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The map label for this gene is pyrR

Identifier: 39996372

GI number: 39996372

Start: 1385037

End: 1385570

Strand: Direct

Name: pyrR

Synonym: GSU1270

Alternate gene names: 39996372

Gene position: 1385037-1385570 (Clockwise)

Preceding gene: 39996369

Following gene: 39996373

Centisome position: 36.31

GC content: 62.92

Gene sequence:

>534_bases
GTGGCAGACGGAACGGTGATTCTTGACACGGCTGGGGTGAAACGGGCGCTGACCCGCATCGCCCACGAAATCCTGGAACG
TAACAAGGGGGTCGACGGCCTGGTGCTGGTTGGCATCAGGACCGGCGGTGTCCATCTGGCGCGGGAGATCGTCGCGCGGC
TCGAAGAGATCGAGGGTGCTACCGTGCCGGTGGGAGAGGTGGATATCACCCTCTATCGTGACGATTTCAAGGGGCATGCT
CCCCATCTGCCGGTTGGCAAGACCGACATTCCCTTCTCCCTCGAAACCAAGAGGGTGGTTCTGGTCGACGACGTCCTCTT
TACCGGCCGCACCATTCGTGCCGCCATGGACGCCATCATGGACCACGGTCGCCCCGCCTGCATCCAACTGGCCGTCCTCG
TGGACCGCGGGCACCGTGAACTGCCGATCCGGGCCGACTTCGTGGGCCGCAACGTACCCACCAGTCTCAAGGAGAAGATC
GCGGTCCTGTTCGATGCAGCCAACCGGCCCACTGATGTTGTGCTGGAGAAGTGA

Upstream 100 bases:

>100_bases
ATTATGGTCACTACTCCACGAGCCTTTCCGCCTATAGTCCGCGGGAGGGCTTTTTTTGTGGGATGCACGCGGCCGGTGAA
CCGGCGAAAGGGGGAGCACG

Downstream 100 bases:

>100_bases
ACAGGGACGAGACGCAGCGAACAACTACCATTACCTGCCCGCGACGCGGGCAAACGGGGGGAACGATGGGGTTCAAGCAT
AAGGATATCATCGGGTTGCA

Product: bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase

Products: NA

Alternate protein names: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase; UPRTase

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MADGTVILDTAGVKRALTRIAHEILERNKGVDGLVLVGIRTGGVHLAREIVARLEEIEGATVPVGEVDITLYRDDFKGHA
PHLPVGKTDIPFSLETKRVVLVDDVLFTGRTIRAAMDAIMDHGRPACIQLAVLVDRGHRELPIRADFVGRNVPTSLKEKI
AVLFDAANRPTDVVLEK

Sequences:

>Translated_177_residues
MADGTVILDTAGVKRALTRIAHEILERNKGVDGLVLVGIRTGGVHLAREIVARLEEIEGATVPVGEVDITLYRDDFKGHA
PHLPVGKTDIPFSLETKRVVLVDDVLFTGRTIRAAMDAIMDHGRPACIQLAVLVDRGHRELPIRADFVGRNVPTSLKEKI
AVLFDAANRPTDVVLEK
>Mature_176_residues
ADGTVILDTAGVKRALTRIAHEILERNKGVDGLVLVGIRTGGVHLAREIVARLEEIEGATVPVGEVDITLYRDDFKGHAP
HLPVGKTDIPFSLETKRVVLVDDVLFTGRTIRAAMDAIMDHGRPACIQLAVLVDRGHRELPIRADFVGRNVPTSLKEKIA
VLFDAANRPTDVVLEK

Specific function: Displays also a weak uracil phosphoribosyltransferase activity which is not physiologically significant

COG id: COG2065

COG function: function code F; Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRR_GEOSL (Q74DP6)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952323.1
- HSSP:   P41007
- ProteinModelPortal:   Q74DP6
- SMR:   Q74DP6
- GeneID:   2685922
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1270
- NMPDR:   fig|243231.1.peg.1261
- TIGR:   GSU1270
- HOGENOM:   HBG641958
- OMA:   IAHEVLE
- ProtClustDB:   PRK05205
- BioCyc:   GSUL243231:GSU_1270-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_01219
- InterPro:   IPR000836
- InterPro:   IPR023050

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 19296; Mature: 19165

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADGTVILDTAGVKRALTRIAHEILERNKGVDGLVLVGIRTGGVHLAREIVARLEEIEGA
CCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCC
TVPVGEVDITLYRDDFKGHAPHLPVGKTDIPFSLETKRVVLVDDVLFTGRTIRAAMDAIM
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEECCCEEEEEECHHHCCHHHHHHHHHHH
DHGRPACIQLAVLVDRGHRELPIRADFVGRNVPTSLKEKIAVLFDAANRPTDVVLEK
HCCCHHHEEEEEEECCCCCCCCEEHEECCCCCCHHHHHHHHHEEECCCCCCEEEEEC
>Mature Secondary Structure 
ADGTVILDTAGVKRALTRIAHEILERNKGVDGLVLVGIRTGGVHLAREIVARLEEIEGA
CCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCC
TVPVGEVDITLYRDDFKGHAPHLPVGKTDIPFSLETKRVVLVDDVLFTGRTIRAAMDAIM
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEECCCEEEEEECHHHCCHHHHHHHHHHH
DHGRPACIQLAVLVDRGHRELPIRADFVGRNVPTSLKEKIAVLFDAANRPTDVVLEK
HCCCHHHEEEEEEECCCCCCCCEEHEECCCCCCHHHHHHHHHEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA