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The map label for this gene is folP

Identifier: 41406548

GI number: 41406548

Start: 478918

End: 479730

Strand: Direct

Name: folP

Synonym: MAP0450

Alternate gene names: 41406548

Gene position: 478918-479730 (Clockwise)

Preceding gene: 41406547

Following gene: 41406549

Centisome position: 9.92

GC content: 72.08

Gene sequence:

>813_bases
TTGCAGGTAATGGGAGTCTTGAACGTCACTGACGATTCGTTCTCCGACGGTGGCCGCTACCTCGACCCCGACAAGGCCGT
CGCACACGGACTGGCGCTGGTCGCCGAGGGCGCCGGCATCGTCGACGTGGGCGGCGAATCCACCCGCCCCGGCGCCACCC
GGATCGACCCGCGCGTGGAGACCTCCCGCGTCGTCCCGGTCGTCAAAGCGCTTGCGGCAGAAGGTGTCACGGTGAGCATC
GACACCATGCACGCCGACGTCGCGCGGGCGGCGCTGGGCAGCGGCGCGCGGATCGTCAACGACGTGTCCGGCGGGCGCGC
CGATCCGGCGATGGCGCCGCTGCTGGCCGAGGCGAAAGTGCCCTGGGTGCTGATGCATTGGCGATCGGTGTCGGCCGAGC
GCCCGCACGCGGCGCCGCAGTACCGCGACGTGGTCGCCGAGGTGCGCGCCGAACTGCTGGCCAGCGTCGACGCCGCGGTG
GCCGCCGGCGTCGATTCCGCCCGGCTGATGATCGATCCGGGGTTGGGATTCGCCAAGACCGGACAACACAATTGGGCCCT
GCTGCACGCGTTGCCGCAGTTGGTCGCCACCGGGATCCCGGTACTGCTGGGCGCCTCCCGCAAACGGTTCCTCGGCACGC
TGCTGGCCGGGCCCGACGGCACGCCACGGCCGCCCGACGGGCGGGAGACGGCGACCGCGGTGATTTCCGCGCTGGCCGCG
CTGCACGGGGCGTGGGGGGTGCGGGTGCACGACGTGCGGGCCACGGTCGATGCGCTCAAGGTGCTCGGCGCTTGGATGGG
AGACGATGGCTGA

Upstream 100 bases:

>100_bases
GCCGTCACCACGACGTCGGCGGTGCGCGGGCTGTTCAAGACCAACGCGGCTTCTCGGGCGGAGGCGCTCGACCTGATCCT
GCGTAAGTGAGTCCGGCGCC

Downstream 100 bases:

>100_bases
TCGAATCGAGTTGCGCGGCTTGAGGGTTCGCGGACAACACGGAGTGTTCGACCACGAGCGCGTCGACGGGCAGGACTTCG
TCATCGACGTCACGGTCTGG

Product: hypothetical protein

Products: NA

Alternate protein names: DHPS 1; Dihydropteroate pyrophosphorylase 1 [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MQVMGVLNVTDDSFSDGGRYLDPDKAVAHGLALVAEGAGIVDVGGESTRPGATRIDPRVETSRVVPVVKALAAEGVTVSI
DTMHADVARAALGSGARIVNDVSGGRADPAMAPLLAEAKVPWVLMHWRSVSAERPHAAPQYRDVVAEVRAELLASVDAAV
AAGVDSARLMIDPGLGFAKTGQHNWALLHALPQLVATGIPVLLGASRKRFLGTLLAGPDGTPRPPDGRETATAVISALAA
LHGAWGVRVHDVRATVDALKVLGAWMGDDG

Sequences:

>Translated_270_residues
MQVMGVLNVTDDSFSDGGRYLDPDKAVAHGLALVAEGAGIVDVGGESTRPGATRIDPRVETSRVVPVVKALAAEGVTVSI
DTMHADVARAALGSGARIVNDVSGGRADPAMAPLLAEAKVPWVLMHWRSVSAERPHAAPQYRDVVAEVRAELLASVDAAV
AAGVDSARLMIDPGLGFAKTGQHNWALLHALPQLVATGIPVLLGASRKRFLGTLLAGPDGTPRPPDGRETATAVISALAA
LHGAWGVRVHDVRATVDALKVLGAWMGDDG
>Mature_270_residues
MQVMGVLNVTDDSFSDGGRYLDPDKAVAHGLALVAEGAGIVDVGGESTRPGATRIDPRVETSRVVPVVKALAAEGVTVSI
DTMHADVARAALGSGARIVNDVSGGRADPAMAPLLAEAKVPWVLMHWRSVSAERPHAAPQYRDVVAEVRAELLASVDAAV
AAGVDSARLMIDPGLGFAKTGQHNWALLHALPQLVATGIPVLLGASRKRFLGTLLAGPDGTPRPPDGRETATAVISALAA
LHGAWGVRVHDVRATVDALKVLGAWMGDDG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=266, Percent_Identity=39.0977443609023, Blast_Score=180, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=30.188679245283, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 27861; Mature: 27861

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVMGVLNVTDDSFSDGGRYLDPDKAVAHGLALVAEGAGIVDVGGESTRPGATRIDPRVE
CCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHEECCCCEEEECCCCCCCCCCCCCCCCC
TSRVVPVVKALAAEGVTVSIDTMHADVARAALGSGARIVNDVSGGRADPAMAPLLAEAKV
HHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHCCC
PWVLMHWRSVSAERPHAAPQYRDVVAEVRAELLASVDAAVAAGVDSARLMIDPGLGFAKT
CEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCC
GQHNWALLHALPQLVATGIPVLLGASRKRFLGTLLAGPDGTPRPPDGRETATAVISALAA
CCCCHHHHHHHHHHHHCCCHHEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LHGAWGVRVHDVRATVDALKVLGAWMGDDG
HHCCCCCEEEHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQVMGVLNVTDDSFSDGGRYLDPDKAVAHGLALVAEGAGIVDVGGESTRPGATRIDPRVE
CCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHEECCCCEEEECCCCCCCCCCCCCCCCC
TSRVVPVVKALAAEGVTVSIDTMHADVARAALGSGARIVNDVSGGRADPAMAPLLAEAKV
HHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHCCC
PWVLMHWRSVSAERPHAAPQYRDVVAEVRAELLASVDAAVAAGVDSARLMIDPGLGFAKT
CEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCC
GQHNWALLHALPQLVATGIPVLLGASRKRFLGTLLAGPDGTPRPPDGRETATAVISALAA
CCCCHHHHHHHHHHHHCCCHHEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LHGAWGVRVHDVRATVDALKVLGAWMGDDG
HHCCCCCEEEHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10474189; 10542185; 11234002 [H]