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The map label for this gene is pdxY [H]

Identifier: 38234286

GI number: 38234286

Start: 1751817

End: 1752677

Strand: Reverse

Name: pdxY [H]

Synonym: DIP1715

Alternate gene names: 38234286

Gene position: 1752677-1751817 (Counterclockwise)

Preceding gene: 38234287

Following gene: 38234285

Centisome position: 70.43

GC content: 54.7

Gene sequence:

>861_bases
ATGAACCCCATGAACATTTTGTCGATCCAGTCCCATGTTTCCTACGGCCACGTTGGTAACTCTGCCGCAGTGTTCCCATT
GCAACGCATTGGGCATGAAGTATGGCCGGTTCATACGGTGAACTTCTCTAACCACACCGGCTATGGGCAGTGGGGTGGCG
AGCTCATTCCTGCAGCGCAGGTGCGTAACGTGATCGACGGCATGGAACAGCGCGGCGCTTTCGAGCGTATCGACGCCATC
TTGTCCGGCTACCAAGGTGGTTCTGACATAGCTGATGTGATCGTCGACGCAGTTGCGCGGATCAAAGAGGCGAATCCTCA
AGCTGTGTATGCCTGCGATCCCGTCATGGGCAATGCCAAATCTGGCTGTTTTGTATCGGATCTCATCCCGCCATTGCTGC
GCGACAAGGTGGTCCCAGTGGCAGACATCATCACGCCTAACCAGTTTGAGCTGGAGTACTTGACCGGTGTGCCAGCGCAC
GATACTACCTCGACGCTTGAAGCTATCGCTGCTGCACAGGAAATGGGGCCCAATACCGTCCTCGTGACCTCGGTGCGTCG
CCCAGAAACTCCCGCTGATGCGATCGAGATGATCGCTGCTAATGAGCAGGGAGCATGGTTGGTGCGAACTCCGTTCATCG
ACTTTAAACGCAATGGTTCCGGTGATGTGACTGCTGCACTGTTTACGGGTCATTACATTCGCGAGCGCGACGCTGCAGAC
GCTCTCGCACGTACAGCATCGTCAGTATTCGATTTGATCGAAACTACCTTCACAGCGGATTCGCGCGAATTGCTTATTAT
CGAGTCCCAAGAAGCCATTGCACATCCTCGCCTTCAGTTTGAGGTTGAGCAGATCGCCTAA

Upstream 100 bases:

>100_bases
CAGCTTCAAGCCGAAGGCGGACGTGATAGGCGCGGTCGGATTCAGGTTCGATCTGTGCTCGTGTCTGTTTTGCCTGTCGA
ATCGCTTTCCGAACTATAGG

Downstream 100 bases:

>100_bases
CATTGGCATAGAATCACTTTTTAAGTTCTTTCACACAACATAAGGAGATAGGTGAGCTTCACCGACACACCCGAGGGATT
TCGCTCTGGTTTTATTAGCT

Product: pyridoxamine kinase

Products: NA

Alternate protein names: PM kinase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MNPMNILSIQSHVSYGHVGNSAAVFPLQRIGHEVWPVHTVNFSNHTGYGQWGGELIPAAQVRNVIDGMEQRGAFERIDAI
LSGYQGGSDIADVIVDAVARIKEANPQAVYACDPVMGNAKSGCFVSDLIPPLLRDKVVPVADIITPNQFELEYLTGVPAH
DTTSTLEAIAAAQEMGPNTVLVTSVRRPETPADAIEMIAANEQGAWLVRTPFIDFKRNGSGDVTAALFTGHYIRERDAAD
ALARTASSVFDLIETTFTADSRELLIIESQEAIAHPRLQFEVEQIA

Sequences:

>Translated_286_residues
MNPMNILSIQSHVSYGHVGNSAAVFPLQRIGHEVWPVHTVNFSNHTGYGQWGGELIPAAQVRNVIDGMEQRGAFERIDAI
LSGYQGGSDIADVIVDAVARIKEANPQAVYACDPVMGNAKSGCFVSDLIPPLLRDKVVPVADIITPNQFELEYLTGVPAH
DTTSTLEAIAAAQEMGPNTVLVTSVRRPETPADAIEMIAANEQGAWLVRTPFIDFKRNGSGDVTAALFTGHYIRERDAAD
ALARTASSVFDLIETTFTADSRELLIIESQEAIAHPRLQFEVEQIA
>Mature_286_residues
MNPMNILSIQSHVSYGHVGNSAAVFPLQRIGHEVWPVHTVNFSNHTGYGQWGGELIPAAQVRNVIDGMEQRGAFERIDAI
LSGYQGGSDIADVIVDAVARIKEANPQAVYACDPVMGNAKSGCFVSDLIPPLLRDKVVPVADIITPNQFELEYLTGVPAH
DTTSTLEAIAAAQEMGPNTVLVTSVRRPETPADAIEMIAANEQGAWLVRTPFIDFKRNGSGDVTAALFTGHYIRERDAAD
ALARTASSVFDLIETTFTADSRELLIIESQEAIAHPRLQFEVEQIA

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine [H]

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family [H]

Homologues:

Organism=Homo sapiens, GI4505701, Length=269, Percent_Identity=34.5724907063197, Blast_Score=164, Evalue=9e-41,
Organism=Escherichia coli, GI1787924, Length=287, Percent_Identity=37.9790940766551, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1788758, Length=265, Percent_Identity=29.0566037735849, Blast_Score=115, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17507759, Length=297, Percent_Identity=31.3131313131313, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17507757, Length=307, Percent_Identity=30.2931596091205, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320806, Length=228, Percent_Identity=34.2105263157895, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324354, Length=246, Percent_Identity=29.6747967479675, Blast_Score=102, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45553007, Length=295, Percent_Identity=30.8474576271186, Blast_Score=157, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004625 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.35 [H]

Molecular weight: Translated: 30978; Mature: 30978

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPMNILSIQSHVSYGHVGNSAAVFPLQRIGHEVWPVHTVNFSNHTGYGQWGGELIPAAQ
CCCCCEEEEHHHCCCCCCCCCCEEEEHHHCCCHHCCEEEEECCCCCCCCCCCCCCCCHHH
VRNVIDGMEQRGAFERIDAILSGYQGGSDIADVIVDAVARIKEANPQAVYACDPVMGNAK
HHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
SGCFVSDLIPPLLRDKVVPVADIITPNQFELEYLTGVPAHDTTSTLEAIAAAQEMGPNTV
CCCCHHHHHHHHHHCCCCCHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEE
LVTSVRRPETPADAIEMIAANEQGAWLVRTPFIDFKRNGSGDVTAALFTGHYIRERDAAD
EEEECCCCCCHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCEEEEEHHHHHHHHHHHHH
ALARTASSVFDLIETTFTADSRELLIIESQEAIAHPRLQFEVEQIA
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCEEEHHHCC
>Mature Secondary Structure
MNPMNILSIQSHVSYGHVGNSAAVFPLQRIGHEVWPVHTVNFSNHTGYGQWGGELIPAAQ
CCCCCEEEEHHHCCCCCCCCCCEEEEHHHCCCHHCCEEEEECCCCCCCCCCCCCCCCHHH
VRNVIDGMEQRGAFERIDAILSGYQGGSDIADVIVDAVARIKEANPQAVYACDPVMGNAK
HHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
SGCFVSDLIPPLLRDKVVPVADIITPNQFELEYLTGVPAHDTTSTLEAIAAAQEMGPNTV
CCCCHHHHHHHHHHCCCCCHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEE
LVTSVRRPETPADAIEMIAANEQGAWLVRTPFIDFKRNGSGDVTAALFTGHYIRERDAAD
EEEECCCCCCHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCEEEEEHHHHHHHHHHHHH
ALARTASSVFDLIETTFTADSRELLIIESQEAIAHPRLQFEVEQIA
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCEEEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910 [H]