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The map label for this gene is ugd [H]

Identifier: 39996915

GI number: 39996915

Start: 1981485

End: 1982846

Strand: Reverse

Name: ugd [H]

Synonym: GSU1816

Alternate gene names: 39996915

Gene position: 1982846-1981485 (Counterclockwise)

Preceding gene: 39996917

Following gene: 39996914

Centisome position: 51.99

GC content: 59.03

Gene sequence:

>1362_bases
ATGAAAATCTGCGTCATTGGCACCGGCTATGTGGGGCTCGTTGCCGGAACCTGTTTTGCCGAAAGCGGCAATACCGTTGT
CTGCGTGGATGTAAATGAAGAGAAAATAGCCGGACTCCGGGAGGGAGTCATCCCTATCTACGAGCCGGGGCTCAAGGAGA
TGGTGATCCGCAACAGCGCTGAGGGGCGGCTAACCTTTACCACCGATCTCGCCGCTGCGGTGAAGACATCCTTGGTGAAC
TTCATTGCCGTGGGTACCCCGCCGGGTGAAGACGGGTCCGCAGACCTCAAGTACGTGCTCGATGTGGCTCGCGCCATCGG
GAGCCACATGGAAGGGTTCAAAATCATCGTCGACAAGTCCACCGTTCCGGTCGGCACGGCCGATCAGGTGCGGCGCGCCG
TGCAGGAGGAACTGGACCGTCGCGGCGTCAGCTATGAGTTCGATGTGGTGTCCAATCCCGAGTTTCTCAAGGAGGGGGCG
GCCATTGACGACTTCATGAAGCCCGACCGTGTCGTCATCGGCGTTGACAACGTGCGGACCGCCGAACTGATGAAGGAGCT
CTATTCCCCCTTCATGCGCAAGACCAACCGTATGATCCTGATGGACGTACGCAGTGCCGAGATGACTAAATATGCCGCGA
ATGCCATGCTTGCCACGCGGATTTCCTTCATGAACCAGATTGCCAATCTCTGTGAACGGATGGGCGCCGATGTCTCCGCG
GTCCGGGAAGGTATCGGGTCAGATTCGCGCATCGGCTACGATTTTCTGTTTCCCGGCGTGGGCTACGGCGGTTCATGCTT
TCCCAAGGACGTGAAGGCCCTGGTTCGGACCGCGGAAGAGTGCGGCTACGACTTCATGCTTCTCAAGGCGGTTGAAGAGG
TGAACGAGCGGCAAAAGATGCTCATCCCCGAGAAGATCCTCCGGCACTTTTCCGGAGATCGGGCAGGAGAGTCACGTCCC
CTCGCCGGCAAGACCATTGCCGTGTGGGGCCTGTCATTCAAGCCGCGCACCGATGACATGCGCGAGGCACCTTCCATTGT
CGTGATCGAGCGGCTGCTGGCGGAGGGAGCCTCGGTCCGCGCCCATGACCCCGAGGCGGTCAAGGAGGCGCAAAAAATCT
TCGGTGATCGCATTGCCTACAGCTGTTCCAGTCCCTACGACATCCTTGCCGGTGCCGACGCACTCGCCATCGTTACCGAG
TGGAACGAGTATCGCAACCCCGATTTCGAACGGATCGCCGAGCAGCTCAGAACGCCGGTCATCTTTGATGGGCGCAATCT
TTACAATCCGCGCCGCCTGAAAGAAATGGGCTTCATTTACCACGGAATCGGCCGCAACGGCTCCGGCTTCGTGGAAAAGT
AG

Upstream 100 bases:

>100_bases
TCCCCGTCTCCTTGACGCTGCCGGGATACGGAAATCTCTGGAAGTGACCGGGGTTTCCATGTTATAAAAATCCGCTGATG
TTTCCGTCTGGAGGGCGTTC

Downstream 100 bases:

>100_bases
GCGACTTATGCGCATCCTGGTAACCGGCGGCGCCGGATTCATCGGTTCTCATCTGTGCGAACGGCTTCTGGAGCAGGGGC
ATGACGTGCTCTGCCTCGAC

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKICVIGTGYVGLVAGTCFAESGNTVVCVDVNEEKIAGLREGVIPIYEPGLKEMVIRNSAEGRLTFTTDLAAAVKTSLVN
FIAVGTPPGEDGSADLKYVLDVARAIGSHMEGFKIIVDKSTVPVGTADQVRRAVQEELDRRGVSYEFDVVSNPEFLKEGA
AIDDFMKPDRVVIGVDNVRTAELMKELYSPFMRKTNRMILMDVRSAEMTKYAANAMLATRISFMNQIANLCERMGADVSA
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALVRTAEECGYDFMLLKAVEEVNERQKMLIPEKILRHFSGDRAGESRP
LAGKTIAVWGLSFKPRTDDMREAPSIVVIERLLAEGASVRAHDPEAVKEAQKIFGDRIAYSCSSPYDILAGADALAIVTE
WNEYRNPDFERIAEQLRTPVIFDGRNLYNPRRLKEMGFIYHGIGRNGSGFVEK

Sequences:

>Translated_453_residues
MKICVIGTGYVGLVAGTCFAESGNTVVCVDVNEEKIAGLREGVIPIYEPGLKEMVIRNSAEGRLTFTTDLAAAVKTSLVN
FIAVGTPPGEDGSADLKYVLDVARAIGSHMEGFKIIVDKSTVPVGTADQVRRAVQEELDRRGVSYEFDVVSNPEFLKEGA
AIDDFMKPDRVVIGVDNVRTAELMKELYSPFMRKTNRMILMDVRSAEMTKYAANAMLATRISFMNQIANLCERMGADVSA
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALVRTAEECGYDFMLLKAVEEVNERQKMLIPEKILRHFSGDRAGESRP
LAGKTIAVWGLSFKPRTDDMREAPSIVVIERLLAEGASVRAHDPEAVKEAQKIFGDRIAYSCSSPYDILAGADALAIVTE
WNEYRNPDFERIAEQLRTPVIFDGRNLYNPRRLKEMGFIYHGIGRNGSGFVEK
>Mature_453_residues
MKICVIGTGYVGLVAGTCFAESGNTVVCVDVNEEKIAGLREGVIPIYEPGLKEMVIRNSAEGRLTFTTDLAAAVKTSLVN
FIAVGTPPGEDGSADLKYVLDVARAIGSHMEGFKIIVDKSTVPVGTADQVRRAVQEELDRRGVSYEFDVVSNPEFLKEGA
AIDDFMKPDRVVIGVDNVRTAELMKELYSPFMRKTNRMILMDVRSAEMTKYAANAMLATRISFMNQIANLCERMGADVSA
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALVRTAEECGYDFMLLKAVEEVNERQKMLIPEKILRHFSGDRAGESRP
LAGKTIAVWGLSFKPRTDDMREAPSIVVIERLLAEGASVRAHDPEAVKEAQKIFGDRIAYSCSSPYDILAGADALAIVTE
WNEYRNPDFERIAEQLRTPVIFDGRNLYNPRRLKEMGFIYHGIGRNGSGFVEK

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=481, Percent_Identity=36.5904365904366, Blast_Score=258, Evalue=5e-69,
Organism=Homo sapiens, GI296040438, Length=383, Percent_Identity=35.509138381201, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI296040443, Length=323, Percent_Identity=35.6037151702786, Blast_Score=175, Evalue=6e-44,
Organism=Escherichia coli, GI1788340, Length=380, Percent_Identity=27.1052631578947, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI48994968, Length=421, Percent_Identity=25.8907363420428, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17560350, Length=473, Percent_Identity=36.3636363636364, Blast_Score=264, Evalue=8e-71,
Organism=Drosophila melanogaster, GI17136908, Length=475, Percent_Identity=36.8421052631579, Blast_Score=275, Evalue=6e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 49918; Mature: 49918

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKICVIGTGYVGLVAGTCFAESGNTVVCVDVNEEKIAGLREGVIPIYEPGLKEMVIRNSA
CEEEEEECCHHHHHHHHHEECCCCEEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHCCC
EGRLTFTTDLAAAVKTSLVNFIAVGTPPGEDGSADLKYVLDVARAIGSHMEGFKIIVDKS
CCEEEEEHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
TVPVGTADQVRRAVQEELDRRGVSYEFDVVSNPEFLKEGAAIDDFMKPDRVVIGVDNVRT
CCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCHHHHCCCCEEEEECCCCCH
AELMKELYSPFMRKTNRMILMDVRSAEMTKYAANAMLATRISFMNQIANLCERMGADVSA
HHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALVRTAEECGYDFMLLKAVEEVNERQKM
HHHCCCCCCCCCHHEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LIPEKILRHFSGDRAGESRPLAGKTIAVWGLSFKPRTDDMREAPSIVVIERLLAEGASVR
CCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCHHHHHHHHHHCCCCCC
AHDPEAVKEAQKIFGDRIAYSCSSPYDILAGADALAIVTEWNEYRNPDFERIAEQLRTPV
CCCHHHHHHHHHHHHHHHEECCCCCCHHHCCCCEEEEEECCHHHCCCCHHHHHHHHCCCE
IFDGRNLYNPRRLKEMGFIYHGIGRNGSGFVEK
EECCCCCCCHHHHHHHCHHEECCCCCCCCCCCC
>Mature Secondary Structure
MKICVIGTGYVGLVAGTCFAESGNTVVCVDVNEEKIAGLREGVIPIYEPGLKEMVIRNSA
CEEEEEECCHHHHHHHHHEECCCCEEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHCCC
EGRLTFTTDLAAAVKTSLVNFIAVGTPPGEDGSADLKYVLDVARAIGSHMEGFKIIVDKS
CCEEEEEHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
TVPVGTADQVRRAVQEELDRRGVSYEFDVVSNPEFLKEGAAIDDFMKPDRVVIGVDNVRT
CCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCHHHHCCCCEEEEECCCCCH
AELMKELYSPFMRKTNRMILMDVRSAEMTKYAANAMLATRISFMNQIANLCERMGADVSA
HHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALVRTAEECGYDFMLLKAVEEVNERQKM
HHHCCCCCCCCCHHEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LIPEKILRHFSGDRAGESRPLAGKTIAVWGLSFKPRTDDMREAPSIVVIERLLAEGASVR
CCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCHHHHHHHHHHCCCCCC
AHDPEAVKEAQKIFGDRIAYSCSSPYDILAGADALAIVTEWNEYRNPDFERIAEQLRTPV
CCCHHHHHHHHHHHHHHHEECCCCCCHHHCCCCEEEEEECCHHHCCCCHHHHHHHHCCCE
IFDGRNLYNPRRLKEMGFIYHGIGRNGSGFVEK
EECCCCCCCHHHHHHHCHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]