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The map label for this gene is ppnK

Identifier: 38233771

GI number: 38233771

Start: 1178790

End: 1179743

Strand: Direct

Name: ppnK

Synonym: DIP1181

Alternate gene names: 38233771

Gene position: 1178790-1179743 (Clockwise)

Preceding gene: 38233770

Following gene: 38233772

Centisome position: 47.37

GC content: 48.74

Gene sequence:

>954_bases
ATGACTATCGATTGCCATGAAGATCGCAGAGTTTTACTAGTTCCGCATACCGGAAGACCGCAAAATGTTGCTTCAGCTGC
GCTAGCTGCCGAGCTTCTCGACGATTCAGGCGTCGGAGTTCGTGTTCTCGTTCCGGCCGAAGACACAACAGTTGCAACGC
ATCCAGTTTTGGGACAATTTGAACGAGTTTCTCATTCTCCTCAAGCGACTCAAAGTGTTGATCTAGTACTGGTATTAGGC
GGCGACGGTACATTTCTGCGTGCAGCTGATCTCGCCCATGGTGCTGATCTACCAGTGTTAGGTATCAACCTAGGACATGT
CGGTTTTTTGGCTGAATGGGAGAAAGATTCCTTAGACGAAGCTGTCCGTAGAGTTACAAAAGGAAGTTTCAGAATTGAAG
AACGTATGACTCTCGATGTCAGCGTTTACGATTCAAATGGTACTGCAATTGGTCGAGGGTGGGCTTTGAATGAAGTTAGT
ATCGAAAATAGCAACCGAAGTGGTGTTTTGGATGCAACATTAGAAATTGATAGTCGGCCTGTAAGTTCATTTGGGTGTGA
CGGCATCATAGTTTCAACACCTACGGGCTCGACCGCTTATGCTTTTTCCGCAGGTGGTCCCGTATTGTGGCCTGAACTAG
ACGCAATTTTGGTCGTACCGAACAACGCACATGCACTATTCACCAAGCCACTAGTAGTAAGCCCCCGGTCATCTGTGGCA
GTGGAATCGCATCCTAGCGCATTTCCTGCTACTGCTGTCATGGATGGATTCCGTTCGATTTCCGTCCCACCAGGTGCACG
AGTAGAAGTCAAGCGCGGTTCTCGGTCGATTAAGTGGGTACGGTTGGATGACATCCCGTTCACGGACAGACTTGTCACGA
AATTGCGACTGCCCGTAGAAGGGTGGAGGGGACCTAAGAACATGATTCCACAGATTAATCCCCATTCAGCGTAA

Upstream 100 bases:

>100_bases
AATATTTCCTCTGGCTAAAAAAGGATTCAGGTAGGTCTGCTAAGGGGTTACATGAGATTCATGAAAAAGTCGCGGAAGCA
GTCCAGAAAGGTCCGCAGTA

Downstream 100 bases:

>100_bases
CTTTCGCCAGTATTTAGTTGGCGATTGGTGAAAAATGCTGTGGCAGAAAATTTGATATTCGAACACAATAGAACACCTGT
TCCTTAATCGGATGATTTTG

Product: inorganic polyphosphate/ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MTIDCHEDRRVLLVPHTGRPQNVASAALAAELLDDSGVGVRVLVPAEDTTVATHPVLGQFERVSHSPQATQSVDLVLVLG
GDGTFLRAADLAHGADLPVLGINLGHVGFLAEWEKDSLDEAVRRVTKGSFRIEERMTLDVSVYDSNGTAIGRGWALNEVS
IENSNRSGVLDATLEIDSRPVSSFGCDGIIVSTPTGSTAYAFSAGGPVLWPELDAILVVPNNAHALFTKPLVVSPRSSVA
VESHPSAFPATAVMDGFRSISVPPGARVEVKRGSRSIKWVRLDDIPFTDRLVTKLRLPVEGWRGPKNMIPQINPHSA

Sequences:

