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The map label for this gene is gcp

Identifier: 57233782

GI number: 57233782

Start: 1296570

End: 1297550

Strand: Direct

Name: gcp

Synonym: DET1426

Alternate gene names: 57233782

Gene position: 1296570-1297550 (Clockwise)

Preceding gene: 57233796

Following gene: 57233781

Centisome position: 88.22

GC content: 56.27

Gene sequence:

>981_bases
ATGAAGATACTCGGTATAGAAAGCTCCTGTGATGAAACCGCTGCCGCAGTAGTGGCAGACGGGGTAAATATTTTATCCAA
CCGGGTATCCTCGCAGATAGATATCCACTCCCGTTACGGCGGGGTAGTCCCCGAAGTGGCTTCCCGCCAGCACCTGCTTT
CCATATTACCGGTCATAAGTGACGCACTTAAGGAAGCACGTACCGGATTTGATGAAATTTCGGCCATAGCTGTAACCAAC
GGGCCGGGTCTGGCAGGCTCTCTGATAGTGGGGGTAAATGCCGCCAAAGCCATAGCCGCCGCCCGCGGCATACCCCTGGT
GGCGGTAAACCACCTGCACGGCCATATCTATGCCAACTGGCTTTCCGGCAGGATACCGGAATTCCCCTGCCTGTGCCTGA
CTGTCTCAGGCGGGCATACCGACCTGGTGCTGATGAAAGGGCATGGTCAGTATCAGCTGCTGGGACGTACCCGTGATGAT
GCCGCCGGAGAAGCCTTTGACAAAGCCGCCAGAATACTGGGTTTAAGCTATCCAGGCGGGCCGGCCATAGACAGAGCTTC
GCAGGACGGTGAGGCAGTACTGGATTTGCCGCGCTCGTGGATACCCGGCAGCCATGACTTCAGCTTTAGCGGACTGAAAA
CCGCCCTGCTCCGGCTGGTGGAAAACGGCGAAGTCTGTTCGGTAAATGACGCCGCCGCCAGCTTTCAAAAAGCGGTGGTA
GATGTACTGGTAACCAAGACCCTGAACTGCGCCCATGAGTACAACGTAAAGCAGATACTGCTGGCAGGCGGAGTGGCCGC
CAATAACCTGCTGCGTAAACAGCTAAGCGAACAATCCCCTCTGCCGGTTTCCATACCACCCATAGGCTTATGTACCGACA
ATGCCGCCGTAATAGCCTCCTGCGGCTATTTCCGCTTTATATCCGGCGGTCAGGACAGGCTGGACATGGATGTACTGCCG
GCGCTGTCCGTTGTTTCCTGA

Upstream 100 bases:

>100_bases
AACCTAGGCTACATGGCCTGGATATTTATAATAACATTGCCCTATATAGGTGTCAAAGGGTTTAGCCCCTTGACATTGTC
TATGCTATAATCCTGCATAT

Downstream 100 bases:

>100_bases
TATCTAAAGCATTTCTTCGCCAAATAAAAAAGGAACTCGTTTCCGAGCTCCCTTTTACAAACTGTACAGTATTTGAGGCG
GCCTGTACAGTATTTCAAAG

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MKILGIESSCDETAAAVVADGVNILSNRVSSQIDIHSRYGGVVPEVASRQHLLSILPVISDALKEARTGFDEISAIAVTN
GPGLAGSLIVGVNAAKAIAAARGIPLVAVNHLHGHIYANWLSGRIPEFPCLCLTVSGGHTDLVLMKGHGQYQLLGRTRDD
AAGEAFDKAARILGLSYPGGPAIDRASQDGEAVLDLPRSWIPGSHDFSFSGLKTALLRLVENGEVCSVNDAAASFQKAVV
DVLVTKTLNCAHEYNVKQILLAGGVAANNLLRKQLSEQSPLPVSIPPIGLCTDNAAVIASCGYFRFISGGQDRLDMDVLP
ALSVVS

Sequences:

>Translated_326_residues
MKILGIESSCDETAAAVVADGVNILSNRVSSQIDIHSRYGGVVPEVASRQHLLSILPVISDALKEARTGFDEISAIAVTN
GPGLAGSLIVGVNAAKAIAAARGIPLVAVNHLHGHIYANWLSGRIPEFPCLCLTVSGGHTDLVLMKGHGQYQLLGRTRDD
AAGEAFDKAARILGLSYPGGPAIDRASQDGEAVLDLPRSWIPGSHDFSFSGLKTALLRLVENGEVCSVNDAAASFQKAVV
DVLVTKTLNCAHEYNVKQILLAGGVAANNLLRKQLSEQSPLPVSIPPIGLCTDNAAVIASCGYFRFISGGQDRLDMDVLP
ALSVVS
>Mature_326_residues
MKILGIESSCDETAAAVVADGVNILSNRVSSQIDIHSRYGGVVPEVASRQHLLSILPVISDALKEARTGFDEISAIAVTN
GPGLAGSLIVGVNAAKAIAAARGIPLVAVNHLHGHIYANWLSGRIPEFPCLCLTVSGGHTDLVLMKGHGQYQLLGRTRDD
AAGEAFDKAARILGLSYPGGPAIDRASQDGEAVLDLPRSWIPGSHDFSFSGLKTALLRLVENGEVCSVNDAAASFQKAVV
DVLVTKTLNCAHEYNVKQILLAGGVAANNLLRKQLSEQSPLPVSIPPIGLCTDNAAVIASCGYFRFISGGQDRLDMDVLP
ALSVVS

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=337, Percent_Identity=33.2344213649852, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI8923380, Length=317, Percent_Identity=29.6529968454259, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1789445, Length=328, Percent_Identity=44.5121951219512, Blast_Score=258, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17557464, Length=335, Percent_Identity=30.7462686567164, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71995670, Length=322, Percent_Identity=29.8136645962733, Blast_Score=104, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6320099, Length=368, Percent_Identity=30.7065217391304, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322891, Length=298, Percent_Identity=27.5167785234899, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20129063, Length=356, Percent_Identity=32.5842696629214, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21357207, Length=328, Percent_Identity=28.9634146341463, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_DEHE1 (Q3Z6L5)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_182134.1
- ProteinModelPortal:   Q3Z6L5
- SMR:   Q3Z6L5
- STRING:   Q3Z6L5
- MEROPS:   M22.001
- GeneID:   3229245
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET1426
- NMPDR:   fig|243164.3.peg.1394
- TIGR:   DET1426
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   Q3Z6L5
- ProtClustDB:   PRK09604
- BioCyc:   DETH243164:DET_1426-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 34119; Mature: 34119

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILGIESSCDETAAAVVADGVNILSNRVSSQIDIHSRYGGVVPEVASRQHLLSILPVIS
CEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEHHHCCCCCHHHHHHHHHHHHHHHHH
DALKEARTGFDEISAIAVTNGPGLAGSLIVGVNAAKAIAAARGIPLVAVNHLHGHIYANW
HHHHHHHCCHHHEEEEEEECCCCCCCEEEEECCHHHHHHHHCCCCEEEEECCCCEEEEEE
LSGRIPEFPCLCLTVSGGHTDLVLMKGHGQYQLLGRTRDDAAGEAFDKAARILGLSYPGG
CCCCCCCCCEEEEEECCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHEEECCCCC
PAIDRASQDGEAVLDLPRSWIPGSHDFSFSGLKTALLRLVENGEVCSVNDAAASFQKAVV
CCCCCCCCCCCHHHHCCHHCCCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
DVLVTKTLNCAHEYNVKQILLAGGVAANNLLRKQLSEQSPLPVSIPPIGLCTDNAAVIAS
HHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEEEC
CGYFRFISGGQDRLDMDVLPALSVVS
CCEEEEECCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKILGIESSCDETAAAVVADGVNILSNRVSSQIDIHSRYGGVVPEVASRQHLLSILPVIS
CEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEHHHCCCCCHHHHHHHHHHHHHHHHH
DALKEARTGFDEISAIAVTNGPGLAGSLIVGVNAAKAIAAARGIPLVAVNHLHGHIYANW
HHHHHHHCCHHHEEEEEEECCCCCCCEEEEECCHHHHHHHHCCCCEEEEECCCCEEEEEE
LSGRIPEFPCLCLTVSGGHTDLVLMKGHGQYQLLGRTRDDAAGEAFDKAARILGLSYPGG
CCCCCCCCCEEEEEECCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHEEECCCCC
PAIDRASQDGEAVLDLPRSWIPGSHDFSFSGLKTALLRLVENGEVCSVNDAAASFQKAVV
CCCCCCCCCCCHHHHCCHHCCCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
DVLVTKTLNCAHEYNVKQILLAGGVAANNLLRKQLSEQSPLPVSIPPIGLCTDNAAVIAS
HHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEEEC
CGYFRFISGGQDRLDMDVLPALSVVS
CCEEEEECCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA