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The map label for this gene is merA1

Identifier: 52841792

GI number: 52841792

Start: 1727278

End: 1729422

Strand: Direct

Name: merA1

Synonym: lpg1562

Alternate gene names: 52841792

Gene position: 1727278-1729422 (Clockwise)

Preceding gene: 52841791

Following gene: 52841795

Centisome position: 50.84

GC content: 40.28

Gene sequence:

>2145_bases
ATGATTAAAAAAATACATCGTTGGTTGCCTTTGCTTGTATTAATCGGGCTATTGGTGCTTTTCTTCAGCCTACACCTTGA
TAAATACTTAAGTTTTAATGCGTTAAGAGAAAATCATGCTTTACTCATTGCGTGGACCCAAACTCATTATTTTATTGCGC
CACTGATTTTTATTGTTTTTTATACCACTGCTGTAGCCATCTCTATTCCAGGAGCAGTTCTTCTTACTTTAACTGGAGGA
TTTTTATTCGGAGTATTCTGGGGCGTGTTATTTGTAGTCATCAGCGCTACGCTTGGGGCCACCATACTGTTTTTTGCCGT
TCGCACTGCTTTGGGCGACTGGTTTGCCCAAAAGGCATCTGGATGGATAGAGCGTATGCGTCAGGGATTTCAGCATAATG
CTTTTTCTTATTTAGTTACACTGCGATTAATTCCATTATTTCCCTTTTGGGCAGTTAATATTGTACCGGCTCTTTTAAAC
ATTCGAGCAAAAACATTCATTACAGCGACTTTTATTGGCATCATTCCAGGAACAACAGTATATGTAATGGTTGGAAATGG
TTTAAGCCAAATATTTGCAGCCAATCAGACGCCTAATCTTGGGATCATATTTGAACTGCAAATATTAGGTCCACTGCTCG
CGTTGGCTGTTCTCTCTCTAATGCCAGTTCTTTATCAATTCTCAACTCGCAAGCATCAGAATCATCACAGTTTCTCAGAT
ATTAGTCGAGTAATAAATTGTGATTTAGCCATTATAGGTGGTGGTGCCGGAGGTTTGAGTTTAGCTTCCGGTTGTTCACA
GTTAGGACTCAAAGTTGTTTTGGTGGAATCAGGGAAAATGGGAGGAGACTGTTTAAATTACGGTTGTATCCCATCCAAAT
CCTTACTTGCTGCAGCCAAGACGTTTTATTATGCAAAACATGCAACACATTTTGGAGTACATACTGAAGCAATAAAAATT
AATTTTCAACAAGTAATGCAACATGTGCATCAAATCATAGACAACATTTCTGAACACGATTCTGTCCAACGTTTTGAGTC
GCTAGGAGTGCAGGTCATTAAACAAGTTGGGAAATTTTTAAACCCTGATACCTTACAAGCTGGCGATAGCATTATTAAAG
CGAAACGCTTCGTGGTTGCAACAGGTTCATCACCATTTATCCCACCCATTCCCGGATTGGATGCAGTCTCCTACTTCACC
AATGAAACGATTTTTGATTTAAAGGAACAACCTGAGCACTTGATTGTCATCGGTGGTGGCCCTATTGGTTGTGAACTTGC
TCAAGCGTTCGCCATGCTCGGTTCTAAAGTTACTCTGCTCGAAGGATTGAATCTTCTTCCCAAGGACGATCCTGATTGTG
TTGCTGTCCTACGCACACAGATGAAATCGATGAGTATTGTCATTCATGAACAAATCGAGATTACGCAAATAAACTCTCAT
CCTGATACGGGTATCTCCGTATGTTTTGAATTTCAAAACACACAATTCACAATTACAGCCAGTCATCTGCTCATTGCAAC
TGGGCGTCGGGCGAATGTAAAGCCTCTTGATTTGGAAAAAGCAGGGGTTAAACTCACCAGCAAAGGTGTCGAAGTAAATA
AATACCTACAAACCAGTAATAAAAAAATCTATGCTCTGGGTGATGTAACAGGGCTTTACCAGTTTACTCATATGGCGAGT
TATCAGGCCAGTATAGTGCTTCGTAATATTGTTTTTAAACTACCGTCTAAAGTGGATTATAGAGCGATTCCATGGGTCAC
TTATACTGATCCCGAATTAGCTCATGTTGGAATAGGAGTCAGTGATGCCTTGAAGCACCCTGATGCCCAAATAATCGAAT
GGCCATTTGTCGATAATGATCGAGCACAAACTGAACGCTCGTTAAATGGAAAAATAAAAATCATCACGGACAAGAAAGCA
AGGATCCTTGGAGTCACCATAGTTGGCCCACATGCCGGAGAACTCATTTTACCTTGGGTTATGGCGATTCGTGAGAAAAA
AAACCTCCGAAGTTTTACTGATGTAATCGTTCCTTACCCTACTCTGAGTGAAATCAGCAAACGAGTTGCTGGTAGTTTTT
ATGCACCTAAATTATTTTCCAATAAAACACGAATGTTAGTTCGCTGGTTGCAAAAAATTGGGTAA

Upstream 100 bases:

>100_bases
ATTAAACCCTATCGATAATTAAGATATGACCTCAAAGTAAATTCCTGTTAGGATCTTCATATAATTTATATCAGCTTATC
GGGTTAAAGGAATAACATGA

Downstream 100 bases:

>100_bases
ATAGATTTTTAACTAACTATATGTTTTTTGGCTGAAAGAAAAAATTACAAGCTATTTAATTCAATCTTAAACGATGTTTG
ACTTCTTTTTCATCAGATAA

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 714; Mature: 714

Protein sequence:

>714_residues
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVFYTTAVAISIPGAVLLTLTGG
FLFGVFWGVLFVVISATLGATILFFAVRTALGDWFAQKASGWIERMRQGFQHNAFSYLVTLRLIPLFPFWAVNIVPALLN
IRAKTFITATFIGIIPGTTVYVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFSTRKHQNHHSFSD
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAKTFYYAKHATHFGVHTEAIKI
NFQQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFLNPDTLQAGDSIIKAKRFVVATGSSPFIPPIPGLDAVSYFT
NETIFDLKEQPEHLIVIGGGPIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMSIVIHEQIEITQINSH
PDTGISVCFEFQNTQFTITASHLLIATGRRANVKPLDLEKAGVKLTSKGVEVNKYLQTSNKKIYALGDVTGLYQFTHMAS
YQASIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGIGVSDALKHPDAQIIEWPFVDNDRAQTERSLNGKIKIITDKKA
RILGVTIVGPHAGELILPWVMAIREKKNLRSFTDVIVPYPTLSEISKRVAGSFYAPKLFSNKTRMLVRWLQKIG

Sequences:

>Translated_714_residues
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVFYTTAVAISIPGAVLLTLTGG
FLFGVFWGVLFVVISATLGATILFFAVRTALGDWFAQKASGWIERMRQGFQHNAFSYLVTLRLIPLFPFWAVNIVPALLN
IRAKTFITATFIGIIPGTTVYVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFSTRKHQNHHSFSD
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAKTFYYAKHATHFGVHTEAIKI
NFQQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFLNPDTLQAGDSIIKAKRFVVATGSSPFIPPIPGLDAVSYFT
NETIFDLKEQPEHLIVIGGGPIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMSIVIHEQIEITQINSH
PDTGISVCFEFQNTQFTITASHLLIATGRRANVKPLDLEKAGVKLTSKGVEVNKYLQTSNKKIYALGDVTGLYQFTHMAS
YQASIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGIGVSDALKHPDAQIIEWPFVDNDRAQTERSLNGKIKIITDKKA
RILGVTIVGPHAGELILPWVMAIREKKNLRSFTDVIVPYPTLSEISKRVAGSFYAPKLFSNKTRMLVRWLQKIG
>Mature_714_residues
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVFYTTAVAISIPGAVLLTLTGG
FLFGVFWGVLFVVISATLGATILFFAVRTALGDWFAQKASGWIERMRQGFQHNAFSYLVTLRLIPLFPFWAVNIVPALLN
IRAKTFITATFIGIIPGTTVYVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFSTRKHQNHHSFSD
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAKTFYYAKHATHFGVHTEAIKI
NFQQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFLNPDTLQAGDSIIKAKRFVVATGSSPFIPPIPGLDAVSYFT
NETIFDLKEQPEHLIVIGGGPIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMSIVIHEQIEITQINSH
PDTGISVCFEFQNTQFTITASHLLIATGRRANVKPLDLEKAGVKLTSKGVEVNKYLQTSNKKIYALGDVTGLYQFTHMAS
YQASIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGIGVSDALKHPDAQIIEWPFVDNDRAQTERSLNGKIKIITDKKA
RILGVTIVGPHAGELILPWVMAIREKKNLRSFTDVIVPYPTLSEISKRVAGSFYAPKLFSNKTRMLVRWLQKIG

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=497, Percent_Identity=29.7786720321932, Blast_Score=183, Evalue=5e-46,
Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=25.2136752136752, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI33519430, Length=449, Percent_Identity=24.2761692650334, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI33519428, Length=449, Percent_Identity=24.2761692650334, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI33519426, Length=449, Percent_Identity=24.2761692650334, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI148277065, Length=449, Percent_Identity=24.2761692650334, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI148277071, Length=449, Percent_Identity=24.2761692650334, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI22035672, Length=467, Percent_Identity=24.4111349036403, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI291045266, Length=447, Percent_Identity=23.0425055928412, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI66392190, Length=190, Percent_Identity=26.8421052631579, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI291045268, Length=442, Percent_Identity=22.3981900452489, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1786307, Length=455, Percent_Identity=30.989010989011, Blast_Score=181, Evalue=2e-46,
Organism=Escherichia coli, GI87081717, Length=446, Percent_Identity=29.372197309417, Blast_Score=156, Evalue=5e-39,
Organism=Escherichia coli, GI87082354, Length=470, Percent_Identity=27.2340425531915, Blast_Score=139, Evalue=8e-34,
Organism=Escherichia coli, GI1789915, Length=430, Percent_Identity=26.9767441860465, Blast_Score=128, Evalue=2e-30,
Organism=Escherichia coli, GI1789065, Length=182, Percent_Identity=30.2197802197802, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI32565766, Length=483, Percent_Identity=30.6418219461698, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17557007, Length=469, Percent_Identity=25.5863539445629, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71983419, Length=353, Percent_Identity=26.3456090651558, Blast_Score=106, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71983429, Length=353, Percent_Identity=26.3456090651558, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71982272, Length=473, Percent_Identity=26.215644820296, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17532687, Length=236, Percent_Identity=22.8813559322034, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=506, Percent_Identity=31.2252964426877, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=26.2931034482759, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6325240, Length=477, Percent_Identity=25.5765199161426, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21358499, Length=477, Percent_Identity=29.3501048218029, Blast_Score=172, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=26.6949152542373, Blast_Score=133, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=26.6949152542373, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=26.6949152542373, Blast_Score=132, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=23.8900634249471, Blast_Score=110, Evalue=4e-24,
Organism=Drosophila melanogaster, GI18859941, Length=195, Percent_Identity=23.0769230769231, Blast_Score=74, Evalue=5e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 78790; Mature: 78790

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHH
YTTAVAISIPGAVLLTLTGGFLFGVFWGVLFVVISATLGATILFFAVRTALGDWFAQKAS
HHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GWIERMRQGFQHNAFSYLVTLRLIPLFPFWAVNIVPALLNIRAKTFITATFIGIIPGTTV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
YVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFSTRKHQNHHSFSD
EEEECCCHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAK
HHHHHCCCEEEEECCCCHHHHHHCHHHCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
TFYYAKHATHFGVHTEAIKINFQQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFL
HHHHHHHCCCCCCEEHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NPDTLQAGDSIIKAKRFVVATGSSPFIPPIPGLDAVSYFTNETIFDLKEQPEHLIVIGGG
CCCHHHCCHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCCCCEEEEECCC
PIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMSIVIHEQIEITQINSH
CCHHHHHHHHHHHCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHHEEEEEEEEEEEEECCC
PDTGISVCFEFQNTQFTITASHLLIATGRRANVKPLDLEKAGVKLTSKGVEVNKYLQTSN
CCCCEEEEEEECCCEEEEEEEEEEEEECCCCCCCCCCCHHCCCEEECCCCCHHHHHHCCC
KKIYALGDVTGLYQFTHMASYQASIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGIGV
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEECCCCCEEECCCH
SDALKHPDAQIIEWPFVDNDRAQTERSLNGKIKIITDKKARILGVTIVGPHAGELILPWV
HHHHCCCCCCEEECCCCCCCHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCCHHHHHH
MAIREKKNLRSFTDVIVPYPTLSEISKRVAGSFYAPKLFSNKTRMLVRWLQKIG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHH
YTTAVAISIPGAVLLTLTGGFLFGVFWGVLFVVISATLGATILFFAVRTALGDWFAQKAS
HHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GWIERMRQGFQHNAFSYLVTLRLIPLFPFWAVNIVPALLNIRAKTFITATFIGIIPGTTV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
YVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFSTRKHQNHHSFSD
EEEECCCHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAK
HHHHHCCCEEEEECCCCHHHHHHCHHHCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
TFYYAKHATHFGVHTEAIKINFQQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFL
HHHHHHHCCCCCCEEHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NPDTLQAGDSIIKAKRFVVATGSSPFIPPIPGLDAVSYFTNETIFDLKEQPEHLIVIGGG
CCCHHHCCHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCCCCEEEEECCC
PIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMSIVIHEQIEITQINSH
CCHHHHHHHHHHHCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHHEEEEEEEEEEEEECCC
PDTGISVCFEFQNTQFTITASHLLIATGRRANVKPLDLEKAGVKLTSKGVEVNKYLQTSN
CCCCEEEEEEECCCEEEEEEEEEEEEECCCCCCCCCCCHHCCCEEECCCCCHHHHHHCCC
KKIYALGDVTGLYQFTHMASYQASIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGIGV
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEECCCCCEEECCCH
SDALKHPDAQIIEWPFVDNDRAQTERSLNGKIKIITDKKARILGVTIVGPHAGELILPWV
HHHHCCCCCCEEECCCCCCCHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCCHHHHHH
MAIREKKNLRSFTDVIVPYPTLSEISKRVAGSFYAPKLFSNKTRMLVRWLQKIG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]