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The map label for this gene is umuD

Identifier: 52841463

GI number: 52841463

Start: 1359266

End: 1359772

Strand: Direct

Name: umuD

Synonym: lpg1231

Alternate gene names: 52841463

Gene position: 1359266-1359772 (Clockwise)

Preceding gene: 52841462

Following gene: 52841464

Centisome position: 40.0

GC content: 46.94

Gene sequence:

>507_bases
ATGTCACCACGAGGCGGAAAAAGAGTAGGGGCGGGTCGCCCAAGGGGTGAGCCTACCAAAGCAGTTCGTATATCATTATC
CCAACTTGCTGAATTAGAGCGTCTAAAGAGTCACGCATCGTATCAATTGCCGGTATTTGCTAGCAAAATTCAAGCAGGAT
TTCCATCACCGGCCGATGATTACATCGAGGGGTATCTTGATTTAAACACCAAATTCATTAAACACCCATCGTCTACCTTT
GTTTTGCAAGCCACAGGGGAGTCTATGGTGGAGGCTGGAATTTTTTCTGGCGACTGGCTGTTAGTGGATAGAAGCATAGA
ACCTTCGGATGGACGCATTGTCATTGCAGCTGTGAACGGTGAACTCACGGTGAAACGCTTGTCGAAAAAAGGGGGAAGGG
TGCAATTACTTCCTGCTAATCCCAAATTTCAACCCATTGACATTACAGAGGACAGTGAGATGGTGATTTGGGGAGTGGTG
ACTTTGGTTCTACATGAGCTTGCCTGA

Upstream 100 bases:

>100_bases
GGCTTAGTGTGGTTTTCATTTCCAGTTGTTCTGAGATGGGATTTACAGTTTATTTTTCCTTGTCTATGATATTTGTACGT
AAATCAAAAAAAGAATCATC

Downstream 100 bases:

>100_bases
GATGTTTGCCCTTATCGATTGCAACAATTTTTACGCCAGTTGTGAGCGTTTGTTTCGTCCTGATTTAAAGGACGTCCCCA
TCGTGGTGCTATCCAATAAC

Product: SOS response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MSPRGGKRVGAGRPRGEPTKAVRISLSQLAELERLKSHASYQLPVFASKIQAGFPSPADDYIEGYLDLNTKFIKHPSSTF
VLQATGESMVEAGIFSGDWLLVDRSIEPSDGRIVIAAVNGELTVKRLSKKGGRVQLLPANPKFQPIDITEDSEMVIWGVV
TLVLHELA

Sequences:

>Translated_168_residues
MSPRGGKRVGAGRPRGEPTKAVRISLSQLAELERLKSHASYQLPVFASKIQAGFPSPADDYIEGYLDLNTKFIKHPSSTF
VLQATGESMVEAGIFSGDWLLVDRSIEPSDGRIVIAAVNGELTVKRLSKKGGRVQLLPANPKFQPIDITEDSEMVIWGVV
TLVLHELA
>Mature_167_residues
SPRGGKRVGAGRPRGEPTKAVRISLSQLAELERLKSHASYQLPVFASKIQAGFPSPADDYIEGYLDLNTKFIKHPSSTFV
LQATGESMVEAGIFSGDWLLVDRSIEPSDGRIVIAAVNGELTVKRLSKKGGRVQLLPANPKFQPIDITEDSEMVIWGVVT
LVLHELA

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1787431, Length=125, Percent_Identity=46.4, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790476, Length=113, Percent_Identity=38.0530973451327, Blast_Score=84, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 18282; Mature: 18151

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPRGGKRVGAGRPRGEPTKAVRISLSQLAELERLKSHASYQLPVFASKIQAGFPSPADD
CCCCCCCCCCCCCCCCCCCHHEEEEHHHHHHHHHHHHCCCEECCEEHHHHHCCCCCCHHH
YIEGYLDLNTKFIKHPSSTFVLQATGESMVEAGIFSGDWLLVDRSIEPSDGRIVIAAVNG
HHHEECCCCEEEEECCCCEEEEEECCCHHHHHCCCCCCEEEEECCCCCCCCEEEEEEECC
ELTVKRLSKKGGRVQLLPANPKFQPIDITEDSEMVIWGVVTLVLHELA
CEEEEEHHCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SPRGGKRVGAGRPRGEPTKAVRISLSQLAELERLKSHASYQLPVFASKIQAGFPSPADD
CCCCCCCCCCCCCCCCCCHHEEEEHHHHHHHHHHHHCCCEECCEEHHHHHCCCCCCHHH
YIEGYLDLNTKFIKHPSSTFVLQATGESMVEAGIFSGDWLLVDRSIEPSDGRIVIAAVNG
HHHEECCCCEEEEECCCCEEEEEECCCHHHHHCCCCCCEEEEECCCCCCCCEEEEEEECC
ELTVKRLSKKGGRVQLLPANPKFQPIDITEDSEMVIWGVVTLVLHELA
CEEEEEHHCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]