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The map label for this gene is lepB [H]

Identifier: 39996369

GI number: 39996369

Start: 1379195

End: 1379863

Strand: Direct

Name: lepB [H]

Synonym: GSU1267

Alternate gene names: 39996369

Gene position: 1379195-1379863 (Clockwise)

Preceding gene: 39996368

Following gene: 39996372

Centisome position: 36.16

GC content: 56.05

Gene sequence:

>669_bases
ATGGACTACAAGGAAACCCAGTACGGCCAGTCAACCCCGTCGGAGCAGGCTGCCGAGCCGGTCAAGAAAAAGCACATTGT
CCGGGAATACGCCGAGTCGATCATTATCGCCGTCATTTTGGCCCTCATTATCCGGACTTTCGTGGTACAGGCATTCAAGA
TTCCCTCCGGCTCCATGGAGGACACGCTTGCCATCGGCGATCATATCCTCGTCAGCAAATTCATCTACGGCACCAAGATC
CCCTTTGTGGACGGCCGCTACCTGAAGATCCGCGACCCGAAGCGGGGTGACGTGATCGTCTTCGAATACCCCGAAGACCC
CAGCAAGGATTTCATCAAGCGGGTAATCGGTCTGCCGGGCGATACGATTCAAGTGGTGCAGAAGCAAGTCTTCATCAACG
GCAAGCCGTTCTCGGTTCCCCAGGAGGTCCACAAGGAAAAGGACGTAATCCCCGCGGCCCAGAATCCCCGCGACAATTTC
GGACCAGTCACGGTGCCGGAGAACAGCTATTTCGTAATGGGCGACAACCGGGACCGTTCCTACGATAGCCGGTTCTGGGG
CTTCGTCAAGAACAGCCAGATCAAGGGACTTGCCTTCATCAAGTACTGGTCCTGGGACCGGGAAAAGTTCCGCGTACGCT
GGGGAAGCATCGGCGACATCATCAAATAG

Upstream 100 bases:

>100_bases
GCGGATGAAAAACGTGGGGAACGTCGAACTCCCCCAGGAAGCATTTCTCGCCATCCTCAAGGTGGAAGAGAAGTAGTTAC
CCTTTCCGAAAGGAACATCA

Downstream 100 bases:

>100_bases
CCGCGTTGTTCGTGACGGCACTGTTCAGAGGGGCCCTCCTGCCGGAGGGCCTTTTTTTATGCCATCGGCTGCCGGGGCCG
TCACCGGGCATGGACACCGC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MDYKETQYGQSTPSEQAAEPVKKKHIVREYAESIIIAVILALIIRTFVVQAFKIPSGSMEDTLAIGDHILVSKFIYGTKI
PFVDGRYLKIRDPKRGDVIVFEYPEDPSKDFIKRVIGLPGDTIQVVQKQVFINGKPFSVPQEVHKEKDVIPAAQNPRDNF
GPVTVPENSYFVMGDNRDRSYDSRFWGFVKNSQIKGLAFIKYWSWDREKFRVRWGSIGDIIK

Sequences:

>Translated_222_residues
MDYKETQYGQSTPSEQAAEPVKKKHIVREYAESIIIAVILALIIRTFVVQAFKIPSGSMEDTLAIGDHILVSKFIYGTKI
PFVDGRYLKIRDPKRGDVIVFEYPEDPSKDFIKRVIGLPGDTIQVVQKQVFINGKPFSVPQEVHKEKDVIPAAQNPRDNF
GPVTVPENSYFVMGDNRDRSYDSRFWGFVKNSQIKGLAFIKYWSWDREKFRVRWGSIGDIIK
>Mature_222_residues
MDYKETQYGQSTPSEQAAEPVKKKHIVREYAESIIIAVILALIIRTFVVQAFKIPSGSMEDTLAIGDHILVSKFIYGTKI
PFVDGRYLKIRDPKRGDVIVFEYPEDPSKDFIKRVIGLPGDTIQVVQKQVFINGKPFSVPQEVHKEKDVIPAAQNPRDNF
GPVTVPENSYFVMGDNRDRSYDSRFWGFVKNSQIKGLAFIKYWSWDREKFRVRWGSIGDIIK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=247, Percent_Identity=34.412955465587, Blast_Score=130, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 25491; Mature: 25491

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKETQYGQSTPSEQAAEPVKKKHIVREYAESIIIAVILALIIRTFVVQAFKIPSGSME
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DTLAIGDHILVSKFIYGTKIPFVDGRYLKIRDPKRGDVIVFEYPEDPSKDFIKRVIGLPG
CHHHHCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHCCCC
DTIQVVQKQVFINGKPFSVPQEVHKEKDVIPAAQNPRDNFGPVTVPENSYFVMGDNRDRS
HHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCC
YDSRFWGFVKNSQIKGLAFIKYWSWDREKFRVRWGSIGDIIK
CHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MDYKETQYGQSTPSEQAAEPVKKKHIVREYAESIIIAVILALIIRTFVVQAFKIPSGSME
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DTLAIGDHILVSKFIYGTKIPFVDGRYLKIRDPKRGDVIVFEYPEDPSKDFIKRVIGLPG
CHHHHCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHCCCC
DTIQVVQKQVFINGKPFSVPQEVHKEKDVIPAAQNPRDNFGPVTVPENSYFVMGDNRDRS
HHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCC
YDSRFWGFVKNSQIKGLAFIKYWSWDREKFRVRWGSIGDIIK
CHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]