>Translated_317_residues
MTIDCHEDRRVLLVPHTGRPQNVASAALAAELLDDSGVGVRVLVPAEDTTVATHPVLGQFERVSHSPQATQSVDLVLVLG
GDGTFLRAADLAHGADLPVLGINLGHVGFLAEWEKDSLDEAVRRVTKGSFRIEERMTLDVSVYDSNGTAIGRGWALNEVS
IENSNRSGVLDATLEIDSRPVSSFGCDGIIVSTPTGSTAYAFSAGGPVLWPELDAILVVPNNAHALFTKPLVVSPRSSVA
VESHPSAFPATAVMDGFRSISVPPGARVEVKRGSRSIKWVRLDDIPFTDRLVTKLRLPVEGWRGPKNMIPQINPHSA
>Mature_316_residues
TIDCHEDRRVLLVPHTGRPQNVASAALAAELLDDSGVGVRVLVPAEDTTVATHPVLGQFERVSHSPQATQSVDLVLVLGG
DGTFLRAADLAHGADLPVLGINLGHVGFLAEWEKDSLDEAVRRVTKGSFRIEERMTLDVSVYDSNGTAIGRGWALNEVSI
ENSNRSGVLDATLEIDSRPVSSFGCDGIIVSTPTGSTAYAFSAGGPVLWPELDAILVVPNNAHALFTKPLVVSPRSSVAV
ESHPSAFPATAVMDGFRSISVPPGARVEVKRGSRSIKWVRLDDIPFTDRLVTKLRLPVEGWRGPKNMIPQINPHSA

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=189, Percent_Identity=31.7460317460317, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788968, Length=232, Percent_Identity=32.7586206896552, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322509, Length=207, Percent_Identity=30.9178743961353, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320794, Length=174, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6325068, Length=172, Percent_Identity=29.6511627906977, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI28573832, Length=181, Percent_Identity=34.2541436464088, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161077047, Length=181, Percent_Identity=34.2541436464088, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573830, Length=181, Percent_Identity=34.2541436464088, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573828, Length=181, Percent_Identity=34.2541436464088, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573826, Length=181, Percent_Identity=34.2541436464088, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK_CORDI (Q6NHF7)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939538.1
- ProteinModelPortal:   Q6NHF7
- SMR:   Q6NHF7
- GeneID:   2649736
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1181
- NMPDR:   fig|257309.1.peg.1129
- HOGENOM:   HBG713904
- OMA:   FLERIRN
- PhylomeDB:   Q6NHF7
- ProtClustDB:   PRK03372
- BioCyc:   CDIP257309:DIP1181-MONOMER
- BRENDA:   2.7.1.23
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 33897; Mature: 33766

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDCHEDRRVLLVPHTGRPQNVASAALAAELLDDSGVGVRVLVPAEDTTVATHPVLGQF
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCHHHH
ERVSHSPQATQSVDLVLVLGGDGTFLRAADLAHGADLPVLGINLGHVGFLAEWEKDSLDE
HHHCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCEEEEECCCEEEEEECCCCCHHH
AVRRVTKGSFRIEERMTLDVSVYDSNGTAIGRGWALNEVSIENSNRSGVLDATLEIDSRP
HHHHHHCCCEEEEEEEEEEEEEECCCCCEEECCEEEEEEEEECCCCCCEEEEEEEECCCC
VSSFGCDGIIVSTPTGSTAYAFSAGGPVLWPELDAILVVPNNAHALFTKPLVVSPRSSVA
CCCCCCCEEEEECCCCCEEEEEECCCCEECCCCCEEEEECCCCCEEEECCEEECCCCCEE
VESHPSAFPATAVMDGFRSISVPPGARVEVKRGSRSIKWVRLDDIPFTDRLVTKLRLPVE
ECCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEECCCCCHHHHHHHEECCHH
GWRGPKNMIPQINPHSA
CCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
TIDCHEDRRVLLVPHTGRPQNVASAALAAELLDDSGVGVRVLVPAEDTTVATHPVLGQF
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCHHHH
ERVSHSPQATQSVDLVLVLGGDGTFLRAADLAHGADLPVLGINLGHVGFLAEWEKDSLDE
HHHCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCEEEEECCCEEEEEECCCCCHHH
AVRRVTKGSFRIEERMTLDVSVYDSNGTAIGRGWALNEVSIENSNRSGVLDATLEIDSRP
HHHHHHCCCEEEEEEEEEEEEEECCCCCEEECCEEEEEEEEECCCCCCEEEEEEEECCCC
VSSFGCDGIIVSTPTGSTAYAFSAGGPVLWPELDAILVVPNNAHALFTKPLVVSPRSSVA
CCCCCCCEEEEECCCCCEEEEEECCCCEECCCCCEEEEECCCCCEEEECCEEECCCCCEE
VESHPSAFPATAVMDGFRSISVPPGARVEVKRGSRSIKWVRLDDIPFTDRLVTKLRLPVE
ECCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEECCCCCHHHHHHHEECCHH
GWRGPKNMIPQINPHSA
CCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910