BacMap

Definition	Corynebacterium diphtheriae NCTC 13129 chromosome, complete genome.
Accession	NC_002935
Length	2,488,635

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The map label for this gene is yqhE [C]

Identifier: 38233387

GI number: 38233387

Start: 769059

End: 769931

Strand: Direct

Name: yqhE [C]

Synonym: DIP0788

Alternate gene names: 38233387

Gene position: 769059-769931 (Clockwise)

Preceding gene: 38233385

Following gene: 38233388

Centisome position: 30.9

GC content: 54.41

Gene sequence:

>873_bases
ATGGTGACCATGAAACAACACGAGAACATCATTCCCACCATCACGCTCAATGATGGTACGGAAATGCCCGCGATTGGTTT
TGGTACATATAAGTTGCGTGAACAAGATGCCTATAGGGCAGTGCGTAGCGCCATCGAGGTGGGGTATCGCCATATTGATA
CTGCTTCTTTGTATAAGAACGAAGAGGAGGTAGGCCGTGCGGTGGCTGACGCGATCACTGCAGGCGAGGTAGCTCGTGAC
GAGCTTTTTATCACCACCAAGGTGTGGAATGACATGCACGGGGACCAGCTCACGCAGCGCTCGTTCCAAGAATCCCTCCA
CCGGCTTGGCCTAGATTACATCGATTGCTGCATGGTGCATTGGCCGTGGCCGCAAAAGGGGCTCTACGTAGAATCCTTTG
CAGCATTGGCAAAGATTCAGGGGTTGGGGCAGCTGCAGTCGGTTGCGGTAGCTAATTTCTATCCTGAAGTTCTGCGCGAG
ATCGTCGCGGAGACTGGTATTGCGCCTGTGTTGAATCAGGTGGAATTGCATCCTGGTTTTTCTCAAGCCGAGCAGCGCGC
CGTGGACCGTGAATTGGGAGTGGTTACGGAGGCATGGTCGCCTTTGGGGCGGGGTGATTCGCTGAACGCGGAGGCTATTA
CGTTGATCGCGCAGTGTTATGAGAAAACGCCGGCGCAGGTGACGTTGCGGTGGATTCATCAGTTGGGTTGCTCTGTGGTG
CCTAAATCGGCGAACCCTCAGCGGCAGCGTGAGAACCTCGACATTTTCGATTTTGAGCTCAACACGGAGGACATGAACAG
CATTACATCGCTCGACGAGCAAGGTGGTCGGCTGTTTGTTGATCCGCACGACTTCCCAGGCGAGGTGGAGTAG

Upstream 100 bases:

>100_bases
CGGGTCATGGCACCACCCTATAAAGAACACGAGTGGTTGGTGCAGAAATTGTGCAAAAATTTGCCAATAGGGGGTGCATA
GGGTGGATTATCGGTGTTGA

Downstream 100 bases:

>100_bases
TGGCGCAGGTAGAGGTGCGTATCGACGGCCACCTGATGTGTGTCACCGTAAATAGACACGAGGCTCGCAACGCACTTTCT
GCACAGATGTGCGATGATAT

Product: putative oxidoreductase

Products: 2-keto-L-gulonate; NADP [C]

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MVTMKQHENIIPTITLNDGTEMPAIGFGTYKLREQDAYRAVRSAIEVGYRHIDTASLYKNEEEVGRAVADAITAGEVARD
ELFITTKVWNDMHGDQLTQRSFQESLHRLGLDYIDCCMVHWPWPQKGLYVESFAALAKIQGLGQLQSVAVANFYPEVLRE
IVAETGIAPVLNQVELHPGFSQAEQRAVDRELGVVTEAWSPLGRGDSLNAEAITLIAQCYEKTPAQVTLRWIHQLGCSVV
PKSANPQRQRENLDIFDFELNTEDMNSITSLDEQGGRLFVDPHDFPGEVE

Sequences:

>Translated_290_residues
MVTMKQHENIIPTITLNDGTEMPAIGFGTYKLREQDAYRAVRSAIEVGYRHIDTASLYKNEEEVGRAVADAITAGEVARD
ELFITTKVWNDMHGDQLTQRSFQESLHRLGLDYIDCCMVHWPWPQKGLYVESFAALAKIQGLGQLQSVAVANFYPEVLRE
IVAETGIAPVLNQVELHPGFSQAEQRAVDRELGVVTEAWSPLGRGDSLNAEAITLIAQCYEKTPAQVTLRWIHQLGCSVV
PKSANPQRQRENLDIFDFELNTEDMNSITSLDEQGGRLFVDPHDFPGEVE
>Mature_290_residues
MVTMKQHENIIPTITLNDGTEMPAIGFGTYKLREQDAYRAVRSAIEVGYRHIDTASLYKNEEEVGRAVADAITAGEVARD
ELFITTKVWNDMHGDQLTQRSFQESLHRLGLDYIDCCMVHWPWPQKGLYVESFAALAKIQGLGQLQSVAVANFYPEVLRE
IVAETGIAPVLNQVELHPGFSQAEQRAVDRELGVVTEAWSPLGRGDSLNAEAITLIAQCYEKTPAQVTLRWIHQLGCSVV
PKSANPQRQRENLDIFDFELNTEDMNSITSLDEQGGRLFVDPHDFPGEVE

Specific function: Reduction [C]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI310109922, Length=294, Percent_Identity=35.0340136054422, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI310109920, Length=312, Percent_Identity=33.6538461538462, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI45446745, Length=312, Percent_Identity=33.3333333333333, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI4503285, Length=312, Percent_Identity=33.3333333333333, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI5453543, Length=312, Percent_Identity=33.6538461538462, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI24497577, Length=289, Percent_Identity=32.1799307958478, Blast_Score=168, Evalue=4e-42,
Organism=Homo sapiens, GI5174391, Length=289, Percent_Identity=32.1799307958478, Blast_Score=168, Evalue=4e-42,
Organism=Homo sapiens, GI24497583, Length=294, Percent_Identity=33.6734693877551, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI223468663, Length=289, Percent_Identity=32.5259515570934, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI24497585, Length=302, Percent_Identity=33.7748344370861, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI5174695, Length=296, Percent_Identity=33.7837837837838, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4502049, Length=289, Percent_Identity=34.2560553633218, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI93277124, Length=318, Percent_Identity=29.874213836478, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI291291012, Length=285, Percent_Identity=31.9298245614035, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=32.8519855595668, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI300116271, Length=278, Percent_Identity=31.294964028777, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI310109926, Length=112, Percent_Identity=43.75, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI207028673, Length=112, Percent_Identity=42.8571428571429, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI310109924, Length=168, Percent_Identity=30.952380952381, Blast_Score=81, Evalue=9e-16,
Organism=Escherichia coli, GI87082198, Length=279, Percent_Identity=42.6523297491039, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1786400, Length=254, Percent_Identity=35.4330708661417, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1788081, Length=272, Percent_Identity=27.2058823529412, Blast_Score=84, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17537077, Length=293, Percent_Identity=34.8122866894198, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17537075, Length=302, Percent_Identity=35.0993377483444, Blast_Score=184, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71998625, Length=275, Percent_Identity=37.0909090909091, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17564128, Length=304, Percent_Identity=32.5657894736842, Blast_Score=172, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17566692, Length=285, Percent_Identity=31.2280701754386, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17537079, Length=297, Percent_Identity=31.986531986532, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17538386, Length=270, Percent_Identity=31.4814814814815, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17550248, Length=296, Percent_Identity=31.7567567567568, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17561298, Length=269, Percent_Identity=30.1115241635688, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17552492, Length=263, Percent_Identity=30.7984790874525, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17561300, Length=274, Percent_Identity=31.3868613138686, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17562292, Length=280, Percent_Identity=29.6428571428571, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17550246, Length=77, Percent_Identity=48.0519480519481, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324694, Length=307, Percent_Identity=35.8306188925081, Blast_Score=185, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6320576, Length=305, Percent_Identity=33.7704918032787, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6322556, Length=262, Percent_Identity=30.9160305343511, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319625, Length=302, Percent_Identity=30.1324503311258, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321896, Length=303, Percent_Identity=27.3927392739274, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320079, Length=285, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24663317, Length=283, Percent_Identity=37.4558303886926, Blast_Score=203, Evalue=9e-53,
Organism=Drosophila melanogaster, GI24657054, Length=275, Percent_Identity=37.8181818181818, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI20129731, Length=279, Percent_Identity=39.426523297491, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21356425, Length=312, Percent_Identity=34.6153846153846, Blast_Score=190, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24644950, Length=297, Percent_Identity=33.3333333333333, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI45553081, Length=289, Percent_Identity=32.1799307958478, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24662789, Length=295, Percent_Identity=32.5423728813559, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI221378297, Length=317, Percent_Identity=31.2302839116719, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24662781, Length=296, Percent_Identity=34.7972972972973, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24662785, Length=295, Percent_Identity=34.9152542372881, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI281366140, Length=252, Percent_Identity=30.1587301587302, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 32487; Mature: 32487

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTMKQHENIIPTITLNDGTEMPAIGFGTYKLREQDAYRAVRSAIEVGYRHIDTASLYKN
CCCCCCCCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
EEEVGRAVADAITAGEVARDELFITTKVWNDMHGDQLTQRSFQESLHRLGLDYIDCCMVH
HHHHHHHHHHHHHHHHHHHHHEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHEE
WPWPQKGLYVESFAALAKIQGLGQLQSVAVANFYPEVLREIVAETGIAPVLNQVELHPGF
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCH
SQAEQRAVDRELGVVTEAWSPLGRGDSLNAEAITLIAQCYEKTPAQVTLRWIHQLGCSVV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
PKSANPQRQRENLDIFDFELNTEDMNSITSLDEQGGRLFVDPHDFPGEVE
CCCCCCHHHHCCCCEEEEEECCHHHHHHHHHHHCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MVTMKQHENIIPTITLNDGTEMPAIGFGTYKLREQDAYRAVRSAIEVGYRHIDTASLYKN
CCCCCCCCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
EEEVGRAVADAITAGEVARDELFITTKVWNDMHGDQLTQRSFQESLHRLGLDYIDCCMVH
HHHHHHHHHHHHHHHHHHHHHEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHEE
WPWPQKGLYVESFAALAKIQGLGQLQSVAVANFYPEVLREIVAETGIAPVLNQVELHPGF
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCH
SQAEQRAVDRELGVVTEAWSPLGRGDSLNAEAITLIAQCYEKTPAQVTLRWIHQLGCSVV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
PKSANPQRQRENLDIFDFELNTEDMNSITSLDEQGGRLFVDPHDFPGEVE
CCCCCCHHHHCCCCEEEEEECCHHHHHHHHHHHCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2,5-diketo-D-gluconate; NADPH [C]

Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA