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The map label for this gene is selA

Identifier: 39998458

GI number: 39998458

Start: 3702160

End: 3703548

Strand: Reverse

Name: selA

Synonym: GSU3369

Alternate gene names: 39998458

Gene position: 3703548-3702160 (Counterclockwise)

Preceding gene: 39998459

Following gene: 39998457

Centisome position: 97.1

GC content: 66.16

Gene sequence:

>1389_bases
GTGACCATCTTTAGCCGCATTCCCAAGGTTGACCGCATCCTTGAACAGGACGAAGTCAGGCGGTTGCTGGCAGACCATCC
TCGACCCACGGTTCTCGCCGCCGTTCGCACCGCGCTCGATGCCTTGCGCGCCGAGGCCCGCGCAGGATCGCTACGTGAGC
AAGACCTGGCAGACGGTGCGGTTGCCGGCCGAGTCGGTCGCGAGGTGGCCCGCAGCACGGCGTGCAGTCTTCGCCGGGTG
GTGAACGGCACCGGCGTCGTCATTCACACGAACCTGGGGCGTTCTCCCCTGGCAGAGCGGGTGCGGCAACGTGTCGACGA
CACCGCCTACGGCTACTCCAACCTGGAATTCGATCTGGAGCGGGGCGAGAGGGGGAGCCGATACTCCCATGTGGAGAAGC
TTCTTTGTGAACTGACCGGCGCAGAGGCCGCGCTCGTGGTCAACAACAACGCAGCGGCGGTCCTCCTGGCTCTGTCCGCC
CTGGCCGGCGGAAAAGAGGTCATTGTCTCCCGGGGAGAACTGGTGGAGATCGGCGGGTCGTTCCGGATCCCGGACGTCAT
GCAGCAGGGCGGGGCCGTTCTCCGCGAGGTGGGAACCACCAACCGGACCCACTCACGCGACTACCGCCAGGCGGTAACTT
CCGAGACGGGACTCTTGCTCAAGGTTCACTCCAGCAATTTCGCGGTGGTCGGTTTTACCGCAGAGGTGACGGCCCCGGAG
ATGGTCGCCATCGGCCGCGAATTGGGCCTGCCGGTCATGGCCGACATCGGCAGCGGCTGTCTCATTGATCTCTCCCGTTT
CGGTATCCGGGGGGAGCCCACGGTGCAGGAATTCGTCTCCGTCGGGGTGGATGTGGTCACCTTCAGCGGCGATAAACTCC
TGGGCGGTCCCCAGGCCGGGATCATCGTGGGGCGCAAGGCGTATGTGGATCCCTTGAAAAAGCATCCCCTGCTCCGGGCC
ATTCGTATCGACAAGCTGACCCTGGCGGCCCTTGAGGGAACCCTGCGCCTCTACCGGGATGAACGCCAGGCCCTGGCGGA
GGTTCCAACCCTCCGGATGCTGACCGCCTCGGCCGAGGAACTGCGGCTCCGCGCCCGGCAGTTCATGCGCCGTCTGCGCC
GCGGCGTCCCTTCTTCCGTGCGGCTTGCTTCCCTTGACGGCGTTTCCCAGGTGGGTGGGGGTGCCTATCCCCTCCTGGAG
TTGCCCACGACCCTCATCGCTGTAGACGTGGACGGGGTGTCTCCCCAGGAGATGGAGGCGCGGCTCCGGCGCATGACCGT
GCCGGTGGTCGGGCGCATCAACCGGGGACGTTTCCTGCTCGATGCGCGGACCCTCCTGGACGACGATGCCCCGGCGGTTA
TCTCCGCCCTGCGGGAACTGGCCAGCTGA

Upstream 100 bases:

>100_bases
CGTTCACCTTCCCTTCACCCGCCTTGACAGCCCTGAGTCAATCTGGTACTGAGGTCTAAGCTGGCTTTGCGCCGCCATTT
TTGTGCCCGGGGAGACTACC

Downstream 100 bases:

