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The map label for this gene is gpmA [H]

Identifier: 38233003

GI number: 38233003

Start: 356496

End: 357281

Strand: Direct

Name: gpmA [H]

Synonym: DIP0389

Alternate gene names: 38233003

Gene position: 356496-357281 (Clockwise)

Preceding gene: 38233002

Following gene: 38233004

Centisome position: 14.32

GC content: 56.62

Gene sequence:

>786_bases
TTGCTCGCGTTGCTGCGATTCGTGGCAAACTTGACAAGTATGACTACTGGAAAACTGATTCTTCTTCGTCACGGACAAAG
CGAATGGAACGCTTCCAACCAATTCACCGGCTGGGTGGACGTCAACCTCACCGAAAAGGGCGAGGCAGAGGCTAAGCGCG
GCGGCGAGCTGCTCAAGGCTCAGGGGGTCCTGCCAAGCGTGGTGTACACCTCTTTGCTGCGCCGTGCTATCCGCACCGCC
AACATTGCTCTGAACGCTGCTGATCGCCATTGGATCCCAGTTGTTCGCGATTGGCGCCTCAACGAGCGCCACTACGGTGC
GCTGCAGGGCCTGAACAAGGCTGAGACTAAGGAAAAGTACGGCGACGAGCAGTTCATGGCATGGCGTCGTTCTTATGGCA
CCCCACCACCAGAGCTTGAGGATTCCAGCGAGTTCTCCCAGGCAAACGATCCTCGTTACGCCAACCTTGACGTGGTTCCT
CGCACCGAGTGCTTGAAGGACGTTGTTGAGCGTTTCGTTCCTTACTTCAAGGAAGAGATCCTGCCACGTGTGAAGAACGG
TGAGACTGTTTTGATCGCTGCACACGGTAACTCCCTGCGTGCATTGGTCAAGCACCTAGACAACATCTCTGATGCAGACA
TCGCTGAGCTCAACATCCCTACCGGTATTCCACTGGTTTATGAGCTCGACGAGGCTGGCACGGTGCTCAACCCAGGTGGC
ACCTACCTTGACCCAGAAGCTGCTGCTGCCGGTGCTGCCGCAGTTGCTGCTCAGGGCGCTAAGTAG

Upstream 100 bases:

>100_bases
GAGTCGGTGTATGGCGATGCGGCGATGTTGGATGTTGCGCAGTGCCATGACCGCTACGCCGCGGGTTCCGATCGGGCATA
AGTGTAAATAATCCCACATT

Downstream 100 bases:

>100_bases
TAGCGAGGCACGTGTACGTCGTTATCGCATTTGTGTTGGGCGTGGTCCTTTCGGGCCTCGCCCTACCTGCGTTGAAATGG
GTGCGCGGCCGTAGTTATCG

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MLALLRFVANLTSMTTGKLILLRHGQSEWNASNQFTGWVDVNLTEKGEAEAKRGGELLKAQGVLPSVVYTSLLRRAIRTA
NIALNAADRHWIPVVRDWRLNERHYGALQGLNKAETKEKYGDEQFMAWRRSYGTPPPELEDSSEFSQANDPRYANLDVVP
RTECLKDVVERFVPYFKEEILPRVKNGETVLIAAHGNSLRALVKHLDNISDADIAELNIPTGIPLVYELDEAGTVLNPGG
TYLDPEAAAAGAAAVAAQGAK

Sequences:

>Translated_261_residues
MLALLRFVANLTSMTTGKLILLRHGQSEWNASNQFTGWVDVNLTEKGEAEAKRGGELLKAQGVLPSVVYTSLLRRAIRTA
NIALNAADRHWIPVVRDWRLNERHYGALQGLNKAETKEKYGDEQFMAWRRSYGTPPPELEDSSEFSQANDPRYANLDVVP
RTECLKDVVERFVPYFKEEILPRVKNGETVLIAAHGNSLRALVKHLDNISDADIAELNIPTGIPLVYELDEAGTVLNPGG
TYLDPEAAAAGAAAVAAQGAK
>Mature_261_residues
MLALLRFVANLTSMTTGKLILLRHGQSEWNASNQFTGWVDVNLTEKGEAEAKRGGELLKAQGVLPSVVYTSLLRRAIRTA
NIALNAADRHWIPVVRDWRLNERHYGALQGLNKAETKEKYGDEQFMAWRRSYGTPPPELEDSSEFSQANDPRYANLDVVP
RTECLKDVVERFVPYFKEEILPRVKNGETVLIAAHGNSLRALVKHLDNISDADIAELNIPTGIPLVYELDEAGTVLNPGG
TYLDPEAAAAGAAAVAAQGAK

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate [H]

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily [H]

Homologues:

Organism=Homo sapiens, GI50593010, Length=250, Percent_Identity=50, Blast_Score=253, Evalue=8e-68,
Organism=Homo sapiens, GI4505753, Length=250, Percent_Identity=51.2, Blast_Score=245, Evalue=3e-65,
Organism=Homo sapiens, GI4502445, Length=252, Percent_Identity=47.2222222222222, Blast_Score=232, Evalue=2e-61,
Organism=Homo sapiens, GI40353764, Length=252, Percent_Identity=47.2222222222222, Blast_Score=232, Evalue=2e-61,
Organism=Homo sapiens, GI71274132, Length=250, Percent_Identity=48.8, Blast_Score=231, Evalue=3e-61,
Organism=Homo sapiens, GI310129614, Length=165, Percent_Identity=50.3030303030303, Blast_Score=157, Evalue=7e-39,
Organism=Escherichia coli, GI1786970, Length=220, Percent_Identity=58.6363636363636, Blast_Score=268, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6322697, Length=246, Percent_Identity=63.4146341463415, Blast_Score=288, Evalue=5e-79,
Organism=Saccharomyces cerevisiae, GI6324516, Length=299, Percent_Identity=35.1170568561873, Blast_Score=163, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320183, Length=295, Percent_Identity=36.271186440678, Blast_Score=162, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24646216, Length=247, Percent_Identity=48.9878542510121, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI85725270, Length=247, Percent_Identity=48.9878542510121, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI85725272, Length=247, Percent_Identity=48.9878542510121, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24650981, Length=247, Percent_Identity=48.9878542510121, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI28571815, Length=270, Percent_Identity=36.6666666666667, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI28571817, Length=253, Percent_Identity=37.5494071146245, Blast_Score=157, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24648979, Length=253, Percent_Identity=37.5494071146245, Blast_Score=157, Evalue=7e-39,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =5.4.2.1 [H]

Molecular weight: Translated: 28734; Mature: 28734

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALLRFVANLTSMTTGKLILLRHGQSEWNASNQFTGWVDVNLTEKGEAEAKRGGELLKA
CHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEEEECCCCCHHHHHCCHHHHH
QGVLPSVVYTSLLRRAIRTANIALNAADRHWIPVVRDWRLNERHYGALQGLNKAETKEKY
CCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCEECCCCCCHHHHHHHCCCHHHHHHHH
GDEQFMAWRRSYGTPPPELEDSSEFSQANDPRYANLDVVPRTECLKDVVERFVPYFKEEI
CCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHH
LPRVKNGETVLIAAHGNSLRALVKHLDNISDADIAELNIPTGIPLVYELDEAGTVLNPGG
CCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCEECCCC
TYLDPEAAAAGAAAVAAQGAK
CEECCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLALLRFVANLTSMTTGKLILLRHGQSEWNASNQFTGWVDVNLTEKGEAEAKRGGELLKA
CHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEEEECCCCCHHHHHCCHHHHH
QGVLPSVVYTSLLRRAIRTANIALNAADRHWIPVVRDWRLNERHYGALQGLNKAETKEKY
CCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCEECCCCCCHHHHHHHCCCHHHHHHHH
GDEQFMAWRRSYGTPPPELEDSSEFSQANDPRYANLDVVPRTECLKDVVERFVPYFKEEI
CCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHH
LPRVKNGETVLIAAHGNSLRALVKHLDNISDADIAELNIPTGIPLVYELDEAGTVLNPGG
CCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCEECCCC
TYLDPEAAAAGAAAVAAQGAK
CEECCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910 [H]