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The map label for this gene is umuC

Identifier: 52841464

GI number: 52841464

Start: 1359759

End: 1361036

Strand: Direct

Name: umuC

Synonym: lpg1232

Alternate gene names: 52841464

Gene position: 1359759-1361036 (Clockwise)

Preceding gene: 52841463

Following gene: 52841468

Centisome position: 40.02

GC content: 42.57

Gene sequence:

>1278_bases
ATGAGCTTGCCTGAGATGTTTGCCCTTATCGATTGCAACAATTTTTACGCCAGTTGTGAGCGTTTGTTTCGTCCTGATTT
AAAGGACGTCCCCATCGTGGTGCTATCCAATAACGATGGCTGTTGTATCGCACGCTCGAATGAAGCCAAAGCATTGGGCA
TTGCCATGGGCGAGCCGTACTTCAAAATTAAACATTTGTGCAAACAGCATGGAGTGAAAGCTTTTTCCTCAAATTATACG
CTGTATGGCAACATGAGTCATCGTGTGATGTGCACTATTGAAGAAGCCTGGCCCCATATAGAAGTTTACTCGATTGATGA
AGCGTTTCTTGATTTAAGGAGTTTACCGGTTGATAGCTATGATTCGTTTTGCGAGCAGTTACAAAAGAAAATCTTGAAGC
ACACAGGAATACCCACTTCCATCGGTATTGGACCTACTAAAACACTAGCTAAAGCCGCCAATCATTTATGCAAAAAAGTT
TATAAAATTCCTGTGTTTAATATCACCTCGAATCGTGGGCGGTTATTGCAACAGATTTCCGTTGGGGACATTTGGGGAGT
AGGGCGGCAATGGGCCAATAAATTAATTTCGCGAGGCATTCATACGGCTTATGATTTGGCAATGACCAATCCTCACCTTC
TGAAGAAATGTTTTAACGCCGTGTTGATGCGAACTGCTATGGAGCTTCAAGGAATTGCTTGTGGCGGTTTAGAGGTAATA
GAGCCTAAGCAAAGTATTATGTCATCCAAAAGTTTTGGTCAGATGCAAACTCAAATTGCTTCGATTGAGGAATCAATCAG
TAGCCATTGTGCTCGTGCGGTGGAGAAAATGCGTCGCCAACAATTGGTGGCGACGCGTCTGGTTGTATTTGTGCATACGA
ACCGATTTCGGGAAGATTTGGCTCAGCACTTTCAGTCCATCGAATTTAAGCTGATTAATCCTACAGATGATTTGCGCTTA
ATTACCAAAATAGCCAAAAGATGTCTGCAACGCATTTTTAAACCAGGGTATTACTATAAAAAGGCAGGGGTATGTCTTGA
AGACTTAATTCCTAAAAAACCACGACAGCTGGATATGTTTCATCAACCAAGTGATGAGCATCTAAAACACACCGAACAAT
TGATGGGTGTCTTTGACCAAATCAATCAAAAGTATGGAAGAAGCACGATTCGGTTAGCCGCCGAAGGCTATTCAAAACCC
TGGGAGATGCGTGCTGAGCTGAAATCACCTGCTTATACCACGCGATGGTCTCAAGTTCCCAAAGTTCATTTGTATTAA

Upstream 100 bases:

>100_bases
GGAAGGGTGCAATTACTTCCTGCTAATCCCAAATTTCAACCCATTGACATTACAGAGGACAGTGAGATGGTGATTTGGGG
AGTGGTGACTTTGGTTCTAC

Downstream 100 bases:

>100_bases
GAAAACTCACAAAATAACTCAGTTTTTGGTGTTCACCTTCCCAAGAATACACAATAGCAAGAACATGCTTACTTAAAGGC
TCTAAAACTTTGGATCGAGC

Product: UmuC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSLPEMFALIDCNNFYASCERLFRPDLKDVPIVVLSNNDGCCIARSNEAKALGIAMGEPYFKIKHLCKQHGVKAFSSNYT
LYGNMSHRVMCTIEEAWPHIEVYSIDEAFLDLRSLPVDSYDSFCEQLQKKILKHTGIPTSIGIGPTKTLAKAANHLCKKV
YKIPVFNITSNRGRLLQQISVGDIWGVGRQWANKLISRGIHTAYDLAMTNPHLLKKCFNAVLMRTAMELQGIACGGLEVI
EPKQSIMSSKSFGQMQTQIASIEESISSHCARAVEKMRRQQLVATRLVVFVHTNRFREDLAQHFQSIEFKLINPTDDLRL
ITKIAKRCLQRIFKPGYYYKKAGVCLEDLIPKKPRQLDMFHQPSDEHLKHTEQLMGVFDQINQKYGRSTIRLAAEGYSKP
WEMRAELKSPAYTTRWSQVPKVHLY

Sequences:

