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The map label for this gene is garR [H]

Identifier: 39996474

GI number: 39996474

Start: 1500642

End: 1501502

Strand: Reverse

Name: garR [H]

Synonym: GSU1372

Alternate gene names: 39996474

Gene position: 1501502-1500642 (Counterclockwise)

Preceding gene: 39996476

Following gene: 39996473

Centisome position: 39.37

GC content: 69.22

Gene sequence:

>861_bases
ATGACAACATACGGCTTTCTCGGGCTCGGCATCATGGGAGGCCCCATGGCGGCCAACCTGGTGCGGGCTGGATTCGACGT
TACCGTCTGGAACCGCAATCCCGCCAAGTGCGCCCCCCTGGTCGCCCTGGGCGCCCGGCAGGCATCGAGCCCCGCTGAGG
TCTGCGCCGCCTGCGACATCACCATTGCCATGCTGGCCGACCCGGCCGCGGCGAGGGAGGTCTGCTTCGGGGCCAACGGG
GTGCTGGAGGGGATCGGCGGCGGCCGCGGCTACATCGACATGTCCACGGTGGACGACGAAACCAGCACCGCCATCGGCGC
GGCTGTGACCGCGCGGGGGGGACGGTTCCTGGAAGCCCCGGTCTCGGGCACCAAAAAGCCGGCCGAGGACGGCACCCTGA
TCATCCTGGCCGCGGGCGACCAGAGCCTCTTTACCGACGCCGGGCCGGCCTTTGCCGCACTGGGCAAGAAATGCCTCCAC
CTGGGCGAGGTGGGCCAGGGGGCGCGGATGAAGCTGGTGGTCAACATGATCATGGGCCAGATGATGACGGCCCTGGGCGA
AGGGATGGCCCTGGGCCGGAACTGCGGCCTCGACGGCGGCCAGCTGCTGGAGGTGCTCGATGCCGGGGCAATGGCCAACC
CCATGTTCAAGGGCAAGGGGCAGATGCTCCTGAGCGGTGAATTCCCGACCAGCTTCCCCCTCAAGCACATGCAGAAGGAC
CTGCGCCTGGCCGTCGAGCTGGGCGACCGGCTCGGCCAGCCGCTCCACGGCGCGGCCACGGCCAACGAGAGTTTCAAGCG
CGCCCGCGCCGCTGGCCATGCCGACGAGGATTTCGCGGCGGTATTCCGGGTGCTGGAGTAG

Upstream 100 bases:

>100_bases
GCACTATTTCGGCAGGAACCGCTCTTGAACTCGACGCCGGTCGGGACTATCCTCATACCAGCAACCACCACGAACACACC
AGATTGGAAAGGAGCAGCAG

Downstream 100 bases:

>100_bases
CGCCATTCCTGCCGGGGCAGCTCCCGGTTCGCAACGGTGAATTCGGTGCTATGCTGTAACCAGGGCACCGGACCCATGAA
CCACCAGCCAAGGAGGCACG

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTTYGFLGLGIMGGPMAANLVRAGFDVTVWNRNPAKCAPLVALGARQASSPAEVCAACDITIAMLADPAAAREVCFGANG
VLEGIGGGRGYIDMSTVDDETSTAIGAAVTARGGRFLEAPVSGTKKPAEDGTLIILAAGDQSLFTDAGPAFAALGKKCLH
LGEVGQGARMKLVVNMIMGQMMTALGEGMALGRNCGLDGGQLLEVLDAGAMANPMFKGKGQMLLSGEFPTSFPLKHMQKD
LRLAVELGDRLGQPLHGAATANESFKRARAAGHADEDFAAVFRVLE

Sequences:

>Translated_286_residues
MTTYGFLGLGIMGGPMAANLVRAGFDVTVWNRNPAKCAPLVALGARQASSPAEVCAACDITIAMLADPAAAREVCFGANG
VLEGIGGGRGYIDMSTVDDETSTAIGAAVTARGGRFLEAPVSGTKKPAEDGTLIILAAGDQSLFTDAGPAFAALGKKCLH
LGEVGQGARMKLVVNMIMGQMMTALGEGMALGRNCGLDGGQLLEVLDAGAMANPMFKGKGQMLLSGEFPTSFPLKHMQKD
LRLAVELGDRLGQPLHGAATANESFKRARAAGHADEDFAAVFRVLE
>Mature_285_residues
TTYGFLGLGIMGGPMAANLVRAGFDVTVWNRNPAKCAPLVALGARQASSPAEVCAACDITIAMLADPAAAREVCFGANGV
LEGIGGGRGYIDMSTVDDETSTAIGAAVTARGGRFLEAPVSGTKKPAEDGTLIILAAGDQSLFTDAGPAFAALGKKCLHL
GEVGQGARMKLVVNMIMGQMMTALGEGMALGRNCGLDGGQLLEVLDAGAMANPMFKGKGQMLLSGEFPTSFPLKHMQKDL
RLAVELGDRLGQPLHGAATANESFKRARAAGHADEDFAAVFRVLE

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=279, Percent_Identity=47.6702508960573, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=30.8219178082192, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI145693186, Length=277, Percent_Identity=32.8519855595668, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1786719, Length=282, Percent_Identity=32.6241134751773, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790315, Length=284, Percent_Identity=30.9859154929577, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789092, Length=284, Percent_Identity=28.5211267605634, Blast_Score=90, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17557316, Length=295, Percent_Identity=29.1525423728814, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=35.2313167259786, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24655230, Length=289, Percent_Identity=26.9896193771626, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19922568, Length=289, Percent_Identity=26.9896193771626, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 29444; Mature: 29313

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTYGFLGLGIMGGPMAANLVRAGFDVTVWNRNPAKCAPLVALGARQASSPAEVCAACDI
CCCCCEEECCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHCE
TIAMLADPAAAREVCFGANGVLEGIGGGRGYIDMSTVDDETSTAIGAAVTARGGRFLEAP
EEEECCCCHHHHHHHCCCCCHHHCCCCCCCEEEECCCCCCHHHHHHHHEECCCCEEEECC
VSGTKKPAEDGTLIILAAGDQSLFTDAGPAFAALGKKCLHLGEVGQGARMKLVVNMIMGQ
CCCCCCCCCCCCEEEEECCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MMTALGEGMALGRNCGLDGGQLLEVLDAGAMANPMFKGKGQMLLSGEFPTSFPLKHMQKD
HHHHHHCCCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHH
LRLAVELGDRLGQPLHGAATANESFKRARAAGHADEDFAAVFRVLE
HHHHHHHHHHHCCCCCCCHHCHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TTYGFLGLGIMGGPMAANLVRAGFDVTVWNRNPAKCAPLVALGARQASSPAEVCAACDI
CCCCEEECCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHCE
TIAMLADPAAAREVCFGANGVLEGIGGGRGYIDMSTVDDETSTAIGAAVTARGGRFLEAP
EEEECCCCHHHHHHHCCCCCHHHCCCCCCCEEEECCCCCCHHHHHHHHEECCCCEEEECC
VSGTKKPAEDGTLIILAAGDQSLFTDAGPAFAALGKKCLHLGEVGQGARMKLVVNMIMGQ
CCCCCCCCCCCCEEEEECCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MMTALGEGMALGRNCGLDGGQLLEVLDAGAMANPMFKGKGQMLLSGEFPTSFPLKHMQKD
HHHHHHCCCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHH
LRLAVELGDRLGQPLHGAATANESFKRARAAGHADEDFAAVFRVLE
HHHHHHHHHHHCCCCCCCHHCHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]