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The map label for this gene is fadA6_2

Identifier: 41406822

GI number: 41406822

Start: 748112

End: 749266

Strand: Direct

Name: fadA6_2

Synonym: MAP0724

Alternate gene names: 41406822

Gene position: 748112-749266 (Clockwise)

Preceding gene: 41406821

Following gene: 41406823

Centisome position: 15.49

GC content: 70.22

Gene sequence:

>1155_bases
ATGCGTGAAACAGTCATCGTCGAGGCCGTGCGCACCCCGGTGGGTAAACGCAACGGCGCGCTGTCCGGCATGCACGCCGC
CGACCTGTCCGCGATCGTGCTCAACGAACTCGTCGAACGCACGGGCATCGGACCCGAGCTCATCGACGACGTGGTCTGGG
GCTGCGTCTCCCAGGTGGGCGACCAGTCCAGCAACATCGGCCGCTACGCGGTGCTGGCCGCGGGCTGGCCGGAAAGCATT
CCCGGGACCACCGTCAACCGGGCCTGCGGCTCCAGCCAGCAGGCGCTGGACTTCGCCGTGCAGGCGGTGATGTCGGGTCA
GCAGGACGTCGTGGTGGCCGGCGGGGTGGAGGTGATGAGCCGCGTCCCGCTCGGTGCGGCCCGGGCGACCGGCATGCCGT
ACGGCCCCAAAGTGCTTGCCCGCTATGACGACTTCTCCTTCAACCAGGGCCTGTCGGCGGAGATGATCGCCAAGAAGTGG
GGGTTCACGCGCACCCAGCTCGACGAGTACTCAGTCCGCTCGCACGAGCGGGCGGCCGCCGCCCAGGACGCCGGCGCCTT
CACCGACCAGATCGTCCCGGTGTTCGTCGAGGACGCCGAGAACAAGGTCGTCGCCGCCGACGAGGGCGTGCGGCGGGGAA
GCAGCGTGGAGAAGCTGGCCGCGCTCAAACCGGCCTTCGCCGAGGACGGCGTGATCCATGCCGGGAATTCCTCGCAGATC
TCCGACGGTGCGGCCGCGCTGCTGGTGACCACCGCCGAGATGGCCGTCGAGCTGGGACTGACGCCGATCGTGCGGTATGT
GGCCGGCGCGGTCACCGGCGCCGACCCGGTGCTGATGCTCACCGGCCCGATCCCGGCGACCGAGAAGGTGTTGAAGAAGG
CCGGCGTCGCGCTGTCGGATGTGGGCGTGTTCGAGGTCAACGAGGCGTTCGCGCCGGTGCCGCTGGCCTGGCTGGCCGAG
ACCGGGGCCGATGCGGCCCGGACGAATCCGCTGGGCGGCGCCATCGCGCTGGGGCACCCGCTGGGCGCGTCCGGGGCCGT
GCTGATGACGCGCATGGCACATCACATGCGCGACAACGGAATTCGTTACGGGCTGCAGACCATGTGCGAGGGCGGGGGCA
CCGCCAACGCCACCCTGGTCGAGCTGGTGAGCTGA

Upstream 100 bases:

>100_bases
TCGAACGTGTACTCACGGCTGATTTTTGGCGATTTTTTCGCTACCAGTACACGTTCGGCAATGATGGGACGGTCGGGCAT
GAGGAATCGGAGTAACAGTT

Downstream 100 bases:

>100_bases
CCGCGGAAAAACACCGGTGGGTGACCCTTGTCACAGCGGCCAAACTAACCTACTGTGTGTTCACTAGGTTGGTTTTCCCA
CGTCGCCCGGCTCGAGGAGT

Product: FadA6_2

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MRETVIVEAVRTPVGKRNGALSGMHAADLSAIVLNELVERTGIGPELIDDVVWGCVSQVGDQSSNIGRYAVLAAGWPESI
PGTTVNRACGSSQQALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGAARATGMPYGPKVLARYDDFSFNQGLSAEMIAKKW
GFTRTQLDEYSVRSHERAAAAQDAGAFTDQIVPVFVEDAENKVVAADEGVRRGSSVEKLAALKPAFAEDGVIHAGNSSQI
SDGAAALLVTTAEMAVELGLTPIVRYVAGAVTGADPVLMLTGPIPATEKVLKKAGVALSDVGVFEVNEAFAPVPLAWLAE
TGADAARTNPLGGAIALGHPLGASGAVLMTRMAHHMRDNGIRYGLQTMCEGGGTANATLVELVS

Sequences:

>Translated_384_residues
MRETVIVEAVRTPVGKRNGALSGMHAADLSAIVLNELVERTGIGPELIDDVVWGCVSQVGDQSSNIGRYAVLAAGWPESI
PGTTVNRACGSSQQALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGAARATGMPYGPKVLARYDDFSFNQGLSAEMIAKKW
GFTRTQLDEYSVRSHERAAAAQDAGAFTDQIVPVFVEDAENKVVAADEGVRRGSSVEKLAALKPAFAEDGVIHAGNSSQI
SDGAAALLVTTAEMAVELGLTPIVRYVAGAVTGADPVLMLTGPIPATEKVLKKAGVALSDVGVFEVNEAFAPVPLAWLAE
TGADAARTNPLGGAIALGHPLGASGAVLMTRMAHHMRDNGIRYGLQTMCEGGGTANATLVELVS
>Mature_384_residues
MRETVIVEAVRTPVGKRNGALSGMHAADLSAIVLNELVERTGIGPELIDDVVWGCVSQVGDQSSNIGRYAVLAAGWPESI
PGTTVNRACGSSQQALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGAARATGMPYGPKVLARYDDFSFNQGLSAEMIAKKW
GFTRTQLDEYSVRSHERAAAAQDAGAFTDQIVPVFVEDAENKVVAADEGVRRGSSVEKLAALKPAFAEDGVIHAGNSSQI
SDGAAALLVTTAEMAVELGLTPIVRYVAGAVTGADPVLMLTGPIPATEKVLKKAGVALSDVGVFEVNEAFAPVPLAWLAE
TGADAARTNPLGGAIALGHPLGASGAVLMTRMAHHMRDNGIRYGLQTMCEGGGTANATLVELVS

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=388, Percent_Identity=39.6907216494845, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI4557237, Length=395, Percent_Identity=37.9746835443038, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=34.5268542199489, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=34.8837209302326, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI4501853, Length=387, Percent_Identity=35.6589147286822, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI194353979, Length=381, Percent_Identity=25.9842519685039, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=42.1836228287841, Blast_Score=291, Evalue=3e-80,
Organism=Escherichia coli, GI48994986, Length=391, Percent_Identity=42.9667519181586, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=41.3705583756345, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=40.0510204081633, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI1788683, Length=408, Percent_Identity=32.5980392156863, Blast_Score=183, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=37.4358974358974, Blast_Score=243, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=34.2710997442455, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17535921, Length=392, Percent_Identity=32.9081632653061, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=33.6470588235294, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17535917, Length=390, Percent_Identity=29.7435897435897, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6325229, Length=408, Percent_Identity=33.578431372549, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6322031, Length=391, Percent_Identity=33.5038363171356, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=37.1501272264631, Blast_Score=245, Evalue=5e-65,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=36.4102564102564, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17648125, Length=394, Percent_Identity=33.248730964467, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=34.1176470588235, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 39749; Mature: 39749

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRETVIVEAVRTPVGKRNGALSGMHAADLSAIVLNELVERTGIGPELIDDVVWGCVSQVG
CCCCEEHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
DQSSNIGRYAVLAAGWPESIPGTTVNRACGSSQQALDFAVQAVMSGQQDVVVAGGVEVMS
CCCCCCCCEEEEECCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHH
RVPLGAARATGMPYGPKVLARYDDFSFNQGLSAEMIAKKWGFTRTQLDEYSVRSHERAAA
HCCCCHHHHCCCCCCCHHEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AQDAGAFTDQIVPVFVEDAENKVVAADEGVRRGSSVEKLAALKPAFAEDGVIHAGNSSQI
HHHCCCHHHCCCEEEEECCCCCEEECCCCCCCCCHHHHHHHHCCCHHCCCEEECCCCCCC
SDGAAALLVTTAEMAVELGLTPIVRYVAGAVTGADPVLMLTGPIPATEKVLKKAGVALSD
CCCCEEEEEEHHHHHHHHCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCEEEC
VGVFEVNEAFAPVPLAWLAETGADAARTNPLGGAIALGHPLGASGAVLMTRMAHHMRDNG
CCEEEECCCCCCCCHHHHHHCCCCHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCC
IRYGLQTMCEGGGTANATLVELVS
HHHHHHHHHCCCCCCCCCEEEECC
>Mature Secondary Structure
MRETVIVEAVRTPVGKRNGALSGMHAADLSAIVLNELVERTGIGPELIDDVVWGCVSQVG
CCCCEEHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
DQSSNIGRYAVLAAGWPESIPGTTVNRACGSSQQALDFAVQAVMSGQQDVVVAGGVEVMS
CCCCCCCCEEEEECCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHH
RVPLGAARATGMPYGPKVLARYDDFSFNQGLSAEMIAKKWGFTRTQLDEYSVRSHERAAA
HCCCCHHHHCCCCCCCHHEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AQDAGAFTDQIVPVFVEDAENKVVAADEGVRRGSSVEKLAALKPAFAEDGVIHAGNSSQI
HHHCCCHHHCCCEEEEECCCCCEEECCCCCCCCCHHHHHHHHCCCHHCCCEEECCCCCCC
SDGAAALLVTTAEMAVELGLTPIVRYVAGAVTGADPVLMLTGPIPATEKVLKKAGVALSD
CCCCEEEEEEHHHHHHHHCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCEEEC
VGVFEVNEAFAPVPLAWLAETGADAARTNPLGGAIALGHPLGASGAVLMTRMAHHMRDNG
CCEEEECCCCCCCCHHHHHHCCCCHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCC
IRYGLQTMCEGGGTANATLVELVS
HHHHHHHHHCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 10766858 [H]