>Translated_425_residues
MSLPEMFALIDCNNFYASCERLFRPDLKDVPIVVLSNNDGCCIARSNEAKALGIAMGEPYFKIKHLCKQHGVKAFSSNYT
LYGNMSHRVMCTIEEAWPHIEVYSIDEAFLDLRSLPVDSYDSFCEQLQKKILKHTGIPTSIGIGPTKTLAKAANHLCKKV
YKIPVFNITSNRGRLLQQISVGDIWGVGRQWANKLISRGIHTAYDLAMTNPHLLKKCFNAVLMRTAMELQGIACGGLEVI
EPKQSIMSSKSFGQMQTQIASIEESISSHCARAVEKMRRQQLVATRLVVFVHTNRFREDLAQHFQSIEFKLINPTDDLRL
ITKIAKRCLQRIFKPGYYYKKAGVCLEDLIPKKPRQLDMFHQPSDEHLKHTEQLMGVFDQINQKYGRSTIRLAAEGYSKP
WEMRAELKSPAYTTRWSQVPKVHLY
>Mature_424_residues
SLPEMFALIDCNNFYASCERLFRPDLKDVPIVVLSNNDGCCIARSNEAKALGIAMGEPYFKIKHLCKQHGVKAFSSNYTL
YGNMSHRVMCTIEEAWPHIEVYSIDEAFLDLRSLPVDSYDSFCEQLQKKILKHTGIPTSIGIGPTKTLAKAANHLCKKVY
KIPVFNITSNRGRLLQQISVGDIWGVGRQWANKLISRGIHTAYDLAMTNPHLLKKCFNAVLMRTAMELQGIACGGLEVIE
PKQSIMSSKSFGQMQTQIASIEESISSHCARAVEKMRRQQLVATRLVVFVHTNRFREDLAQHFQSIEFKLINPTDDLRLI
TKIAKRCLQRIFKPGYYYKKAGVCLEDLIPKKPRQLDMFHQPSDEHLKHTEQLMGVFDQINQKYGRSTIRLAAEGYSKPW
EMRAELKSPAYTTRWSQVPKVHLY

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=424, Percent_Identity=43.6320754716981, Blast_Score=335, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 48506; Mature: 48375

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPEMFALIDCNNFYASCERLFRPDLKDVPIVVLSNNDGCCIARSNEAKALGIAMGEPY
CCCCHHEEEEECHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCEEEEECCCCH
FKIKHLCKQHGVKAFSSNYTLYGNMSHRVMCTIEEAWPHIEVYSIDEAFLDLRSLPVDSY
HHHHHHHHHCCCHHHCCCEEEEECCCCEEEEEEHHCCCCEEEEEHHHHHHHHHHCCCCHH
DSFCEQLQKKILKHTGIPTSIGIGPTKTLAKAANHLCKKVYKIPVFNITSNRGRLLQQIS
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHC
VGDIWGVGRQWANKLISRGIHTAYDLAMTNPHLLKKCFNAVLMRTAMELQGIACGGLEVI
CCHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
EPKQSIMSSKSFGQMQTQIASIEESISSHCARAVEKMRRQQLVATRLVVFVHTNRFREDL
CCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQHFQSIEFKLINPTDDLRLITKIAKRCLQRIFKPGYYYKKAGVCLEDLIPKKPRQLDMF
HHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEHHCCCCHHHHCCCCCCCCCCC
HQPSDEHLKHTEQLMGVFDQINQKYGRSTIRLAAEGYSKPWEMRAELKSPAYTTRWSQVP
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCCCCHHHHHHHCCCCCCCHHHCCC
KVHLY
CEECC
>Mature Secondary Structure 
SLPEMFALIDCNNFYASCERLFRPDLKDVPIVVLSNNDGCCIARSNEAKALGIAMGEPY
CCCHHEEEEECHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCEEEEECCCCH
FKIKHLCKQHGVKAFSSNYTLYGNMSHRVMCTIEEAWPHIEVYSIDEAFLDLRSLPVDSY
HHHHHHHHHCCCHHHCCCEEEEECCCCEEEEEEHHCCCCEEEEEHHHHHHHHHHCCCCHH
DSFCEQLQKKILKHTGIPTSIGIGPTKTLAKAANHLCKKVYKIPVFNITSNRGRLLQQIS
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHC
VGDIWGVGRQWANKLISRGIHTAYDLAMTNPHLLKKCFNAVLMRTAMELQGIACGGLEVI
CCHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
EPKQSIMSSKSFGQMQTQIASIEESISSHCARAVEKMRRQQLVATRLVVFVHTNRFREDL
CCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQHFQSIEFKLINPTDDLRLITKIAKRCLQRIFKPGYYYKKAGVCLEDLIPKKPRQLDMF
HHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEHHCCCCHHHHCCCCCCCCCCC
HQPSDEHLKHTEQLMGVFDQINQKYGRSTIRLAAEGYSKPWEMRAELKSPAYTTRWSQVP
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCCCCHHHHHHHCCCCCCCHHHCCC
KVHLY
CEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]