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The map label for this gene is lysA [H]

Identifier: 39995269

GI number: 39995269

Start: 176159

End: 177412

Strand: Direct

Name: lysA [H]

Synonym: GSU0158

Alternate gene names: 39995269

Gene position: 176159-177412 (Clockwise)

Preceding gene: 39995268

Following gene: 39995270

Centisome position: 4.62

GC content: 63.72

Gene sequence:

>1254_bases
ATGAATCACTTCCAGTACAAGGGGAACGAGCTCCACGCCGAGGAGGTTTCGCTCAAGGAGATCGTGGCCCGGGTTGGTAG
CCCGGTCTATGTTTATTCCCACGCCACCCTGACCCGGCACTTCACTGCCTTTGACGAGGCCTTCGCCGGCGTGCCCCACA
CCATCTGCTACTCGGTCAAGGCCAACTCCACCCAGGCAGTGCTCAGGACGTTCATCACCCTGGGCGGTGGCGCCGACATC
GTTTCCGGCGGCGAGCTCTACCGCGCCCTCCAGGCCGGCGTCGATCCGAAAAAAGTGGTCTATTCCGGGGTGGGTAAGAA
GGACGACGAGATCGAGTACGCCCTGAACACCGGCATCCTCATGTTCAACGTGGAGTCGGAGCAGGAGCTGACCCGCATCT
CCGAGATCGCCTCCCGCATGGGCAAGAAGGCGGGCATCGCCATCCGGGTCAACCCCGACGTGGACCCCCAGACCCATCCC
TACATCACCACGGGCCTCAAGAACGCCAAGTTCGGCATCACCATCGACCGGGCCATGGCCGAATACGCCCGCGCCAAGAC
GCTCCCCGGCATCGATGTGATCGGCATCGACATGCACATCGGCTCCCAGCTGACCAAGGTCACTCCCTTCGTGGACTCCA
TCGAGAAGCTGAAGACGATGATCGCCAACCTGCGCGGCCAGGGGATCGACCTGCAGTACTTCGACTGCGGCGGCGGCCTG
GGGATCCAGTACAGCACCGAAGAGCCGCCGCTCCCCGCCGACTACGGCAAGGAGATCGTCGCGGCCACCAAAGAGCTGGG
CATGCACCTGCTCTTCGAGCCGGGCCGCAACATCGTGGGCAACGCTGGCATCCTGGTGGCCACGTGCCTCTTCACCAAGG
AGCGGGACGAGAAGAACTTCATCATGATCGACGCCGGCATGAACGACCTGGCCCGTCCGGCCCTCTACGGCTCTTTCCAC
GGCGTACAGCCGGTGGTCAAGGACCAGGACGGCATGATCGTGGCCGATATCGTGGGTCCCATCTGCGAGTCGGGCGACTT
CCTGGTGAAGGACCGGGAGGTACCCATGTTCCGCCAGGGCGATCTGATGGCCTTCATGTCGGCCGGCGCCTACGGCTTCG
CCATGAGCAGCACCTACAACAGCCGCCCCCGGGTGGCCGAGGTGATGGTCAAGGGTAACCAGTTCGAAGTGGTCCGCGAG
CGGGAGACGGTGGAAGACCTGATCCGGGGCGAGCGGGTGCCGTCGTTCCTGTAA

Upstream 100 bases:

>100_bases
TAAGCCGCTAATCTTTTGACTTTTTAGGCCTTGCATGTTAAAAATATCCACTTTTGTTTACAGCGTGACGATTATTCACT
TTTCATAAACGGAGGACACC

Downstream 100 bases:

>100_bases
CGAAAGACAACCCCAGAGAGGGAGGATACGGATATGTTCAAGGGAAGCATTGTCGCCATCGTCACCCCGTTCACCAACGG
CGCGGTGGACCAGGAGAAAC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MNHFQYKGNELHAEEVSLKEIVARVGSPVYVYSHATLTRHFTAFDEAFAGVPHTICYSVKANSTQAVLRTFITLGGGADI
VSGGELYRALQAGVDPKKVVYSGVGKKDDEIEYALNTGILMFNVESEQELTRISEIASRMGKKAGIAIRVNPDVDPQTHP
YITTGLKNAKFGITIDRAMAEYARAKTLPGIDVIGIDMHIGSQLTKVTPFVDSIEKLKTMIANLRGQGIDLQYFDCGGGL
GIQYSTEEPPLPADYGKEIVAATKELGMHLLFEPGRNIVGNAGILVATCLFTKERDEKNFIMIDAGMNDLARPALYGSFH
GVQPVVKDQDGMIVADIVGPICESGDFLVKDREVPMFRQGDLMAFMSAGAYGFAMSSTYNSRPRVAEVMVKGNQFEVVRE
RETVEDLIRGERVPSFL

Sequences:

