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The map label for this gene is fgd1 [H]

Identifier: 41406469

GI number: 41406469

Start: 397698

End: 398684

Strand: Direct

Name: fgd1 [H]

Synonym: MAP0371

Alternate gene names: 41406469

Gene position: 397698-398684 (Clockwise)

Preceding gene: 41406468

Following gene: 41406470

Centisome position: 8.23

GC content: 69.6

Gene sequence:

>987_bases
ATGACGAATTTTGGCTACACTTTGATGACCGAGCAGAGTGGACCCAAAGAGCTTGTCCGGTACGCGATTTCGGCCGAAGA
GCGCGGTTTCGACTTCCACGTGTGCAGTGACCACTTCTCACCATGGCTCACCTCGCAGGGACACGCGCCCAACGCCTGGG
CGGTGCTGGGCGCGGTGGCGCAGGCCACCGAGCGGGTCGACCTGTACACCTACGTGACGTGCCCGACGATGCGCTATCAC
CCGGCCATCGTCGCCCAGCAGGCGGCCACCGTGCAGATCCTGTCCGACGGCCGGTTCACCCTGGGCCTGGGCAGCGGCGA
AAACCTCAACGAGCATGTCGTCGGCAAAGGCTGGCCGACCATCACCCGCCGGCAGGACATGCTGCGCGAGGCCATCAAGA
TCATCCGGGAGCTGTTCGGCGGGCAGCTGGTGGACTTCACCGGCGACTATTTCCGGGTCGACTCCGCGCGGCTGTGGGAC
GTGCCCGACGTGCCGGTCGGCATCGGGGTGGCCATCGGCGGCACCCGGGCGGTCGACAAGTTCGCCAAGCTGGCCGACCA
CCTGATCGCCACCGAACCCAACGCCGACCTGGTCGACGCCTGGCACGGCGCCCGCCAGGCCGCCAACCTCGCCGGCGGCG
GGCGGGTGGTCGGGCAGATCCCGGTGTCGTGGGACCCCGACCCCGACACCGCCGTCAAACGCGCGCACGACCAGTTCCGC
TGGTTCGCGGGCGGCTGGAAGGTGAACGCCGACCTGCCCACCCCGGCCGGGTTCGCCGGCGCCACCCAGTTCGTGCGCCC
CGAGGACGTCGCCGACGCCATTCCCTGCGGCCCCGACCTGGACGCGATCGTCGAGGGGGTCCGGCCGTACTGGGAGGCCG
GGTTCACCGACATCGCGCTGGTCCAGATCGGCGGGGACACCCAGGAGAGATTCCTCAAGGAAGCCGCCGAACCGCTGCTG
GCGGCGCTGCGCGACGCGGCGAAGTAG

Upstream 100 bases:

>100_bases
CGCCCGCCGCGCGGCCGGGATCACGTCGGACTCCATCACCACCGCGGGCTGAGCGCGCCCGCGTCGTTTGCCCTCGGTGC
AGCCGGGTATCCCGGTGCGC

Downstream 100 bases:

>100_bases
CGGCGAACGAGAAAGGGGAACCGAGATGTCAAATGAGTTGCAAGGCAAGAAGATAGCGATCCTGGCGGCCGACGGGGTGG
AAAAGGTGGAGCTGGAGCAG

Product: hypothetical protein

Products: NA

Alternate protein names: F420_G6P_DH [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MTNFGYTLMTEQSGPKELVRYAISAEERGFDFHVCSDHFSPWLTSQGHAPNAWAVLGAVAQATERVDLYTYVTCPTMRYH
PAIVAQQAATVQILSDGRFTLGLGSGENLNEHVVGKGWPTITRRQDMLREAIKIIRELFGGQLVDFTGDYFRVDSARLWD
VPDVPVGIGVAIGGTRAVDKFAKLADHLIATEPNADLVDAWHGARQAANLAGGGRVVGQIPVSWDPDPDTAVKRAHDQFR
WFAGGWKVNADLPTPAGFAGATQFVRPEDVADAIPCGPDLDAIVEGVRPYWEAGFTDIALVQIGGDTQERFLKEAAEPLL
AALRDAAK

