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The map label for this gene is thiL [H]

Identifier: 39998284

GI number: 39998284

Start: 3502085

End: 3503071

Strand: Direct

Name: thiL [H]

Synonym: GSU3194

Alternate gene names: 39998284

Gene position: 3502085-3503071 (Clockwise)

Preceding gene: 39998283

Following gene: 39998285

Centisome position: 91.82

GC content: 66.26

Gene sequence:

>987_bases
GTGAGACTCGGCGAGATCGGTGAATTCGGCCTTATCGACAGGATTGCCGGCAAAGTAGCCGCCGGTGCCGGGGTTCGCCT
CGGCATCGGCGACGACGCTGCCGTTACCGAAACGGAAGCGGGGCGCCTCCTGCTGTCCACCGCCGACATGCTCGTTGAAG
GCATCCACTTTGACCTCTCCTTCACCGACCCCTTCAGGCTCGGCCGCAAATCCCTGGCGGTCAACGTCTCCGACATTGCC
GCCATGGGGGGACACCCTCGCCATGCGCTGCTCTGTCTTGCCATTCCAACCGATCTGCCGGTTGAATTTCTCGACCGGTT
CGCCGACGGCGTCATCTCCCTGGCAGAGGAATTCGGTGTCACCCTCATCGGCGGCGATACCTGCCGCTCCTCCTCCGGGC
TTGTCATCTCCATCACCCTCCACGGCGAACAGGTCCCCACACGGATCATCCCGCGCAACGGGGCTCGGCCGGGCGACGAC
GTGTTCGTCACCGGTACCGTCGGAGATTCAGCCCTGGGGCTCGAACTGCTGCGCAGAGGCGAACGCTCCGGACATGCCGT
CGAACGCCACCTCAACCCCTCGCCCCGCGTCTCCGCCGGCCTGAGCCTGGCCGAATCGGGCATGGCCTCGGCCATGATCG
ACGTGAGCGACGGTGTCCTTGCCGACCTGGGGCACATCCTGACCGGCTCGGGGGTCGGCGCCCGCATCGACGCATCCCTC
ATCCCCCTTTCTCCCTACTTCAGCCAACGGGCGCCCGACGTGGCACCTGACCCCCTCTCTCTGGCACTGGCGGGAGGCGA
GGACTACGAACTACTCTTTACTGCGGCGCCGGGACGGACGGCCGAGGTGGAAACGCTGCTGGCGGCGTGCGGCGTTACAG
CGACCCGGATCGGTTCCATCGTTGCCGGGTCGGACGTCACGGTCACCGCAGCAGACGGGACCCTTATCCCTCCGAGACGC
CGCGGCTTCAACCATTTCGCGCCGTAA

Upstream 100 bases:

>100_bases
CGCCCGCCGCCGCCGAGGGGAAACCGGCCGCAAAGGCGCGTACCGCTCCGCGTCGCGGCATAGCGGCTCCCACTAAAGCC
ACTGCCGCCGGGGCCAAGGG

Downstream 100 bases:

>100_bases
ATCCTGCGCCGGCCCACTGCCTCGCGGCATCGCGCGTGCGCCGTCACGGAACACTTCTTGCTGTCTGTGGAAAGACGGAT
CAATCACCACATGATAAACA

Product: thiamine monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MRLGEIGEFGLIDRIAGKVAAGAGVRLGIGDDAAVTETEAGRLLLSTADMLVEGIHFDLSFTDPFRLGRKSLAVNVSDIA
AMGGHPRHALLCLAIPTDLPVEFLDRFADGVISLAEEFGVTLIGGDTCRSSSGLVISITLHGEQVPTRIIPRNGARPGDD
VFVTGTVGDSALGLELLRRGERSGHAVERHLNPSPRVSAGLSLAESGMASAMIDVSDGVLADLGHILTGSGVGARIDASL
IPLSPYFSQRAPDVAPDPLSLALAGGEDYELLFTAAPGRTAEVETLLAACGVTATRIGSIVAGSDVTVTAADGTLIPPRR
RGFNHFAP

Sequences:

>Translated_328_residues
MRLGEIGEFGLIDRIAGKVAAGAGVRLGIGDDAAVTETEAGRLLLSTADMLVEGIHFDLSFTDPFRLGRKSLAVNVSDIA
AMGGHPRHALLCLAIPTDLPVEFLDRFADGVISLAEEFGVTLIGGDTCRSSSGLVISITLHGEQVPTRIIPRNGARPGDD
VFVTGTVGDSALGLELLRRGERSGHAVERHLNPSPRVSAGLSLAESGMASAMIDVSDGVLADLGHILTGSGVGARIDASL
IPLSPYFSQRAPDVAPDPLSLALAGGEDYELLFTAAPGRTAEVETLLAACGVTATRIGSIVAGSDVTVTAADGTLIPPRR
RGFNHFAP
>Mature_328_residues
MRLGEIGEFGLIDRIAGKVAAGAGVRLGIGDDAAVTETEAGRLLLSTADMLVEGIHFDLSFTDPFRLGRKSLAVNVSDIA
AMGGHPRHALLCLAIPTDLPVEFLDRFADGVISLAEEFGVTLIGGDTCRSSSGLVISITLHGEQVPTRIIPRNGARPGDD
VFVTGTVGDSALGLELLRRGERSGHAVERHLNPSPRVSAGLSLAESGMASAMIDVSDGVLADLGHILTGSGVGARIDASL
IPLSPYFSQRAPDVAPDPLSLALAGGEDYELLFTAAPGRTAEVETLLAACGVTATRIGSIVAGSDVTVTAADGTLIPPRR
RGFNHFAP

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=329, Percent_Identity=39.8176291793313, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1788062, Length=223, Percent_Identity=28.6995515695067, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 33859; Mature: 33859

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLGEIGEFGLIDRIAGKVAAGAGVRLGIGDDAAVTETEAGRLLLSTADMLVEGIHFDLS
CCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEECCCCEEEEEHHHHHHHCEEEEEE
FTDPFRLGRKSLAVNVSDIAAMGGHPRHALLCLAIPTDLPVEFLDRFADGVISLAEEFGV
ECCHHHHCCHHEEEEHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCE
TLIGGDTCRSSSGLVISITLHGEQVPTRIIPRNGARPGDDVFVTGTVGDSALGLELLRRG
EEEECCCCCCCCCEEEEEEECCCCCCCEECCCCCCCCCCCEEEEECCCCHHHHHHHHHCC
ERSGHAVERHLNPSPRVSAGLSLAESGMASAMIDVSDGVLADLGHILTGSGVGARIDASL
CCCCCHHHHCCCCCCCHHHCCHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCEECCEE
IPLSPYFSQRAPDVAPDPLSLALAGGEDYELLFTAAPGRTAEVETLLAACGVTATRIGSI
ECCCHHHHCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHCCE
VAGSDVTVTAADGTLIPPRRRGFNHFAP
EECCCEEEEECCCCCCCCHHCCCCCCCC
>Mature Secondary Structure
MRLGEIGEFGLIDRIAGKVAAGAGVRLGIGDDAAVTETEAGRLLLSTADMLVEGIHFDLS
CCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEECCCCEEEEEHHHHHHHCEEEEEE
FTDPFRLGRKSLAVNVSDIAAMGGHPRHALLCLAIPTDLPVEFLDRFADGVISLAEEFGV
ECCHHHHCCHHEEEEHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCE
TLIGGDTCRSSSGLVISITLHGEQVPTRIIPRNGARPGDDVFVTGTVGDSALGLELLRRG
EEEECCCCCCCCCEEEEEEECCCCCCCEECCCCCCCCCCCEEEEECCCCHHHHHHHHHCC
ERSGHAVERHLNPSPRVSAGLSLAESGMASAMIDVSDGVLADLGHILTGSGVGARIDASL
CCCCCHHHHCCCCCCCHHHCCHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCEECCEE
IPLSPYFSQRAPDVAPDPLSLALAGGEDYELLFTAAPGRTAEVETLLAACGVTATRIGSI
ECCCHHHHCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHCCE
VAGSDVTVTAADGTLIPPRRRGFNHFAP
EECCCEEEEECCCCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]