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The map label for this gene is gltA [H]

Identifier: 161598677

GI number: 161598677

Start: 765550

End: 766848

Strand: Direct

Name: gltA [H]

Synonym: DIP0785

Alternate gene names: 161598677

Gene position: 765550-766848 (Clockwise)

Preceding gene: 38233380

Following gene: 38233385

Centisome position: 30.76

GC content: 54.81

Gene sequence:

>1299_bases
ATGCTTGTGGCTACTGAAAACAAGGATAAGGCGGTTCTTCACTACCCTGGTGGCGAGTATGAGATGGATATCATCCATGC
AACCGAGGGCAACGATGGTGTTGTACTGGATAAATTGCTGTCCCAAACCGGCATGGTCACTTTTGACCCCGGCTATGTAA
GCACCGGTTCCACTGAATCGAAGATCACCTACATTGACGGCGACAACGGCATCCTGCGCCACCGCGGCTATGACATCGCG
GATCTAGCGGAAAACGCAACCTTCAACGAAGTCTCCTACCTTCTGATCAAAGGCCACCTGCCAACCGTTGATGAACTCCA
CAAGTTCAACAACGAAATCCGTCACCACACCCTGCTGGACGAGGACTTTAAGAGCCAGTTCAACATCTTCCCACGTGACG
CACACCCAATGTCCGTGCTGGCTTCCTCCGTGAACATCTTGTCCACCTACTACCAAGATCAGCTCAACCCACTCGATGAG
GAGCAGCTAGACAAGGCAACCGTTCGCCTGCTGGCTAAGGTCCCAATGCTCGCGGCTTACGCATACCGCGCATCCAAGGG
CGCACCATACATGTACCCAGACAACTCCTTGAATGCTCGTGAGAACTTCCTGCGCATGATGTTCGGTTACCCAACCGAGC
CATACGAGGTTGACCCAGTAGTAGCAAAGGCACTGGATAAGCTGCTCATTCTGCACGCAGACCACGAGCAAAACTGCTCA
ACCTCCACCGTCCGCATGATCGGTTCCGCGCAGGCTAACATGTTTGTTGCTGTTGCTGGTGGCATCAACGCCCTTTCCGG
CCCACTGCACGGTGGCGCAAACCAGGCCGTTTTGGAAATGCTCGAAGAGATCAAGGCCAACGGCGGCGACGCTACCGACT
TTATGAACCGCGTGAAGAACAAGGAAAAAGGCGTTCGCCTGATGGGCTTCGGCCACCGCGTGTACAAGAACTACGACCCA
CGTGCAGCCATCGTGAAGGAAACCGCACACGAGATCCTCGAACACCTCGGTGGTGACGAACTTTTGGATCTTGCCATGAA
GCTCGAAGAGATCGCACTGAGCGACGACTACTTCGTATCGCGCAAGCTATACCCGAACGTCGACTTCTACACCGGCTTGA
TCTACCGCGCAATGGGATTCCCCACGGACTTCTTCACCGTCCTCTTTGCCATCGGTCGTCTGCCAGGCTGGATCGCTCAG
TACCGCGAGCAGTTGGCAACCACCACCAAGATCAACCGCCCACGTCAGATTTACACCGGAGAAACCTTGCGAAAGGTCAC
TCCACGCGAGCAGCGCTAA

Upstream 100 bases:

>100_bases
CTAACCTAAGGCAGAAGGCGAGTAACACTGCAGTCTTGGATCTCAACAGTGCACTTTCACACAACAGTGCAAAAGTGCAC
GGAAAAACAAATTGAAAGGG

Downstream 100 bases:

>100_bases
GTTGATGACCTGCTAATTTCGACCGAGCGAGTGGATTTTCAGTACACTGTTATCCACGCGCTCGGTTTTCGCTGTGTTGA
TACACCTCCTCGGCGGCGAT

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MLVATENKDKAVLHYPGGEYEMDIIHATEGNDGVVLDKLLSQTGMVTFDPGYVSTGSTESKITYIDGDNGILRHRGYDIA
DLAENATFNEVSYLLIKGHLPTVDELHKFNNEIRHHTLLDEDFKSQFNIFPRDAHPMSVLASSVNILSTYYQDQLNPLDE
EQLDKATVRLLAKVPMLAAYAYRASKGAPYMYPDNSLNARENFLRMMFGYPTEPYEVDPVVAKALDKLLILHADHEQNCS
TSTVRMIGSAQANMFVAVAGGINALSGPLHGGANQAVLEMLEEIKANGGDATDFMNRVKNKEKGVRLMGFGHRVYKNYDP
RAAIVKETAHEILEHLGGDELLDLAMKLEEIALSDDYFVSRKLYPNVDFYTGLIYRAMGFPTDFFTVLFAIGRLPGWIAQ
YREQLATTTKINRPRQIYTGETLRKVTPREQR

Sequences:

