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The map label for this gene is lysA [H]

Identifier: 57234679

GI number: 57234679

Start: 487604

End: 488908

Strand: Direct

Name: lysA [H]

Synonym: DET0534

Alternate gene names: 57234679

Gene position: 487604-488908 (Clockwise)

Preceding gene: 57234691

Following gene: 57234678

Centisome position: 33.18

GC content: 51.26

Gene sequence:

>1305_bases
ATGGAACCAAGAATACAGGTATTCCCCAAAAACACTGAAGTAAAAAATAACCGCCTGGTTATCGGCGGTGCAGATGTTGC
CGGGCTTTGTGCCAAATACGGCACGCCCCTGTACGTTTTTGACGAGGCTACTATCCGCCAGAACTGCCGTGACTTTAAAC
GGGAGTTTTCCCGCCGCTACGCAGACAGTTCGGTGAGTTATGCCTCAAAAGCCTTTTTGCATCCGGCCTTGCTGAAGATA
CTTGCCGAAGAGGGTATGAGTCTGGACGTGGTTTCCGGCGGAGAGCTGTCTATTGCCAGCAGCGCCGGTTTCCCTATGGA
TATGGTCTATTTCCATGGAAATAACAAATCTGCTGATGAACTAAGGCTGGCGCTCCGTCTGCATGTCGGGCGGATTGTGG
TAGACAGCTTTGATGAAATCAAACTGCTGTCAAAACTGGCGGATGAGAGCGGGCATATTCCGGATATACTCCTCAGGCTT
ACTCCGGGAGTAGATGCCCATACCCATCACCATATTACTACCGGCAAGCTGGATTCCAAATTTGGTTTCCCCCTGTTTCA
GGCAGCCGAAGCGGTAGGTTTGGCTATGGCGCAGGCCAGTCTGAATCTGGTCGGTTTCCATTTCCATATCGGTTCCCAGA
TATTTGAAACCCAGCCCTTCCTTGATGCTATAGATTTGGTGCTGGAATTTGCCGCTCAGGTTCAGGAACGCTATGGTTTT
GACATAGAGGAGCTGGATATCGGCGGCGGTTACGGCGTTCAGTACGAAGTGGATAAACCTGCACCCCAGGTATCTGTTTA
TGCGGAGGCTATCGGCGCTAAGATTGTCTCCAAGTGCCACAGCTTAAAGCTGACTCCCCCCAGCCTTAATATTGAACCGG
GGCGGGCTGTCATAGCTCAGGCAGGGGTGGCCTTGTATACGGTGGGGGTTATTAAAGATATTCCCGGTATCCGGGTGTAT
GCCTCGGTGGACGGGGGCATGGGTGATAATATCCGCCCGGCTTTGTATGAGGCAAAGTATGAGGCGGTGGTGGCAAATAA
TGTCCAGTCTTCAGAAAAACAAAAGGTAACTGTAGCAGGCAAGTTTTGCGAATCCGGTGATATACTTATAACCGATATTG
AGCTGCCTGTCCTCAAGACAGGTGATATACTGGCAGTGCCCTGCTGCGGGGCTTACTGTTTGCCTATGTCCAGCAATTAC
AACGGCTATCAGCGCCCGGCTGTAGTGATGCTGAAAAATGGTGAAGACCGCCTGATACGGCGGCGCGAAACTGTGGAAGA
CCTTAGCCGTCTGGATTCGGTCTAA

Upstream 100 bases:

>100_bases
TAATAAAATAAATTAAAGCAAATTTGAACGGAGGGCAGGTTTAATTAACATGGCAATCTTCATTGACGCAGTTGCTTTAG
CACTGGTATGATAAGCAATT

Downstream 100 bases:

>100_bases
GCCGGGTTTCTTATATGTGGCAGATAATAGGTCAGGACAAGGCAGTCTCCTTCCTCTGTAACAGCCTCAATCAGGACAAG
CTTTGCCACGCCTATGTGTT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MEPRIQVFPKNTEVKNNRLVIGGADVAGLCAKYGTPLYVFDEATIRQNCRDFKREFSRRYADSSVSYASKAFLHPALLKI
LAEEGMSLDVVSGGELSIASSAGFPMDMVYFHGNNKSADELRLALRLHVGRIVVDSFDEIKLLSKLADESGHIPDILLRL
TPGVDAHTHHHITTGKLDSKFGFPLFQAAEAVGLAMAQASLNLVGFHFHIGSQIFETQPFLDAIDLVLEFAAQVQERYGF
DIEELDIGGGYGVQYEVDKPAPQVSVYAEAIGAKIVSKCHSLKLTPPSLNIEPGRAVIAQAGVALYTVGVIKDIPGIRVY
ASVDGGMGDNIRPALYEAKYEAVVANNVQSSEKQKVTVAGKFCESGDILITDIELPVLKTGDILAVPCCGAYCLPMSSNY
NGYQRPAVVMLKNGEDRLIRRRETVEDLSRLDSV

Sequences:

>Translated_434_residues
MEPRIQVFPKNTEVKNNRLVIGGADVAGLCAKYGTPLYVFDEATIRQNCRDFKREFSRRYADSSVSYASKAFLHPALLKI
LAEEGMSLDVVSGGELSIASSAGFPMDMVYFHGNNKSADELRLALRLHVGRIVVDSFDEIKLLSKLADESGHIPDILLRL
TPGVDAHTHHHITTGKLDSKFGFPLFQAAEAVGLAMAQASLNLVGFHFHIGSQIFETQPFLDAIDLVLEFAAQVQERYGF
DIEELDIGGGYGVQYEVDKPAPQVSVYAEAIGAKIVSKCHSLKLTPPSLNIEPGRAVIAQAGVALYTVGVIKDIPGIRVY
ASVDGGMGDNIRPALYEAKYEAVVANNVQSSEKQKVTVAGKFCESGDILITDIELPVLKTGDILAVPCCGAYCLPMSSNY
NGYQRPAVVMLKNGEDRLIRRRETVEDLSRLDSV
>Mature_434_residues
MEPRIQVFPKNTEVKNNRLVIGGADVAGLCAKYGTPLYVFDEATIRQNCRDFKREFSRRYADSSVSYASKAFLHPALLKI
LAEEGMSLDVVSGGELSIASSAGFPMDMVYFHGNNKSADELRLALRLHVGRIVVDSFDEIKLLSKLADESGHIPDILLRL
TPGVDAHTHHHITTGKLDSKFGFPLFQAAEAVGLAMAQASLNLVGFHFHIGSQIFETQPFLDAIDLVLEFAAQVQERYGF
DIEELDIGGGYGVQYEVDKPAPQVSVYAEAIGAKIVSKCHSLKLTPPSLNIEPGRAVIAQAGVALYTVGVIKDIPGIRVY
ASVDGGMGDNIRPALYEAKYEAVVANNVQSSEKQKVTVAGKFCESGDILITDIELPVLKTGDILAVPCCGAYCLPMSSNY
NGYQRPAVVMLKNGEDRLIRRRETVEDLSRLDSV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=367, Percent_Identity=23.433242506812, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1789203, Length=417, Percent_Identity=31.89448441247, Blast_Score=150, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322664, Length=379, Percent_Identity=21.6358839050132, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24586474, Length=426, Percent_Identity=26.2910798122066, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24586472, Length=423, Percent_Identity=23.6406619385343, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47282; Mature: 47282

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPRIQVFPKNTEVKNNRLVIGGADVAGLCAKYGTPLYVFDEATIRQNCRDFKREFSRRY
CCCCEEEECCCCCCCCCEEEEECCCHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHH
ADSSVSYASKAFLHPALLKILAEEGMSLDVVSGGELSIASSAGFPMDMVYFHGNNKSADE
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCEEEEEEECCCCCHHH
LRLALRLHVGRIVVDSFDEIKLLSKLADESGHIPDILLRLTPGVDAHTHHHITTGKLDSK
HHHHHHHHHCCCEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEECCCCCC
FGFPLFQAAEAVGLAMAQASLNLVGFHFHIGSQIFETQPFLDAIDLVLEFAAQVQERYGF
CCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCC
DIEELDIGGGYGVQYEVDKPAPQVSVYAEAIGAKIVSKCHSLKLTPPSLNIEPGRAVIAQ
CCEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHH
AGVALYTVGVIKDIPGIRVYASVDGGMGDNIRPALYEAKYEAVVANNVQSSEKQKVTVAG
CCCCEEEEHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHEEEECCCCCCCCCEEEEEE
KFCESGDILITDIELPVLKTGDILAVPCCGAYCLPMSSNYNGYQRPAVVMLKNGEDRLIR
EECCCCCEEEEEEEECEEECCCEEEECCCCEEEECCCCCCCCCCCCEEEEEECCCHHHHH
RRETVEDLSRLDSV
HHHHHHHHHHHCCC
>Mature Secondary Structure
MEPRIQVFPKNTEVKNNRLVIGGADVAGLCAKYGTPLYVFDEATIRQNCRDFKREFSRRY
CCCCEEEECCCCCCCCCEEEEECCCHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHH
ADSSVSYASKAFLHPALLKILAEEGMSLDVVSGGELSIASSAGFPMDMVYFHGNNKSADE
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCEEEEEEECCCCCHHH
LRLALRLHVGRIVVDSFDEIKLLSKLADESGHIPDILLRLTPGVDAHTHHHITTGKLDSK
HHHHHHHHHCCCEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEECCCCCC
FGFPLFQAAEAVGLAMAQASLNLVGFHFHIGSQIFETQPFLDAIDLVLEFAAQVQERYGF
CCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCC
DIEELDIGGGYGVQYEVDKPAPQVSVYAEAIGAKIVSKCHSLKLTPPSLNIEPGRAVIAQ
CCEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHH
AGVALYTVGVIKDIPGIRVYASVDGGMGDNIRPALYEAKYEAVVANNVQSSEKQKVTVAG
CCCCEEEEHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHEEEECCCCCCCCCEEEEEE
KFCESGDILITDIELPVLKTGDILAVPCCGAYCLPMSSNYNGYQRPAVVMLKNGEDRLIR
EECCCCCEEEEEEEECEEECCCEEEECCCCEEEECCCCCCCCCCCCEEEEEECCCHHHHH
RRETVEDLSRLDSV
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]