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The map label for this gene is hisS

Identifier: 39996759

GI number: 39996759

Start: 1821195

End: 1822436

Strand: Direct

Name: hisS

Synonym: GSU1659

Alternate gene names: 39996759

Gene position: 1821195-1822436 (Clockwise)

Preceding gene: 39996758

Following gene: 39996760

Centisome position: 47.75

GC content: 58.29

Gene sequence:

>1242_bases
ATGATTACAGGTATCAAGGGATTCAACGACATTCTTCCCGGGGAAGTGGAGCGGTGGCAGCACATCGAAGCCACAGCACG
CCGGGTTTTCAGTCTCTACGGATTTTCGGAGATCCGCATCCCGATTCTTGAAAAAACCGAATTGTTCCGGCGGTCCATCG
GCGATACCACTGATATCGTGGAAAAAGAAATGTACTCCTTTGTGGATAAGGGAGAGAACGCTGTAACCATGCGTCCTGAA
GGGACAGCAAGCGTAATGAGGTCGTACATAGAGCACAAGCTCTATGCCCAGGATCCGGTGGCAAAGCTCTACTACATGGG
CCCCATGTTTCGATACGAGCGGCCCCAGAAAGGGCGTTACCGCCAGTTCCACCAGATCGGTGCCGAGGTGACCGGAGTTA
CCGACCCCAAGGTCGATGCCCAGGTTCTCACCATGCTCTGCCACTATTTCGCCGAGCTTGGACTGACTGAACCGACACTT
CAGATCAACTCCCTCGGATGCCCCGAATGCCGTCCCGCATATCGTCAAGCCCTGATCGATTTCCTCCGGGAACGGCTCGA
CAGCCTCTGCGAAGACTGCAAGCGCCGCTATCAGACCAATCCCCTGCGTGCGCTTGACTGCAAATCGGCCCACTGCAAGG
AGGCGACCGCCTCCGCTCCGGCCATGCTTGATAGCCTCTGTGCAGGCTGCGACGATCATTTCACCGCTACCCGACGCCAT
TTGGAGCGGGCAGGCACCACTTACAGCATCAATAACCGGATGGTCCGCGGGCTTGATTACTATACCCGAACCACCTTCGA
ACTGGTGACCGGCCTGCTTGGTGCTCAGAGCGCGGTTGCTGCTGGAGGCCGGTACGACGGTCTTATCTCTGACCTTGGCG
GGCCCGCCATTCCCGGTATTGGATTTGCCATGGGGGTGGAGCGGATAGCCCTCCTGCTGGGGGACCAACACTTCGTCGGC
CGGCCGGATCTCTTCATAGCCGCCCTTGGCGAGGAGGCCCAGGACGAGGCGTTTCGCCTCATGTGCGGCCTGCAGCGAAA
CGGGGTGGCCGTGGAAATGGACTATGAAGGCAAGAGCCTCAAGAGCCAGATGCGCCGGTCGGACAAGTTCAACGCGCGTT
TTACCCTGATCATCGGTGGTGATGAGTTGGCAATAGGGGCGGCTGTACTCAAGGCAATGGACACCGGTGTCCAGGTGGAA
GTCCCGTTGACGCCGGAAGAGGTCGCCGCACGAATAACGTGA

Upstream 100 bases:

>100_bases
GTATAGGGGCAAGGAAGAGGGCAAAAACCGTGTATTCCGGGCAACGGCAATCCGTTGACCTTGAGTGTGTTTCAATGCAA
TTAAAGGAGTAGGTACGTAC

Downstream 100 bases:

>100_bases
CGGTGTAATAGCAATACCTGCATTGGACGGAAAGCGAGCCGGGCGACGATACGCGTTGTCCCGGCTCTTTTTTCTCTTCT
GATTCCACGGGATGATTACT

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MITGIKGFNDILPGEVERWQHIEATARRVFSLYGFSEIRIPILEKTELFRRSIGDTTDIVEKEMYSFVDKGENAVTMRPE
GTASVMRSYIEHKLYAQDPVAKLYYMGPMFRYERPQKGRYRQFHQIGAEVTGVTDPKVDAQVLTMLCHYFAELGLTEPTL
QINSLGCPECRPAYRQALIDFLRERLDSLCEDCKRRYQTNPLRALDCKSAHCKEATASAPAMLDSLCAGCDDHFTATRRH
LERAGTTYSINNRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLISDLGGPAIPGIGFAMGVERIALLLGDQHFVG
RPDLFIAALGEEAQDEAFRLMCGLQRNGVAVEMDYEGKSLKSQMRRSDKFNARFTLIIGGDELAIGAAVLKAMDTGVQVE
VPLTPEEVAARIT

Sequences:

>Translated_413_residues
MITGIKGFNDILPGEVERWQHIEATARRVFSLYGFSEIRIPILEKTELFRRSIGDTTDIVEKEMYSFVDKGENAVTMRPE
GTASVMRSYIEHKLYAQDPVAKLYYMGPMFRYERPQKGRYRQFHQIGAEVTGVTDPKVDAQVLTMLCHYFAELGLTEPTL
QINSLGCPECRPAYRQALIDFLRERLDSLCEDCKRRYQTNPLRALDCKSAHCKEATASAPAMLDSLCAGCDDHFTATRRH
LERAGTTYSINNRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLISDLGGPAIPGIGFAMGVERIALLLGDQHFVG
RPDLFIAALGEEAQDEAFRLMCGLQRNGVAVEMDYEGKSLKSQMRRSDKFNARFTLIIGGDELAIGAAVLKAMDTGVQVE
VPLTPEEVAARIT
>Mature_413_residues
MITGIKGFNDILPGEVERWQHIEATARRVFSLYGFSEIRIPILEKTELFRRSIGDTTDIVEKEMYSFVDKGENAVTMRPE
GTASVMRSYIEHKLYAQDPVAKLYYMGPMFRYERPQKGRYRQFHQIGAEVTGVTDPKVDAQVLTMLCHYFAELGLTEPTL
QINSLGCPECRPAYRQALIDFLRERLDSLCEDCKRRYQTNPLRALDCKSAHCKEATASAPAMLDSLCAGCDDHFTATRRH
LERAGTTYSINNRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLISDLGGPAIPGIGFAMGVERIALLLGDQHFVG
RPDLFIAALGEEAQDEAFRLMCGLQRNGVAVEMDYEGKSLKSQMRRSDKFNARFTLIIGGDELAIGAAVLKAMDTGVQVE
VPLTPEEVAARIT

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI15029520, Length=465, Percent_Identity=24.5161290322581, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1788861, Length=419, Percent_Identity=47.0167064439141, Blast_Score=380, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_GEOSL (P60915)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952710.1
- ProteinModelPortal:   P60915
- SMR:   P60915
- GeneID:   2685305
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1659
- NMPDR:   fig|243231.1.peg.1648
- TIGR:   GSU1659
- HOGENOM:   HBG616575
- OMA:   RYETNIL
- ProtClustDB:   PRK00037
- BioCyc:   GSUL243231:GSU_1659-MONOMER
- BRENDA:   6.1.1.21
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 45997; Mature: 45997

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITGIKGFNDILPGEVERWQHIEATARRVFSLYGFSEIRIPILEKTELFRRSIGDTTDIV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCHHHHH
EKEMYSFVDKGENAVTMRPEGTASVMRSYIEHKLYAQDPVAKLYYMGPMFRYERPQKGRY
HHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHCCCCCCCHH
RQFHQIGAEVTGVTDPKVDAQVLTMLCHYFAELGLTEPTLQINSLGCPECRPAYRQALID
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHH
FLRERLDSLCEDCKRRYQTNPLRALDCKSAHCKEATASAPAMLDSLCAGCDDHFTATRRH
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
LERAGTTYSINNRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLISDLGGPAIPGI
HHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHCCCCCCCCH
GFAMGVERIALLLGDQHFVGRPDLFIAALGEEAQDEAFRLMCGLQRNGVAVEMDYEGKSL
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCHHH
KSQMRRSDKFNARFTLIIGGDELAIGAAVLKAMDTGVQVEVPLTPEEVAARIT
HHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHCCC
>Mature Secondary Structure
MITGIKGFNDILPGEVERWQHIEATARRVFSLYGFSEIRIPILEKTELFRRSIGDTTDIV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCHHHHH
EKEMYSFVDKGENAVTMRPEGTASVMRSYIEHKLYAQDPVAKLYYMGPMFRYERPQKGRY
HHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHCCCCCCCHH
RQFHQIGAEVTGVTDPKVDAQVLTMLCHYFAELGLTEPTLQINSLGCPECRPAYRQALID
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHH
FLRERLDSLCEDCKRRYQTNPLRALDCKSAHCKEATASAPAMLDSLCAGCDDHFTATRRH
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
LERAGTTYSINNRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLISDLGGPAIPGI
HHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHCCCCCCCCH
GFAMGVERIALLLGDQHFVGRPDLFIAALGEEAQDEAFRLMCGLQRNGVAVEMDYEGKSL
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCHHH
KSQMRRSDKFNARFTLIIGGDELAIGAAVLKAMDTGVQVEVPLTPEEVAARIT
HHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA