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The map label for this gene is dapA [H]

Identifier: 39995270

GI number: 39995270

Start: 177446

End: 178318

Strand: Direct

Name: dapA [H]

Synonym: GSU0159

Alternate gene names: 39995270

Gene position: 177446-178318 (Clockwise)

Preceding gene: 39995269

Following gene: 39995271

Centisome position: 4.65

GC content: 63.69

Gene sequence:

>873_bases
ATGTTCAAGGGAAGCATTGTCGCCATCGTCACCCCGTTCACCAACGGCGCGGTGGACCAGGAGAAACTGCGGGAACTCGT
GGAGTTCCAGATCACCAACGGCACCGACGCCATCGTTCCGTGCGGCACCACCGGCGAATCATCGACGCTGGACTATGACG
AGCACATGGACGTGGTGAAGATCGTCATCGAGCAGGTGAACAAGCGGGTTCCGGTCATCGCCGGCACCGGCTCCAATTCC
ACCGCCGAGGCCATCGAGCTCTCCCGCAAGGCCAAGGAGGCCGGGGCCGACGGCGTGCTGCTGGTCACCCCCTACTACAA
CAAGCCGACCCAGGAGGGGCTCGTCCGCCACTACACCGCCATCGCTGATGCCGTGGCCATCCCCCAGATCCTCTACAACG
TGCCGGGCCGCACCGGGGTCAACATGCTCCCCGAGACCGTCGCCCGGCTGGCGCCCCACAAGAACATCGTCGCCATAAAG
GAGGCCACCGGTTCGCTCCAGCAGGCCTCGGAGATCCTGGCCCTCTGCGGCGACCAGATCGATGTCCTCTCGGGCGACGA
CTTCATCACCTTCCCCATGATGGCGTGCGGCGCCAAGGGGGTCATCTCGGTGCTGGCCAACATCATGCCCAAGGCCGTGG
CCGACCTGACCGACGCCTTCTTTGCCGGTGATCTGGAGACGGCGCGTCGGCTCCACCTGAACACCCTCAAGATCAGCAAC
GCCATGTTCATCGAGTCGAACCCGATCCCGGTGAAGACGGCGCTCGGTCTCATGGGCAAGTGCTCCGACGAGGTCCGCCT
CCCGCTCTGCCCCATGTCCGAGGGGAACAAGGCGAAACTGACCGCCATCATGAAAGAGTACCAGCTGATTTAA

Upstream 100 bases:

>100_bases
AGTGGTCCGCGAGCGGGAGACGGTGGAAGACCTGATCCGGGGCGAGCGGGTGCCGTCGTTCCTGTAACGAAAGACAACCC
CAGAGAGGGAGGATACGGAT

Downstream 100 bases:

>100_bases
CGCGCGAACTGCGAGGTTGATATGACCAAGATAGCTGTCTGTGGCGCCGCCGGGCGTATGGGCCAGAGGATCATCGTTGC
CGCCAGGGAGGCTGGCTGCA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MFKGSIVAIVTPFTNGAVDQEKLRELVEFQITNGTDAIVPCGTTGESSTLDYDEHMDVVKIVIEQVNKRVPVIAGTGSNS
TAEAIELSRKAKEAGADGVLLVTPYYNKPTQEGLVRHYTAIADAVAIPQILYNVPGRTGVNMLPETVARLAPHKNIVAIK
EATGSLQQASEILALCGDQIDVLSGDDFITFPMMACGAKGVISVLANIMPKAVADLTDAFFAGDLETARRLHLNTLKISN
AMFIESNPIPVKTALGLMGKCSDEVRLPLCPMSEGNKAKLTAIMKEYQLI

Sequences:

>Translated_290_residues
MFKGSIVAIVTPFTNGAVDQEKLRELVEFQITNGTDAIVPCGTTGESSTLDYDEHMDVVKIVIEQVNKRVPVIAGTGSNS
TAEAIELSRKAKEAGADGVLLVTPYYNKPTQEGLVRHYTAIADAVAIPQILYNVPGRTGVNMLPETVARLAPHKNIVAIK
EATGSLQQASEILALCGDQIDVLSGDDFITFPMMACGAKGVISVLANIMPKAVADLTDAFFAGDLETARRLHLNTLKISN
AMFIESNPIPVKTALGLMGKCSDEVRLPLCPMSEGNKAKLTAIMKEYQLI
>Mature_290_residues
MFKGSIVAIVTPFTNGAVDQEKLRELVEFQITNGTDAIVPCGTTGESSTLDYDEHMDVVKIVIEQVNKRVPVIAGTGSNS
TAEAIELSRKAKEAGADGVLLVTPYYNKPTQEGLVRHYTAIADAVAIPQILYNVPGRTGVNMLPETVARLAPHKNIVAIK
EATGSLQQASEILALCGDQIDVLSGDDFITFPMMACGAKGVISVLANIMPKAVADLTDAFFAGDLETARRLHLNTLKISN
AMFIESNPIPVKTALGLMGKCSDEVRLPLCPMSEGNKAKLTAIMKEYQLI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=277, Percent_Identity=30.6859205776173, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI13540533, Length=238, Percent_Identity=27.7310924369748, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788823, Length=294, Percent_Identity=46.9387755102041, Blast_Score=268, Evalue=3e-73,
Organism=Escherichia coli, GI1786463, Length=286, Percent_Identity=33.2167832167832, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI87082415, Length=250, Percent_Identity=34.4, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1789620, Length=292, Percent_Identity=31.1643835616438, Blast_Score=128, Evalue=4e-31,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31046; Mature: 31046

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKGSIVAIVTPFTNGAVDQEKLRELVEFQITNGTDAIVPCGTTGESSTLDYDEHMDVVK
CCCCCEEEEEECCCCCCCCHHHHHHHHHEEECCCCCCEEECCCCCCCCCCCHHHHHHHHH
IVIEQVNKRVPVIAGTGSNSTAEAIELSRKAKEAGADGVLLVTPYYNKPTQEGLVRHYTA
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
IADAVAIPQILYNVPGRTGVNMLPETVARLAPHKNIVAIKEATGSLQQASEILALCGDQI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCE
DVLSGDDFITFPMMACGAKGVISVLANIMPKAVADLTDAFFAGDLETARRLHLNTLKISN
EEECCCCEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEEECC
AMFIESNPIPVKTALGLMGKCSDEVRLPLCPMSEGNKAKLTAIMKEYQLI
EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFKGSIVAIVTPFTNGAVDQEKLRELVEFQITNGTDAIVPCGTTGESSTLDYDEHMDVVK
CCCCCEEEEEECCCCCCCCHHHHHHHHHEEECCCCCCEEECCCCCCCCCCCHHHHHHHHH
IVIEQVNKRVPVIAGTGSNSTAEAIELSRKAKEAGADGVLLVTPYYNKPTQEGLVRHYTA
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
IADAVAIPQILYNVPGRTGVNMLPETVARLAPHKNIVAIKEATGSLQQASEILALCGDQI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCE
DVLSGDDFITFPMMACGAKGVISVLANIMPKAVADLTDAFFAGDLETARRLHLNTLKISN
EEECCCCEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEEECC
AMFIESNPIPVKTALGLMGKCSDEVRLPLCPMSEGNKAKLTAIMKEYQLI
EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA