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The map label for this gene is glmS [H]

Identifier: 57234691

GI number: 57234691

Start: 484507

End: 486288

Strand: Direct

Name: glmS [H]

Synonym: DET0531

Alternate gene names: 57234691

Gene position: 484507-486288 (Clockwise)

Preceding gene: 57234692

Following gene: 57234679

Centisome position: 32.97

GC content: 51.52

Gene sequence:

>1782_bases
ATGTGCGGTATAGTGGGTTACACCGGTAAACGCCAGGCACAGGCTGTTTTATATGATTGTTTGTGCCGTCTGGAGTACCG
CGGGTATGATTCCTGCGGCATAGCCGTAAACACGCCTGAGGTGCAGGTTTTTAAAGATGCAGGCAAAGTCCGTAACATAC
TTCAAAATGCCCCCCGGTTTGAGGGTACAGCCGGTCTGGGGCATACCCGCTGGGCTACCTGCGGTGAACCAACCCGGATA
AATGCCCACCCCCACATAGACTGCACCGGCAAAATCAGCCTGGTGCATAACGGGGTAATAAATAACTATGCCCAACTCCG
CAAACGGCTTGAGGCTAATGGCCACAAGGTTGTTTCAGATACGGACACCGAGCTTATTGCCCATTTGATAGAGGAGTACG
ATAAAGGAAACCTAGAAGAAGCCGTCCGTCAGGCAGTGAAGGAGATAGATGGCTCTTATGCTCTGGTGGTGATGCGTTCC
GGGGATAATACCCTGGTAGCGGTGCGGAAGGACAGTCCGCTGGTTATCGGGGTGGGGGACAGTGAGTATCTGGTAGCTTC
AGATGTGCCTGCTATTTTAGGATATACCAACCGGGTTATATATCCGGAAGAGGGGGATATTGCCGTTATCAGCCCGGACA
GCCTGAAAATAAACCGGAATGGCGAATATATTATTCCCCGTGTAGAGAAGATAAACTGGACGCCGGATGAAGCCCAGAAG
GGCGGCTACAGCCACTATATGCTTAAAGAAATACACGAACAGCCGCAGGTTATTCAAAATACCCTGATAAATATGCCCCT
GACGGAGTCTTTTTATAAATCCCCGCTGCTGGAGCAGGGCCGTAAGACCGGCATACTGTTTCTAGCCTGCGGCAGTTCAT
ACCATGCGGCTCTGACCGGCCGCTATTTGGTAGAGGAACATCTGAATATACCCGTCCGTCTGGAGGTGGCTTCAGAGTTC
AACTATATGCAGCATTTACCGCCCTGCAAACTGGCCGTGGTGCTTAGCCAGTCTGGCGAAACCGCAGACATTTTGCGGGC
CATGCGCCGTTTAAAGCAAGCCGGTTGTATGATAGTGGCCATAACAAATGTAGCCGGCAGTACGGCTGCCCGTCTGGCAG
ACCATGTTATATATACTCAGGCTGGGCCGGAAATAGGGGTAGCAGCTACCAAGAGTTTTATTGCCCAGCTGGTAGTCCTG
TACGCTTTGTGTTTTGCCTGTGCTTCTGCTGCCAGCCCGCGTTATCAGGATTATTTAAGCACTATGCGGCTTTTACCCGG
TGCTGTCCAGAAAATACTGGGCAGCCACCAGAATATTAAAGATGCGGCTATAGAAGTAGCCAAAGCTAAAAGTGCCTTTT
TTATAGGCCGGGGGATTAACTATCCTATTGCCCTGGAGGGTGCTTTGAAGCTAAAGGAGATTTCGTATATCCATGCGGAG
GGCTATGCTGCCGGGGAACTGAAACACGGGCCGTTTGCCCTGCTTTCTCCGGAAACGCCGGTGCTGGCGTTGGTTAGCCG
TGACCAAACCTATGAAGCCATGTTGACTGGGCTGCGGGAAATAAAGGTACGGCGCGCACCTTTGATTGTTATCGGTGAAG
ACGGAGACGACCAGCTTGAACAGCTGGCAGACCGGGTGATAAAAATTCCGCCCTTCAACCGGCTGTTCAGTCCCATACTC
TTTTCAGTAGTGCTTCAGCTGCTGGCATTTTATGCGGCTTATGAGCTGGGGCGTGACATAGATACCCCCCGCAATCTGGC
TAAAAGCGTCACAGTAGAGTAG

Upstream 100 bases:

>100_bases
GCAGTTCTTCAGGGCGGTACGGTGGTGGGAAATTCCAGCCGTATAGCCCCTTTAAAAACCCTGTCGGGCAGTATACCTGA
CGGCAGTCTGGTGGTCTAGA

Downstream 100 bases:

>100_bases
GTATTTCTCAGGCTACAAACAGGCCGGTAAGGTCTGTCTGGTCAATTATATGCCCTTCCATAGCCTTGATAAGGTCTGCC
TGGTGGCTGCCGGCTTTCAG

Product: glucosamine--fructose-6-phosphate aminotransferase, isomerizing

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MCGIVGYTGKRQAQAVLYDCLCRLEYRGYDSCGIAVNTPEVQVFKDAGKVRNILQNAPRFEGTAGLGHTRWATCGEPTRI
NAHPHIDCTGKISLVHNGVINNYAQLRKRLEANGHKVVSDTDTELIAHLIEEYDKGNLEEAVRQAVKEIDGSYALVVMRS
GDNTLVAVRKDSPLVIGVGDSEYLVASDVPAILGYTNRVIYPEEGDIAVISPDSLKINRNGEYIIPRVEKINWTPDEAQK
GGYSHYMLKEIHEQPQVIQNTLINMPLTESFYKSPLLEQGRKTGILFLACGSSYHAALTGRYLVEEHLNIPVRLEVASEF
NYMQHLPPCKLAVVLSQSGETADILRAMRRLKQAGCMIVAITNVAGSTAARLADHVIYTQAGPEIGVAATKSFIAQLVVL
YALCFACASAASPRYQDYLSTMRLLPGAVQKILGSHQNIKDAAIEVAKAKSAFFIGRGINYPIALEGALKLKEISYIHAE
GYAAGELKHGPFALLSPETPVLALVSRDQTYEAMLTGLREIKVRRAPLIVIGEDGDDQLEQLADRVIKIPPFNRLFSPIL
FSVVLQLLAFYAAYELGRDIDTPRNLAKSVTVE

Sequences:

>Translated_593_residues
MCGIVGYTGKRQAQAVLYDCLCRLEYRGYDSCGIAVNTPEVQVFKDAGKVRNILQNAPRFEGTAGLGHTRWATCGEPTRI
NAHPHIDCTGKISLVHNGVINNYAQLRKRLEANGHKVVSDTDTELIAHLIEEYDKGNLEEAVRQAVKEIDGSYALVVMRS
GDNTLVAVRKDSPLVIGVGDSEYLVASDVPAILGYTNRVIYPEEGDIAVISPDSLKINRNGEYIIPRVEKINWTPDEAQK
GGYSHYMLKEIHEQPQVIQNTLINMPLTESFYKSPLLEQGRKTGILFLACGSSYHAALTGRYLVEEHLNIPVRLEVASEF
NYMQHLPPCKLAVVLSQSGETADILRAMRRLKQAGCMIVAITNVAGSTAARLADHVIYTQAGPEIGVAATKSFIAQLVVL
YALCFACASAASPRYQDYLSTMRLLPGAVQKILGSHQNIKDAAIEVAKAKSAFFIGRGINYPIALEGALKLKEISYIHAE
GYAAGELKHGPFALLSPETPVLALVSRDQTYEAMLTGLREIKVRRAPLIVIGEDGDDQLEQLADRVIKIPPFNRLFSPIL
FSVVLQLLAFYAAYELGRDIDTPRNLAKSVTVE
>Mature_593_residues
MCGIVGYTGKRQAQAVLYDCLCRLEYRGYDSCGIAVNTPEVQVFKDAGKVRNILQNAPRFEGTAGLGHTRWATCGEPTRI
NAHPHIDCTGKISLVHNGVINNYAQLRKRLEANGHKVVSDTDTELIAHLIEEYDKGNLEEAVRQAVKEIDGSYALVVMRS
GDNTLVAVRKDSPLVIGVGDSEYLVASDVPAILGYTNRVIYPEEGDIAVISPDSLKINRNGEYIIPRVEKINWTPDEAQK
GGYSHYMLKEIHEQPQVIQNTLINMPLTESFYKSPLLEQGRKTGILFLACGSSYHAALTGRYLVEEHLNIPVRLEVASEF
NYMQHLPPCKLAVVLSQSGETADILRAMRRLKQAGCMIVAITNVAGSTAARLADHVIYTQAGPEIGVAATKSFIAQLVVL
YALCFACASAASPRYQDYLSTMRLLPGAVQKILGSHQNIKDAAIEVAKAKSAFFIGRGINYPIALEGALKLKEISYIHAE
GYAAGELKHGPFALLSPETPVLALVSRDQTYEAMLTGLREIKVRRAPLIVIGEDGDDQLEQLADRVIKIPPFNRLFSPIL
FSVVLQLLAFYAAYELGRDIDTPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=683, Percent_Identity=34.6998535871157, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI4826742, Length=690, Percent_Identity=34.3478260869565, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI29570798, Length=200, Percent_Identity=29.5, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790167, Length=614, Percent_Identity=42.3452768729642, Blast_Score=433, Evalue=1e-122,
Organism=Escherichia coli, GI1788651, Length=220, Percent_Identity=31.3636363636364, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17532897, Length=472, Percent_Identity=33.8983050847458, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17532899, Length=472, Percent_Identity=34.5338983050847, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=34.338747099768, Blast_Score=238, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6322745, Length=435, Percent_Identity=33.5632183908046, Blast_Score=244, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6323731, Length=427, Percent_Identity=26.2295081967213, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=39.3203883495146, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6323958, Length=214, Percent_Identity=28.0373831775701, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21357745, Length=685, Percent_Identity=35.036496350365, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI28573187, Length=278, Percent_Identity=27.6978417266187, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24659604, Length=175, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24659598, Length=175, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65122; Mature: 65122

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYTGKRQAQAVLYDCLCRLEYRGYDSCGIAVNTPEVQVFKDAGKVRNILQNAPRF
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEHHHHHHHHHHHCCCCC
EGTAGLGHTRWATCGEPTRINAHPHIDCTGKISLVHNGVINNYAQLRKRLEANGHKVVSD
CCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEECC
TDTELIAHLIEEYDKGNLEEAVRQAVKEIDGSYALVVMRSGDNTLVAVRKDSPLVIGVGD
CHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCEEEEECC
SEYLVASDVPAILGYTNRVIYPEEGDIAVISPDSLKINRNGEYIIPRVEKINWTPDEAQK
CCEEEECCCCHHHCCCCEEEECCCCCEEEECCCCEEECCCCCEEEEEHEECCCCCCHHHC
GGYSHYMLKEIHEQPQVIQNTLINMPLTESFYKSPLLEQGRKTGILFLACGSSYHAALTG
CCCHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHCHHHHCCCCCCEEEEEECCCCCHHHHH
RYLVEEHLNIPVRLEVASEFNYMQHLPPCKLAVVLSQSGETADILRAMRRLKQAGCMIVA
HHHHHHHCCCCEEEEECHHCHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCEEEEE
ITNVAGSTAARLADHVIYTQAGPEIGVAATKSFIAQLVVLYALCFACASAASPRYQDYLS
EECCCCHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TMRLLPGAVQKILGSHQNIKDAAIEVAKAKSAFFIGRGINYPIALEGALKLKEISYIHAE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCEEECCCEEEEHEEEEEEC
GYAAGELKHGPFALLSPETPVLALVSRDQTYEAMLTGLREIKVRRAPLIVIGEDGDDQLE
CCCCCCCCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHEECCCEEEEECCCHHHHH
QLADRVIKIPPFNRLFSPILFSVVLQLLAFYAAYELGRDIDTPRNLAKSVTVE
HHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYTGKRQAQAVLYDCLCRLEYRGYDSCGIAVNTPEVQVFKDAGKVRNILQNAPRF
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEHHHHHHHHHHHCCCCC
EGTAGLGHTRWATCGEPTRINAHPHIDCTGKISLVHNGVINNYAQLRKRLEANGHKVVSD
CCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEECC
TDTELIAHLIEEYDKGNLEEAVRQAVKEIDGSYALVVMRSGDNTLVAVRKDSPLVIGVGD
CHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCEEEEECC
SEYLVASDVPAILGYTNRVIYPEEGDIAVISPDSLKINRNGEYIIPRVEKINWTPDEAQK
CCEEEECCCCHHHCCCCEEEECCCCCEEEECCCCEEECCCCCEEEEEHEECCCCCCHHHC
GGYSHYMLKEIHEQPQVIQNTLINMPLTESFYKSPLLEQGRKTGILFLACGSSYHAALTG
CCCHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHCHHHHCCCCCCEEEEEECCCCCHHHHH
RYLVEEHLNIPVRLEVASEFNYMQHLPPCKLAVVLSQSGETADILRAMRRLKQAGCMIVA
HHHHHHHCCCCEEEEECHHCHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCEEEEE
ITNVAGSTAARLADHVIYTQAGPEIGVAATKSFIAQLVVLYALCFACASAASPRYQDYLS
EECCCCHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TMRLLPGAVQKILGSHQNIKDAAIEVAKAKSAFFIGRGINYPIALEGALKLKEISYIHAE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCEEECCCEEEEHEEEEEEC
GYAAGELKHGPFALLSPETPVLALVSRDQTYEAMLTGLREIKVRRAPLIVIGEDGDDQLE
CCCCCCCCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHEECCCEEEEECCCHHHHH
QLADRVIKIPPFNRLFSPILFSVVLQLLAFYAAYELGRDIDTPRNLAKSVTVE
HHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]