Click here to switch to the map view.

The map label for this gene is proW

Identifier: 41406372

GI number: 41406372

Start: 292974

End: 293660

Strand: Direct

Name: proW

Synonym: MAP0274

Alternate gene names: 41406372

Gene position: 292974-293660 (Clockwise)

Preceding gene: 41406371

Following gene: 41406373

Centisome position: 6.07

GC content: 70.45

Gene sequence:

>687_bases
ATGCACTATCTGCTCACCCATCTCGACGACGCGGCCCGGCTCACCGTCGTGCACCTGCGGCTGGCGCTGGTGCCGGTGCT
GATCGGGTTGGCGATCGCGCTGCCGCTGGGAATGCTGGTGCAGCGCAGGCGGTTTGCCCGGCGCCTGACGACGGCGGTCG
CCAGCGTGGTGTTCACCATCCCGTCGCTGGCGCTGTTCGTGGTGTTGCCGATGATCATCGGAACCCGCATCCTCGACGAG
GCCAACGTGATGGTCGCCCTGACCGCTTACACCGCCGCGCTGCTGGTGCGGGCGGTGCTCGAGGCGCTGGACGCGGTCCC
CGCCCAGATATCGGATGCCGCCACCGCGGTCGGCTACCCGCGGCTCAGCCGGATGATGAAAGTCGAACTGCCGCTTGCGG
TTCCGGTCCTGATCGCCGGGCTTCGGGTGGTGGTGGTGACCAACATCGCCATGGTCTCGGTCGGCTCGGTGATCGGGATC
GGCGGACTGGGCAGCTGGTTCACCCAGGGCTACCAGACCGGCAAGAGCGATCAGATCCTGGCCGGCATCATCGCGCTGTT
CGCGCTGGCGGTCGCCGTCGACGGGCTCATCGTGCTGGGCGGCCGGCTGGTCACCCCGTGGGCGCACGCGGTGCGCGGCG
GCGCCCGCCGCTCGGTCGTCGCGCCGGTGGTGGGGGGTGCCCGGTGA

Upstream 100 bases:

>100_bases
CGGGAATCGGTGTCGCCGTCGACGACGACGGCAGGGTGATCGGCGGTGTGCTGGCCGCCGACGTGCTGGCCGCGGTGGAA
TCGCAGCGAAAGAGCCGCTG

Downstream 100 bases:

>100_bases
ACTTCGTGCAGCGGGCCATCGCGTATCTGCTGAGCGCCGACAACTGGACCGGCCCCGTCGGGCTGGCGGCCCGCATCCTC
GAGCATCTCGAGTACACCGG

Product: ProW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MHYLLTHLDDAARLTVVHLRLALVPVLIGLAIALPLGMLVQRRRFARRLTTAVASVVFTIPSLALFVVLPMIIGTRILDE
ANVMVALTAYTAALLVRAVLEALDAVPAQISDAATAVGYPRLSRMMKVELPLAVPVLIAGLRVVVVTNIAMVSVGSVIGI
GGLGSWFTQGYQTGKSDQILAGIIALFALAVAVDGLIVLGGRLVTPWAHAVRGGARRSVVAPVVGGAR

Sequences:

>Translated_228_residues
MHYLLTHLDDAARLTVVHLRLALVPVLIGLAIALPLGMLVQRRRFARRLTTAVASVVFTIPSLALFVVLPMIIGTRILDE
ANVMVALTAYTAALLVRAVLEALDAVPAQISDAATAVGYPRLSRMMKVELPLAVPVLIAGLRVVVVTNIAMVSVGSVIGI
GGLGSWFTQGYQTGKSDQILAGIIALFALAVAVDGLIVLGGRLVTPWAHAVRGGARRSVVAPVVGGAR
>Mature_228_residues
MHYLLTHLDDAARLTVVHLRLALVPVLIGLAIALPLGMLVQRRRFARRLTTAVASVVFTIPSLALFVVLPMIIGTRILDE
ANVMVALTAYTAALLVRAVLEALDAVPAQISDAATAVGYPRLSRMMKVELPLAVPVLIAGLRVVVVTNIAMVSVGSVIGI
GGLGSWFTQGYQTGKSDQILAGIIALFALAVAVDGLIVLGGRLVTPWAHAVRGGARRSVVAPVVGGAR

Specific function: Involved in a high affinity multicomponent binding- protein-dependent transport system for glycine betaine, carnitine and choline; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG1174

COG function: function code E; ABC-type proline/glycine betaine transport systems, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788451, Length=205, Percent_Identity=32.1951219512195, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788449, Length=159, Percent_Identity=31.4465408805031, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 23861; Mature: 23861

Theoretical pI: Translated: 11.70; Mature: 11.70

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYLLTHLDDAARLTVVHLRLALVPVLIGLAIALPLGMLVQRRRFARRLTTAVASVVFTI
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PSLALFVVLPMIIGTRILDEANVMVALTAYTAALLVRAVLEALDAVPAQISDAATAVGYP
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCH
RLSRMMKVELPLAVPVLIAGLRVVVVTNIAMVSVGSVIGIGGLGSWFTQGYQTGKSDQIL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHH
AGIIALFALAVAVDGLIVLGGRLVTPWAHAVRGGARRSVVAPVVGGAR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MHYLLTHLDDAARLTVVHLRLALVPVLIGLAIALPLGMLVQRRRFARRLTTAVASVVFTI
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PSLALFVVLPMIIGTRILDEANVMVALTAYTAALLVRAVLEALDAVPAQISDAATAVGYP
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCH
RLSRMMKVELPLAVPVLIAGLRVVVVTNIAMVSVGSVIGIGGLGSWFTQGYQTGKSDQIL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHH
AGIIALFALAVAVDGLIVLGGRLVTPWAHAVRGGARRSVVAPVVGGAR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10216873; 9384377 [H]