>100_bases
CGGGGCCGGGGGCAATCCTTCGCACTACTTTTGGCTGGTCTTTTAGCGATCCTTCGGTATAATCAGCTCATTCCGGCCCG
ACCGGCGCCGTTTTCCGCGC

Product: selenocysteine synthase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTIFSRIPKVDRILEQDEVRRLLADHPRPTVLAAVRTALDALRAEARAGSLREQDLADGAVAGRVGREVARSTACSLRRV
VNGTGVVIHTNLGRSPLAERVRQRVDDTAYGYSNLEFDLERGERGSRYSHVEKLLCELTGAEAALVVNNNAAAVLLALSA
LAGGKEVIVSRGELVEIGGSFRIPDVMQQGGAVLREVGTTNRTHSRDYRQAVTSETGLLLKVHSSNFAVVGFTAEVTAPE
MVAIGRELGLPVMADIGSGCLIDLSRFGIRGEPTVQEFVSVGVDVVTFSGDKLLGGPQAGIIVGRKAYVDPLKKHPLLRA
IRIDKLTLAALEGTLRLYRDERQALAEVPTLRMLTASAEELRLRARQFMRRLRRGVPSSVRLASLDGVSQVGGGAYPLLE
LPTTLIAVDVDGVSPQEMEARLRRMTVPVVGRINRGRFLLDARTLLDDDAPAVISALRELAS

Sequences:

>Translated_462_residues
MTIFSRIPKVDRILEQDEVRRLLADHPRPTVLAAVRTALDALRAEARAGSLREQDLADGAVAGRVGREVARSTACSLRRV
VNGTGVVIHTNLGRSPLAERVRQRVDDTAYGYSNLEFDLERGERGSRYSHVEKLLCELTGAEAALVVNNNAAAVLLALSA
LAGGKEVIVSRGELVEIGGSFRIPDVMQQGGAVLREVGTTNRTHSRDYRQAVTSETGLLLKVHSSNFAVVGFTAEVTAPE
MVAIGRELGLPVMADIGSGCLIDLSRFGIRGEPTVQEFVSVGVDVVTFSGDKLLGGPQAGIIVGRKAYVDPLKKHPLLRA
IRIDKLTLAALEGTLRLYRDERQALAEVPTLRMLTASAEELRLRARQFMRRLRRGVPSSVRLASLDGVSQVGGGAYPLLE
LPTTLIAVDVDGVSPQEMEARLRRMTVPVVGRINRGRFLLDARTLLDDDAPAVISALRELAS
>Mature_461_residues
TIFSRIPKVDRILEQDEVRRLLADHPRPTVLAAVRTALDALRAEARAGSLREQDLADGAVAGRVGREVARSTACSLRRVV
NGTGVVIHTNLGRSPLAERVRQRVDDTAYGYSNLEFDLERGERGSRYSHVEKLLCELTGAEAALVVNNNAAAVLLALSAL
AGGKEVIVSRGELVEIGGSFRIPDVMQQGGAVLREVGTTNRTHSRDYRQAVTSETGLLLKVHSSNFAVVGFTAEVTAPEM
VAIGRELGLPVMADIGSGCLIDLSRFGIRGEPTVQEFVSVGVDVVTFSGDKLLGGPQAGIIVGRKAYVDPLKKHPLLRAI
RIDKLTLAALEGTLRLYRDERQALAEVPTLRMLTASAEELRLRARQFMRRLRRGVPSSVRLASLDGVSQVGGGAYPLLEL
PTTLIAVDVDGVSPQEMEARLRRMTVPVVGRINRGRFLLDARTLLDDDAPAVISALRELAS

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family

Homologues:

Organism=Escherichia coli, GI2367248, Length=450, Percent_Identity=46.2222222222222, Blast_Score=359, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SELA_GEOSL (P61736)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954409.1
- ProteinModelPortal:   P61736
- GeneID:   2688213
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3369
- NMPDR:   fig|243231.1.peg.3347
- TIGR:   GSU3369
- HOGENOM:   HBG564950
- OMA:   KRGDRDD
- ProtClustDB:   PRK04311
- BioCyc:   GSUL243231:GSU_3369-MONOMER
- BRENDA:   2.9.1.1
- GO:   GO:0005737
- HAMAP:   MF_00423
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534
- Gene3D:   G3DSA:3.40.640.10
- TIGRFAMs:   TIGR00474

Pfam domain/function: PF03841 SelA; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.9.1.1

Molecular weight: Translated: 49937; Mature: 49806

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIFSRIPKVDRILEQDEVRRLLADHPRPTVLAAVRTALDALRAEARAGSLREQDLADGA
CCHHHHCCHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCHH
VAGRVGREVARSTACSLRRVVNGTGVVIHTNLGRSPLAERVRQRVDDTAYGYSNLEFDLE
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCHHHCCCCCCEEEEC
RGERGSRYSHVEKLLCELTGAEAALVVNNNAAAVLLALSALAGGKEVIVSRGELVEIGGS
CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEECCCEEEECCC
FRIPDVMQQGGAVLREVGTTNRTHSRDYRQAVTSETGLLLKVHSSNFAVVGFTAEVTAPE
CCCHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCEEEEEEEECCCCCH
MVAIGRELGLPVMADIGSGCLIDLSRFGIRGEPTVQEFVSVGVDVVTFSGDKLLGGPQAG
HHHHHHHHCCCCEECCCCCCEEEHHHCCCCCCCHHHHHHHCCCEEEEECCCEECCCCCCC
IIVGRKAYVDPLKKHPLLRAIRIDKLTLAALEGTLRLYRDERQALAEVPTLRMLTASAEE
EEECCHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHH
LRLRARQFMRRLRRGVPSSVRLASLDGVSQVGGGAYPLLELPTTLIAVDVDGVSPQEMEA
HHHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCCCCCHHHCCCEEEEEEECCCCHHHHHH
RLRRMTVPVVGRINRGRFLLDARTLLDDDAPAVISALRELAS
HHHHCCCHHHEECCCCEEEEEHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TIFSRIPKVDRILEQDEVRRLLADHPRPTVLAAVRTALDALRAEARAGSLREQDLADGA
CHHHHCCHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCHH
VAGRVGREVARSTACSLRRVVNGTGVVIHTNLGRSPLAERVRQRVDDTAYGYSNLEFDLE
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCHHHCCCCCCEEEEC
RGERGSRYSHVEKLLCELTGAEAALVVNNNAAAVLLALSALAGGKEVIVSRGELVEIGGS
CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEECCCEEEECCC
FRIPDVMQQGGAVLREVGTTNRTHSRDYRQAVTSETGLLLKVHSSNFAVVGFTAEVTAPE
CCCHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCEEEEEEEECCCCCH
MVAIGRELGLPVMADIGSGCLIDLSRFGIRGEPTVQEFVSVGVDVVTFSGDKLLGGPQAG
HHHHHHHHCCCCEECCCCCCEEEHHHCCCCCCCHHHHHHHCCCEEEEECCCEECCCCCCC
IIVGRKAYVDPLKKHPLLRAIRIDKLTLAALEGTLRLYRDERQALAEVPTLRMLTASAEE
EEECCHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHH
LRLRARQFMRRLRRGVPSSVRLASLDGVSQVGGGAYPLLELPTTLIAVDVDGVSPQEMEA
HHHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCCCCCHHHCCCEEEEEEECCCCHHHHHH
RLRRMTVPVVGRINRGRFLLDARTLLDDDAPAVISALRELAS
HHHHCCCHHHEECCCCEEEEEHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA