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The map label for this gene is loN-3 [H]

Identifier: 39998283

GI number: 39998283

Start: 3499629

End: 3502088

Strand: Direct

Name: loN-3 [H]

Synonym: GSU3193

Alternate gene names: 39998283

Gene position: 3499629-3502088 (Clockwise)

Preceding gene: 39998282

Following gene: 39998284

Centisome position: 91.75

GC content: 61.75

Gene sequence:

>2460_bases
ATGGATGACCATAAACAGGAAAACGAGGAGCTAAAAATACCGGACGTGCTGCCCCTGTTGCCGGTTCGGGACGTTGTGGT
CTATCCGTACATGATTCTTCCGCTTTTCGTGGGCCGGGAGATTTCGATCAACGCCGTTGACCAGGCGCTTTCCAAGGACC
GGCTCATCTTCCTGGCCACCCAGAAAGAGATCGGCGACGAAGATCCGACCCCCGAGGGGATCTACCCCGTGGGCACCGTA
GCGATGATCATGAGGATGCTCAAGCTGCCGGACGGACGGGTCAAGATTCTCGTTCAGGGCCTTGCCAAAGGGCGGATCAC
TTCGTTCGTAGAATCGAAGCCCTACTACTCCGTAGCTATCGAGCGGGTGGTCGAGCCGACCCCTCCCGAGGATTCGCTGG
AGGTGGAGGCCCTCATGCGGGCCGTGAAGGAGCAGCTCACCAAGATCGTCTCCCTCGGCAAGCCCGTCTCGCCCGAGGTG
CTCGTCATCGTCGAGAACATGCAGGAGCCCGGCAGCCTCGCCGACCTGGTCGCCAGCAATATCGGCCTCAAGGTGGAAGA
GGCCCAAAAGCTTCTGGAGATCATCGACCCGGTGGAACGCCTCCAGCGGGTGAACGAACTCCTGAGCAAAGAGCACGAGC
TCCTGGACATGCAGGCGAAGATCCAGACTGCAGCCAAGGAGGAGATGGGCAAAAGCCAGCGCGAATATTTTCTGCGCGAG
CAGTTGCGAGCCATCCAGCAGGAGCTGGGCGAGACCGATGCCAGGTCCGAAGAAATCATGGAATTGCGCAAGGCCATCGA
GCAGGCCAAGATGCCTCCGCCCGTCGAGAAGGAGGCCCTCAAGCAACTGGGACGCCTGGAGCAGATGCATCCGGAGGCCG
CCGAAGCCGGAATGCTCAGGACCTACCTCGACTGGATGGTGGAACTCCCCTGGAGCACCTCGACCCGCGACATTCTCGAC
ATCAAACGGGCGAGGAATATCCTGGACGAGGACCATTACTACCTGGACAAGATCAAAGAGCGGATTCTTGAATTCCTGGC
GGTGCGCAAGCTCCGCAAGAAGATGAAGGGACCGATCCTTTGCTTCGTGGGCCCTCCTGGGGTCGGCAAAACCTCTCTCG
GCAAGTCCATTGCCCGGGCCCTGGGCAGGAAGTTCGTACGCATCTCCCTCGGGGGCGTGCGGGACGAGGCCGAAATACGG
GGCCATCGGCGCACCTACGTGGGAGCGTTGCCGGGGCGGATCATCCAGGGACTCAAGCAGGCGGGCTCCAACAACCCGGT
CTTCATGCTCGACGAACTTGACAAACTCGGCGCCGATTTCAGAGGCGACCCCTCTTCGGCGCTCCTCGAGGTGCTCGATC
CGGAACAGAACCACATGTTCTCGGATCACTACATCAACCTCCCCTTCAACCTTTCCAACGTGATGTTCATCGCCACCGCG
AACCAGTACGACACCATTCCGGGGCCGCTGCTGGACCGGATGGAAATGATCAACCTGTCGGGTTACACCGAGGAAGAGAA
GCTGGAAATCGCCAAACGGTATCTCATCCCACGCCAGACCAAAGAGAACGGGATTACCGGCAAACACATCAGCTTTACCG
ACGACGCGCTCCGCACCATCATCGCCAAGTACACCCGCGAAGCAGGACTGCGGAACCTGGAACGGGAGATCGGCAGCGTC
TGCCGCAAGGTAGCGCGCAAGATCGCCGAGGGGGAGAAGAAACTCTATCGCATCACCCCCGCCACGGTGGCCAAGTACCT
CGGTCCGGCCAAGTATCTGCGCGAAGTGGAGATGGAGCACAACGACGTGGGCGTGGTCACCGGCCTTGCCTGGACGCCGG
TGGGGGGAGAGGTTCTCTTCGTGGAGGCCACCATTATGAAGGGCAAGGGTGGGCTTACCCTCACGGGACACCTGGGAGAC
GTGATGAAGGAGTCGGTCCAGGCCGCCCTGTCCTACATCCGCTCCAAGGCACAGGAACTTCACCTGCCTGAGGATTTCCT
GGCCGGGGTCGACATCCACGTTCACGTGCCAGCCGGCGCCATCCCCAAGGACGGCCCCTCAGCCGGCATCACCATGGCAA
CCGCCCTGGTCTCGGCCCTGACCCGCGTGCCGGTCCGCAAGGACGTGGCCATGACCGGCGAGATCACCCTGCGGGGCAAA
GTGCTTCCCATCGGCGGGCTCAAGGAGAAGATGCTGGCCGCCATCCGGGCGGGGATCACCACCATCGTCATCCCCGAGCA
GAACGTCAAGGACCTGGACGAGGTACCCAAGCCCATCCTCAAAAAGGTCACGGTGGTGTCCGCCAAGGTTATCGACGACG
TACTGAAGGTGGCCCTGGAAAGCTATCCGCCGCCTCCGCCCGCCGCCGCCGAGGGGAAACCGGCCGCAAAGGCGCGTACC
GCTCCGCGTCGCGGCATAGCGGCTCCCACTAAAGCCACTGCCGCCGGGGCCAAGGGGTGA

Upstream 100 bases:

>100_bases
GTGCCGACTATCGCCGCGGCGTACTGACAGTGACCTTTCCCCGCCTCAGCGACCGGCGGAAGGTCATGCGGGATATACCG
ATCATACAAGGAGACAACTG

Downstream 100 bases:

>100_bases
GACTCGGCGAGATCGGTGAATTCGGCCTTATCGACAGGATTGCCGGCAAAGTAGCCGCCGGTGCCGGGGTTCGCCTCGGC
ATCGGCGACGACGCTGCCGT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 819; Mature: 819

Protein sequence:

>819_residues
MDDHKQENEELKIPDVLPLLPVRDVVVYPYMILPLFVGREISINAVDQALSKDRLIFLATQKEIGDEDPTPEGIYPVGTV
AMIMRMLKLPDGRVKILVQGLAKGRITSFVESKPYYSVAIERVVEPTPPEDSLEVEALMRAVKEQLTKIVSLGKPVSPEV
LVIVENMQEPGSLADLVASNIGLKVEEAQKLLEIIDPVERLQRVNELLSKEHELLDMQAKIQTAAKEEMGKSQREYFLRE
QLRAIQQELGETDARSEEIMELRKAIEQAKMPPPVEKEALKQLGRLEQMHPEAAEAGMLRTYLDWMVELPWSTSTRDILD
IKRARNILDEDHYYLDKIKERILEFLAVRKLRKKMKGPILCFVGPPGVGKTSLGKSIARALGRKFVRISLGGVRDEAEIR
GHRRTYVGALPGRIIQGLKQAGSNNPVFMLDELDKLGADFRGDPSSALLEVLDPEQNHMFSDHYINLPFNLSNVMFIATA
NQYDTIPGPLLDRMEMINLSGYTEEEKLEIAKRYLIPRQTKENGITGKHISFTDDALRTIIAKYTREAGLRNLEREIGSV
CRKVARKIAEGEKKLYRITPATVAKYLGPAKYLREVEMEHNDVGVVTGLAWTPVGGEVLFVEATIMKGKGGLTLTGHLGD
VMKESVQAALSYIRSKAQELHLPEDFLAGVDIHVHVPAGAIPKDGPSAGITMATALVSALTRVPVRKDVAMTGEITLRGK
VLPIGGLKEKMLAAIRAGITTIVIPEQNVKDLDEVPKPILKKVTVVSAKVIDDVLKVALESYPPPPPAAAEGKPAAKART
APRRGIAAPTKATAAGAKG

Sequences:

>Translated_819_residues
MDDHKQENEELKIPDVLPLLPVRDVVVYPYMILPLFVGREISINAVDQALSKDRLIFLATQKEIGDEDPTPEGIYPVGTV
AMIMRMLKLPDGRVKILVQGLAKGRITSFVESKPYYSVAIERVVEPTPPEDSLEVEALMRAVKEQLTKIVSLGKPVSPEV
LVIVENMQEPGSLADLVASNIGLKVEEAQKLLEIIDPVERLQRVNELLSKEHELLDMQAKIQTAAKEEMGKSQREYFLRE
QLRAIQQELGETDARSEEIMELRKAIEQAKMPPPVEKEALKQLGRLEQMHPEAAEAGMLRTYLDWMVELPWSTSTRDILD
IKRARNILDEDHYYLDKIKERILEFLAVRKLRKKMKGPILCFVGPPGVGKTSLGKSIARALGRKFVRISLGGVRDEAEIR
GHRRTYVGALPGRIIQGLKQAGSNNPVFMLDELDKLGADFRGDPSSALLEVLDPEQNHMFSDHYINLPFNLSNVMFIATA
NQYDTIPGPLLDRMEMINLSGYTEEEKLEIAKRYLIPRQTKENGITGKHISFTDDALRTIIAKYTREAGLRNLEREIGSV
CRKVARKIAEGEKKLYRITPATVAKYLGPAKYLREVEMEHNDVGVVTGLAWTPVGGEVLFVEATIMKGKGGLTLTGHLGD
VMKESVQAALSYIRSKAQELHLPEDFLAGVDIHVHVPAGAIPKDGPSAGITMATALVSALTRVPVRKDVAMTGEITLRGK
VLPIGGLKEKMLAAIRAGITTIVIPEQNVKDLDEVPKPILKKVTVVSAKVIDDVLKVALESYPPPPPAAAEGKPAAKART
APRRGIAAPTKATAAGAKG
>Mature_819_residues
MDDHKQENEELKIPDVLPLLPVRDVVVYPYMILPLFVGREISINAVDQALSKDRLIFLATQKEIGDEDPTPEGIYPVGTV
AMIMRMLKLPDGRVKILVQGLAKGRITSFVESKPYYSVAIERVVEPTPPEDSLEVEALMRAVKEQLTKIVSLGKPVSPEV
LVIVENMQEPGSLADLVASNIGLKVEEAQKLLEIIDPVERLQRVNELLSKEHELLDMQAKIQTAAKEEMGKSQREYFLRE
QLRAIQQELGETDARSEEIMELRKAIEQAKMPPPVEKEALKQLGRLEQMHPEAAEAGMLRTYLDWMVELPWSTSTRDILD
IKRARNILDEDHYYLDKIKERILEFLAVRKLRKKMKGPILCFVGPPGVGKTSLGKSIARALGRKFVRISLGGVRDEAEIR
GHRRTYVGALPGRIIQGLKQAGSNNPVFMLDELDKLGADFRGDPSSALLEVLDPEQNHMFSDHYINLPFNLSNVMFIATA
NQYDTIPGPLLDRMEMINLSGYTEEEKLEIAKRYLIPRQTKENGITGKHISFTDDALRTIIAKYTREAGLRNLEREIGSV
CRKVARKIAEGEKKLYRITPATVAKYLGPAKYLREVEMEHNDVGVVTGLAWTPVGGEVLFVEATIMKGKGGLTLTGHLGD
VMKESVQAALSYIRSKAQELHLPEDFLAGVDIHVHVPAGAIPKDGPSAGITMATALVSALTRVPVRKDVAMTGEITLRGK
VLPIGGLKEKMLAAIRAGITTIVIPEQNVKDLDEVPKPILKKVTVVSAKVIDDVLKVALESYPPPPPAAAEGKPAAKART
APRRGIAAPTKATAAGAKG

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=835, Percent_Identity=41.0778443113772, Blast_Score=599, Evalue=1e-171,
Organism=Homo sapiens, GI21396489, Length=842, Percent_Identity=38.8361045130641, Blast_Score=542, Evalue=1e-154,
Organism=Escherichia coli, GI1786643, Length=768, Percent_Identity=50.9114583333333, Blast_Score=786, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=684, Percent_Identity=39.1812865497076, Blast_Score=486, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17556486, Length=796, Percent_Identity=36.6834170854271, Blast_Score=478, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6319449, Length=671, Percent_Identity=40.9836065573771, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=685, Percent_Identity=44.3795620437956, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24666867, Length=685, Percent_Identity=44.3795620437956, Blast_Score=548, Evalue=1e-156,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90474; Mature: 90474

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDHKQENEELKIPDVLPLLPVRDVVVYPYMILPLFVGREISINAVDQALSKDRLIFLAT
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEE
QKEIGDEDPTPEGIYPVGTVAMIMRMLKLPDGRVKILVQGLAKGRITSFVESKPYYSVAI
CHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ERVVEPTPPEDSLEVEALMRAVKEQLTKIVSLGKPVSPEVLVIVENMQEPGSLADLVASN
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHH
IGLKVEEAQKLLEIIDPVERLQRVNELLSKEHELLDMQAKIQTAAKEEMGKSQREYFLRE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
QLRAIQQELGETDARSEEIMELRKAIEQAKMPPPVEKEALKQLGRLEQMHPEAAEAGMLR
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
TYLDWMVELPWSTSTRDILDIKRARNILDEDHYYLDKIKERILEFLAVRKLRKKMKGPIL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
CFVGPPGVGKTSLGKSIARALGRKFVRISLGGVRDEAEIRGHRRTYVGALPGRIIQGLKQ
EEECCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHCCCHHHHHHCCHHHHHHHHHH
AGSNNPVFMLDELDKLGADFRGDPSSALLEVLDPEQNHMFSDHYINLPFNLSNVMFIATA
CCCCCCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEEEEEC
NQYDTIPGPLLDRMEMINLSGYTEEEKLEIAKRYLIPRQTKENGITGKHISFTDDALRTI
CCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
IAKYTREAGLRNLEREIGSVCRKVARKIAEGEKKLYRITPATVAKYLGPAKYLREVEMEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECHHHHHHHHCHHHHHHHHHHCC
NDVGVVTGLAWTPVGGEVLFVEATIMKGKGGLTLTGHLGDVMKESVQAALSYIRSKAQEL
CCCEEEECCEECCCCCEEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHC
HLPEDFLAGVDIHVHVPAGAIPKDGPSAGITMATALVSALTRVPVRKDVAMTGEITLRGK
CCCHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECEEEEEEE
VLPIGGLKEKMLAAIRAGITTIVIPEQNVKDLDEVPKPILKKVTVVSAKVIDDVLKVALE
EEECCCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
SYPPPPPAAAEGKPAAKARTAPRRGIAAPTKATAAGAKG
CCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDDHKQENEELKIPDVLPLLPVRDVVVYPYMILPLFVGREISINAVDQALSKDRLIFLAT
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEE
QKEIGDEDPTPEGIYPVGTVAMIMRMLKLPDGRVKILVQGLAKGRITSFVESKPYYSVAI
CHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ERVVEPTPPEDSLEVEALMRAVKEQLTKIVSLGKPVSPEVLVIVENMQEPGSLADLVASN
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHH
IGLKVEEAQKLLEIIDPVERLQRVNELLSKEHELLDMQAKIQTAAKEEMGKSQREYFLRE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
QLRAIQQELGETDARSEEIMELRKAIEQAKMPPPVEKEALKQLGRLEQMHPEAAEAGMLR
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
TYLDWMVELPWSTSTRDILDIKRARNILDEDHYYLDKIKERILEFLAVRKLRKKMKGPIL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
CFVGPPGVGKTSLGKSIARALGRKFVRISLGGVRDEAEIRGHRRTYVGALPGRIIQGLKQ
EEECCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHCCCHHHHHHCCHHHHHHHHHH
AGSNNPVFMLDELDKLGADFRGDPSSALLEVLDPEQNHMFSDHYINLPFNLSNVMFIATA
CCCCCCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEEEEEC
NQYDTIPGPLLDRMEMINLSGYTEEEKLEIAKRYLIPRQTKENGITGKHISFTDDALRTI
CCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
IAKYTREAGLRNLEREIGSVCRKVARKIAEGEKKLYRITPATVAKYLGPAKYLREVEMEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECHHHHHHHHCHHHHHHHHHHCC
NDVGVVTGLAWTPVGGEVLFVEATIMKGKGGLTLTGHLGDVMKESVQAALSYIRSKAQEL
CCCEEEECCEECCCCCEEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHC
HLPEDFLAGVDIHVHVPAGAIPKDGPSAGITMATALVSALTRVPVRKDVAMTGEITLRGK
CCCHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECEEEEEEE
VLPIGGLKEKMLAAIRAGITTIVIPEQNVKDLDEVPKPILKKVTVVSAKVIDDVLKVALE
EEECCCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
SYPPPPPAAAEGKPAAKARTAPRRGIAAPTKATAAGAKG
CCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA