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The map label for this gene is fabH [H]

Identifier: 52842441

GI number: 52842441

Start: 2518922

End: 2519983

Strand: Direct

Name: fabH [H]

Synonym: lpg2228

Alternate gene names: 52842441

Gene position: 2518922-2519983 (Clockwise)

Preceding gene: 52842437

Following gene: 52842442

Centisome position: 74.13

GC content: 39.64

Gene sequence:

>1062_bases
ATGAATATCTTAAAACCTAACATACAATTTGAAATTACTGGCGCATCAAGGATTCTGCCTGCATCAGGCCCTATCACAAA
CCTGGAAATTTTAAAGAATTTTCCGAGAACTGCAGATAAGTCTCAAGGTTTTCTCGAAAAATTCGCAGAAAAAATAGGCG
AAGAATTTGGCTTTCATACTCGATACTGGTGCCACAAACCTTGGGAATCACTCGATAATTCAAGAGAACTGTCTTCCGAA
TCACTAGCTATGCAAGCAGTAGATAAACTGATAACCCACAGTATGTCAAAAGATGTCGACGCATTTCTCTTAGGCTCGAC
AACTAATAAACGCTTTACGGGATCTCAAGCGGCTGCTGTACTTGGAAACCTGAAGTTGAATGCGCCCGCTTACGATTTAA
AAACCGGTTGCTCCACTTCTTTATCGACCTTGCATTTTGCCTACGCATTGATGGCTTTGGGTTATCAAAAAATATTGGTT
TGTTGCTCTGAAACACTTTCCAAAGTGATTGACCCTGAGAATGAAAAAACCTGGATAGGTTTGGCTGATGGAGCTGCCTC
CTTACTTTTAGAAAAAAGCAAGGAGGGGTCTTTTACCATTGAAAAGAGTTTTTTTTCTACTGATGGTCAATACGTCAACG
CATTTACGACTCAAGGGGTATTCCCGCCAACTCATGAGCAAATCGATTCGGTTGGTTATCATCTGGTGGGTGATGAAACC
CTAATGAAAGAATTAGCCTATTCCAGATACATGCAAATGCTTGATCATTTATTGCCAACAGAAAAGGAAAAAAACGAGAT
AACATGGGTAATCCCCCATCAGGTCAATCGAAAATTAATAGACCAAGTACTTCATGAAAATAATTTAAACAACAAAATAA
TAATCTGGGATGCTGATACGATAGGCAATATAGGTGGCGCATCAGTTCTCTACACATTAGCAAGGGCAGTTGAGGAAAAA
TTGTTTGACAGATCAGGGAAAATTCTCCTGATGAGTGTTGGTGGTGGTCTATCCTATGCGGGACAAGTCCTAAACTATCA
AAAAGCATCATATAGCAATTAA

Upstream 100 bases:

>100_bases
TTATATGAAAAAGATAAAAATTCTTGATCTGGCAGGATAGAAAGAGTGTAATTTCAATAATTGTAACCTCTATGCGCTCC
AGACAAGATAAGGCCACTTT

Downstream 100 bases:

>100_bases
GGTGTTTTATAGTGAAAAAAGAATATTTGCAGTGCCAGTCTCTGGTTGACGTCGTCAGGTTACGTGCTTTACACAGCCCT
AACAAGAAAAGCTGTACTTT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MNILKPNIQFEITGASRILPASGPITNLEILKNFPRTADKSQGFLEKFAEKIGEEFGFHTRYWCHKPWESLDNSRELSSE
SLAMQAVDKLITHSMSKDVDAFLLGSTTNKRFTGSQAAAVLGNLKLNAPAYDLKTGCSTSLSTLHFAYALMALGYQKILV
CCSETLSKVIDPENEKTWIGLADGAASLLLEKSKEGSFTIEKSFFSTDGQYVNAFTTQGVFPPTHEQIDSVGYHLVGDET
LMKELAYSRYMQMLDHLLPTEKEKNEITWVIPHQVNRKLIDQVLHENNLNNKIIIWDADTIGNIGGASVLYTLARAVEEK
LFDRSGKILLMSVGGGLSYAGQVLNYQKASYSN