>Translated_417_residues
MNHFQYKGNELHAEEVSLKEIVARVGSPVYVYSHATLTRHFTAFDEAFAGVPHTICYSVKANSTQAVLRTFITLGGGADI
VSGGELYRALQAGVDPKKVVYSGVGKKDDEIEYALNTGILMFNVESEQELTRISEIASRMGKKAGIAIRVNPDVDPQTHP
YITTGLKNAKFGITIDRAMAEYARAKTLPGIDVIGIDMHIGSQLTKVTPFVDSIEKLKTMIANLRGQGIDLQYFDCGGGL
GIQYSTEEPPLPADYGKEIVAATKELGMHLLFEPGRNIVGNAGILVATCLFTKERDEKNFIMIDAGMNDLARPALYGSFH
GVQPVVKDQDGMIVADIVGPICESGDFLVKDREVPMFRQGDLMAFMSAGAYGFAMSSTYNSRPRVAEVMVKGNQFEVVRE
RETVEDLIRGERVPSFL
>Mature_417_residues
MNHFQYKGNELHAEEVSLKEIVARVGSPVYVYSHATLTRHFTAFDEAFAGVPHTICYSVKANSTQAVLRTFITLGGGADI
VSGGELYRALQAGVDPKKVVYSGVGKKDDEIEYALNTGILMFNVESEQELTRISEIASRMGKKAGIAIRVNPDVDPQTHP
YITTGLKNAKFGITIDRAMAEYARAKTLPGIDVIGIDMHIGSQLTKVTPFVDSIEKLKTMIANLRGQGIDLQYFDCGGGL
GIQYSTEEPPLPADYGKEIVAATKELGMHLLFEPGRNIVGNAGILVATCLFTKERDEKNFIMIDAGMNDLARPALYGSFH
GVQPVVKDQDGMIVADIVGPICESGDFLVKDREVPMFRQGDLMAFMSAGAYGFAMSSTYNSRPRVAEVMVKGNQFEVVRE
RETVEDLIRGERVPSFL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=384, Percent_Identity=28.125, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI22538418, Length=374, Percent_Identity=24.8663101604278, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI21361583, Length=374, Percent_Identity=24.8663101604278, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI16506287, Length=349, Percent_Identity=22.3495702005731, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789203, Length=420, Percent_Identity=29.5238095238095, Blast_Score=161, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17562780, Length=368, Percent_Identity=23.6413043478261, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24586472, Length=340, Percent_Identity=24.7058823529412, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24586474, Length=390, Percent_Identity=22.5641025641026, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45634; Mature: 45634

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFQYKGNELHAEEVSLKEIVARVGSPVYVYSHATLTRHFTAFDEAFAGVPHTICYSVK
CCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEE
ANSTQAVLRTFITLGGGADIVSGGELYRALQAGVDPKKVVYSGVGKKDDEIEYALNTGIL
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEECCCEE
MFNVESEQELTRISEIASRMGKKAGIAIRVNPDVDPQTHPYITTGLKNAKFGITIDRAMA
EEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCCCCEECEEEHHHHH
EYARAKTLPGIDVIGIDMHIGSQLTKVTPFVDSIEKLKTMIANLRGQGIDLQYFDCGGGL
HHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
GIQYSTEEPPLPADYGKEIVAATKELGMHLLFEPGRNIVGNAGILVATCLFTKERDEKNF
CEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCE
IMIDAGMNDLARPALYGSFHGVQPVVKDQDGMIVADIVGPICESGDFLVKDREVPMFRQG
EEEECCCCHHHCHHHHCCCCCCCCCEECCCCEEEHHHHHHHHCCCCEEEECCCCCCEECC
DLMAFMSAGAYGFAMSSTYNSRPRVAEVMVKGNQFEVVRERETVEDLIRGERVPSFL
CCCEEHHCCCCEEEECCCCCCCCCEEEEEECCCEEEEHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNHFQYKGNELHAEEVSLKEIVARVGSPVYVYSHATLTRHFTAFDEAFAGVPHTICYSVK
CCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEE
ANSTQAVLRTFITLGGGADIVSGGELYRALQAGVDPKKVVYSGVGKKDDEIEYALNTGIL
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEECCCEE
MFNVESEQELTRISEIASRMGKKAGIAIRVNPDVDPQTHPYITTGLKNAKFGITIDRAMA
EEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCCCCEECEEEHHHHH
EYARAKTLPGIDVIGIDMHIGSQLTKVTPFVDSIEKLKTMIANLRGQGIDLQYFDCGGGL
HHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
GIQYSTEEPPLPADYGKEIVAATKELGMHLLFEPGRNIVGNAGILVATCLFTKERDEKNF
CEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCE
IMIDAGMNDLARPALYGSFHGVQPVVKDQDGMIVADIVGPICESGDFLVKDREVPMFRQG
EEEECCCCHHHCHHHHCCCCCCCCCEECCCCEEEHHHHHHHHCCCCEEEECCCCCCEECC
DLMAFMSAGAYGFAMSSTYNSRPRVAEVMVKGNQFEVVRERETVEDLIRGERVPSFL
CCCEEHHCCCCEEEECCCCCCCCCEEEEEECCCEEEEHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]