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The map label for this gene is fklB [C]

Identifier: 38233385

GI number: 38233385

Start: 767015

End: 767374

Strand: Direct

Name: fklB [C]

Synonym: DIP0786

Alternate gene names: 38233385

Gene position: 767015-767374 (Clockwise)

Preceding gene: 161598677

Following gene: 38233387

Centisome position: 30.82

GC content: 59.72

Gene sequence:

>360_bases
ATGGAAAAGCCCCAGATCCAGGTTCCCGAAGGACCAGCCCCAGAAGACATCGTTATCGTCGACCTCATTGAGGGCGATGG
CGCAGAAGCACAGCCAGGTGGCCTTGTAGAGGTTCACTACGTAGGCGTCGACTTTGAAAACGGCCAAGAGTTCGACTCCT
CTTGGGACCGCGGCCAAAGCATCGAGTTCCCATTGTCTGGCCTCATCGCTGGCTGGCAAGAAGGCATCCCAGGCATGAAG
GTTGGCGGACGCCGCCAGCTCACCATTCCACCAGAGGCAGCCTACGGTCCTGCCGGTGGCGGACACCCACTGTCCGGTCG
CACCCTCGTGTTCGTGATTGACCTTCTCAACGTCGGCTAG

Upstream 100 bases:

>100_bases
TTTCGCTGTGTTGATACACCTCCTCGGCGGCGATCCGCAGCCGAGTTCACACATTAATATTCCGAGCAATTTGTACATCG
ATCCAAGGAGTTAGAGATCC

Downstream 100 bases:

>100_bases
TCGCACACAACAATAAGAAGCAACAATAACGCCCGTAGACAAATTCGCGATCTACGGGCGTTATGCATCAAATCACCGTC
ACATCGTTAGATCAATGTGT

Product: putative FK506-binding protein

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 119; Mature: 119

Protein sequence:

>119_residues
MEKPQIQVPEGPAPEDIVIVDLIEGDGAEAQPGGLVEVHYVGVDFENGQEFDSSWDRGQSIEFPLSGLIAGWQEGIPGMK
VGGRRQLTIPPEAAYGPAGGGHPLSGRTLVFVIDLLNVG

Sequences:

>Translated_119_residues
MEKPQIQVPEGPAPEDIVIVDLIEGDGAEAQPGGLVEVHYVGVDFENGQEFDSSWDRGQSIEFPLSGLIAGWQEGIPGMK
VGGRRQLTIPPEAAYGPAGGGHPLSGRTLVFVIDLLNVG
>Mature_119_residues
MEKPQIQVPEGPAPEDIVIVDLIEGDGAEAQPGGLVEVHYVGVDFENGQEFDSSWDRGQSIEFPLSGLIAGWQEGIPGMK
VGGRRQLTIPPEAAYGPAGGGHPLSGRTLVFVIDLLNVG

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=100, Percent_Identity=43, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI4503725, Length=100, Percent_Identity=43, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082390, Length=98, Percent_Identity=44.8979591836735, Blast_Score=69, Evalue=6e-14,
Organism=Escherichia coli, GI1789745, Length=96, Percent_Identity=45.8333333333333, Blast_Score=64, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71993519, Length=101, Percent_Identity=39.6039603960396, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=94, Percent_Identity=45.7446808510638, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324194, Length=106, Percent_Identity=46.2264150943396, Blast_Score=69, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24647110, Length=125, Percent_Identity=41.6, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI281363946, Length=94, Percent_Identity=39.3617021276596, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17352457, Length=94, Percent_Identity=39.3617021276596, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21356629, Length=76, Percent_Identity=46.0526315789474, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 12546; Mature: 12546

Theoretical pI: Translated: 3.95; Mature: 3.95

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKPQIQVPEGPAPEDIVIVDLIEGDGAEAQPGGLVEVHYVGVDFENGQEFDSSWDRGQS
CCCCCEECCCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCE
IEFPLSGLIAGWQEGIPGMKVGGRRQLTIPPEAAYGPAGGGHPLSGRTLVFVIDLLNVG
EECCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCC
>Mature Secondary Structure
MEKPQIQVPEGPAPEDIVIVDLIEGDGAEAQPGGLVEVHYVGVDFENGQEFDSSWDRGQS
CCCCCEECCCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCE
IEFPLSGLIAGWQEGIPGMKVGGRRQLTIPPEAAYGPAGGGHPLSGRTLVFVIDLLNVG
EECCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7522844; 12948626 [H]