| Definition | Corynebacterium diphtheriae NCTC 13129 chromosome, complete genome. |
|---|---|
| Accession | NC_002935 |
| Length | 2,488,635 |
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The map label for this gene is hemD [H]
Identifier: 38233016
GI number: 38233016
Start: 367058
End: 368728
Strand: Direct
Name: hemD [H]
Synonym: DIP0402
Alternate gene names: 38233016
Gene position: 367058-368728 (Clockwise)
Preceding gene: 38233015
Following gene: 38233017
Centisome position: 14.75
GC content: 58.05
Gene sequence:
>1671_bases ATGCGATTAATCATGAAGCCCGAGCACTCAACGCGAGGACGTGTCATCTTCGTCGGCGCCGGTCCCGGCAACCCAGATCT TTTGACGGTTCGAGCCCGCGAGGTGCTGGGCTCCACAGCCAATGCAGTGGTGGATTCCACTGTTGGCGTAGGTATTCGCG CAGTTATTGCTGAACATCTTGAGGTGCCGCAGGCCAAGCTTGATGCAGCTGAGGCTGAGTATGAGCGCATGTGTGCGGCT GCGAAGCGTCGTAAGCCTCCGCGTCCCGACGCCCCCACCGCCGCGGAAATCACTGAGGTGTCCGCTGATGCGAGCGTCGA TGAAGTGATGGCGGTGCTGTTGCCTTTGCTAGACGAAGGCGATGTGATCCGCCTAGTGCAGGGTAACCCGTTGGCGGATT CCCGCGCGTTAGATGAGATTACGGCTGTTACACAGGTGGGCGCGGATTTCCAGATTGTGCCAGGTATGTCGTTGCCGGCT GCGGTTCCTGCTTTCGCGGGAATCACGTTGGGTGATTCTTATACCAAGACCACGGTGAGTGAGGATACTAACTGGGATCA GTTGGCAACCGCCCCGCTGCCGTTGATTTTGCAGGCGAGTAAAGACGACTTGCTGACTATCGCTATGGAGTTGAAGGATC GCAAACTGCCGGCGAGCACTCCGGTGACGGTGACGATGAATGGCACGACGCGTTTGCAGCGGAGCTTTGACGTGACGCTT AAAACTATGAAGTCGCTGGTCAAGCAGGAGCTCGATGGCACTCTTGTGGTCACAGTGGGTGTATCGGATCGCAGTACATT TTCGTGGTGGGAAAGCCGCGCGTTGTTTGGCTGGCGGGTGTTGGTTCCTCGTGCGAAGGATCAAGCTGGTCCGATGAGCA GCCGAATCGCCGCTTATGGTGCTATTGCCCAAGAGGTTCCCACTATTTCTGTGGAGCCGCCGCGTAATCCGGCGCAGTTG GAGCGTGCGATTAAGGGCATTGTGGAGGGGCGCTACCAGTGGGTGGTGTTTACCAGCGTGAATGCTGTTAAGGCGGTGCG TGAGAAGATCGTGTCGTTTGGTTTGGATTCTCGCGCGTTCGCGGGGGTGCATATCGCTGCGGTGGGGGCTAAGACTGCGG CGGCGATTCGTGAGTTTGGCATTACTCCTGAGCTAATTCCGCCACGTAAGGAGCATAATGCTGCGGGTATGGTGTCGGTT TTCCCTAATTATGTGGAGGGCTTGGACCCGGTAGGTCGGGTGTTGCTGCCGCGGGCTGATATTGCCACTGATGTGCTGGT TGATGGTTTGGTCAACCTTGGCTGGGAAGTTGATGATGTGGTGGCGTATCGTACGGTGCGTGCCGCGCCGCCGAGTGCGG AAGTCCGCGACATGATTAAGTCCGGCGATTTTGATGCGGTGTGTTTTACCTCTGCGTCGACGGTGCGCAATTTGGTGGGT ATTGCGGGTAAGCCGCATGCGCGCACGATCATTGCATGTATTGGGCCGATGACCGCCGCGGAGGCAGAGAAGCAAGGGCT GCGTGTCGACGTCATCCCCGAGGTGGCTAACGTTGCGGCTCTTGTGGATGCGCTCGCGGAGCATGTGGAGAAACTGCGTG CTGCGGGTGAGTTGCCGCCGCCGCGTAAGAAGCGTCGGGCCCGTCGCAAATCTAAGGAAGGTGCTGTATGA
Upstream 100 bases:
>100_bases TGCTTTGATTGCTGATGGTGCTGCGACCATCTTGGGATAATTCCGTAACTTCAATTATGGTTATGGTTTTAGTTTCCTTC TATCGGCAGCACGCCTAGAA
Downstream 100 bases:
>100_bases ATCTAGATCTTATTCGTCGTCCTCGTCGGTTGCGTTCGACTCCGGTGATGCGTGAATTTGTTGCGGAAACCACGCTGCGT CCGGCTGATCTTATTTTGCC
Product: putative uroporphyrin-III C-methyltransferase
Products: NA
Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Uroporphyrinogen-III synthase; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]
Number of amino acids: Translated: 556; Mature: 556
Protein sequence:
>556_residues MRLIMKPEHSTRGRVIFVGAGPGNPDLLTVRAREVLGSTANAVVDSTVGVGIRAVIAEHLEVPQAKLDAAEAEYERMCAA AKRRKPPRPDAPTAAEITEVSADASVDEVMAVLLPLLDEGDVIRLVQGNPLADSRALDEITAVTQVGADFQIVPGMSLPA AVPAFAGITLGDSYTKTTVSEDTNWDQLATAPLPLILQASKDDLLTIAMELKDRKLPASTPVTVTMNGTTRLQRSFDVTL KTMKSLVKQELDGTLVVTVGVSDRSTFSWWESRALFGWRVLVPRAKDQAGPMSSRIAAYGAIAQEVPTISVEPPRNPAQL ERAIKGIVEGRYQWVVFTSVNAVKAVREKIVSFGLDSRAFAGVHIAAVGAKTAAAIREFGITPELIPPRKEHNAAGMVSV FPNYVEGLDPVGRVLLPRADIATDVLVDGLVNLGWEVDDVVAYRTVRAAPPSAEVRDMIKSGDFDAVCFTSASTVRNLVG IAGKPHARTIIACIGPMTAAEAEKQGLRVDVIPEVANVAALVDALAEHVEKLRAAGELPPPRKKRRARRKSKEGAV
Sequences:
>Translated_556_residues MRLIMKPEHSTRGRVIFVGAGPGNPDLLTVRAREVLGSTANAVVDSTVGVGIRAVIAEHLEVPQAKLDAAEAEYERMCAA AKRRKPPRPDAPTAAEITEVSADASVDEVMAVLLPLLDEGDVIRLVQGNPLADSRALDEITAVTQVGADFQIVPGMSLPA AVPAFAGITLGDSYTKTTVSEDTNWDQLATAPLPLILQASKDDLLTIAMELKDRKLPASTPVTVTMNGTTRLQRSFDVTL KTMKSLVKQELDGTLVVTVGVSDRSTFSWWESRALFGWRVLVPRAKDQAGPMSSRIAAYGAIAQEVPTISVEPPRNPAQL ERAIKGIVEGRYQWVVFTSVNAVKAVREKIVSFGLDSRAFAGVHIAAVGAKTAAAIREFGITPELIPPRKEHNAAGMVSV FPNYVEGLDPVGRVLLPRADIATDVLVDGLVNLGWEVDDVVAYRTVRAAPPSAEVRDMIKSGDFDAVCFTSASTVRNLVG IAGKPHARTIIACIGPMTAAEAEKQGLRVDVIPEVANVAALVDALAEHVEKLRAAGELPPPRKKRRARRKSKEGAV >Mature_556_residues MRLIMKPEHSTRGRVIFVGAGPGNPDLLTVRAREVLGSTANAVVDSTVGVGIRAVIAEHLEVPQAKLDAAEAEYERMCAA AKRRKPPRPDAPTAAEITEVSADASVDEVMAVLLPLLDEGDVIRLVQGNPLADSRALDEITAVTQVGADFQIVPGMSLPA AVPAFAGITLGDSYTKTTVSEDTNWDQLATAPLPLILQASKDDLLTIAMELKDRKLPASTPVTVTMNGTTRLQRSFDVTL KTMKSLVKQELDGTLVVTVGVSDRSTFSWWESRALFGWRVLVPRAKDQAGPMSSRIAAYGAIAQEVPTISVEPPRNPAQL ERAIKGIVEGRYQWVVFTSVNAVKAVREKIVSFGLDSRAFAGVHIAAVGAKTAAAIREFGITPELIPPRKEHNAAGMVSV FPNYVEGLDPVGRVLLPRADIATDVLVDGLVNLGWEVDDVVAYRTVRAAPPSAEVRDMIKSGDFDAVCFTSASTVRNLVG IAGKPHARTIIACIGPMTAAEAEKQGLRVDVIPEVANVAALVDALAEHVEKLRAAGELPPPRKKRRARRKSKEGAV
Specific function: May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses [H]
COG id: COG1587
COG function: function code H; Uroporphyrinogen-III synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the precorrin methyltransferase family [H]
Homologues:
Organism=Escherichia coli, GI1789768, Length=286, Percent_Identity=24.8251748251748, Blast_Score=75, Evalue=1e-14,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000878 - InterPro: IPR003754 - InterPro: IPR014777 - InterPro: IPR014776 - InterPro: IPR006366 - InterPro: IPR003043 [H]
Pfam domain/function: PF02602 HEM4; PF00590 TP_methylase [H]
EC number: =2.1.1.107; =4.2.1.75 [H]
Molecular weight: Translated: 59440; Mature: 59440
Theoretical pI: Translated: 7.14; Mature: 7.14
Prosite motif: PS00839 SUMT_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRLIMKPEHSTRGRVIFVGAGPGNPDLLTVRAREVLGSTANAVVDSTVGVGIRAVIAEHL CCEEECCCCCCCCCEEEEECCCCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHH EVPQAKLDAAEAEYERMCAAAKRRKPPRPDAPTAAEITEVSADASVDEVMAVLLPLLDEG CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCC DVIRLVQGNPLADSRALDEITAVTQVGADFQIVPGMSLPAAVPAFAGITLGDSYTKTTVS CEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHCEEECCCCCCCCCC EDTNWDQLATAPLPLILQASKDDLLTIAMELKDRKLPASTPVTVTMNGTTRLQRSFDVTL CCCCHHHHHCCCCCEEEECCCCCEEEEEEEHHCCCCCCCCCEEEEECCCHHHHHHHHHHH KTMKSLVKQELDGTLVVTVGVSDRSTFSWWESRALFGWRVLVPRAKDQAGPMSSRIAAYG HHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHH AIAQEVPTISVEPPRNPAQLERAIKGIVEGRYQWVVFTSVNAVKAVREKIVSFGLDSRAF HHHHHCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHCCCCCCCC AGVHIAAVGAKTAAAIREFGITPELIPPRKEHNAAGMVSVFPNYVEGLDPVGRVLLPRAD CCEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCHHHHHCCCHHHHHHCCCHH IATDVLVDGLVNLGWEVDDVVAYRTVRAAPPSAEVRDMIKSGDFDAVCFTSASTVRNLVG HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHH IAGKPHARTIIACIGPMTAAEAEKQGLRVDVIPEVANVAALVDALAEHVEKLRAAGELPP CCCCCCHHEEEEECCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCC PRKKRRARRKSKEGAV CHHHHHHHHHHCCCCC >Mature Secondary Structure MRLIMKPEHSTRGRVIFVGAGPGNPDLLTVRAREVLGSTANAVVDSTVGVGIRAVIAEHL CCEEECCCCCCCCCEEEEECCCCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHH EVPQAKLDAAEAEYERMCAAAKRRKPPRPDAPTAAEITEVSADASVDEVMAVLLPLLDEG CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCC DVIRLVQGNPLADSRALDEITAVTQVGADFQIVPGMSLPAAVPAFAGITLGDSYTKTTVS CEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHCEEECCCCCCCCCC EDTNWDQLATAPLPLILQASKDDLLTIAMELKDRKLPASTPVTVTMNGTTRLQRSFDVTL CCCCHHHHHCCCCCEEEECCCCCEEEEEEEHHCCCCCCCCCEEEEECCCHHHHHHHHHHH KTMKSLVKQELDGTLVVTVGVSDRSTFSWWESRALFGWRVLVPRAKDQAGPMSSRIAAYG HHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHH AIAQEVPTISVEPPRNPAQLERAIKGIVEGRYQWVVFTSVNAVKAVREKIVSFGLDSRAF HHHHHCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHCCCCCCCC AGVHIAAVGAKTAAAIREFGITPELIPPRKEHNAAGMVSVFPNYVEGLDPVGRVLLPRAD CCEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCHHHHHCCCHHHHHHCCCHH IATDVLVDGLVNLGWEVDDVVAYRTVRAAPPSAEVRDMIKSGDFDAVCFTSASTVRNLVG HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHH IAGKPHARTIIACIGPMTAAEAEKQGLRVDVIPEVANVAALVDALAEHVEKLRAAGELPP CCCCCCHHEEEEECCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCC PRKKRRARRKSKEGAV CHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7665501 [H]