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The map label for this gene is maeB [H]

Identifier: 39996800

GI number: 39996800

Start: 1861362

End: 1863620

Strand: Reverse

Name: maeB [H]

Synonym: GSU1700

Alternate gene names: 39996800

Gene position: 1863620-1861362 (Counterclockwise)

Preceding gene: 39996810

Following gene: 39996799

Centisome position: 48.86

GC content: 57.64

Gene sequence:

>2259_bases
ATGAGCAAAAAGCAGGACGCCCTTGATTATCACTCCACAGGACGAAAAGGGAAGATAGAGGTAATTCCGTCAAAACCATG
TCTTACCCAGCGCGACCTCTCCCTTGCCTACTCACCCGGTGTAGCCGAACCTTGTCTTGAAATCGAAAAAAACCCTGAAG
ACGCATATAAATATACTGCCAAGGGGAATCTGGTGGCGGTATTGTCCAACGGTACGGCCGTTCTCGGTCTCGGTGACATC
GGCGCCTTGGCCGGCAAACCGGTCATGGAGGGCAAAGGGGTTCTCTTCAAGCGTTTTGCCGATATCGATGTCTTCGACAT
CGAGGTTGACACCAAAAACGCTGACGAAATAATCAAGGTCTGCCAGTTGCTGGAACCGACCTTCGGCGGCATAAACCTTG
AGGACATCAAGGCACCTGAATGCTTTTATATCGAGGAAAAGCTCAAGGAGACCATGAACATTCCGGTCTTCCACGACGAT
CAGCATGGCACCGCCATCATTTCCGGCGCAGCCCTCATCAATGCCCTTGAACTGGTCGGCAAGAAGATCGAAGACATCAA
GATCGTGGTCAACGGCGCCGGAGCCTCCGGCATCGCCTGCGCCCAGATGGCGGTTGAACTTGGTGCGAAAAAGGAGAACA
TCATTCTCTGCGATACCAAGGGCGTCATCTTCAAGGGACGTAGCGCCGGCATGAACGAGTACAAGGAGCGCTTCGCCGTC
GAAACCGAAGACCGCACCCTGGAAGATGCCTTCAAAAATGCCGATGTGGCCTACGGCCTCTCCAGCAAGGGGGCATTCAC
CCCCGAAATGATCCGTGACATGGCGCCCAACCCGATCATCTTCGCCATGGCAAACCCCGATCCCGAAATCACCCCCGAGG
AGGTGGCGGCGGTCCGGGCCGACGCCATCATGGCCACCGGCCGCTCCGACTATCCTAACCAGGTGAATAACGTTCTGGGC
TTCCCCTTCATCTTCCGCGGCGCACTCGATGTGCGGGCCACGACCATCAATGAGACCATGAAAAAGGCGTGCGTCTTCGC
TCTGGCCGAACTGGCCAAAGAGGACTGCCCGGACTCGGTGTGTCGTGCGTACGGCAATAAGAAATTCGCCTTCGGTCGCG
AGTACATCATTCCTAAGCCCTTTGATCCCCGCGCGCTCCTGAGGGTGGCTCCTGCCGTTGCCAAGGCGGCCATGGAGTCG
GGGGTCGCCCGCCAGCCCATTGCCGACATGGAAAAGTACATGGAGCATCTGGAGACGCTCCAGGGCAAGGCCAAGGAGAC
TCTGCGCCTCATCATCAACAAGGCGAAGACCGATCCCAAGCGGGTCGTCTTGCCCGAGGGCGAGAATGAAAAGATCCTTC
GGGCCGCACAAGTGATGATCGAAGAGGGGATCGCCTATCCGATCCTCCTGGGCAATCGGCAGGAAATCCGCAAAAAGATC
GAAGAGCTCAACCTTGATCTTAATGGCGGCGTCACTATCATTGACCCAGACGACAGCCCCGACACTGAGCGTTACTCCCA
AGCCCTGTTCGAGCAGCGGCAGCGGAAAGGGATCACCCTGACCGAGGCCCGCCGCATGATCCGGCGCCGGGGCCGCACTT
ATTTCGGCTGCGAGATGGTCCGTTGCGGCGATGCCGATGCTCTGCTTTCTGGCATTGATGCCCATTATCCCGACATCATC
CGCCCTGCCCTTGAAGTGATCGGCAAGCAGGAAGGCCTCTCCAGCGTCCACGGCCTTTACCTCATGGTTTTCAAGCGGGG
CATTTTCCTGCTGGCCGACACCACGGTCTGCATCGAGCCTACCGCCGAGGAACTGGCCGAAACCGCCATACTGGCAGCCG
AGAAGGCACGGCTTCTGGATCTCGACCCCCGTATCGCCATGCTTTCATTTTCCAACTTTGGTTCCGTCAACCACCCCCAG
GCCCTCAAGGTCAAGCGGGCTGCGGAGATCGTCAAACAGCGGGCGCCGGAACTGATAATCGACGGCGAGATGCAGGCCGA
CACCGCCGTTGTGCCTGACATTCTGGAGTCCCATTATCCCTTTGCCACACTCAAAGGCGGAGCAAACATCCTCATTTTCC
CCGACCTGAACTCGGGCAACATCAGCTACAAGCTCCTTACCCGCCTTGGCGGAGCCGACGCCATCGGCCCGATTCTCATG
GGAATGAAGAAGCCGGTGCACGTACTGCAGCGCGGCGATGACGTAATGGATATCGTCAACATGGCAGCCATTGCCGTTGT
CGACGCGCAAAGCAACTGA

Upstream 100 bases:

>100_bases
AAAAACGCTGGCGATAAAACCGTGTTGGGCTCGTCACAGCATATCAAAACAAATTTTAGCTTCACTAAAACGTGCGGGCC
GCGAAAGGAGCGAACACCAC

Downstream 100 bases:

>100_bases
AGCGCCAACATATGGAAATGACAAAGGGGGCCGTCGGCCCCCTTTTTTTGTCGCAAAATCCGATAGGTAAACAAGAAATC
GGGTTGTCACGGCCTTGGGG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 752; Mature: 751

Protein sequence:

>752_residues
MSKKQDALDYHSTGRKGKIEVIPSKPCLTQRDLSLAYSPGVAEPCLEIEKNPEDAYKYTAKGNLVAVLSNGTAVLGLGDI
GALAGKPVMEGKGVLFKRFADIDVFDIEVDTKNADEIIKVCQLLEPTFGGINLEDIKAPECFYIEEKLKETMNIPVFHDD
QHGTAIISGAALINALELVGKKIEDIKIVVNGAGASGIACAQMAVELGAKKENIILCDTKGVIFKGRSAGMNEYKERFAV
ETEDRTLEDAFKNADVAYGLSSKGAFTPEMIRDMAPNPIIFAMANPDPEITPEEVAAVRADAIMATGRSDYPNQVNNVLG
FPFIFRGALDVRATTINETMKKACVFALAELAKEDCPDSVCRAYGNKKFAFGREYIIPKPFDPRALLRVAPAVAKAAMES
GVARQPIADMEKYMEHLETLQGKAKETLRLIINKAKTDPKRVVLPEGENEKILRAAQVMIEEGIAYPILLGNRQEIRKKI
EELNLDLNGGVTIIDPDDSPDTERYSQALFEQRQRKGITLTEARRMIRRRGRTYFGCEMVRCGDADALLSGIDAHYPDII
RPALEVIGKQEGLSSVHGLYLMVFKRGIFLLADTTVCIEPTAEELAETAILAAEKARLLDLDPRIAMLSFSNFGSVNHPQ
ALKVKRAAEIVKQRAPELIIDGEMQADTAVVPDILESHYPFATLKGGANILIFPDLNSGNISYKLLTRLGGADAIGPILM
GMKKPVHVLQRGDDVMDIVNMAAIAVVDAQSN

Sequences:

>Translated_752_residues
MSKKQDALDYHSTGRKGKIEVIPSKPCLTQRDLSLAYSPGVAEPCLEIEKNPEDAYKYTAKGNLVAVLSNGTAVLGLGDI
GALAGKPVMEGKGVLFKRFADIDVFDIEVDTKNADEIIKVCQLLEPTFGGINLEDIKAPECFYIEEKLKETMNIPVFHDD
QHGTAIISGAALINALELVGKKIEDIKIVVNGAGASGIACAQMAVELGAKKENIILCDTKGVIFKGRSAGMNEYKERFAV
ETEDRTLEDAFKNADVAYGLSSKGAFTPEMIRDMAPNPIIFAMANPDPEITPEEVAAVRADAIMATGRSDYPNQVNNVLG
FPFIFRGALDVRATTINETMKKACVFALAELAKEDCPDSVCRAYGNKKFAFGREYIIPKPFDPRALLRVAPAVAKAAMES
GVARQPIADMEKYMEHLETLQGKAKETLRLIINKAKTDPKRVVLPEGENEKILRAAQVMIEEGIAYPILLGNRQEIRKKI
EELNLDLNGGVTIIDPDDSPDTERYSQALFEQRQRKGITLTEARRMIRRRGRTYFGCEMVRCGDADALLSGIDAHYPDII
RPALEVIGKQEGLSSVHGLYLMVFKRGIFLLADTTVCIEPTAEELAETAILAAEKARLLDLDPRIAMLSFSNFGSVNHPQ
ALKVKRAAEIVKQRAPELIIDGEMQADTAVVPDILESHYPFATLKGGANILIFPDLNSGNISYKLLTRLGGADAIGPILM
GMKKPVHVLQRGDDVMDIVNMAAIAVVDAQSN
>Mature_751_residues
SKKQDALDYHSTGRKGKIEVIPSKPCLTQRDLSLAYSPGVAEPCLEIEKNPEDAYKYTAKGNLVAVLSNGTAVLGLGDIG
ALAGKPVMEGKGVLFKRFADIDVFDIEVDTKNADEIIKVCQLLEPTFGGINLEDIKAPECFYIEEKLKETMNIPVFHDDQ
HGTAIISGAALINALELVGKKIEDIKIVVNGAGASGIACAQMAVELGAKKENIILCDTKGVIFKGRSAGMNEYKERFAVE
TEDRTLEDAFKNADVAYGLSSKGAFTPEMIRDMAPNPIIFAMANPDPEITPEEVAAVRADAIMATGRSDYPNQVNNVLGF
PFIFRGALDVRATTINETMKKACVFALAELAKEDCPDSVCRAYGNKKFAFGREYIIPKPFDPRALLRVAPAVAKAAMESG
VARQPIADMEKYMEHLETLQGKAKETLRLIINKAKTDPKRVVLPEGENEKILRAAQVMIEEGIAYPILLGNRQEIRKKIE
ELNLDLNGGVTIIDPDDSPDTERYSQALFEQRQRKGITLTEARRMIRRRGRTYFGCEMVRCGDADALLSGIDAHYPDIIR
PALEVIGKQEGLSSVHGLYLMVFKRGIFLLADTTVCIEPTAEELAETAILAAEKARLLDLDPRIAMLSFSNFGSVNHPQA
LKVKRAAEIVKQRAPELIIDGEMQADTAVVPDILESHYPFATLKGGANILIFPDLNSGNISYKLLTRLGGADAIGPILMG
MKKPVHVLQRGDDVMDIVNMAAIAVVDAQSN

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=359, Percent_Identity=28.6908077994429, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI62420882, Length=368, Percent_Identity=27.445652173913, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI62420880, Length=368, Percent_Identity=27.445652173913, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI239049447, Length=368, Percent_Identity=27.445652173913, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI4505145, Length=319, Percent_Identity=29.153605015674, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI270265879, Length=320, Percent_Identity=29.0625, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1788806, Length=754, Percent_Identity=53.448275862069, Blast_Score=778, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=317, Percent_Identity=35.3312302839117, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1788635, Length=345, Percent_Identity=35.6521739130435, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI87081919, Length=284, Percent_Identity=26.4084507042254, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17537199, Length=416, Percent_Identity=23.7980769230769, Blast_Score=73, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=29.8507462686567, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24646388, Length=400, Percent_Identity=27.25, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646386, Length=400, Percent_Identity=27.25, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281362674, Length=408, Percent_Identity=24.7549019607843, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356279, Length=408, Percent_Identity=24.7549019607843, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281362672, Length=408, Percent_Identity=24.7549019607843, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI78707242, Length=411, Percent_Identity=26.2773722627737, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI78707238, Length=411, Percent_Identity=26.2773722627737, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI78707240, Length=395, Percent_Identity=26.0759493670886, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82151; Mature: 82020

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKQDALDYHSTGRKGKIEVIPSKPCLTQRDLSLAYSPGVAEPCLEIEKNPEDAYKYTA
CCCCCCCCHHHCCCCCCEEEEECCCCCCCCCCCCEEECCCCCCHHHHCCCCCHHHEEEEC
KGNLVAVLSNGTAVLGLGDIGALAGKPVMEGKGVLFKRFADIDVFDIEVDTKNADEIIKV
CCCEEEEEECCEEEEEECCHHHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCHHHHHHH
CQLLEPTFGGINLEDIKAPECFYIEEKLKETMNIPVFHDDQHGTAIISGAALINALELVG
HHHHCCCCCCCCHHHCCCCCEEEHHHHHHHHCCCCEEECCCCCCEEEHHHHHHHHHHHHC
KKIEDIKIVVNGAGASGIACAQMAVELGAKKENIILCDTKGVIFKGRSAGMNEYKERFAV
CCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCHHHHHHHHCC
ETEDRTLEDAFKNADVAYGLSSKGAFTPEMIRDMAPNPIIFAMANPDPEITPEEVAAVRA
CCCCCHHHHHHCCCCEEECCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHH
DAIMATGRSDYPNQVNNVLGFPFIFRGALDVRATTINETMKKACVFALAELAKEDCPDSV
HHHEECCCCCCCHHHHHHCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHH
CRAYGNKKFAFGREYIIPKPFDPRALLRVAPAVAKAAMESGVARQPIADMEKYMEHLETL
HHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QGKAKETLRLIINKAKTDPKRVVLPEGENEKILRAAQVMIEEGIAYPILLGNRQEIRKKI
HHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
EELNLDLNGGVTIIDPDDSPDTERYSQALFEQRQRKGITLTEARRMIRRRGRTYFGCEMV
HHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECEEEE
RCGDADALLSGIDAHYPDIIRPALEVIGKQEGLSSVHGLYLMVFKRGIFLLADTTVCIEP
EECCHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCEEEECC
TAEELAETAILAAEKARLLDLDPRIAMLSFSNFGSVNHPQALKVKRAAEIVKQRAPELII
CHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
DGEMQADTAVVPDILESHYPFATLKGGANILIFPDLNSGNISYKLLTRLGGADAIGPILM
CCCCCCCCHHHHHHHHCCCCEEEECCCCEEEEEECCCCCCEEEEHHHHCCCCHHHHHHHH
GMKKPVHVLQRGDDVMDIVNMAAIAVVDAQSN
CCCCHHHHHHCCCHHHHHHHHHHEEEEECCCC
>Mature Secondary Structure 
SKKQDALDYHSTGRKGKIEVIPSKPCLTQRDLSLAYSPGVAEPCLEIEKNPEDAYKYTA
CCCCCCCHHHCCCCCCEEEEECCCCCCCCCCCCEEECCCCCCHHHHCCCCCHHHEEEEC
KGNLVAVLSNGTAVLGLGDIGALAGKPVMEGKGVLFKRFADIDVFDIEVDTKNADEIIKV
CCCEEEEEECCEEEEEECCHHHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCHHHHHHH
CQLLEPTFGGINLEDIKAPECFYIEEKLKETMNIPVFHDDQHGTAIISGAALINALELVG
HHHHCCCCCCCCHHHCCCCCEEEHHHHHHHHCCCCEEECCCCCCEEEHHHHHHHHHHHHC
KKIEDIKIVVNGAGASGIACAQMAVELGAKKENIILCDTKGVIFKGRSAGMNEYKERFAV
CCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCHHHHHHHHCC
ETEDRTLEDAFKNADVAYGLSSKGAFTPEMIRDMAPNPIIFAMANPDPEITPEEVAAVRA
CCCCCHHHHHHCCCCEEECCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHH
DAIMATGRSDYPNQVNNVLGFPFIFRGALDVRATTINETMKKACVFALAELAKEDCPDSV
HHHEECCCCCCCHHHHHHCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHH
CRAYGNKKFAFGREYIIPKPFDPRALLRVAPAVAKAAMESGVARQPIADMEKYMEHLETL
HHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QGKAKETLRLIINKAKTDPKRVVLPEGENEKILRAAQVMIEEGIAYPILLGNRQEIRKKI
HHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
EELNLDLNGGVTIIDPDDSPDTERYSQALFEQRQRKGITLTEARRMIRRRGRTYFGCEMV
HHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECEEEE
RCGDADALLSGIDAHYPDIIRPALEVIGKQEGLSSVHGLYLMVFKRGIFLLADTTVCIEP
EECCHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCEEEECC
TAEELAETAILAAEKARLLDLDPRIAMLSFSNFGSVNHPQALKVKRAAEIVKQRAPELII
CHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
DGEMQADTAVVPDILESHYPFATLKGGANILIFPDLNSGNISYKLLTRLGGADAIGPILM
CCCCCCCCHHHHHHHHCCCCEEEECCCCEEEEEECCCCCCEEEEHHHHCCCCHHHHHHHH
GMKKPVHVLQRGDDVMDIVNMAAIAVVDAQSN
CCCCHHHHHHCCCHHHHHHHHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]