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The map label for this gene is iorB [H]

Identifier: 39995311

GI number: 39995311

Start: 210646

End: 212817

Strand: Direct

Name: iorB [H]

Synonym: GSU0201

Alternate gene names: 39995311

Gene position: 210646-212817 (Clockwise)

Preceding gene: 39995310

Following gene: 39995312

Centisome position: 5.52

GC content: 66.99

Gene sequence:

>2172_bases
ATGAGCAATGACAATGGAGTGAGTCGCCGACAGTTCATGAAGACCAGTGCCCTGGCTGCCGGCGGGCTGCTGCTGGCCTG
CCATCTCCCCCTGGGGCGACGAGATGCCGCTGCTGCAACGGCGGAGGCATTCACGCCCAACGCCTTTCTGCATATCGGCA
CTGACGAACGCGTAACCGTCATTGTCAACAAGTCTGAAATGGGGCAGGGTGTCTACACTTCGCTCCCCATGCTGGTGGCC
GAGGAACTTTGCTGCGACTGGAAGCGGGTGACCTTCAGGCCCTCGCCGGTGGCGCCGGAATACAACCACACCCAGTTCGG
GCCGATCATGGTCACCGGCGGCAGCACCAGCGTCCGCTCCGAGTGGTCCCGGCTTTCTCTTGCCGGCGCGGCGGCGCGCG
AGATGCTGATCGCGGCGGCGGCGCAGGAATGGCGAGTGGAGCCGGCTGCCTGCCGGGCCGAGAAGGGGTTCGTGCTCGGT
CCCGGGGGCCGGAAGCTCAGCTTCGGCACCCTGGCCCCCAAGGCAGCCTCCCTGCCCGTACCCAAGGAGCCGAAACTGAA
ACCGGGCGCCAAGACCCTTCTCGGGAAGCCGCTCAAACGTCTGGACAGTCCGGCCAAGATCAAGGGTACGGCCGTATTCG
GCATCGATGTCCGGGCTCCCGGCATGCTGACCGCCCTCATAGCCCGGCCGCCGGTCTTTGGCGGCACGGTGAAAGGCTTC
GATGCTGCCAAGGCTAAGGCGGTGCCGGGCGTTCTGGACGTGGTGGCGGTGGATGCGGGGGTCGCGGTGGTGGCCGACGG
CTTCTGGCCGGCACTGAAGGGACGGGAGGCTCTGGCGATTTCCTGGGACGAAGGGGACGGGGCGCGGGTCTCGACGGACG
CCATGAGAGAGGAGTATGCCCGCCTGGCAGCCACCCCGGGCGCCGTGGCCCGGAAGGACGGCGACGCCCCGGCCGAGTTG
GCGAAAGCCGCCCGGCGGTTCGAGGCTGAGTACGAGGTTCCCTACCTGGCCCATGCCACCATGGAGCCCCTGAACTGTTT
CGTGGATTTACAGAGCGACAGCTGCCTCATCCGTACCGGCAGCCAGTTTCAGACCGGCGACCGCAATGCCGCGGCCCGGG
TGGCCGGACTCAAGCCCGAGCAGGTCACTCTGGAGACCACTTTTCTGGGGGGCGGCTTTGGCCGCCGGGCCTGCCCGGCA
TCTGATTTCGTGATCGAGGCGGTACAGGTGGCCAAGACCGTCGGCAAACCGGTCATGGTGATCCGCACCCGGGAGGACGA
CATGCGGGCCGGCTTCTACCGCCCCCTGTGGCGCGACCGCGTGGCAGCCTGTCTGGACGGGAGGGGGTATCCGCTGGCCT
GGCATCACTGCATCGTAGGGCAGTCGATCATGATCGGGACCCCCTTCGAGGCGATGATCAGGAACGGCATTGACGATACG
TCTGTGGAGGGGGCCGCCGACACCCCCTACGCCATCCCCAATCTCCAGGTGGAGCTGCATAGCCCCAGGAATCCCGTGCC
GGTGCTCTGGTGGCGGTCGGTGGGACATTCTCACACCGCCTTTGTGGTAGAGAGCTTCCTGGACGAACTTGCCCACGCGG
CCGGCAAGGATCCTTACCAGTACCGCCGTGCCCTGCTGGCGAAGCATCCGCGTCACCTGAAGGTCCTGGAAACCGCCGCC
CGGAAGGCCGGCTGGGGAAAGCCACTGCCCAAAGGCCGTGGGCGGGGCATTGCCGTGCACGAGTCCTTCGGCAGCTTCAT
TGCCCAGGTGGCCGAAGTCTCACTGTCCGGCGACGGACGGATCAGGGTCCACCGGGTAGTCTGCGCAGTGGATTGCGGTC
GCATCGTCAATCCTGACACCATCGAGGCCCAGATGGAGTCGGGGATCACCTTCGGCCTTTCCGCTGCCCTGCACGGGGCC
ATAACCCTCAGGAACGGCAGGGTCGAGCAGGGGAACTTCGACGACTATCCCCTGGTTCGCATGGCGGAGATGCCCACGGT
AGAGGTGCACATCGTCCTGAGCGGGGAGGACCCGGGCGGCATCGGGGAACCGGGGGTGCCGCCGATCGCGCCGGCGGTGG
CCAATGCCCTGTTCGCGGCCAGCGGCATCCGGGTAAGATCGCTGCCGCTGACACCGGAAACCGTCAAGCGGGCCGGCGGC
CGGGCCGCCTGA

Upstream 100 bases:

>100_bases
CCATGAGCGGCAATCTCTGCCGCTGCGGAACCTACGGCCGCATCCGCCGTGCAATTCATGCCGCCGGCGGCAGAAGGGCC
CGGAAGGGAGGGAGCCGGTC

Downstream 100 bases:

>100_bases
GGGGCTGAACTCATCGAATCGAAAAGGACATATCAGTGACCGATCTGGAACTGTACGAGGAAATGGCGCGGCTCGCCCGG
CTGGGCGAGCCTTTTGCGCT

Product: isoquinoline 1-oxidoreductase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 723; Mature: 722

Protein sequence:

>723_residues
MSNDNGVSRRQFMKTSALAAGGLLLACHLPLGRRDAAAATAEAFTPNAFLHIGTDERVTVIVNKSEMGQGVYTSLPMLVA
EELCCDWKRVTFRPSPVAPEYNHTQFGPIMVTGGSTSVRSEWSRLSLAGAAAREMLIAAAAQEWRVEPAACRAEKGFVLG
PGGRKLSFGTLAPKAASLPVPKEPKLKPGAKTLLGKPLKRLDSPAKIKGTAVFGIDVRAPGMLTALIARPPVFGGTVKGF
DAAKAKAVPGVLDVVAVDAGVAVVADGFWPALKGREALAISWDEGDGARVSTDAMREEYARLAATPGAVARKDGDAPAEL
AKAARRFEAEYEVPYLAHATMEPLNCFVDLQSDSCLIRTGSQFQTGDRNAAARVAGLKPEQVTLETTFLGGGFGRRACPA
SDFVIEAVQVAKTVGKPVMVIRTREDDMRAGFYRPLWRDRVAACLDGRGYPLAWHHCIVGQSIMIGTPFEAMIRNGIDDT
SVEGAADTPYAIPNLQVELHSPRNPVPVLWWRSVGHSHTAFVVESFLDELAHAAGKDPYQYRRALLAKHPRHLKVLETAA
RKAGWGKPLPKGRGRGIAVHESFGSFIAQVAEVSLSGDGRIRVHRVVCAVDCGRIVNPDTIEAQMESGITFGLSAALHGA
ITLRNGRVEQGNFDDYPLVRMAEMPTVEVHIVLSGEDPGGIGEPGVPPIAPAVANALFAASGIRVRSLPLTPETVKRAGG
RAA

Sequences:

>Translated_723_residues
MSNDNGVSRRQFMKTSALAAGGLLLACHLPLGRRDAAAATAEAFTPNAFLHIGTDERVTVIVNKSEMGQGVYTSLPMLVA
EELCCDWKRVTFRPSPVAPEYNHTQFGPIMVTGGSTSVRSEWSRLSLAGAAAREMLIAAAAQEWRVEPAACRAEKGFVLG
PGGRKLSFGTLAPKAASLPVPKEPKLKPGAKTLLGKPLKRLDSPAKIKGTAVFGIDVRAPGMLTALIARPPVFGGTVKGF
DAAKAKAVPGVLDVVAVDAGVAVVADGFWPALKGREALAISWDEGDGARVSTDAMREEYARLAATPGAVARKDGDAPAEL
AKAARRFEAEYEVPYLAHATMEPLNCFVDLQSDSCLIRTGSQFQTGDRNAAARVAGLKPEQVTLETTFLGGGFGRRACPA
SDFVIEAVQVAKTVGKPVMVIRTREDDMRAGFYRPLWRDRVAACLDGRGYPLAWHHCIVGQSIMIGTPFEAMIRNGIDDT
SVEGAADTPYAIPNLQVELHSPRNPVPVLWWRSVGHSHTAFVVESFLDELAHAAGKDPYQYRRALLAKHPRHLKVLETAA
RKAGWGKPLPKGRGRGIAVHESFGSFIAQVAEVSLSGDGRIRVHRVVCAVDCGRIVNPDTIEAQMESGITFGLSAALHGA
ITLRNGRVEQGNFDDYPLVRMAEMPTVEVHIVLSGEDPGGIGEPGVPPIAPAVANALFAASGIRVRSLPLTPETVKRAGG
RAA
>Mature_722_residues
SNDNGVSRRQFMKTSALAAGGLLLACHLPLGRRDAAAATAEAFTPNAFLHIGTDERVTVIVNKSEMGQGVYTSLPMLVAE
ELCCDWKRVTFRPSPVAPEYNHTQFGPIMVTGGSTSVRSEWSRLSLAGAAAREMLIAAAAQEWRVEPAACRAEKGFVLGP
GGRKLSFGTLAPKAASLPVPKEPKLKPGAKTLLGKPLKRLDSPAKIKGTAVFGIDVRAPGMLTALIARPPVFGGTVKGFD
AAKAKAVPGVLDVVAVDAGVAVVADGFWPALKGREALAISWDEGDGARVSTDAMREEYARLAATPGAVARKDGDAPAELA
KAARRFEAEYEVPYLAHATMEPLNCFVDLQSDSCLIRTGSQFQTGDRNAAARVAGLKPEQVTLETTFLGGGFGRRACPAS
DFVIEAVQVAKTVGKPVMVIRTREDDMRAGFYRPLWRDRVAACLDGRGYPLAWHHCIVGQSIMIGTPFEAMIRNGIDDTS
VEGAADTPYAIPNLQVELHSPRNPVPVLWWRSVGHSHTAFVVESFLDELAHAAGKDPYQYRRALLAKHPRHLKVLETAAR
KAGWGKPLPKGRGRGIAVHESFGSFIAQVAEVSLSGDGRIRVHRVVCAVDCGRIVNPDTIEAQMESGITFGLSAALHGAI
TLRNGRVEQGNFDDYPLVRMAEMPTVEVHIVLSGEDPGGIGEPGVPPIAPAVANALFAASGIRVRSLPLTPETVKRAGGR
AA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786478, Length=137, Percent_Identity=35.036496350365, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1789230, Length=140, Percent_Identity=29.2857142857143, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012368
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 77012; Mature: 76881

