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The map label for this gene is hutU [H]

Identifier: 52841609

GI number: 52841609

Start: 1526021

End: 1527688

Strand: Direct

Name: hutU [H]

Synonym: lpg1379

Alternate gene names: 52841609

Gene position: 1526021-1527688 (Clockwise)

Preceding gene: 52841603

Following gene: 52841610

Centisome position: 44.91

GC content: 43.35

Gene sequence:

>1668_bases
TTGATGAACAAGGACAAGAATAAACGTGTTATTTCTGCCCCTAGAGGTACCGAAATTCAAGCTAAAAATTGGTTAACTGA
GGCGGCATTAAGGATGATTTGCAATAATTTGGATCCCAATGTTGCAGAGGATCCCGATTCTTTGATTGTTTATGGTGGAT
TGGGCAAGGCAGCCAGAAACTGGGAATGTTTTGATGAAATTGTTCATGTATTGAAATTATTAAATAATGATCAGACTTTA
CTCATTCAGTCCGGAAAACCTGTCGGTGTATTTACTACCCATGAAGAGGCTCCCAGAATACTAATTGCCAATTCTAATTT
GGTACCGCGCTGGGCTACTTGGGAGCATTTTAACGAACTGGATAAGAAAGGCCTGATGATGTATGGCCAGATGACCGCCG
GCAGCTGGATTTATATTGGTTCTCAAGGCATTGTGCAAGGAACTTATGAGACATTTGTTGCGGCAGCTAAAAAACATTAT
CAGGGTGATTTGTCCGGGCGTTGGATTTTAACAGCGGGTTTAGGGGGAATGGGGGGAGCTCAACCCTTGGCTGGAACTAT
GGCTGGTGCCAGCGTTCTTGCTGTAGAATGTGACAGACAAAGGATTGAGAAACGTTTACAGACAAAGTATCTGGATCGGT
ACACTGATAATTTAAGTGAAGCATTAGACTGGATTAATGAATCCTGTCGCCGTAAAAAGCCAGTTTCAGTAGCTGTTTTG
GGAAATGCTGCTGAAATATTTCCTCAACTGGTTAAGTTGGGAGTGCAGCCTTCTCTGGTTACCGATCAAACCAGCGCTCA
TGATCCGCTCAATGGCTATTTGCCATTAGGATGGACATTAGAACAAGCTGTTGAAATGAGAAAAAAATCACCAGAAGAGG
TTGTTGATGCAGCCAAGAAATCGATGGCTGTTCAAGTGCATGCAATGCTTGAATTTCATAATAGAGGCATTCCTGTATTT
GATTATGGCAATAACATCAGACAAATGGCATTTGAAGCGGGAGAAAAAAACGCTTTTTCCTTTGAGGGATTTGTACCTGC
TTATATCAGGCCATTATTTTGCGAAGGAATTGGACCATTTCGATGGGTTGCATTGTCAGGTGATCCAGAAGATATTTATG
CAACGGATGAGCGAGTAAAGCAGTTAATTCCTGACGCTCCTCATTTGCATCATTGGTTAGATATGGCCAGGGAAAAAATT
TCATTTCAGGGATTACCAGCAAGGATATGTTGGGTAGGGTTAAAGGATAGAGCACGCCTTGCCCTGGCTTTCAATGAAAT
GGTTAAAAATAAACAAGTTAAAGCGCCTATTGTGATTGGCCGTGACCATTTGGATTCTGGTTCTGTGGCTAGCCCCAATC
GTGAAACAGAAGGTATGCTGGATGGCAGTGATGCTGTTTCTGATTGGCCTTTGCTTAATGCGCTGTTAAATTGTGCCAGT
GGGGCTACTTGGGTAAGTATTCACCACGGAGGAGGGGTTGGTATGGGCTTTTCGCAACATGCTGGCGTTGTGATTGTTGC
TGATGGGACAGAAAAGGCAGCTAAACGATTAGCCCGTGTGTTACACAATGATCCTGCGACAGGGGTAATGAGGCATGCTG
ATGCAGGTTATCAAATTGCCAAGCAATGTGCCAAAGAGAACTCGCTTTGGCTACCCATGGAATCTTAA

