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The map label for this gene is arsM [H]

Identifier: 57233796

GI number: 57233796

Start: 1290435

End: 1291277

Strand: Direct

Name: arsM [H]

Synonym: DET1420

Alternate gene names: 57233796

Gene position: 1290435-1291277 (Clockwise)

Preceding gene: 57233797

Following gene: 57233782

Centisome position: 87.8

GC content: 52.43

Gene sequence:

>843_bases
GTGACAGACATCAAAAAACTGGTTCGTGACGAATATGGACATATCGCCGAAAGAGCGGCTTCGCCAGCCAGCGGCTGCAG
CTGTTGCAGCTGCAATTCTGACATAGCCGCCGAATCCAGCCTTCAGGCAGGCTACACCGAAGAGGAAATAAACTCCGTTC
CCGAAGGGGCAAACCTGGGGCTGGGGTGCGGCAACCCTCTGGCACTGGCTGAAATAAAAGAGGGTGAGACCGTACTGGAC
CTGGGGTCAGGCGGCGGCTTTGACTGCTTTCTGGCAAGCCCGCGGGTAGGTGCAAAAGGCAAAGTAATAGGTGTTGACAT
GACACCCCAAATGCTGTCTATAGCCAAACGCAATGCTTTTCAGGGCGGCTATACCAATGTAGAGTTTATCCAGGGGGAGA
TTGAAAACCTGCCGCTGGAGTCAGACAGCATAGACCTTATCATCTCCAACTGCGTAATAAACCTGTCACCGGACAAGCCT
GCCGTTTTCAAGGAAGCCCTGCGGGTGCTCAAGCCGGGCGGGCGGATAGTTATATCTGATATTGTACTGGAAGGTGAACT
GCCGGACGAAGTCCGCAAATCTGCCGCTGCCTATATAAGCTGTATTGCCGGGGCAGAACAGTTTGACGATTATCTGGATA
TCATCAATGAGGCCGGCTTTGTTGACATAACATTACTTTCCAAAGAAACCTATGGCGCAGATAGCTGCTGTAACGACGAT
GAAGGTTGCGGATGCAGCTGCGGCTGTTCAGGCGAATCCTGCCAGAGCGGTGAAGATACTGAAACCAACGCACTGGACGG
CCTGATAAGCAGTCTCAGGTTAAGGGCTTACAAACCGCTTTAA

Upstream 100 bases:

>100_bases
CTGTCTGCTGCTTATCAAAGCAGACGAATTTTCAGAACTGGCAAACGAAATAGTCAGCCCTATTTTAAAAAATATGACAG
TGGCAGGAGGAAATTAGCCC

Downstream 100 bases:

>100_bases
TTTTGGAGTTTAAATTCCACCCGAAGCACCCGGCGGGTATTTTCATCTACCTTGGCAGACTGGCCGATACGGTAGCCCAC
CAGCCAGAGTATTTCTGCGC

Product: arsenite S-adenosylmethyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: gerC2 protein homolog [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTDIKKLVRDEYGHIAERAASPASGCSCCSCNSDIAAESSLQAGYTEEEINSVPEGANLGLGCGNPLALAEIKEGETVLD
LGSGGGFDCFLASPRVGAKGKVIGVDMTPQMLSIAKRNAFQGGYTNVEFIQGEIENLPLESDSIDLIISNCVINLSPDKP
AVFKEALRVLKPGGRIVISDIVLEGELPDEVRKSAAAYISCIAGAEQFDDYLDIINEAGFVDITLLSKETYGADSCCNDD
EGCGCSCGCSGESCQSGEDTETNALDGLISSLRLRAYKPL

Sequences:

>Translated_280_residues
MTDIKKLVRDEYGHIAERAASPASGCSCCSCNSDIAAESSLQAGYTEEEINSVPEGANLGLGCGNPLALAEIKEGETVLD
LGSGGGFDCFLASPRVGAKGKVIGVDMTPQMLSIAKRNAFQGGYTNVEFIQGEIENLPLESDSIDLIISNCVINLSPDKP
AVFKEALRVLKPGGRIVISDIVLEGELPDEVRKSAAAYISCIAGAEQFDDYLDIINEAGFVDITLLSKETYGADSCCNDD
EGCGCSCGCSGESCQSGEDTETNALDGLISSLRLRAYKPL
>Mature_279_residues
TDIKKLVRDEYGHIAERAASPASGCSCCSCNSDIAAESSLQAGYTEEEINSVPEGANLGLGCGNPLALAEIKEGETVLDL
GSGGGFDCFLASPRVGAKGKVIGVDMTPQMLSIAKRNAFQGGYTNVEFIQGEIENLPLESDSIDLIISNCVINLSPDKPA
VFKEALRVLKPGGRIVISDIVLEGELPDEVRKSAAAYISCIAGAEQFDDYLDIINEAGFVDITLLSKETYGADSCCNDDE
GCGCSCGCSGESCQSGEDTETNALDGLISSLRLRAYKPL

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI109389364, Length=230, Percent_Identity=36.0869565217391, Blast_Score=125, Evalue=3e-29,
Organism=Escherichia coli, GI48994983, Length=110, Percent_Identity=35.4545454545455, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 29430; Mature: 29299

Theoretical pI: Translated: 4.00; Mature: 4.00

Prosite motif: PS00022 EGF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIKKLVRDEYGHIAERAASPASGCSCCSCNSDIAAESSLQAGYTEEEINSVPEGANLG
CCHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCHHCCCCCHHHHHCCCCCCCCC
LGCGNPLALAEIKEGETVLDLGSGGGFDCFLASPRVGAKGKVIGVDMTPQMLSIAKRNAF
CCCCCCEEEEEECCCCEEEEECCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHCC
QGGYTNVEFIQGEIENLPLESDSIDLIISNCVINLSPDKPAVFKEALRVLKPGGRIVISD
CCCCCCHHEEECHHHCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEE
IVLEGELPDEVRKSAAAYISCIAGAEQFDDYLDIINEAGFVDITLLSKETYGADSCCNDD
EEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCC
EGCGCSCGCSGESCQSGEDTETNALDGLISSLRLRAYKPL
CCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDIKKLVRDEYGHIAERAASPASGCSCCSCNSDIAAESSLQAGYTEEEINSVPEGANLG
CHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCHHCCCCCHHHHHCCCCCCCCC
LGCGNPLALAEIKEGETVLDLGSGGGFDCFLASPRVGAKGKVIGVDMTPQMLSIAKRNAF
CCCCCCEEEEEECCCCEEEEECCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHCC
QGGYTNVEFIQGEIENLPLESDSIDLIISNCVINLSPDKPAVFKEALRVLKPGGRIVISD
CCCCCCHHEEECHHHCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEE
IVLEGELPDEVRKSAAAYISCIAGAEQFDDYLDIINEAGFVDITLLSKETYGADSCCNDD
EEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCC
EGCGCSCGCSGESCQSGEDTETNALDGLISSLRLRAYKPL
CCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8366036; 11337471 [H]