=30.5263157894737, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=30.7086614173228, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24660351, Length=371, Percent_Identity=31.8059299191375, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI281363737, Length=358, Percent_Identity=28.4916201117318, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21355753, Length=373, Percent_Identity=27.3458445040214, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19920834, Length=326, Percent_Identity=28.2208588957055, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42943; Mature: 42943

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFALTEDQELIRRSVAELAGKFDDQYWMEKDQAHEFPTEFYNAIAEGGWLGMTIPTEYG
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHCHHHHHCCHHHHHHHHHCCCEEEEECCCCCC
GHGLGITEATILLEEVAKSGGAMNAASSIHLSIFGMQPVVVHGSDELKARTLPAVATGQV
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCEEECCCE
HVCFGVTEPGAGLDTSRITTFAKRDGDRYIVNGRKVWISKAMESDKILLLTRTQAYDEVT
EEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCEEEEEEHHCCCCCEEEEECCHHHHHHH
KKTDGMTLFITDLDRSRVDIRPIRKMGRNAVSSNELFIDNLEVPVEDRIGEEGKGFQYIL
HCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCCCCHHHHC
DGLNPERMLIAAEALGIGRVALDKAVKYGNEREVFGRPIGMNQGLQFPLADSLARLDAAE
CCCCCCCEEEEEHHCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
LMLRKATWLYDNGKPCGREANTAKYLCADAGFTAADRALQTHGGMGYAEEYHITRYFREA
HHHHHHHEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RLMKIAPVSQEMILNFLGANVLKLPRSY
HHEEECCCCHHHHHHHHCCHHHHCCCCC
>Mature Secondary Structure
MDFALTEDQELIRRSVAELAGKFDDQYWMEKDQAHEFPTEFYNAIAEGGWLGMTIPTEYG
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHCHHHHHCCHHHHHHHHHCCCEEEEECCCCCC
GHGLGITEATILLEEVAKSGGAMNAASSIHLSIFGMQPVVVHGSDELKARTLPAVATGQV
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCEEECCCE
HVCFGVTEPGAGLDTSRITTFAKRDGDRYIVNGRKVWISKAMESDKILLLTRTQAYDEVT
EEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCEEEEEEHHCCCCCEEEEECCHHHHHHH
KKTDGMTLFITDLDRSRVDIRPIRKMGRNAVSSNELFIDNLEVPVEDRIGEEGKGFQYIL
HCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCCCCHHHHC
DGLNPERMLIAAEALGIGRVALDKAVKYGNEREVFGRPIGMNQGLQFPLADSLARLDAAE
CCCCCCCEEEEEHHCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
LMLRKATWLYDNGKPCGREANTAKYLCADAGFTAADRALQTHGGMGYAEEYHITRYFREA
HHHHHHHEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RLMKIAPVSQEMILNFLGANVLKLPRSY
HHEEECCCCHHHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]