Upstream 100 bases:

>100_bases
TTCCCGGAGGTAGTTGACTGGTGTATGATGCTAAAAAATTTTTTAATCGCTATTTGATGGGAAATAATAACTGAAGTTTT
CATAGCAATAAGGAGTATTC

Downstream 100 bases:

>100_bases
AAGGAGCAGGTTTATGTCAGAACAGTTTATATTGCAGCCTGGTCAGTTATCGCTACTTTCTATTAAACAAATTTTAGATG
AGGAACTATCTTGCGTTCTT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MMNKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARNWECFDEIVHVLKLLNNDQTL
LIQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNELDKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHY
QGDLSGRWILTAGLGGMGGAQPLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRRKKPVSVAVL
GNAAEIFPQLVKLGVQPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKKSMAVQVHAMLEFHNRGIPVF
DYGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYATDERVKQLIPDAPHLHHWLDMAREKI
SFQGLPARICWVGLKDRARLALAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCAS
GATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIAKQCAKENSLWLPMES

Sequences:

>Translated_555_residues
MMNKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARNWECFDEIVHVLKLLNNDQTL
LIQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNELDKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHY
QGDLSGRWILTAGLGGMGGAQPLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRRKKPVSVAVL
GNAAEIFPQLVKLGVQPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKKSMAVQVHAMLEFHNRGIPVF
DYGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYATDERVKQLIPDAPHLHHWLDMAREKI
SFQGLPARICWVGLKDRARLALAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCAS
GATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIAKQCAKENSLWLPMES
>Mature_555_residues
MMNKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARNWECFDEIVHVLKLLNNDQTL
LIQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNELDKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHY
QGDLSGRWILTAGLGGMGGAQPLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRRKKPVSVAVL
GNAAEIFPQLVKLGVQPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKKSMAVQVHAMLEFHNRGIPVF
DYGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYATDERVKQLIPDAPHLHHWLDMAREKI
SFQGLPARICWVGLKDRARLALAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCAS
GATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIAKQCAKENSLWLPMES

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=554, Percent_Identity=35.1985559566787, Blast_Score=318, Evalue=1e-86,
Organism=Homo sapiens, GI260306182, Length=614, Percent_Identity=32.2475570032573, Blast_Score=292, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI71997891, Length=560, Percent_Identity=35.5357142857143, Blast_Score=333, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61132; Mature: 61132

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARN
CCCCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCC
WECFDEIVHVLKLLNNDQTLLIQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNEL
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHH
DKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHYQGDLSGRWILTAGLGGMGGA
CCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCC
QPLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRRKKPVSVAVL
CCHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
GNAAEIFPQLVKLGVQPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKK
CCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
SMAVQVHAMLEFHNRGIPVFDYGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPF
HHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCE
RWVALSGDPEDIYATDERVKQLIPDAPHLHHWLDMAREKISFQGLPARICWVGLKDRARL
EEEEECCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHH
ALAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCAS
HHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
GATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHH
KQCAKENSLWLPMES
HHHHCCCCEEECCCC
>Mature Secondary Structure
MMNKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARN
CCCCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCC
WECFDEIVHVLKLLNNDQTLLIQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNEL
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHH
DKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHYQGDLSGRWILTAGLGGMGGA
CCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCC
QPLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRRKKPVSVAVL
CCHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
GNAAEIFPQLVKLGVQPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKK
CCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
SMAVQVHAMLEFHNRGIPVFDYGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPF
HHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCE
RWVALSGDPEDIYATDERVKQLIPDAPHLHHWLDMAREKISFQGLPARICWVGLKDRARL
EEEEECCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHH
ALAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCAS
HHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
GATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHH
KQCAKENSLWLPMES
HHHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA