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The map label for this gene is rnd [H]

Identifier: 39995551

GI number: 39995551

Start: 475021

End: 476166

Strand: Direct

Name: rnd [H]

Synonym: GSU0443

Alternate gene names: 39995551

Gene position: 475021-476166 (Clockwise)

Preceding gene: 39995550

Following gene: 39995556

Centisome position: 12.45

GC content: 65.71

Gene sequence:

>1146_bases
TTGCCTCTGCAACCCGCTTCACCTGAGATCATCACCACCGTCGATGGAGTGCGCCGTCTTGCCGACCGCCTCGGGAGCGA
GCCCATCGTGGCGTGCGACCTGGAAGCAGATTCCATGCACCACTATCAGGAGAAGGTCTGCCTGATCCAGTTCGCGGTAC
CCGGCTACGCCGCCATCGTCGACCCCCTGGCAGCCCCGGACATCTCACCGCTGGCGCCGCTGTTTGCGAACGCCGCCATC
CGCAAGGTCTTTCACGGGGCCGACTACGACATCCGCTCCCTCCACCGGGATTTCGGCATAGAGGTGAACAATCTCTTCGA
CACCATGATTGCCTGTCAGCTGTTGGGCGAGCGGGAGTTCGGCCTGGCCGCCCAGCTGCGCAAGCGGTTCGGCGTGGAGT
TGGACAAGCAGTACCAGCGGGCCGATTGGAGCAGGCGCCCTCTCACGGTGGGGATGATTGAGTATGCGGTGAAGGACACG
ACGCTCCTGATCGAGCTGTACCGGCAGCTGGTGGCCGAACTGGAGGAAAAGGGGCGACGCGGCTGGGTTGAGGAAGAGTG
TGAGCTGCTGTCGCGGGTGCGGGTGGCGGAGCGGGGCGATGAGCCGTTCTTTCTCCGGTTCAAGGGGGCATCCCGGATGG
ACGGCCGGACCCTGGCGGTCCTGGAAGAACTTCTGCTGTTCCGCGACGGACGGGCCCGCCAGTTTGATGTACCGCCGTTC
AAGGTGCTGGGTACCGATACCGTGCGTGAACTGGCTGAGCGGCGTCCTCGCCTCCCGGAGGAGCTGCAGGGAATCACCGG
CCTGACGGACAAGGTCGCGGCCCGCTACGGCGAAGGGATTCTGCGTGCCGTCGAACGGGGGTGCGCGGTACCGGCGCAGC
AGTTGCCGGCGTATCCCCGGGAGGAGCGTCGCAAAATGGAGCGGGGGGAAGAAGATCGGCTGAAGCGGCTCAAGGAATGG
CGGACCGAAGAGGCGGGACGGCTCGGCATCGAGCCGGGCTACATCGCCAACAACGCTCTGCTGGAACTGGTGGCCGTCAA
GGCCCCGCGCACCATGGGGGACCTGGAGGCTCTGCCCCCCATGCGCTGCTGGCAGCGCAGCGAGTTCGGCGAACAGATCC
TGTCCATCGTGAGCCCGAGGCGCTGA

Upstream 100 bases:

>100_bases
CTTCGCCTCTTGATGGCATAAGGCAGAATGTTACCGACGCGCTGAATTCTCTGCTACCCTGCGTTATTGCCGCAGTTTAA
TCCCATGACTGGAGTTTTCC

Downstream 100 bases:

>100_bases
CGGCACATCGCAAACAAACTCTGTCGTTCCGGCGGCTCTGCGGCGAAGCTTCAATCGTACCATGCCCGACGTAGCCCTGT
TGCTCAGTCGCGCCAGGGCT

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MPLQPASPEIITTVDGVRRLADRLGSEPIVACDLEADSMHHYQEKVCLIQFAVPGYAAIVDPLAAPDISPLAPLFANAAI
RKVFHGADYDIRSLHRDFGIEVNNLFDTMIACQLLGEREFGLAAQLRKRFGVELDKQYQRADWSRRPLTVGMIEYAVKDT
TLLIELYRQLVAELEEKGRRGWVEEECELLSRVRVAERGDEPFFLRFKGASRMDGRTLAVLEELLLFRDGRARQFDVPPF
KVLGTDTVRELAERRPRLPEELQGITGLTDKVAARYGEGILRAVERGCAVPAQQLPAYPREERRKMERGEEDRLKRLKEW
RTEEAGRLGIEPGYIANNALLELVAVKAPRTMGDLEALPPMRCWQRSEFGEQILSIVSPRR

