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The map label for this gene is proZ

Identifier: 41406373

GI number: 41406373

Start: 293657

End: 294373

Strand: Direct

Name: proZ

Synonym: MAP0275

Alternate gene names: 41406373

Gene position: 293657-294373 (Clockwise)

Preceding gene: 41406372

Following gene: 41406374

Centisome position: 6.08

GC content: 72.25

Gene sequence:

>717_bases
GTGAACTTCGTGCAGCGGGCCATCGCGTATCTGCTGAGCGCCGACAACTGGACCGGCCCCGTCGGGCTGGCGGCCCGCAT
CCTCGAGCATCTCGAGTACACCGGCATCGCGGTGGGCGCCTCGGCGCTGATCGCCGTGCCCGTCGGCCTGCTCATCGGGC
ACACCGGCCGCGGCACCCTGCTGGTGGTGGGCGCCGTCAACGGGCTGCGCGCGCTGCCCACCCTGGGCGTGCTGCTGTTC
GGCACGCTGCTGTTCGGGCTGGGCCTGGGACCCTCGCTGGTGGCGCTGATGCTGCTGGGCGTGCCCGCGCTGCTGGCCGG
AACGTATGCCGGCATCGCCAACGTCGAACCCACCGTGGTCGATGCCGCCCGGGCGATGGGCATGACCGAGTCGCAGGTGC
TGCTGCGCGTCGAGGTGCCCAATGCGCTGCCGTTGATCCTGGGCGGGCTGCGCAGCGCGACGCTGCAGGTGGTCGCGACC
GCCACGGTGGCCGCCTATGCCAGCCTCGGCGGGCTGGGCCGGTACCTGATCGACGGGATCAAGGAGCGCGAGTTCCACCT
GGCCCTGGTCGGGGCGCTGACGGTGGCCGCGTTGGCGCTGGTGCTCGACGGTCTGCTGGCCGTGGCGGTGTGGGCGTCAG
TGCCGGGTACCGGCCGGCTGCGGCGCACATACCGGCCACTTCCGCACCGGTTGGCGGGGACGTCTTACGGTAGATGA

Upstream 100 bases:

>100_bases
GGCTCATCGTGCTGGGCGGCCGGCTGGTCACCCCGTGGGCGCACGCGGTGCGCGGCGGCGCCCGCCGCTCGGTCGTCGCG
CCGGTGGTGGGGGGTGCCCG

Downstream 100 bases:

>100_bases
GTGAACGCAGCCCCTTCTGACCCGTCTCGCCGAGTGTGGCAGGCGATGCTCACCTGGCGCGCACAGGACGTCTCCCGGAT
GGAATCGGTACGACTCCAGG

Product: ProZ

Products: ADP; phosphate; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MNFVQRAIAYLLSADNWTGPVGLAARILEHLEYTGIAVGASALIAVPVGLLIGHTGRGTLLVVGAVNGLRALPTLGVLLF
GTLLFGLGLGPSLVALMLLGVPALLAGTYAGIANVEPTVVDAARAMGMTESQVLLRVEVPNALPLILGGLRSATLQVVAT
ATVAAYASLGGLGRYLIDGIKEREFHLALVGALTVAALALVLDGLLAVAVWASVPGTGRLRRTYRPLPHRLAGTSYGR

Sequences:

>Translated_238_residues
MNFVQRAIAYLLSADNWTGPVGLAARILEHLEYTGIAVGASALIAVPVGLLIGHTGRGTLLVVGAVNGLRALPTLGVLLF
GTLLFGLGLGPSLVALMLLGVPALLAGTYAGIANVEPTVVDAARAMGMTESQVLLRVEVPNALPLILGGLRSATLQVVAT
ATVAAYASLGGLGRYLIDGIKEREFHLALVGALTVAALALVLDGLLAVAVWASVPGTGRLRRTYRPLPHRLAGTSYGR
>Mature_238_residues
MNFVQRAIAYLLSADNWTGPVGLAARILEHLEYTGIAVGASALIAVPVGLLIGHTGRGTLLVVGAVNGLRALPTLGVLLF
GTLLFGLGLGPSLVALMLLGVPALLAGTYAGIANVEPTVVDAARAMGMTESQVLLRVEVPNALPLILGGLRSATLQVVAT
ATVAAYASLGGLGRYLIDGIKEREFHLALVGALTVAALALVLDGLLAVAVWASVPGTGRLRRTYRPLPHRLAGTSYGR

Specific function: Involved in a high affinity multicomponent binding- protein-dependent transport system for choline; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG1174

COG function: function code E; ABC-type proline/glycine betaine transport systems, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789033, Length=163, Percent_Identity=26.9938650306748, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788449, Length=189, Percent_Identity=31.2169312169312, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788451, Length=136, Percent_Identity=36.0294117647059, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24425; Mature: 24425

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFVQRAIAYLLSADNWTGPVGLAARILEHLEYTGIAVGASALIAVPVGLLIGHTGRGTL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCE
LVVGAVNGLRALPTLGVLLFGTLLFGLGLGPSLVALMLLGVPALLAGTYAGIANVEPTVV
EEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DAARAMGMTESQVLLRVEVPNALPLILGGLRSATLQVVATATVAAYASLGGLGRYLIDGI
HHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEREFHLALVGALTVAALALVLDGLLAVAVWASVPGTGRLRRTYRPLPHRLAGTSYGR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHCCCCCCC
>Mature Secondary Structure
MNFVQRAIAYLLSADNWTGPVGLAARILEHLEYTGIAVGASALIAVPVGLLIGHTGRGTL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCE
LVVGAVNGLRALPTLGVLLFGTLLFGLGLGPSLVALMLLGVPALLAGTYAGIANVEPTVV
EEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DAARAMGMTESQVLLRVEVPNALPLILGGLRSATLQVVATATVAAYASLGGLGRYLIDGI
HHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEREFHLALVGALTVAALALVLDGLLAVAVWASVPGTGRLRRTYRPLPHRLAGTSYGR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-proline [Periplasm]; H2O [C]

Specific reaction: ATP + L-proline [Periplasm] + H2O = ADP + phosphate + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7592481; 10216873; 9384377 [H]