Sequences:

>Translated_328_residues
MTNFGYTLMTEQSGPKELVRYAISAEERGFDFHVCSDHFSPWLTSQGHAPNAWAVLGAVAQATERVDLYTYVTCPTMRYH
PAIVAQQAATVQILSDGRFTLGLGSGENLNEHVVGKGWPTITRRQDMLREAIKIIRELFGGQLVDFTGDYFRVDSARLWD
VPDVPVGIGVAIGGTRAVDKFAKLADHLIATEPNADLVDAWHGARQAANLAGGGRVVGQIPVSWDPDPDTAVKRAHDQFR
WFAGGWKVNADLPTPAGFAGATQFVRPEDVADAIPCGPDLDAIVEGVRPYWEAGFTDIALVQIGGDTQERFLKEAAEPLL
AALRDAAK
>Mature_327_residues
TNFGYTLMTEQSGPKELVRYAISAEERGFDFHVCSDHFSPWLTSQGHAPNAWAVLGAVAQATERVDLYTYVTCPTMRYHP
AIVAQQAATVQILSDGRFTLGLGSGENLNEHVVGKGWPTITRRQDMLREAIKIIRELFGGQLVDFTGDYFRVDSARLWDV
PDVPVGIGVAIGGTRAVDKFAKLADHLIATEPNADLVDAWHGARQAANLAGGGRVVGQIPVSWDPDPDTAVKRAHDQFRW
FAGGWKVNADLPTPAGFAGATQFVRPEDVADAIPCGPDLDAIVEGVRPYWEAGFTDIALVQIGGDTQERFLKEAAEPLLA
ALRDAAK

Specific function: Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787247, Length=127, Percent_Identity=33.0708661417323, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019945
- InterPro:   IPR019944
- InterPro:   IPR011251
- InterPro:   IPR016048 [H]

Pfam domain/function: PF00296 Bac_luciferase [H]

EC number: =1.1.99.34 [H]

Molecular weight: Translated: 35625; Mature: 35494

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNFGYTLMTEQSGPKELVRYAISAEERGFDFHVCSDHFSPWLTSQGHAPNAWAVLGAVA
CCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
QATERVDLYTYVTCPTMRYHPAIVAQQAATVQILSDGRFTLGLGSGENLNEHVVGKGWPT
HHHHHEEEEEEEECCCCCCCHHHHHCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCC
ITRRQDMLREAIKIIRELFGGQLVDFTGDYFRVDSARLWDVPDVPVGIGVAIGGTRAVDK
HHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEECCCEECCCCCCCCCEEEEECCHHHHHH
FAKLADHLIATEPNADLVDAWHGARQAANLAGGGRVVGQIPVSWDPDPDTAVKRAHDQFR
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHE
WFAGGWKVNADLPTPAGFAGATQFVRPEDVADAIPCGPDLDAIVEGVRPYWEAGFTDIAL
EEECCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHCCHHHHCCCCEEEE
VQIGGDTQERFLKEAAEPLLAALRDAAK
EEECCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNFGYTLMTEQSGPKELVRYAISAEERGFDFHVCSDHFSPWLTSQGHAPNAWAVLGAVA
CCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
QATERVDLYTYVTCPTMRYHPAIVAQQAATVQILSDGRFTLGLGSGENLNEHVVGKGWPT
HHHHHEEEEEEEECCCCCCCHHHHHCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCC
ITRRQDMLREAIKIIRELFGGQLVDFTGDYFRVDSARLWDVPDVPVGIGVAIGGTRAVDK
HHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEECCCEECCCCCCCCCEEEEECCHHHHHH
FAKLADHLIATEPNADLVDAWHGARQAANLAGGGRVVGQIPVSWDPDPDTAVKRAHDQFR
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHE
WFAGGWKVNADLPTPAGFAGATQFVRPEDVADAIPCGPDLDAIVEGVRPYWEAGFTDIAL
EEECCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHCCHHHHCCCCEEEE
VQIGGDTQERFLKEAAEPLLAALRDAAK
EEECCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]