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDNGVSRRQFMKTSALAAGGLLLACHLPLGRRDAAAATAEAFTPNAFLHIGTDERVTV
CCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCEEEE
IVNKSEMGQGVYTSLPMLVAEELCCDWKRVTFRPSPVAPEYNHTQFGPIMVTGGSTSVRS
EEECHHCCCCHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCCCCEEEECCCCHHHH
EWSRLSLAGAAAREMLIAAAAQEWRVEPAACRAEKGFVLGPGGRKLSFGTLAPKAASLPV
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEECCCCCEEEECCCCCCCCCCCC
PKEPKLKPGAKTLLGKPLKRLDSPAKIKGTAVFGIDVRAPGMLTALIARPPVFGGTVKGF
CCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCHHHHHHHCCCCCCCCCCCC
DAAKAKAVPGVLDVVAVDAGVAVVADGFWPALKGREALAISWDEGDGARVSTDAMREEYA
CCHHHHCCCCCEEEEEECCCEEEEECCCCHHCCCCEEEEEEECCCCCCEECHHHHHHHHH
RLAATPGAVARKDGDAPAELAKAARRFEAEYEVPYLAHATMEPLNCFVDLQSDSCLIRTG
HHHCCCCHHCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEEEECCCCEEEECC
SQFQTGDRNAAARVAGLKPEQVTLETTFLGGGFGRRACPASDFVIEAVQVAKTVGKPVMV
CCCCCCCCCCHHHCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
IRTREDDMRAGFYRPLWRDRVAACLDGRGYPLAWHHCIVGQSIMIGTPFEAMIRNGIDDT
EEECCCHHHCCCCCHHHHHHHHHHHCCCCCCEEEHHHHHCCEEEECCCHHHHHHCCCCCC
SVEGAADTPYAIPNLQVELHSPRNPVPVLWWRSVGHSHTAFVVESFLDELAHAAGKDPYQ
CCCCCCCCCEECCCEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHH
YRRALLAKHPRHLKVLETAARKAGWGKPLPKGRGRGIAVHESFGSFIAQVAEVSLSGDGR
HHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHEECCCCE
IRVHRVVCAVDCGRIVNPDTIEAQMESGITFGLSAALHGAITLRNGRVEQGNFDDYPLVR
EEEEEEEEEECCCCCCCCHHHHHHHHCCCEEEEHHHHEEEEEEECCCCCCCCCCCCCEEE
MAEMPTVEVHIVLSGEDPGGIGEPGVPPIAPAVANALFAASGIRVRSLPLTPETVKRAGG
EECCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHCCC
RAA
CCC
>Mature Secondary Structure 
SNDNGVSRRQFMKTSALAAGGLLLACHLPLGRRDAAAATAEAFTPNAFLHIGTDERVTV
CCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCEEEE
IVNKSEMGQGVYTSLPMLVAEELCCDWKRVTFRPSPVAPEYNHTQFGPIMVTGGSTSVRS
EEECHHCCCCHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCCCCEEEECCCCHHHH
EWSRLSLAGAAAREMLIAAAAQEWRVEPAACRAEKGFVLGPGGRKLSFGTLAPKAASLPV
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEECCCCCEEEECCCCCCCCCCCC
PKEPKLKPGAKTLLGKPLKRLDSPAKIKGTAVFGIDVRAPGMLTALIARPPVFGGTVKGF
CCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCHHHHHHHCCCCCCCCCCCC
DAAKAKAVPGVLDVVAVDAGVAVVADGFWPALKGREALAISWDEGDGARVSTDAMREEYA
CCHHHHCCCCCEEEEEECCCEEEEECCCCHHCCCCEEEEEEECCCCCCEECHHHHHHHHH
RLAATPGAVARKDGDAPAELAKAARRFEAEYEVPYLAHATMEPLNCFVDLQSDSCLIRTG
HHHCCCCHHCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEEEECCCCEEEECC
SQFQTGDRNAAARVAGLKPEQVTLETTFLGGGFGRRACPASDFVIEAVQVAKTVGKPVMV
CCCCCCCCCCHHHCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
IRTREDDMRAGFYRPLWRDRVAACLDGRGYPLAWHHCIVGQSIMIGTPFEAMIRNGIDDT
EEECCCHHHCCCCCHHHHHHHHHHHCCCCCCEEEHHHHHCCEEEECCCHHHHHHCCCCCC
SVEGAADTPYAIPNLQVELHSPRNPVPVLWWRSVGHSHTAFVVESFLDELAHAAGKDPYQ
CCCCCCCCCEECCCEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHH
YRRALLAKHPRHLKVLETAARKAGWGKPLPKGRGRGIAVHESFGSFIAQVAEVSLSGDGR
HHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHEECCCCE
IRVHRVVCAVDCGRIVNPDTIEAQMESGITFGLSAALHGAITLRNGRVEQGNFDDYPLVR
EEEEEEEEEECCCCCCCCHHHHHHHHCCCEEEEHHHHEEEEEEECCCCCCCCCCCCCEEE
MAEMPTVEVHIVLSGEDPGGIGEPGVPPIAPAVANALFAASGIRVRSLPLTPETVKRAGG
EECCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHCCC
RAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]