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The map label for this gene is mshA

Identifier: 38233002

GI number: 38233002

Start: 355193

End: 356476

Strand: Direct

Name: mshA

Synonym: DIP0388

Alternate gene names: 38233002

Gene position: 355193-356476 (Clockwise)

Preceding gene: 38232998

Following gene: 38233003

Centisome position: 14.27

GC content: 59.27

Gene sequence:

>1284_bases
ATGATGACTATGCGCATTGCCATGATCTCTATACACACCTCGCCCCTGCAGCAACCAGGCAGCGGAGACGCAGGTGGAAT
GAACGTCTACATCATTTCCATCGCCCGCGAACTTGCACGTCGCGGCGTAGACGTAGACATTTACACCCGTGCCACTCGCC
CCAGCCAAGGCGACGTTGTAGAGGTGGAGTCGGGGCTGCGCGTGATCAACATTGTGGCCGGCCCCTATGAGGGCCTGAGC
AAAGAAGAACTCCCCACCCAGCTCGCAGCTTTCGCAGGTGGCGTGGTGCAGTTCGCCAAGTGTCACCACATGCGTTACGA
CGTCATCCATTCTCACTATTGGCTTTCCGGCCAAGTCGGCTGGCTACTGCGCGACCTGTGGAACATCCCACTCGTACACA
CCGCGCACACCCTTGCGGCGGTAAAAAATGCGCACCGCAGCGCAGGGGATACCGAAGAATCAGAGGCTAGGCGTATTTGT
GAGCAACAGCTTGTAGATAACGCTGACATCCTCGTGGTGAACACCCCCGAGGAAACCAACGACCTTGTGCGCCACTATGA
CGCCAACCCCGATTCGGTGGCTGTGATCGCGCCGGGTGCCAATGTGGAACTTTTTACTCCTGGTACGCAGCGCAATACGG
AACAGTCGCGGCGGTGCTTGGGTATTCCGTTGCACACCAAGGTGATGGCTTTTGTGGGAAGGTTGCAACAGTTTAAGGGC
CCTGAGGTGTTGTTGCGTGCAGTGGCGGAGATGTTGGAGCGGGATCCGGATCGCGATATGCGTGTGATTATGTGTGGTGG
GCCGTCGGGTGCTGCTGCCACGGTGGAGCATTACATTGAGTTGACGCGCAGTTTGGGTATTGCGCATCGGGTGCGGTTTT
TGGATCCGCGTCCGCCGGAGGAGCTGGTGAGTGTGTATCAGGCGGCTGATGTGGTGGCGGTGCCCTCGTATAACGAGTCG
TTTGGGCTGGTTGCGATGGAAGCGCAGGCTAGTGGTACTCCGGTGGTGGCTGCGCGTGTTGGCGGCTTGCCTATTGCGGT
GGTGGATGGTGAGACGGGCGTGCTTGTCGACGGCCACGATCCCATAATGTGGGCGGATGCGCTGGAGCAATTGCTTGACG
ACGACCCCACGCGTCAGCAGATGGGTGTGGCTGCGGTGGAGCATGCGGCGAACTTTACGTGGGCTGCGGCTGCGGAGAAG
TTGGAGTCGGTGTATGGCGATGCGGCGATGTTGGATGTTGCGCAGTGCCATGACCGCTACGCCGCGGGTTCCGATCGGGC
ATAA

Upstream 100 bases:

>100_bases
GTCTCGTATGCCGACATGAGTTCCCTTCGATCCTCGCAAATAAACGTAAATACGAGCATATACTCATGTTTCGCTTGGTT
GGGTAATAACGGCGCCTAGA

Downstream 100 bases:

>100_bases
GTGTAAATAATCCCACATTTTGCTCGCGTTGCTGCGATTCGTGGCAAACTTGACAAGTATGACTACTGGAAAACTGATTC
TTCTTCGTCACGGACAAAGC

Product: putative glycosyl transferase

Products: NA

Alternate protein names: N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase; GlcNAc-Ins-P N-acetylglucosaminyltransferase

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MMTMRIAMISIHTSPLQQPGSGDAGGMNVYIISIARELARRGVDVDIYTRATRPSQGDVVEVESGLRVINIVAGPYEGLS
KEELPTQLAAFAGGVVQFAKCHHMRYDVIHSHYWLSGQVGWLLRDLWNIPLVHTAHTLAAVKNAHRSAGDTEESEARRIC
EQQLVDNADILVVNTPEETNDLVRHYDANPDSVAVIAPGANVELFTPGTQRNTEQSRRCLGIPLHTKVMAFVGRLQQFKG
PEVLLRAVAEMLERDPDRDMRVIMCGGPSGAAATVEHYIELTRSLGIAHRVRFLDPRPPEELVSVYQAADVVAVPSYNES
FGLVAMEAQASGTPVVAARVGGLPIAVVDGETGVLVDGHDPIMWADALEQLLDDDPTRQQMGVAAVEHAANFTWAAAAEK
LESVYGDAAMLDVAQCHDRYAAGSDRA

Sequences:

>Translated_427_residues
MMTMRIAMISIHTSPLQQPGSGDAGGMNVYIISIARELARRGVDVDIYTRATRPSQGDVVEVESGLRVINIVAGPYEGLS
KEELPTQLAAFAGGVVQFAKCHHMRYDVIHSHYWLSGQVGWLLRDLWNIPLVHTAHTLAAVKNAHRSAGDTEESEARRIC
EQQLVDNADILVVNTPEETNDLVRHYDANPDSVAVIAPGANVELFTPGTQRNTEQSRRCLGIPLHTKVMAFVGRLQQFKG
PEVLLRAVAEMLERDPDRDMRVIMCGGPSGAAATVEHYIELTRSLGIAHRVRFLDPRPPEELVSVYQAADVVAVPSYNES
FGLVAMEAQASGTPVVAARVGGLPIAVVDGETGVLVDGHDPIMWADALEQLLDDDPTRQQMGVAAVEHAANFTWAAAAEK
LESVYGDAAMLDVAQCHDRYAAGSDRA
>Mature_427_residues
MMTMRIAMISIHTSPLQQPGSGDAGGMNVYIISIARELARRGVDVDIYTRATRPSQGDVVEVESGLRVINIVAGPYEGLS
KEELPTQLAAFAGGVVQFAKCHHMRYDVIHSHYWLSGQVGWLLRDLWNIPLVHTAHTLAAVKNAHRSAGDTEESEARRIC
EQQLVDNADILVVNTPEETNDLVRHYDANPDSVAVIAPGANVELFTPGTQRNTEQSRRCLGIPLHTKVMAFVGRLQQFKG
PEVLLRAVAEMLERDPDRDMRVIMCGGPSGAAATVEHYIELTRSLGIAHRVRFLDPRPPEELVSVYQAADVVAVPSYNES
FGLVAMEAQASGTPVVAARVGGLPIAVVDGETGVLVDGHDPIMWADALEQLLDDDPTRQQMGVAAVEHAANFTWAAAAEK
LESVYGDAAMLDVAQCHDRYAAGSDRA

Specific function: Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway

COG id: COG0438

COG function: function code M; Glycosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 1 family. MshA subfamily

Homologues:

Organism=Drosophila melanogaster, GI21357469, Length=264, Percent_Identity=28.030303030303, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSHA_CORDI (Q6NJL3)

Other databases:

- EMBL:   BX248355
- RefSeq:   NP_938769.1
- ProteinModelPortal:   Q6NJL3
- SMR:   Q6NJL3
- GeneID:   2650670
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0388
- NMPDR:   fig|257309.1.peg.360
- HOGENOM:   HBG726846
- OMA:   PLKAPDV
- ProtClustDB:   CLSK2303180
- BioCyc:   CDIP257309:DIP0388-MONOMER
- HAMAP:   MF_01695
- InterPro:   IPR001296
- InterPro:   IPR017814
- InterPro:   IPR013534
- TIGRFAMs:   TIGR03449

Pfam domain/function: PF08323 Glyco_transf_5; PF00534 Glycos_transf_1

EC number: =2.4.1.250

Molecular weight: Translated: 46352; Mature: 46352

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: BINDING 12-12 BINDING 26-26 BINDING 81-81 BINDING 113-113 BINDING 137-137 BINDING 157-157 BINDING 234-234 BINDING 239-239 BINDING 297-297 BINDING 319-319 BINDING 327-327

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTMRIAMISIHTSPLQQPGSGDAGGMNVYIISIARELARRGVDVDIYTRATRPSQGDVV
CCEEEEEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCCCCEE
EVESGLRVINIVAGPYEGLSKEELPTQLAAFAGGVVQFAKCHHMRYDVIHSHYWLSGQVG
EECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHH
WLLRDLWNIPLVHTAHTLAAVKNAHRSAGDTEESEARRICEQQLVDNADILVVNTPEETN
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHH
DLVRHYDANPDSVAVIAPGANVELFTPGTQRNTEQSRRCLGIPLHTKVMAFVGRLQQFKG
HHHHHCCCCCCCEEEEECCCCEEEECCCCCCCCHHHHHEECCCHHHHHHHHHHHHHHCCC
PEVLLRAVAEMLERDPDRDMRVIMCGGPSGAAATVEHYIELTRSLGIAHRVRFLDPRPPE
HHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHEECCCCCHH
ELVSVYQAADVVAVPSYNESFGLVAMEAQASGTPVVAARVGGLPIAVVDGETGVLVDGHD
HHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCCEEEEECCCEEEEEEECCCEEEECCCC
PIMWADALEQLLDDDPTRQQMGVAAVEHAANFTWAAAAEKLESVYGDAAMLDVAQCHDRY
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AAGSDRA
CCCCCCC
>Mature Secondary Structure
MMTMRIAMISIHTSPLQQPGSGDAGGMNVYIISIARELARRGVDVDIYTRATRPSQGDVV
CCEEEEEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCCCCEE
EVESGLRVINIVAGPYEGLSKEELPTQLAAFAGGVVQFAKCHHMRYDVIHSHYWLSGQVG
EECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHH
WLLRDLWNIPLVHTAHTLAAVKNAHRSAGDTEESEARRICEQQLVDNADILVVNTPEETN
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHH
DLVRHYDANPDSVAVIAPGANVELFTPGTQRNTEQSRRCLGIPLHTKVMAFVGRLQQFKG
HHHHHCCCCCCCEEEEECCCCEEEECCCCCCCCHHHHHEECCCHHHHHHHHHHHHHHCCC
PEVLLRAVAEMLERDPDRDMRVIMCGGPSGAAATVEHYIELTRSLGIAHRVRFLDPRPPE
HHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHEECCCCCHH
ELVSVYQAADVVAVPSYNESFGLVAMEAQASGTPVVAARVGGLPIAVVDGETGVLVDGHD
HHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCCEEEEECCCEEEEEEECCCEEEECCCC
PIMWADALEQLLDDDPTRQQMGVAAVEHAANFTWAAAAEKLESVYGDAAMLDVAQCHDRY
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AAGSDRA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910