Sequences:

>Translated_353_residues
MNILKPNIQFEITGASRILPASGPITNLEILKNFPRTADKSQGFLEKFAEKIGEEFGFHTRYWCHKPWESLDNSRELSSE
SLAMQAVDKLITHSMSKDVDAFLLGSTTNKRFTGSQAAAVLGNLKLNAPAYDLKTGCSTSLSTLHFAYALMALGYQKILV
CCSETLSKVIDPENEKTWIGLADGAASLLLEKSKEGSFTIEKSFFSTDGQYVNAFTTQGVFPPTHEQIDSVGYHLVGDET
LMKELAYSRYMQMLDHLLPTEKEKNEITWVIPHQVNRKLIDQVLHENNLNNKIIIWDADTIGNIGGASVLYTLARAVEEK
LFDRSGKILLMSVGGGLSYAGQVLNYQKASYSN
>Mature_353_residues
MNILKPNIQFEITGASRILPASGPITNLEILKNFPRTADKSQGFLEKFAEKIGEEFGFHTRYWCHKPWESLDNSRELSSE
SLAMQAVDKLITHSMSKDVDAFLLGSTTNKRFTGSQAAAVLGNLKLNAPAYDLKTGCSTSLSTLHFAYALMALGYQKILV
CCSETLSKVIDPENEKTWIGLADGAASLLLEKSKEGSFTIEKSFFSTDGQYVNAFTTQGVFPPTHEQIDSVGYHLVGDET
LMKELAYSRYMQMLDHLLPTEKEKNEITWVIPHQVNRKLIDQVLHENNLNNKIIIWDADTIGNIGGASVLYTLARAVEEK
LFDRSGKILLMSVGGGLSYAGQVLNYQKASYSN

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family [H]

Homologues:

Organism=Escherichia coli, GI1787333, Length=223, Percent_Identity=24.2152466367713, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C [H]

EC number: =2.3.1.180 [H]

Molecular weight: Translated: 39191; Mature: 39191

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILKPNIQFEITGASRILPASGPITNLEILKNFPRTADKSQGFLEKFAEKIGEEFGFHT
CCCCCCCCEEEECCCCEEECCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC
RYWCHKPWESLDNSRELSSESLAMQAVDKLITHSMSKDVDAFLLGSTTNKRFTGSQAAAV
EEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHH
LGNLKLNAPAYDLKTGCSTSLSTLHFAYALMALGYQKILVCCSETLSKVIDPENEKTWIG
HHCCEECCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
LADGAASLLLEKSKEGSFTIEKSFFSTDGQYVNAFTTQGVFPPTHEQIDSVGYHLVGDET
ECCCHHHHHHHCCCCCCEEEEHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCEEECCHH
LMKELAYSRYMQMLDHLLPTEKEKNEITWVIPHQVNRKLIDQVLHENNLNNKIIIWDADT
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHCHHHHHHHHHHCCCCCEEEEEECCC
IGNIGGASVLYTLARAVEEKLFDRSGKILLMSVGGGLSYAGQVLNYQKASYSN
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNILKPNIQFEITGASRILPASGPITNLEILKNFPRTADKSQGFLEKFAEKIGEEFGFHT
CCCCCCCCEEEECCCCEEECCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC
RYWCHKPWESLDNSRELSSESLAMQAVDKLITHSMSKDVDAFLLGSTTNKRFTGSQAAAV
EEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHH
LGNLKLNAPAYDLKTGCSTSLSTLHFAYALMALGYQKILVCCSETLSKVIDPENEKTWIG
HHCCEECCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
LADGAASLLLEKSKEGSFTIEKSFFSTDGQYVNAFTTQGVFPPTHEQIDSVGYHLVGDET
ECCCHHHHHHHCCCCCCEEEEHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCEEECCHH
LMKELAYSRYMQMLDHLLPTEKEKNEITWVIPHQVNRKLIDQVLHENNLNNKIIIWDADT
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHCHHHHHHHHHHCCCCCEEEEEECCC
IGNIGGASVLYTLARAVEEKLFDRSGKILLMSVGGGLSYAGQVLNYQKASYSN
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]