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The map label for this gene is hutH [H]

Identifier: 52841610

GI number: 52841610

Start: 1527615

End: 1529222

Strand: Direct

Name: hutH [H]

Synonym: lpg1380

Alternate gene names: 52841610

Gene position: 1527615-1529222 (Clockwise)

Preceding gene: 52841609

Following gene: 52841611

Centisome position: 44.96

GC content: 40.36

Gene sequence:

>1608_bases
ATGCTGATGCAGGTTATCAAATTGCCAAGCAATGTGCCAAAGAGAACTCGCTTTGGCTACCCATGGAATCTTAAAAGGAG
CAGGTTTATGTCAGAACAGTTTATATTGCAGCCTGGTCAGTTATCGCTACTTTCTATTAAACAAATTTTAGATGAGGAAC
TATCTTGCGTTCTTGCTGAGAATTCCTTTGAATTAATTAGAGCCTCTCACCAAACGGTTAAAAAAGTAATTGATGAAAAG
AAAACTGTATACGGAATCAATACAGGTTTTGGTTCTCTGGCAAACCAGACCATTTCTTCAGATTGTTTGAAAGAGTTGCA
GCGTAATATTGTGCTTTCTCATGCTTGTGGAACGGGTAAATTATTGCCGGATGACGTGGTTGCCTTGATTTTGCTTTTGA
AAATTAATAATTTGTCTCAAGGGTATTCCGGAGTTAGGCTGGAATTAATTAATGCCTTGATTGCTTTGTTTAATCATAAA
GTATATCCATGCATTCCCTCTAAAGGTTCGGTAGGTGCGTCCGGAGATTTAGTCCCGCTTGCACATTTGTCTTTACCTTT
GTTAGGAGAAGGCGAAGTAAGACATCAAGGTCAGGTGATCAGTGCTGAGGAAGGACTAAAACTGGCCGGATTGAAACCGC
TTGAATTGGAAGCTAAAGAAGGATTAGCACTGCTTAATGGCTTACAGGTATCTACCGCTTTAGCTTTGTCAGCTCTGTTT
ATTAGTGAGACATTGTTTGAAACTGCGATTATTTCCGGCAGTTTATCAGTAGATGCTGCCAGTGGGAGTGATGTCCCCTT
TGATGACAGAATACACCAAATTCGAGGACATCAAGCTCAAATTTCTGCTGCCAGTATGTACAGAAATTTATTGGCAGGTA
GTCAAATTCGAGAGTCACACAGGCATTGTAATCGTGTTCAGGACCCTTATTCTTTAAGATGTCAGCCACAAATCATGGGT
GCAATTCTTCATCAGATGCAGTTTGTTGGACAAACTCTCCAAGTAGAGGCCAATGCAATTTCCGATAATCCTCTCGTTTT
TGCAGAGCAGGGGGATATTTTGTCTGGGGGAAATTTTCATGGTGAAATCATCGCAATGGCTGCTGACAATTTGGCATTGG
CATTATCCGAGATAGGAGGTAGTGCAGAACGCCGAATTGCTTTATTAATTGATAAAAATTTTAGTGGATTACCCGCGTTC
CTGGTTAGAGAAAGCGGCTTAAATTCAGGTTTTATGATTGCACATGTAACTGCCGCTTCTTGTGCCAGCGATAACAAAGC
GCTTGCTCATCCACACTCCGTTGATAGTTTGCCTACCTCGGCAAATCAGGAAGATCATGTTTCTATGGCAACTAGTGCAG
CACGTCGACTGCATGAAATGATCGATAATACTTCAACAATTCTTGCTATTGAGTTATTGGCAGCTTGTCAAGGGCTGGAG
TTTCATAAACCTCTAAAGACATCACCGCAATTGGATAAAATTTATCAAAGCGTAAGAAGCGTGGTTAAAGAGTATGATAA
AGATCGCTATTTTGCACCTGATATAGAAAAAATTAAAAAGAAGATTTTGGATAAAGAATTCTCATTGCTCACACTCACGA
ACGAATAG

Upstream 100 bases:

>100_bases
CAACATGCTGGCGTTGTGATTGTTGCTGATGGGACAGAAAAGGCAGCTAAACGATTAGCCCGTGTGTTACACAATGATCC
TGCGACAGGGGTAATGAGGC

Downstream 100 bases:

>100_bases
CAGGAAAAATACAATGGAATTGATGGCAGAATATCTAACTTTGCATCAACAACACAAAAACAATCCTTATCCTTCTTTGT
CTGAAAGAAAAAAATTGCTG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MLMQVIKLPSNVPKRTRFGYPWNLKRSRFMSEQFILQPGQLSLLSIKQILDEELSCVLAENSFELIRASHQTVKKVIDEK
KTVYGINTGFGSLANQTISSDCLKELQRNIVLSHACGTGKLLPDDVVALILLLKINNLSQGYSGVRLELINALIALFNHK
VYPCIPSKGSVGASGDLVPLAHLSLPLLGEGEVRHQGQVISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALF
ISETLFETAIISGSLSVDAASGSDVPFDDRIHQIRGHQAQISAASMYRNLLAGSQIRESHRHCNRVQDPYSLRCQPQIMG
AILHQMQFVGQTLQVEANAISDNPLVFAEQGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAF
LVRESGLNSGFMIAHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLE
FHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKIKKKILDKEFSLLTLTNE

Sequences:

>Translated_535_residues
MLMQVIKLPSNVPKRTRFGYPWNLKRSRFMSEQFILQPGQLSLLSIKQILDEELSCVLAENSFELIRASHQTVKKVIDEK
KTVYGINTGFGSLANQTISSDCLKELQRNIVLSHACGTGKLLPDDVVALILLLKINNLSQGYSGVRLELINALIALFNHK
VYPCIPSKGSVGASGDLVPLAHLSLPLLGEGEVRHQGQVISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALF
ISETLFETAIISGSLSVDAASGSDVPFDDRIHQIRGHQAQISAASMYRNLLAGSQIRESHRHCNRVQDPYSLRCQPQIMG
AILHQMQFVGQTLQVEANAISDNPLVFAEQGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAF
LVRESGLNSGFMIAHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLE
FHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKIKKKILDKEFSLLTLTNE
>Mature_535_residues
MLMQVIKLPSNVPKRTRFGYPWNLKRSRFMSEQFILQPGQLSLLSIKQILDEELSCVLAENSFELIRASHQTVKKVIDEK
KTVYGINTGFGSLANQTISSDCLKELQRNIVLSHACGTGKLLPDDVVALILLLKINNLSQGYSGVRLELINALIALFNHK
VYPCIPSKGSVGASGDLVPLAHLSLPLLGEGEVRHQGQVISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALF
ISETLFETAIISGSLSVDAASGSDVPFDDRIHQIRGHQAQISAASMYRNLLAGSQIRESHRHCNRVQDPYSLRCQPQIMG
AILHQMQFVGQTLQVEANAISDNPLVFAEQGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAF
LVRESGLNSGFMIAHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLE
FHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKIKKKILDKEFSLLTLTNE

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=466, Percent_Identity=47.8540772532189, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17567831, Length=498, Percent_Identity=44.1767068273092, Blast_Score=385, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 58267; Mature: 58267

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMQVIKLPSNVPKRTRFGYPWNLKRSRFMSEQFILQPGQLSLLSIKQILDEELSCVLAE
CCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEC
NSFELIRASHQTVKKVIDEKKTVYGINTGFGSLANQTISSDCLKELQRNIVLSHACGTGK
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
LLPDDVVALILLLKINNLSQGYSGVRLELINALIALFNHKVYPCIPSKGSVGASGDLVPL
CCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEEH
AHLSLPLLGEGEVRHQGQVISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALF
HHCCCCCCCCCCCCCCCEEEECCCCCEECCCCCCCCCHHCCHHHHHCHHHHHHHHHHHHH
ISETLFETAIISGSLSVDAASGSDVPFDDRIHQIRGHQAQISAASMYRNLLAGSQIRESH
HHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHH
RHCNRVQDPYSLRCQPQIMGAILHQMQFVGQTLQVEANAISDNPLVFAEQGDILSGGNFH
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCEECCCCCC
GEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAAS
CEEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHEECCCCCCCEEEEEEEHHH
CASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLE
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
FHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKIKKKILDKEFSLLTLTNE
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MLMQVIKLPSNVPKRTRFGYPWNLKRSRFMSEQFILQPGQLSLLSIKQILDEELSCVLAE
CCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEC
NSFELIRASHQTVKKVIDEKKTVYGINTGFGSLANQTISSDCLKELQRNIVLSHACGTGK
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
LLPDDVVALILLLKINNLSQGYSGVRLELINALIALFNHKVYPCIPSKGSVGASGDLVPL
CCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEEH
AHLSLPLLGEGEVRHQGQVISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALF
HHCCCCCCCCCCCCCCCEEEECCCCCEECCCCCCCCCHHCCHHHHHCHHHHHHHHHHHHH
ISETLFETAIISGSLSVDAASGSDVPFDDRIHQIRGHQAQISAASMYRNLLAGSQIRESH
HHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHH
RHCNRVQDPYSLRCQPQIMGAILHQMQFVGQTLQVEANAISDNPLVFAEQGDILSGGNFH
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCEECCCCCC
GEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAAS
CEEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHEECCCCCCCEEEEEEEHHH
CASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLE
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
FHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKIKKKILDKEFSLLTLTNE
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA