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The map label for this gene is virB11

Identifier: 52841478

GI number: 52841478

Start: 1376276

End: 1377313

Strand: Reverse

Name: virB11

Synonym: lpg1246

Alternate gene names: 52841478

Gene position: 1377313-1376276 (Counterclockwise)

Preceding gene: 52841479

Following gene: 52841477

Centisome position: 40.54

GC content: 44.61

Gene sequence:

>1038_bases
TTGATTTCTACCGTGTGGCTGGGAGGGCATAATATGGAAGCCATCAACGCCTGCTTCTCGCCCGGCGCAACAGGACTTTT
ATCTCCATTGCAGGATTTTCTGGAAGATGAGCACGTTTCTGAGATTTTAATCAATAAGCCCAAAGAGGTTTTTATCGAGC
GACACGGGCAATTGACTCGTTTTGATATTCCGGTATTAACGTCTCAATACCTGCGGCGTTTGTTTTTACTCATAGCCAAT
GAAAACAAACAAACTTTATCGGAGTCAACGCCCGTGCTTTCTGGAAATCTGGCCGATGGCTCAAGGGTACAACTGGTGAT
TCCACCAGCTTCCCTATATGAAACACTGTCCATCCGAAAATTTAGCTTAAAACAGGTCAGCTTCGACGAATACAAAACCA
AGGGCTTTTTTTCATCGGCGCGTGGGGTTGGAATTAAGGAGCATTCCGAGTGCCTTGATAAATCCGATGAGCTGCTTGAA
CTCTACGATACGAAAAACTGGCAGGAATTTATAAGGCAAGCTATTGTGAGTAAAAAAAACATTATCATATCGGGTGGAAC
CTCTTCGGGTAAAACGACCTTTTTAAACAGTTGTGTCGGACAAATACCACTTCATGAACGCCTCATTACCCTTGAAGATA
CGTATGAAATGGATGTCCCCCACACCAATATCGTTCGTCTAAAAGCATTAAAACAAGTTGGAGAGCAAACACAAAAAATC
ACCATGCAGGATTTGGTTCAAGCCACTTTAAGACTCAGACCCGACCGCATCATCATGGGCGAAATTCGTGGGCGAGAACT
CTTTGATTTTGTATCAGCCTGTTCCACAGGGCATAGCGGTGCACTGGCTACCATCCATGCCAATAACCCAAAAGTGGCCT
TCATGCGCATGGCGCAACTCTACAAGCTTAATCAGGTTGCAGGCATGGATGAAGCTGATATTTACAAGGTGTTACATGAA
GTCATTGATGTCATCGTCCAGTTACAAAAAACGCCTGACGGCAGGCGTTTGGTGGAGGTGTATTATAAACAGGCGTAA

Upstream 100 bases:

>100_bases
CAACAAGCGGCAAATCAAACTCTACAGCAAGATATGCAAACACGCCCGACTTTGCAAATCAATCAGGGAGCTGCCATTAA
CGTGTTTGTAGCACACGACC

Downstream 100 bases:

>100_bases
TCCATGGGTTGTTACCATTACCTTGATAGGTGGGCTTGCTATAACCGGCCAAATGGCAGTGCTGTTAACTGGGATCGCAG
AATGGGCAAGTCCGTTGGTA

Product: LvhB11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MISTVWLGGHNMEAINACFSPGATGLLSPLQDFLEDEHVSEILINKPKEVFIERHGQLTRFDIPVLTSQYLRRLFLLIAN
ENKQTLSESTPVLSGNLADGSRVQLVIPPASLYETLSIRKFSLKQVSFDEYKTKGFFSSARGVGIKEHSECLDKSDELLE
LYDTKNWQEFIRQAIVSKKNIIISGGTSSGKTTFLNSCVGQIPLHERLITLEDTYEMDVPHTNIVRLKALKQVGEQTQKI
TMQDLVQATLRLRPDRIIMGEIRGRELFDFVSACSTGHSGALATIHANNPKVAFMRMAQLYKLNQVAGMDEADIYKVLHE
VIDVIVQLQKTPDGRRLVEVYYKQA

Sequences:

>Translated_345_residues
MISTVWLGGHNMEAINACFSPGATGLLSPLQDFLEDEHVSEILINKPKEVFIERHGQLTRFDIPVLTSQYLRRLFLLIAN
ENKQTLSESTPVLSGNLADGSRVQLVIPPASLYETLSIRKFSLKQVSFDEYKTKGFFSSARGVGIKEHSECLDKSDELLE
LYDTKNWQEFIRQAIVSKKNIIISGGTSSGKTTFLNSCVGQIPLHERLITLEDTYEMDVPHTNIVRLKALKQVGEQTQKI
TMQDLVQATLRLRPDRIIMGEIRGRELFDFVSACSTGHSGALATIHANNPKVAFMRMAQLYKLNQVAGMDEADIYKVLHE
VIDVIVQLQKTPDGRRLVEVYYKQA
>Mature_345_residues
MISTVWLGGHNMEAINACFSPGATGLLSPLQDFLEDEHVSEILINKPKEVFIERHGQLTRFDIPVLTSQYLRRLFLLIAN
ENKQTLSESTPVLSGNLADGSRVQLVIPPASLYETLSIRKFSLKQVSFDEYKTKGFFSSARGVGIKEHSECLDKSDELLE
LYDTKNWQEFIRQAIVSKKNIIISGGTSSGKTTFLNSCVGQIPLHERLITLEDTYEMDVPHTNIVRLKALKQVGEQTQKI
TMQDLVQATLRLRPDRIIMGEIRGRELFDFVSACSTGHSGALATIHANNPKVAFMRMAQLYKLNQVAGMDEADIYKVLHE
VIDVIVQLQKTPDGRRLVEVYYKQA

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 38841; Mature: 38841

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISTVWLGGHNMEAINACFSPGATGLLSPLQDFLEDEHVSEILINKPKEVFIERHGQLTR
CCEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEE
FDIPVLTSQYLRRLFLLIANENKQTLSESTPVLSGNLADGSRVQLVIPPASLYETLSIRK
ECCHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEECCCCCCCEEEEEECCHHHHHHHHHHH
FSLKQVSFDEYKTKGFFSSARGVGIKEHSECLDKSDELLELYDTKNWQEFIRQAIVSKKN
HHHHHCCHHHHHHCCHHHHCCCCCCCHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCC
IIISGGTSSGKTTFLNSCVGQIPLHERLITLEDTYEMDVPHTNIVRLKALKQVGEQTQKI
EEEECCCCCCCHHHHHHHHHCCCHHHEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHH
TMQDLVQATLRLRPDRIIMGEIRGRELFDFVSACSTGHSGALATIHANNPKVAFMRMAQL
HHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHH
YKLNQVAGMDEADIYKVLHEVIDVIVQLQKTPDGRRLVEVYYKQA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MISTVWLGGHNMEAINACFSPGATGLLSPLQDFLEDEHVSEILINKPKEVFIERHGQLTR
CCEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEE
FDIPVLTSQYLRRLFLLIANENKQTLSESTPVLSGNLADGSRVQLVIPPASLYETLSIRK
ECCHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEECCCCCCCEEEEEECCHHHHHHHHHHH
FSLKQVSFDEYKTKGFFSSARGVGIKEHSECLDKSDELLELYDTKNWQEFIRQAIVSKKN
HHHHHCCHHHHHHCCHHHHCCCCCCCHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCC
IIISGGTSSGKTTFLNSCVGQIPLHERLITLEDTYEMDVPHTNIVRLKALKQVGEQTQKI
EEEECCCCCCCHHHHHHHHHCCCHHHEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHH
TMQDLVQATLRLRPDRIIMGEIRGRELFDFVSACSTGHSGALATIHANNPKVAFMRMAQL
HHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHH
YKLNQVAGMDEADIYKVLHEVIDVIVQLQKTPDGRRLVEVYYKQA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]