>Translated_432_residues
MLVATENKDKAVLHYPGGEYEMDIIHATEGNDGVVLDKLLSQTGMVTFDPGYVSTGSTESKITYIDGDNGILRHRGYDIA
DLAENATFNEVSYLLIKGHLPTVDELHKFNNEIRHHTLLDEDFKSQFNIFPRDAHPMSVLASSVNILSTYYQDQLNPLDE
EQLDKATVRLLAKVPMLAAYAYRASKGAPYMYPDNSLNARENFLRMMFGYPTEPYEVDPVVAKALDKLLILHADHEQNCS
TSTVRMIGSAQANMFVAVAGGINALSGPLHGGANQAVLEMLEEIKANGGDATDFMNRVKNKEKGVRLMGFGHRVYKNYDP
RAAIVKETAHEILEHLGGDELLDLAMKLEEIALSDDYFVSRKLYPNVDFYTGLIYRAMGFPTDFFTVLFAIGRLPGWIAQ
YREQLATTTKINRPRQIYTGETLRKVTPREQR
>Mature_432_residues
MLVATENKDKAVLHYPGGEYEMDIIHATEGNDGVVLDKLLSQTGMVTFDPGYVSTGSTESKITYIDGDNGILRHRGYDIA
DLAENATFNEVSYLLIKGHLPTVDELHKFNNEIRHHTLLDEDFKSQFNIFPRDAHPMSVLASSVNILSTYYQDQLNPLDE
EQLDKATVRLLAKVPMLAAYAYRASKGAPYMYPDNSLNARENFLRMMFGYPTEPYEVDPVVAKALDKLLILHADHEQNCS
TSTVRMIGSAQANMFVAVAGGINALSGPLHGGANQAVLEMLEEIKANGGDATDFMNRVKNKEKGVRLMGFGHRVYKNYDP
RAAIVKETAHEILEHLGGDELLDLAMKLEEIALSDDYFVSRKLYPNVDFYTGLIYRAMGFPTDFFTVLFAIGRLPGWIAQ
YREQLATTTKINRPRQIYTGETLRKVTPREQR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=384, Percent_Identity=29.1666666666667, Blast_Score=135, Evalue=5e-32,
Organism=Escherichia coli, GI1786939, Length=417, Percent_Identity=49.8800959232614, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI1786527, Length=365, Percent_Identity=33.972602739726, Blast_Score=191, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17555174, Length=392, Percent_Identity=26.7857142857143, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319850, Length=426, Percent_Identity=28.169014084507, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324328, Length=382, Percent_Identity=27.7486910994764, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6325257, Length=355, Percent_Identity=27.3239436619718, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24640126, Length=389, Percent_Identity=29.305912596401, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24640124, Length=389, Percent_Identity=29.305912596401, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21356863, Length=400, Percent_Identity=26.5, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48486; Mature: 48486

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVATENKDKAVLHYPGGEYEMDIIHATEGNDGVVLDKLLSQTGMVTFDPGYVSTGSTES
CEEECCCCCCEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCC
KITYIDGDNGILRHRGYDIADLAENATFNEVSYLLIKGHLPTVDELHKFNNEIRHHTLLD
EEEEEECCCCEEECCCCCHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCC
EDFKSQFNIFPRDAHPMSVLASSVNILSTYYQDQLNPLDEEQLDKATVRLLAKVPMLAAY
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AYRASKGAPYMYPDNSLNARENFLRMMFGYPTEPYEVDPVVAKALDKLLILHADHEQNCS
HHHHCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCCCCCCC
TSTVRMIGSAQANMFVAVAGGINALSGPLHGGANQAVLEMLEEIKANGGDATDFMNRVKN
HHHHHHHHCCCCCEEEEEECCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
KEKGVRLMGFGHRVYKNYDPRAAIVKETAHEILEHLGGDELLDLAMKLEEIALSDDYFVS
HHCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEE
RKLYPNVDFYTGLIYRAMGFPTDFFTVLFAIGRLPGWIAQYREQLATTTKINRPRQIYTG
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEECC
ETLRKVTPREQR
CHHHHCCCCCCC
>Mature Secondary Structure
MLVATENKDKAVLHYPGGEYEMDIIHATEGNDGVVLDKLLSQTGMVTFDPGYVSTGSTES
CEEECCCCCCEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCC
KITYIDGDNGILRHRGYDIADLAENATFNEVSYLLIKGHLPTVDELHKFNNEIRHHTLLD
EEEEEECCCCEEECCCCCHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCC
EDFKSQFNIFPRDAHPMSVLASSVNILSTYYQDQLNPLDEEQLDKATVRLLAKVPMLAAY
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AYRASKGAPYMYPDNSLNARENFLRMMFGYPTEPYEVDPVVAKALDKLLILHADHEQNCS
HHHHCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCCCCCCC
TSTVRMIGSAQANMFVAVAGGINALSGPLHGGANQAVLEMLEEIKANGGDATDFMNRVKN
HHHHHHHHCCCCCEEEEEECCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
KEKGVRLMGFGHRVYKNYDPRAAIVKETAHEILEHLGGDELLDLAMKLEEIALSDDYFVS
HHCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEE
RKLYPNVDFYTGLIYRAMGFPTDFFTVLFAIGRLPGWIAQYREQLATTTKINRPRQIYTG
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEECC
ETLRKVTPREQR
CHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7522844; 12948626 [H]