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The map label for this gene is argB

Identifier: 38233759

GI number: 38233759

Start: 1161595

End: 1162527

Strand: Direct

Name: argB

Synonym: DIP1169

Alternate gene names: 38233759

Gene position: 1161595-1162527 (Clockwise)

Preceding gene: 38233758

Following gene: 38233760

Centisome position: 46.68

GC content: 50.48

Gene sequence:

>933_bases
ATGACAGCCACTATCGATAATTTGACCTCCCGAGAGCGTGCAACCGTACTGGCCGATGCATTGCCATGGTTGCAGCGTTA
TCGCGACAAAATTGTCGTCGTTAAATATGGTGGCAATGCCATGGTCGACGAAGAACTCAAAGCTGCTTTCGCGGCAGATA
TGGTTTTTCTTCGCACAGTAGGCGTTCGTCCGGTTGTTGTGCACGGTGGTGGCCCTCAAATTTCACAAATGCTGCAACGC
CTCGGCATCGAGGGTGAGTTTAAAGGGGGATTCCGCGTTACCTCGCCGGAGGTGCTTGAAATCGTTCGGATGGTTCTCTT
TGGTCAAGTAGGTCGTGACCTAGTTGGACTGATTAACTCACACGGCCCTTATGCAGTGGGTACCTCTGGCGAGGATGCTG
GCCTTTTCAGAGCCGAGAAACGACTTGTCGAAATCGATGGAGAGCTAACCGATATTGGCCAAGTTGGCAATATTACTGCA
GTCAACGCTTCAAGCTTGATGGGCATCATTGATGCTGGTCGAATTCCGGTAGTCTCGACCATCGCTCCAGGCGATGATGG
ATCGGTATATAACATCAACGCTGATACGGCTGCAGGGGCGTTGGCTGCTGCGTTGTCTGCCGAACGCCTATTGATTCTCA
CTAATGTTGAGGGTCTTTATACCGACTGGCCGAATAAAGACTCGCTGGTATCCGTGATTGGTGCTGAGAGGTTGCGTGAA
AAGCTTTCAGCGTTGGGTTCGGGAATGATTCCTAAAATGGAAAGCTGTGTAGATGCGGTCATCCATGGTGTTTCGGCAGC
TCACGTAATTGATGGACGAGTCGCGCATTCAGTGCTTCTTGAGTTACTGACTTCGGGCGGTGTTGGGACCATGGTTGTTC
CCGATACAGAAATGACAAATGGGACAGTGTACCGAAAGGATAATCATGTCTAA

Upstream 100 bases:

>100_bases
TTTTGTTCGAACGACCGATTTATCACATCAATACGTTGAAATTAACTCAGCGTATTCCTCGTAACTCAAACATTTCAGAC
AAGAAAGCCGGTGTGGGGCT

Downstream 100 bases:

>100_bases
GAATGCGGCGAACACAGATTCACAATCGTCAGAGACTCAATGGGCTGATGTCATTATGAATACCTACGGCACGCCTCCTC
TGACGATCACAGGAGGAAAT

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTATIDNLTSRERATVLADALPWLQRYRDKIVVVKYGGNAMVDEELKAAFAADMVFLRTVGVRPVVVHGGGPQISQMLQR
LGIEGEFKGGFRVTSPEVLEIVRMVLFGQVGRDLVGLINSHGPYAVGTSGEDAGLFRAEKRLVEIDGELTDIGQVGNITA
VNASSLMGIIDAGRIPVVSTIAPGDDGSVYNINADTAAGALAAALSAERLLILTNVEGLYTDWPNKDSLVSVIGAERLRE
KLSALGSGMIPKMESCVDAVIHGVSAAHVIDGRVAHSVLLELLTSGGVGTMVVPDTEMTNGTVYRKDNHV

Sequences:

>Translated_310_residues
MTATIDNLTSRERATVLADALPWLQRYRDKIVVVKYGGNAMVDEELKAAFAADMVFLRTVGVRPVVVHGGGPQISQMLQR
LGIEGEFKGGFRVTSPEVLEIVRMVLFGQVGRDLVGLINSHGPYAVGTSGEDAGLFRAEKRLVEIDGELTDIGQVGNITA
VNASSLMGIIDAGRIPVVSTIAPGDDGSVYNINADTAAGALAAALSAERLLILTNVEGLYTDWPNKDSLVSVIGAERLRE
KLSALGSGMIPKMESCVDAVIHGVSAAHVIDGRVAHSVLLELLTSGGVGTMVVPDTEMTNGTVYRKDNHV
>Mature_309_residues
TATIDNLTSRERATVLADALPWLQRYRDKIVVVKYGGNAMVDEELKAAFAADMVFLRTVGVRPVVVHGGGPQISQMLQRL
GIEGEFKGGFRVTSPEVLEIVRMVLFGQVGRDLVGLINSHGPYAVGTSGEDAGLFRAEKRLVEIDGELTDIGQVGNITAV
NASSLMGIIDAGRIPVVSTIAPGDDGSVYNINADTAAGALAAALSAERLLILTNVEGLYTDWPNKDSLVSVIGAERLREK
LSALGSGMIPKMESCVDAVIHGVSAAHVIDGRVAHSVLLELLTSGGVGTMVVPDTEMTNGTVYRKDNHV

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family

Homologues:

Organism=Escherichia coli, GI1789181, Length=301, Percent_Identity=24.9169435215947, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI145693208, Length=234, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320913, Length=271, Percent_Identity=26.9372693726937, Blast_Score=83, Evalue=6e-17,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ARGB_CORDI (Q6NHG8)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939526.1
- ProteinModelPortal:   Q6NHG8
- SMR:   Q6NHG8
- GeneID:   2648569
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1169
- NMPDR:   fig|257309.1.peg.1117
- HOGENOM:   HBG497643
- OMA:   DGEYEIN
- ProtClustDB:   PRK00942
- BioCyc:   CDIP257309:DIP1169-MONOMER
- BRENDA:   2.7.2.8
- GO:   GO:0005737
- HAMAP:   MF_00082_B
- InterPro:   IPR004662
- InterPro:   IPR001048
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF000728
- TIGRFAMs:   TIGR00761

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.8

Molecular weight: Translated: 32790; Mature: 32659

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: BINDING 92-92 BINDING 191-191

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATIDNLTSRERATVLADALPWLQRYRDKIVVVKYGGNAMVDEELKAAFAADMVFLRTV
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHC
GVRPVVVHGGGPQISQMLQRLGIEGEFKGGFRVTSPEVLEIVRMVLFGQVGRDLVGLINS
CCCEEEEECCCHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
HGPYAVGTSGEDAGLFRAEKRLVEIDGELTDIGQVGNITAVNASSLMGIIDAGRIPVVST
CCCEEECCCCCCCHHHHHHHHHEEECCCEECCCCCCCEEEECHHHHHHHHCCCCCCEEEE
IAPGDDGSVYNINADTAAGALAAALSAERLLILTNVEGLYTDWPNKDSLVSVIGAERLRE
ECCCCCCCEEEECCCHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHHH
KLSALGSGMIPKMESCVDAVIHGVSAAHVIDGRVAHSVLLELLTSGGVGTMVVPDTEMTN
HHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
GTVYRKDNHV
CEEEECCCCC
>Mature Secondary Structure 
TATIDNLTSRERATVLADALPWLQRYRDKIVVVKYGGNAMVDEELKAAFAADMVFLRTV
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHC
GVRPVVVHGGGPQISQMLQRLGIEGEFKGGFRVTSPEVLEIVRMVLFGQVGRDLVGLINS
CCCEEEEECCCHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
HGPYAVGTSGEDAGLFRAEKRLVEIDGELTDIGQVGNITAVNASSLMGIIDAGRIPVVST
CCCEEECCCCCCCHHHHHHHHHEEECCCEECCCCCCCEEEECHHHHHHHHCCCCCCEEEE
IAPGDDGSVYNINADTAAGALAAALSAERLLILTNVEGLYTDWPNKDSLVSVIGAERLRE
ECCCCCCCEEEECCCHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHHH
KLSALGSGMIPKMESCVDAVIHGVSAAHVIDGRVAHSVLLELLTSGGVGTMVVPDTEMTN
HHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
GTVYRKDNHV
CEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910