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The map label for this gene is virB10 [H]

Identifier: 52841479

GI number: 52841479

Start: 1377282

End: 1378373

Strand: Reverse

Name: virB10 [H]

Synonym: lpg1247

Alternate gene names: 52841479

Gene position: 1378373-1377282 (Counterclockwise)

Preceding gene: 52841480

Following gene: 52841478

Centisome position: 40.57

GC content: 47.25

Gene sequence:

>1092_bases
ATGAGCATTGATGATAAAAAGCGGGAAGACTCTTTGGGCAATCGAACTCAGGTTGCCAAAAATCCAAAGCACACAGCAAT
CAAAGACAAGTTATTGCTCGCAGGCGTTGTGGTGATTTGTATTGTCATCGGTATTGGCGGGTTATTCCCTAAACGAAAAG
CACATGCAGTGAGTGAGCCCGATGAAAAACAAAGTTTAAGCATGGCCTTAAACCAAAATCTGGAGTTGATTGCAGCCCTT
AAGGAGAACAATGCCAAAGCGCAATCGGGTTATAAAGGTGGCGACCCAAGGCGTCCCCCCTTACTAAAAACCATACAAAC
CCAAACGGTCAGCAAGGAAACTCTAGCCCGAATGAATGCACCCTCCACCTTTTTTAGTTCAGGCGGTAATGAGGTGATAA
GTAATACAACGGGTGGCGAAGTTCAAGCCAGCAAAACCCTGACAGGCCGTGATGGAAATTCTGAGTTTTTGAATCAGCAA
AATGATATTACATCGGTTTCTGCAAAACGATTACCGCATCCGGCCATGACCGTACCTGCAGGAGAAATGATTCCAGCAAC
GCTCGAAACCGCCATTAATTCGGAGTTGGCGGGTATGGTACGAGCAATTACAACAAGGGATATCTTTGCCTTGGAAGGCA
GTAAATTACTAATCCCCAAAGGCTCCACGCTAGTCGGACAATTTAATACCGCAATTACCCAAGGCCAAAGCCGAATCTTT
GTCGTATGGAATCGTTTGCAGATGACCAATGGCATCATCGTGACCTTAAATAGCCCCGGCAGTGACCCTATTGGTCGTTC
AGGACAAGCGGCTGATTACATTGACCGCCATTTCTTCGAGCGTTTCGGCACCGGTGCGCTTTTGTCTGTTTTGGGCGCGT
ATACCGCAACAGGTGGCGTTCATGGTCAGGACGAATACAACTCCATGTCACAGTACCGCATGAACATTGCGAGCAGTTTC
CAACAAGCGGCAAATCAAACTCTACAGCAAGATATGCAAACACGCCCGACTTTGCAAATCAATCAGGGAGCTGCCATTAA
CGTGTTTGTAGCACACGACCTTGATTTCTACCGTGTGGCTGGGAGGGCATAA

Upstream 100 bases:

>100_bases
AGCGTTTAGCTCCGCAATTTACTTTAAGACAAGGTGGCCTTACCGCTTCTGTTTTTAATACACCGGAAATCAATCGAATC
AGAGCCAACAGGAGGCCAAA

Downstream 100 bases:

>100_bases
TATGGAAGCCATCAACGCCTGCTTCTCGCCCGGCGCAACAGGACTTTTATCTCCATTGCAGGATTTTCTGGAAGATGAGC
ACGTTTCTGAGATTTTAATC

Product: LvhB10

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSIDDKKREDSLGNRTQVAKNPKHTAIKDKLLLAGVVVICIVIGIGGLFPKRKAHAVSEPDEKQSLSMALNQNLELIAAL
KENNAKAQSGYKGGDPRRPPLLKTIQTQTVSKETLARMNAPSTFFSSGGNEVISNTTGGEVQASKTLTGRDGNSEFLNQQ
NDITSVSAKRLPHPAMTVPAGEMIPATLETAINSELAGMVRAITTRDIFALEGSKLLIPKGSTLVGQFNTAITQGQSRIF
VVWNRLQMTNGIIVTLNSPGSDPIGRSGQAADYIDRHFFERFGTGALLSVLGAYTATGGVHGQDEYNSMSQYRMNIASSF
QQAANQTLQQDMQTRPTLQINQGAAINVFVAHDLDFYRVAGRA

Sequences:

>Translated_363_residues
MSIDDKKREDSLGNRTQVAKNPKHTAIKDKLLLAGVVVICIVIGIGGLFPKRKAHAVSEPDEKQSLSMALNQNLELIAAL
KENNAKAQSGYKGGDPRRPPLLKTIQTQTVSKETLARMNAPSTFFSSGGNEVISNTTGGEVQASKTLTGRDGNSEFLNQQ
NDITSVSAKRLPHPAMTVPAGEMIPATLETAINSELAGMVRAITTRDIFALEGSKLLIPKGSTLVGQFNTAITQGQSRIF
VVWNRLQMTNGIIVTLNSPGSDPIGRSGQAADYIDRHFFERFGTGALLSVLGAYTATGGVHGQDEYNSMSQYRMNIASSF
QQAANQTLQQDMQTRPTLQINQGAAINVFVAHDLDFYRVAGRA
>Mature_362_residues
SIDDKKREDSLGNRTQVAKNPKHTAIKDKLLLAGVVVICIVIGIGGLFPKRKAHAVSEPDEKQSLSMALNQNLELIAALK
ENNAKAQSGYKGGDPRRPPLLKTIQTQTVSKETLARMNAPSTFFSSGGNEVISNTTGGEVQASKTLTGRDGNSEFLNQQN
DITSVSAKRLPHPAMTVPAGEMIPATLETAINSELAGMVRAITTRDIFALEGSKLLIPKGSTLVGQFNTAITQGQSRIFV
VWNRLQMTNGIIVTLNSPGSDPIGRSGQAADYIDRHFFERFGTGALLSVLGAYTATGGVHGQDEYNSMSQYRMNIASSFQ
QAANQTLQQDMQTRPTLQINQGAAINVFVAHDLDFYRVAGRA

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG2948

COG function: function code U; Type IV secretory pathway, VirB10 components

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbI/virB10 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005498 [H]

Pfam domain/function: PF03743 TrbI [H]

EC number: NA

Molecular weight: Translated: 39118; Mature: 38987

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDDKKREDSLGNRTQVAKNPKHTAIKDKLLLAGVVVICIVIGIGGLFPKRKAHAVSEP
CCCCCCCHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCC
DEKQSLSMALNQNLELIAALKENNAKAQSGYKGGDPRRPPLLKTIQTQTVSKETLARMNA
HHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
PSTFFSSGGNEVISNTTGGEVQASKTLTGRDGNSEFLNQQNDITSVSAKRLPHPAMTVPA
CCHHHHCCCCCEECCCCCCCEEECCEECCCCCCHHHHCCCCCHHHHHHHHCCCCCEECCC
GEMIPATLETAINSELAGMVRAITTRDIFALEGSKLLIPKGSTLVGQFNTAITQGQSRIF
CCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEECCCCEEEEHHHHHHHCCCCEEE
VVWNRLQMTNGIIVTLNSPGSDPIGRSGQAADYIDRHFFERFGTGALLSVLGAYTATGGV
EEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
HGQDEYNSMSQYRMNIASSFQQAANQTLQQDMQTRPTLQINQGAAINVFVAHDLDFYRVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEECCCCHHHHC
GRA
CCC
>Mature Secondary Structure 
SIDDKKREDSLGNRTQVAKNPKHTAIKDKLLLAGVVVICIVIGIGGLFPKRKAHAVSEP
CCCCCCHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCC
DEKQSLSMALNQNLELIAALKENNAKAQSGYKGGDPRRPPLLKTIQTQTVSKETLARMNA
HHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
PSTFFSSGGNEVISNTTGGEVQASKTLTGRDGNSEFLNQQNDITSVSAKRLPHPAMTVPA
CCHHHHCCCCCEECCCCCCCEEECCEECCCCCCHHHHCCCCCHHHHHHHHCCCCCEECCC
GEMIPATLETAINSELAGMVRAITTRDIFALEGSKLLIPKGSTLVGQFNTAITQGQSRIF
CCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEECCCCEEEEHHHHHHHCCCCEEE
VVWNRLQMTNGIIVTLNSPGSDPIGRSGQAADYIDRHFFERFGTGALLSVLGAYTATGGV
EEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
HGQDEYNSMSQYRMNIASSFQQAANQTLQQDMQTRPTLQINQGAAINVFVAHDLDFYRVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEECCCCHHHHC
GRA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]