Sequences:

>Translated_381_residues
MPLQPASPEIITTVDGVRRLADRLGSEPIVACDLEADSMHHYQEKVCLIQFAVPGYAAIVDPLAAPDISPLAPLFANAAI
RKVFHGADYDIRSLHRDFGIEVNNLFDTMIACQLLGEREFGLAAQLRKRFGVELDKQYQRADWSRRPLTVGMIEYAVKDT
TLLIELYRQLVAELEEKGRRGWVEEECELLSRVRVAERGDEPFFLRFKGASRMDGRTLAVLEELLLFRDGRARQFDVPPF
KVLGTDTVRELAERRPRLPEELQGITGLTDKVAARYGEGILRAVERGCAVPAQQLPAYPREERRKMERGEEDRLKRLKEW
RTEEAGRLGIEPGYIANNALLELVAVKAPRTMGDLEALPPMRCWQRSEFGEQILSIVSPRR
>Mature_380_residues
PLQPASPEIITTVDGVRRLADRLGSEPIVACDLEADSMHHYQEKVCLIQFAVPGYAAIVDPLAAPDISPLAPLFANAAIR
KVFHGADYDIRSLHRDFGIEVNNLFDTMIACQLLGEREFGLAAQLRKRFGVELDKQYQRADWSRRPLTVGMIEYAVKDTT
LLIELYRQLVAELEEKGRRGWVEEECELLSRVRVAERGDEPFFLRFKGASRMDGRTLAVLEELLLFRDGRARQFDVPPFK
VLGTDTVRELAERRPRLPEELQGITGLTDKVAARYGEGILRAVERGCAVPAQQLPAYPREERRKMERGEEDRLKRLKEWR
TEEAGRLGIEPGYIANNALLELVAVKAPRTMGDLEALPPMRCWQRSEFGEQILSIVSPRR

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI50301240, Length=280, Percent_Identity=31.7857142857143, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4505917, Length=280, Percent_Identity=31.7857142857143, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1788105, Length=289, Percent_Identity=29.0657439446367, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17531757, Length=253, Percent_Identity=35.1778656126482, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32564304, Length=110, Percent_Identity=40, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324574, Length=188, Percent_Identity=34.0425531914894, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI161078302, Length=271, Percent_Identity=29.520295202952, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 43277; Mature: 43146

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLQPASPEIITTVDGVRRLADRLGSEPIVACDLEADSMHHYQEKVCLIQFAVPGYAAIV
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHEEEEECCCCHHHHH
DPLAAPDISPLAPLFANAAIRKVFHGADYDIRSLHRDFGIEVNNLFDTMIACQLLGEREF
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
GLAAQLRKRFGVELDKQYQRADWSRRPLTVGMIEYAVKDTTLLIELYRQLVAELEEKGRR
CHHHHHHHHHCCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GWVEEECELLSRVRVAERGDEPFFLRFKGASRMDGRTLAVLEELLLFRDGRARQFDVPPF
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCH
KVLGTDTVRELAERRPRLPEELQGITGLTDKVAARYGEGILRAVERGCAVPAQQLPAYPR
HEECCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCH
EERRKMERGEEDRLKRLKEWRTEEAGRLGIEPGYIANNALLELVAVKAPRTMGDLEALPP
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCC
MRCWQRSEFGEQILSIVSPRR
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLQPASPEIITTVDGVRRLADRLGSEPIVACDLEADSMHHYQEKVCLIQFAVPGYAAIV
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHEEEEECCCCHHHHH
DPLAAPDISPLAPLFANAAIRKVFHGADYDIRSLHRDFGIEVNNLFDTMIACQLLGEREF
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
GLAAQLRKRFGVELDKQYQRADWSRRPLTVGMIEYAVKDTTLLIELYRQLVAELEEKGRR
CHHHHHHHHHCCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GWVEEECELLSRVRVAERGDEPFFLRFKGASRMDGRTLAVLEELLLFRDGRARQFDVPPF
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCH
KVLGTDTVRELAERRPRLPEELQGITGLTDKVAARYGEGILRAVERGCAVPAQQLPAYPR
HEECCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCH
EERRKMERGEEDRLKRLKEWRTEEAGRLGIEPGYIANNALLELVAVKAPRTMGDLEALPP
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCC
MRCWQRSEFGEQILSIVSPRR
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]