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The map label for this gene is rsbU [H]

Identifier: 39995806

GI number: 39995806

Start: 741330

End: 743243

Strand: Reverse

Name: rsbU [H]

Synonym: GSU0700

Alternate gene names: 39995806

Gene position: 743243-741330 (Counterclockwise)

Preceding gene: 39995812

Following gene: 39995803

Centisome position: 19.49

GC content: 66.56

Gene sequence:

>1914_bases
ATGGGCATTCCACTCCGCGTTCTGATCATCGAAGACTCCGAAGACGACATGCTGTTGGTGCTGCGGGAACTCCGCAAGGG
GGGATACGAGCCTGATCATGTGCGGGTGGAGACCGCCGCCGAGATGGTTGCGGCCATGGCGGCGCGGGACTGGGATCTGG
CCCTCTCGGACTACGTCCTCCCCCGCTTCAGCGGCATGGACGCGCTGCGGCTCTGGCGGGAGCGGGAGGAGGATCTGCCG
TTCATCGTGGTGTCGGGCAAAATCGGCGAGGAAACGGCGGTGGCCGCCATGAAGGCGGGCGCCAACGACTACCTCATCAA
GGGAAGCACCTCCCGGCTGGTGCCTGCCATCGCCCGCGAACTGCAGGAGGCGGAAGTGCGCCGCAAGCGCCGGGAGGCCG
AACAGGCCCTGGCCCGGAGCGAGGAACGGTACCGGCGGCTGGTGGCCGCCGTGTCCAACTACACCTACACCGTGGAATTG
GCGGAAGGGCACGTGATCCGCACCTCCCACGGCCAGGGGTGCCTGCCCGTGACCGGCTACACGAGCGACGAATACAATAC
CCGCCCCACCCTCTGGTACGAGATGATCCACGGCGAAGACCGGGACCGGGTGCTGGCCAGCATCGCCCGGCTGGAGGCAA
AGAAGGGGGTGGTGACCCTCGAGCACCGGATCGTCCGCAAGGACGGTGAAACCCGCTGGGTGCGCAATACCATCGTCCCA
ACCTGGGACGACACGGGCCGGCTCACGGCCTACGACGGACTCATCGCCGACATCACCGAGCGCAAGGAAGGAGAACTGAC
CCGCCAGATTCAGACCGTGGCCCTGAAGGCGGCGGCCAACGCCATCGTCATCTGCGCCCCGGAGGGGAGGATAATCTGGG
CCAACCCCGCCTTCACCCGCCTGACCGGCTACCTGCTGGACGAGGTGGCGGGCCGCGGCATCGGTATCCTCAACTCCGGC
GTGCACGGTAAGGAGTTCTACCGCAATCTGTGGCACACCATTCGCTCGGGTACGGTCTGGCACGGCGAGATGATCAACCG
GCGCCGGGACGGCTCCCTCTACCCGGAAGAGCAGACCATCACGCCGGTGCGGGACGAACGCGGGGCCATCCGCTGCTTCA
TTGCCATCAAGCAGGACATTGCCGAGCGGAAACAGGCCCAGGAAGCGCTGTTGGAGAATGCCCGGCTCGCCTGCGACATG
CAGCTGGCCCGCCAGATCCAGCGATCGCTGCTGCCGGAGACGCCTCCGCCCGTGCCGGGTTGCCGGTGCGCGGGGCGCTG
GGTGCCGGCCGCCCACGTGGGGGGCGATTACTACGATTTCTTCCCCCGGGAGGACGGCTCACTCGACCTGGTCATCGCTG
ACGTGTCCGGCCACAGCGTCGGCGCGGCTCTTATCATGACCGAACTGCGGAGCGTCATCCGCTCCCTGGTCCACGCGGGG
GGAACACCCGCTCAGATCGTCGGTTCGCTCAATGCACTGCTCCATGAAGACCTGTCCCGGGCGGAGCTCATCATAACCCT
CTTCTATGCCTCCTACTCCCCCGCCACCCACACTCTGGCCTTTGCCAGCGCCGGACACAGCCCTCCCCTGGTCTGCCGCC
GCCGGGGGGAATGCCGCCAGATTGACGCGGAGGGGCTGATCCTCGGCGTCAATCCCCTCGTGGAGTATGAGCAGAACGAA
GTCACCATGGCCGCCGGAGACATCCTTCTGCTCTACACCGACGGCATCACCGAGGCGACCGGCGCGGACGGGGAATTCTT
CGGCACGGCCAGGCTCGCCCGGGCCATGGAGGAGGAAAGCGGACGCGAACCGGAAGAACTCCTCGACGCCATTCTGACAC
GACTGCGGATGTTCACGGGGGGAGTGCCGTCCGGCGACGACATCTGTATGGCGCTGCTGAAGGTGGGGGATTAG

Upstream 100 bases:

>100_bases
TTTTTCGCCCGTCGACGCCTCCTTCTTGCCCCACCTGCAACCCGTAGTACACTATGAAACCGGGACGTTATCTCCGGGAC
AGGGCACCAGGAGGCACGCC

Downstream 100 bases:

>100_bases
GCGGCAAGCCGGCTCAAGACCAGCAGAAAATTGCGGGTGAGGAGGGGATGGAAATCCCGGCCCCGCTTCTCCAGCAGGAT
GCCGGCTATCTGACGGAGTT

Product: sensory box/response regulator

Products: NA

Alternate protein names: Sigma factor sigB regulation protein rsbU [H]

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MGIPLRVLIIEDSEDDMLLVLRELRKGGYEPDHVRVETAAEMVAAMAARDWDLALSDYVLPRFSGMDALRLWREREEDLP
FIVVSGKIGEETAVAAMKAGANDYLIKGSTSRLVPAIARELQEAEVRRKRREAEQALARSEERYRRLVAAVSNYTYTVEL
AEGHVIRTSHGQGCLPVTGYTSDEYNTRPTLWYEMIHGEDRDRVLASIARLEAKKGVVTLEHRIVRKDGETRWVRNTIVP
TWDDTGRLTAYDGLIADITERKEGELTRQIQTVALKAAANAIVICAPEGRIIWANPAFTRLTGYLLDEVAGRGIGILNSG
VHGKEFYRNLWHTIRSGTVWHGEMINRRRDGSLYPEEQTITPVRDERGAIRCFIAIKQDIAERKQAQEALLENARLACDM
QLARQIQRSLLPETPPPVPGCRCAGRWVPAAHVGGDYYDFFPREDGSLDLVIADVSGHSVGAALIMTELRSVIRSLVHAG
GTPAQIVGSLNALLHEDLSRAELIITLFYASYSPATHTLAFASAGHSPPLVCRRRGECRQIDAEGLILGVNPLVEYEQNE
VTMAAGDILLLYTDGITEATGADGEFFGTARLARAMEEESGREPEELLDAILTRLRMFTGGVPSGDDICMALLKVGD

Sequences:

>Translated_637_residues
MGIPLRVLIIEDSEDDMLLVLRELRKGGYEPDHVRVETAAEMVAAMAARDWDLALSDYVLPRFSGMDALRLWREREEDLP
FIVVSGKIGEETAVAAMKAGANDYLIKGSTSRLVPAIARELQEAEVRRKRREAEQALARSEERYRRLVAAVSNYTYTVEL
AEGHVIRTSHGQGCLPVTGYTSDEYNTRPTLWYEMIHGEDRDRVLASIARLEAKKGVVTLEHRIVRKDGETRWVRNTIVP
TWDDTGRLTAYDGLIADITERKEGELTRQIQTVALKAAANAIVICAPEGRIIWANPAFTRLTGYLLDEVAGRGIGILNSG
VHGKEFYRNLWHTIRSGTVWHGEMINRRRDGSLYPEEQTITPVRDERGAIRCFIAIKQDIAERKQAQEALLENARLACDM
QLARQIQRSLLPETPPPVPGCRCAGRWVPAAHVGGDYYDFFPREDGSLDLVIADVSGHSVGAALIMTELRSVIRSLVHAG
GTPAQIVGSLNALLHEDLSRAELIITLFYASYSPATHTLAFASAGHSPPLVCRRRGECRQIDAEGLILGVNPLVEYEQNE
VTMAAGDILLLYTDGITEATGADGEFFGTARLARAMEEESGREPEELLDAILTRLRMFTGGVPSGDDICMALLKVGD
>Mature_636_residues
GIPLRVLIIEDSEDDMLLVLRELRKGGYEPDHVRVETAAEMVAAMAARDWDLALSDYVLPRFSGMDALRLWREREEDLPF
IVVSGKIGEETAVAAMKAGANDYLIKGSTSRLVPAIARELQEAEVRRKRREAEQALARSEERYRRLVAAVSNYTYTVELA
EGHVIRTSHGQGCLPVTGYTSDEYNTRPTLWYEMIHGEDRDRVLASIARLEAKKGVVTLEHRIVRKDGETRWVRNTIVPT
WDDTGRLTAYDGLIADITERKEGELTRQIQTVALKAAANAIVICAPEGRIIWANPAFTRLTGYLLDEVAGRGIGILNSGV
HGKEFYRNLWHTIRSGTVWHGEMINRRRDGSLYPEEQTITPVRDERGAIRCFIAIKQDIAERKQAQEALLENARLACDMQ
LARQIQRSLLPETPPPVPGCRCAGRWVPAAHVGGDYYDFFPREDGSLDLVIADVSGHSVGAALIMTELRSVIRSLVHAGG
TPAQIVGSLNALLHEDLSRAELIITLFYASYSPATHTLAFASAGHSPPLVCRRRGECRQIDAEGLILGVNPLVEYEQNEV
TMAAGDILLLYTDGITEATGADGEFFGTARLARAMEEESGREPEELLDAILTRLRMFTGGVPSGDDICMALLKVGD

Specific function: Positive regulator of sigma-B activity. Dephosphorylates rsbV in response to environmental stress conveyed from the rsbXST module [H]

COG id: COG2208

COG function: function code TK; Serine phosphatase RsbU, regulator of sigma subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017944
- InterPro:   IPR001932
- InterPro:   IPR014787
- InterPro:   IPR010822
- ProDom:   PD685490 [H]

Pfam domain/function: PF08673 RsbU_N; PF07228 SpoIIE [H]

EC number: =3.1.3.3 [H]

Molecular weight: Translated: 70582; Mature: 70451

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIPLRVLIIEDSEDDMLLVLRELRKGGYEPDHVRVETAAEMVAAMAARDWDLALSDYVL
CCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHC
PRFSGMDALRLWREREEDLPFIVVSGKIGEETAVAAMKAGANDYLIKGSTSRLVPAIARE
CCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
LQEAEVRRKRREAEQALARSEERYRRLVAAVSNYTYTVELAEGHVIRTSHGQGCLPVTGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEECCCCCCEEECCC
TSDEYNTRPTLWYEMIHGEDRDRVLASIARLEAKKGVVTLEHRIVRKDGETRWVRNTIVP
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCEEECCCCCC
TWDDTGRLTAYDGLIADITERKEGELTRQIQTVALKAAANAIVICAPEGRIIWANPAFTR
CCCCCCCEEEECCHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCHHHH
LTGYLLDEVAGRGIGILNSGVHGKEFYRNLWHTIRSGTVWHGEMINRRRDGSLYPEEQTI
HHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHCCCEEEHHHHCCCCCCCCCCCCCCC
TPVRDERGAIRCFIAIKQDIAERKQAQEALLENARLACDMQLARQIQRSLLPETPPPVPG
CCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
CRCAGRWVPAAHVGGDYYDFFPREDGSLDLVIADVSGHSVGAALIMTELRSVIRSLVHAG
CCCCCCCCCHHHCCCCHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
GTPAQIVGSLNALLHEDLSRAELIITLFYASYSPATHTLAFASAGHSPPLVCRRRGECRQ
CCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCHHEEEEECCCCCCCHHHCCCCCCCE
IDAEGLILGVNPLVEYEQNEVTMAAGDILLLYTDGITEATGADGEFFGTARLARAMEEES
ECCCCEEEECCCCEECCCCCEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
GREPEELLDAILTRLRMFTGGVPSGDDICMALLKVGD
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
GIPLRVLIIEDSEDDMLLVLRELRKGGYEPDHVRVETAAEMVAAMAARDWDLALSDYVL
CCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHC
PRFSGMDALRLWREREEDLPFIVVSGKIGEETAVAAMKAGANDYLIKGSTSRLVPAIARE
CCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
LQEAEVRRKRREAEQALARSEERYRRLVAAVSNYTYTVELAEGHVIRTSHGQGCLPVTGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEECCCCCCEEECCC
TSDEYNTRPTLWYEMIHGEDRDRVLASIARLEAKKGVVTLEHRIVRKDGETRWVRNTIVP
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCEEECCCCCC
TWDDTGRLTAYDGLIADITERKEGELTRQIQTVALKAAANAIVICAPEGRIIWANPAFTR
CCCCCCCEEEECCHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCHHHH
LTGYLLDEVAGRGIGILNSGVHGKEFYRNLWHTIRSGTVWHGEMINRRRDGSLYPEEQTI
HHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHCCCEEEHHHHCCCCCCCCCCCCCCC
TPVRDERGAIRCFIAIKQDIAERKQAQEALLENARLACDMQLARQIQRSLLPETPPPVPG
CCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
CRCAGRWVPAAHVGGDYYDFFPREDGSLDLVIADVSGHSVGAALIMTELRSVIRSLVHAG
CCCCCCCCCHHHCCCCHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
GTPAQIVGSLNALLHEDLSRAELIITLFYASYSPATHTLAFASAGHSPPLVCRRRGECRQ
CCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCHHEEEEECCCCCCCHHHCCCCCCCE
IDAEGLILGVNPLVEYEQNEVTMAAGDILLLYTDGITEATGADGEFFGTARLARAMEEES
ECCCCEEEECCCCEECCCCCEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
GREPEELLDAILTRLRMFTGGVPSGDDICMALLKVGD
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8002610; 8002609; 9384377; 8824586; 9786195; 12499568 [H]