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The map label for this gene is iorA [H]

Identifier: 39995310

GI number: 39995310

Start: 210179

End: 210649

Strand: Direct

Name: iorA [H]

Synonym: GSU0200

Alternate gene names: 39995310

Gene position: 210179-210649 (Clockwise)

Preceding gene: 39995308

Following gene: 39995311

Centisome position: 5.51

GC content: 64.12

Gene sequence:

>471_bases
ATGATTGTTTTTCTGGTGAACGGAAAAGAGCAGCGAGTGGACGTGAGCCCGGACACACCTCTCTTGTGGGTGCTGCGCGA
TAAGCTGGGGCTTACGGGAACCAAGTACGGATGCGGCGAGGGGCTCTGCGGAGCCTGCACAGTCCACATCGACGGTCGCC
CCGAGCGCTCCTGCATCACCCCGGTCGGTGACGTGCAGGGGAAAAAGGTAGTCACCATCGAAGGCATCCCGGAGAACCAT
CCGGTCAAGAAGTCCTGGCTGGCCCAGGATGTGTCCCAGTGCGGCTATTGCCAGCCGGGCCAGATCATGTCCGCCGTGGC
CCTGTTGGCCAGCAAGCCCAGCCCCACCGACGCCGACATCGACAGCGCCATGAGCGGCAATCTCTGCCGCTGCGGAACCT
ACGGCCGCATCCGCCGTGCAATTCATGCCGCCGGCGGCAGAAGGGCCCGGAAGGGAGGGAGCCGGTCATGA

Upstream 100 bases:

>100_bases
GAGTTTTTTGCCTTATTTTAACTGTTTGTTGCGGCACCCCTGCTGAGCGTTATACTTTTCTCCGGATCTCTGCGGAGACT
CGGGGAAAAGGAGGCGCGTC

Downstream 100 bases:

>100_bases
GCAATGACAATGGAGTGAGTCGCCGACAGTTCATGAAGACCAGTGCCCTGGCTGCCGGCGGGCTGCTGCTGGCCTGCCAT
CTCCCCCTGGGGCGACGAGA

Product: isoquinoline 1-oxidoreductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MIVFLVNGKEQRVDVSPDTPLLWVLRDKLGLTGTKYGCGEGLCGACTVHIDGRPERSCITPVGDVQGKKVVTIEGIPENH
PVKKSWLAQDVSQCGYCQPGQIMSAVALLASKPSPTDADIDSAMSGNLCRCGTYGRIRRAIHAAGGRRARKGGSRS

Sequences:

>Translated_156_residues
MIVFLVNGKEQRVDVSPDTPLLWVLRDKLGLTGTKYGCGEGLCGACTVHIDGRPERSCITPVGDVQGKKVVTIEGIPENH
PVKKSWLAQDVSQCGYCQPGQIMSAVALLASKPSPTDADIDSAMSGNLCRCGTYGRIRRAIHAAGGRRARKGGSRS
>Mature_156_residues
MIVFLVNGKEQRVDVSPDTPLLWVLRDKLGLTGTKYGCGEGLCGACTVHIDGRPERSCITPVGDVQGKKVVTIEGIPENH
PVKKSWLAQDVSQCGYCQPGQIMSAVALLASKPSPTDADIDSAMSGNLCRCGTYGRIRRAIHAAGGRRARKGGSRS

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=150, Percent_Identity=42.6666666666667, Blast_Score=90, Evalue=9e-19,
Organism=Homo sapiens, GI71773480, Length=150, Percent_Identity=43.3333333333333, Blast_Score=77, Evalue=8e-15,
Organism=Escherichia coli, GI1786480, Length=164, Percent_Identity=42.0731707317073, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI1789232, Length=142, Percent_Identity=37.3239436619718, Blast_Score=87, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17540638, Length=156, Percent_Identity=46.1538461538462, Blast_Score=126, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI32566215, Length=156, Percent_Identity=39.1025641025641, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17539860, Length=156, Percent_Identity=39.1025641025641, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17737937, Length=150, Percent_Identity=44.6666666666667, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24647197, Length=160, Percent_Identity=35, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24647195, Length=160, Percent_Identity=35, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24647193, Length=156, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24647199, Length=152, Percent_Identity=32.2368421052632, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24647201, Length=152, Percent_Identity=30.9210526315789, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 16593; Mature: 16593

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
5.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVFLVNGKEQRVDVSPDTPLLWVLRDKLGLTGTKYGCGEGLCGACTVHIDGRPERSCIT
CEEEEECCCCCEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
PVGDVQGKKVVTIEGIPENHPVKKSWLAQDVSQCGYCQPGQIMSAVALLASKPSPTDADI
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC
DSAMSGNLCRCGTYGRIRRAIHAAGGRRARKGGSRS
HHHCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MIVFLVNGKEQRVDVSPDTPLLWVLRDKLGLTGTKYGCGEGLCGACTVHIDGRPERSCIT
CEEEEECCCCCEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
PVGDVQGKKVVTIEGIPENHPVKKSWLAQDVSQCGYCQPGQIMSAVALLASKPSPTDADI
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC
DSAMSGNLCRCGTYGRIRRAIHAAGGRRARKGGSRS
HHHCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]