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The map label for this gene is trpC

Identifier: 57233823

GI number: 57233823

Start: 1342259

End: 1343038

Strand: Direct

Name: trpC

Synonym: DET1484

Alternate gene names: 57233823

Gene position: 1342259-1343038 (Clockwise)

Preceding gene: 57233824

Following gene: 57233822

Centisome position: 91.33

GC content: 48.97

Gene sequence:

>780_bases
ATGATTTTGGAACGTATTGTCACCGACAACCTGCCTGATTTGGAGCGGAGAAAAATGCGGCTGCCATTAGCAAAACTGCA
GGAATTGGTACTGGACATACCCTATCTACCCATTGACATGGCCATGAAGCTTAAAGGGCGGCAGGTCAGGCTGATTGCCG
AGGTAAAAAAAGCCTCTCCGTCAAAAGGGATAATCCGCCCGGATTTTGACCCGGTGGATATTGCCGGCATATATGCCCGA
AACGGGGCTTCCGCCATTTCGGTTTTGACAGAAGAACACCATTTTATGGGAAGCCTTGACAACCTGAAGAAAATACGCGA
ATCAGGGGTGGCATCAAAGCTGCCACTTCTCCGTAAGGATTTTATCCATGACCCGTATCAGGTATATGAATCCCGCCTGT
ACGGGGCAGACGCTATTTTGCTGATAGTAGCCATGCTGTCTCCCGAAAGGTTACAGGAACTGCTTTCACTCAGCCATAAG
CTGGGCATGAAATGTCTGGTGGAAGTGCATACCCGGTCAGAGCTGGAAATAGCTTTAGAGAGTAATGCCCGGATTATCGG
CCTGAATAACCGTGATTTGCATACGTTTAAAATAGACCTAACTGTAACCGAAAGGCTTCGCCCCCTGATACCCCCTGAGT
GCATAGTTGTCAGTGAAAGCGGCATTCAGACCAGAGCAGATATTTCCCGTCTGGAAGAACTGGGAGTAGATGCAGTGCTG
GTAGGAGAAGCCTTAACAGCCTCGGTTGATATTGCCGCCAAAATGAGGGAACTGCTGTGA

Upstream 100 bases:

>100_bases
GGTATCTCTCTGGCCGCAGAAATAATTGACAACGGGCTGGCACTTAATAAGCTAGAATCTTTGATTAAACTCAGCCAGTC
TTTGGCAAGCGGGTAAAACC

Downstream 100 bases:

>100_bases
TTAAGACTAAGATTTGCGGCTTGACAGAGGTTGGACAAGCCTTGGCCACAGCCCGGACAGGGGCTGACTTTGCCGGAGTG
GTATTTGCCGAAAGCAAACG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MILERIVTDNLPDLERRKMRLPLAKLQELVLDIPYLPIDMAMKLKGRQVRLIAEVKKASPSKGIIRPDFDPVDIAGIYAR
NGASAISVLTEEHHFMGSLDNLKKIRESGVASKLPLLRKDFIHDPYQVYESRLYGADAILLIVAMLSPERLQELLSLSHK
LGMKCLVEVHTRSELEIALESNARIIGLNNRDLHTFKIDLTVTERLRPLIPPECIVVSESGIQTRADISRLEELGVDAVL
VGEALTASVDIAAKMRELL

Sequences:

>Translated_259_residues
MILERIVTDNLPDLERRKMRLPLAKLQELVLDIPYLPIDMAMKLKGRQVRLIAEVKKASPSKGIIRPDFDPVDIAGIYAR
NGASAISVLTEEHHFMGSLDNLKKIRESGVASKLPLLRKDFIHDPYQVYESRLYGADAILLIVAMLSPERLQELLSLSHK
LGMKCLVEVHTRSELEIALESNARIIGLNNRDLHTFKIDLTVTERLRPLIPPECIVVSESGIQTRADISRLEELGVDAVL
VGEALTASVDIAAKMRELL
>Mature_259_residues
MILERIVTDNLPDLERRKMRLPLAKLQELVLDIPYLPIDMAMKLKGRQVRLIAEVKKASPSKGIIRPDFDPVDIAGIYAR
NGASAISVLTEEHHFMGSLDNLKKIRESGVASKLPLLRKDFIHDPYQVYESRLYGADAILLIVAMLSPERLQELLSLSHK
LGMKCLVEVHTRSELEIALESNARIIGLNNRDLHTFKIDLTVTERLRPLIPPECIVVSESGIQTRADISRLEELGVDAVL
VGEALTASVDIAAKMRELL

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=258, Percent_Identity=42.6356589147287, Blast_Score=181, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6322638, Length=218, Percent_Identity=46.7889908256881, Blast_Score=172, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_DEHE1 (Q3Z6G5)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_182184.1
- HSSP:   Q56319
- ProteinModelPortal:   Q3Z6G5
- SMR:   Q3Z6G5
- STRING:   Q3Z6G5
- GeneID:   3229286
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET1484
- NMPDR:   fig|243164.3.peg.1409
- TIGR:   DET1484
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- PhylomeDB:   Q3Z6G5
- ProtClustDB:   PRK00278
- BioCyc:   DETH243164:DET_1484-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28998; Mature: 28998

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILERIVTDNLPDLERRKMRLPLAKLQELVLDIPYLPIDMAMKLKGRQVRLIAEVKKASP
CCHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCHHHHEECCCCEEEHHHHHHHCCC
SKGIIRPDFDPVDIAGIYARNGASAISVLTEEHHFMGSLDNLKKIRESGVASKLPLLRKD
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHCCHHHHH
FIHDPYQVYESRLYGADAILLIVAMLSPERLQELLSLSHKLGMKCLVEVHTRSELEIALE
HCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEE
SNARIIGLNNRDLHTFKIDLTVTERLRPLIPPECIVVSESGIQTRADISRLEELGVDAVL
CCCEEEEECCCCEEEEEEEEEEHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEE
VGEALTASVDIAAKMRELL
ECHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MILERIVTDNLPDLERRKMRLPLAKLQELVLDIPYLPIDMAMKLKGRQVRLIAEVKKASP
CCHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCHHHHEECCCCEEEHHHHHHHCCC
SKGIIRPDFDPVDIAGIYARNGASAISVLTEEHHFMGSLDNLKKIRESGVASKLPLLRKD
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHCCHHHHH
FIHDPYQVYESRLYGADAILLIVAMLSPERLQELLSLSHKLGMKCLVEVHTRSELEIALE
HCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEE
SNARIIGLNNRDLHTFKIDLTVTERLRPLIPPECIVVSESGIQTRADISRLEELGVDAVL
CCCEEEEECCCCEEEEEEEEEEHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEE
VGEALTASVDIAAKMRELL
ECHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA