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The map label for this gene is tet [H]

Identifier: 38232893

GI number: 38232893

Start: 235061

End: 236425

Strand: Direct

Name: tet [H]

Synonym: DIP0272

Alternate gene names: 38232893

Gene position: 235061-236425 (Clockwise)

Preceding gene: 38232892

Following gene: 38232894

Centisome position: 9.45

GC content: 55.09

Gene sequence:

>1365_bases
ATGACAACGCACAACGCAACCTTGAAGCCTACTGATCCGAAGGCAGCAGTGCCGGTCCTGCTGTTCAGCTTCGTTTTCTG
TTTGATTGTGGACAATGGTTTTAAGACTATGACCGGCCCGATGGCAGAGGGCTTGGGCATTGACCCCAACACAGCCTCGC
TGCAGGCCTCGCTTGCAGGTGTGATCATAGGCATTGGTGCGGTTGTTTATGCTGCACTCGCTGACGCGATCTCGATCCGC
AAACTCATGCTCATCGGCATCGGCCTAGTGGTTGTAGGATCCGTCATCGGATTCGTGTTCTCCGGCTCGTGGCCACTTGT
TCTTGCAGGTCGCCTCATTCAGACCGGTGGCCTCGCTGCAGCGGAAACGCTGTACGTGATCTACGTGACCAAGCACCTCG
CAGCGGAAGACCAAAAGACCTACCTCGGCTTTTCTACCGCCGCATTCCAGTCCGGCTTGCTGGTAGGCGCACTGACCTCT
GGTGCTATCTCTACCTACATCGGCTGGCGCGTGATGTTCTTGGTCCCACTGATTTTGATCGTGGCAGTGCCATTTATCCT
CAAGACCGTTCCAGAAGAAGAAGCCTCCTCGTCGCACCTCGATGTTGTTGGTCTATTCCTGATCGCTATCTTTGCTACCT
CGGTTATCCAGTACATGCAGGCCTTCAAGCTGTTCTGGTTGGCATTCATGCTGGTCAGCATCGTGATTTTCGTTTGGTAC
GTACGCAACGCCAAGAACCCAGTGGTCAACCCAGAGTTCTTCAAAAATGGTCGCTACGTATGGGCAATCCTGCTCGTACT
GATCGTTTACTCCACCCAGCTCGGCTACATCGTGCTGCTGCCATTCGCAGCTAAAGAGTTCCACGGACTAGACCAAGCTC
AGGCATCGTATCTGATGATCCCAGGCTATATCTGTGCAGTCCTGATCGGCATTTTCTCCGGAAAGATCGGCAAGCTGATG
ACGTCGCGACGCACGATCTTCACCGCACTGGGCATGATCATCGTCGCCCTCGTGGTCGGCGCGCTCGCTATCCAGGTGCA
CGTTGCCGTGGCAATTGCCTCGATCATCCTGTTCGCATCCGGATTCGCACTGCTCTACGCACCGCTGGTGAACACTGCGC
TCGCCAACATCCTGCCGGAGAAATCCGGTGTGGCCATTGGCTTCTACAACCTGACCATCAACATTGGTGTCCCACTCGGT
ATCGCCTACACCTTCAAGCTGATGAACCTCAGTATCGGAACCAACGCCGTGATCTGGATTCTTGCCGCGATCGCCGTCGT
CGGAGCCGTGATGTACTTCATTGCTGACCGCGCGCTCTTTAGCCGCGAAAAGGCCGCAGGCATCGATTCCGTAGCAAACC
ACTAA

Upstream 100 bases:

>100_bases
CCGTGTCGGACAACCTGTTCACCGGAGCACGCACCACGGCTGAAGAGCGCGAAAGCGCCTTCACCGACATGATGGAACTC
GCACTACCATTGGCACGCGC

Downstream 100 bases:

>100_bases
AACATCCACCCACTTTTCAAGGAGACTCACCAAAATGACTACTCGCAACGACGTAGCCCAGATGATCGACCACACCCTGC
TCAAGCCAGAGGCAACCACC

Product: putative antibiotic resistance protein membrane protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTTHNATLKPTDPKAAVPVLLFSFVFCLIVDNGFKTMTGPMAEGLGIDPNTASLQASLAGVIIGIGAVVYAALADAISIR
KLMLIGIGLVVVGSVIGFVFSGSWPLVLAGRLIQTGGLAAAETLYVIYVTKHLAAEDQKTYLGFSTAAFQSGLLVGALTS
GAISTYIGWRVMFLVPLILIVAVPFILKTVPEEEASSSHLDVVGLFLIAIFATSVIQYMQAFKLFWLAFMLVSIVIFVWY
VRNAKNPVVNPEFFKNGRYVWAILLVLIVYSTQLGYIVLLPFAAKEFHGLDQAQASYLMIPGYICAVLIGIFSGKIGKLM
TSRRTIFTALGMIIVALVVGALAIQVHVAVAIASIILFASGFALLYAPLVNTALANILPEKSGVAIGFYNLTINIGVPLG
IAYTFKLMNLSIGTNAVIWILAAIAVVGAVMYFIADRALFSREKAAGIDSVANH

Sequences:

>Translated_454_residues
MTTHNATLKPTDPKAAVPVLLFSFVFCLIVDNGFKTMTGPMAEGLGIDPNTASLQASLAGVIIGIGAVVYAALADAISIR
KLMLIGIGLVVVGSVIGFVFSGSWPLVLAGRLIQTGGLAAAETLYVIYVTKHLAAEDQKTYLGFSTAAFQSGLLVGALTS
GAISTYIGWRVMFLVPLILIVAVPFILKTVPEEEASSSHLDVVGLFLIAIFATSVIQYMQAFKLFWLAFMLVSIVIFVWY
VRNAKNPVVNPEFFKNGRYVWAILLVLIVYSTQLGYIVLLPFAAKEFHGLDQAQASYLMIPGYICAVLIGIFSGKIGKLM
TSRRTIFTALGMIIVALVVGALAIQVHVAVAIASIILFASGFALLYAPLVNTALANILPEKSGVAIGFYNLTINIGVPLG
IAYTFKLMNLSIGTNAVIWILAAIAVVGAVMYFIADRALFSREKAAGIDSVANH
>Mature_453_residues
TTHNATLKPTDPKAAVPVLLFSFVFCLIVDNGFKTMTGPMAEGLGIDPNTASLQASLAGVIIGIGAVVYAALADAISIRK
LMLIGIGLVVVGSVIGFVFSGSWPLVLAGRLIQTGGLAAAETLYVIYVTKHLAAEDQKTYLGFSTAAFQSGLLVGALTSG
AISTYIGWRVMFLVPLILIVAVPFILKTVPEEEASSSHLDVVGLFLIAIFATSVIQYMQAFKLFWLAFMLVSIVIFVWYV
RNAKNPVVNPEFFKNGRYVWAILLVLIVYSTQLGYIVLLPFAAKEFHGLDQAQASYLMIPGYICAVLIGIFSGKIGKLMT
SRRTIFTALGMIIVALVVGALAIQVHVAVAIASIILFASGFALLYAPLVNTALANILPEKSGVAIGFYNLTINIGVPLGI
AYTFKLMNLSIGTNAVIWILAAIAVVGAVMYFIADRALFSREKAAGIDSVANH

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48365; Mature: 48234

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHNATLKPTDPKAAVPVLLFSFVFCLIVDNGFKTMTGPMAEGLGIDPNTASLQASLAG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCHHHHHHHHH
VIIGIGAVVYAALADAISIRKLMLIGIGLVVVGSVIGFVFSGSWPLVLAGRLIQTGGLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHH
AETLYVIYVTKHLAAEDQKTYLGFSTAAFQSGLLVGALTSGAISTYIGWRVMFLVPLILI
HHHEEEEEEHHHHHCCCCHHHCCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
VAVPFILKTVPEEEASSSHLDVVGLFLIAIFATSVIQYMQAFKLFWLAFMLVSIVIFVWY
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRNAKNPVVNPEFFKNGRYVWAILLVLIVYSTQLGYIVLLPFAAKEFHGLDQAQASYLMI
HHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCHHCCCEEEE
PGYICAVLIGIFSGKIGKLMTSRRTIFTALGMIIVALVVGALAIQVHVAVAIASIILFAS
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFALLYAPLVNTALANILPEKSGVAIGFYNLTINIGVPLGIAYTFKLMNLSIGTNAVIWI
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCHHHHHHHHHHEECCCCHHHHHH
LAAIAVVGAVMYFIADRALFSREKAAGIDSVANH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
TTHNATLKPTDPKAAVPVLLFSFVFCLIVDNGFKTMTGPMAEGLGIDPNTASLQASLAG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCHHHHHHHHH
VIIGIGAVVYAALADAISIRKLMLIGIGLVVVGSVIGFVFSGSWPLVLAGRLIQTGGLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHH
AETLYVIYVTKHLAAEDQKTYLGFSTAAFQSGLLVGALTSGAISTYIGWRVMFLVPLILI
HHHEEEEEEHHHHHCCCCHHHCCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
VAVPFILKTVPEEEASSSHLDVVGLFLIAIFATSVIQYMQAFKLFWLAFMLVSIVIFVWY
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRNAKNPVVNPEFFKNGRYVWAILLVLIVYSTQLGYIVLLPFAAKEFHGLDQAQASYLMI
HHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCHHCCCEEEE
PGYICAVLIGIFSGKIGKLMTSRRTIFTALGMIIVALVVGALAIQVHVAVAIASIILFAS
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFALLYAPLVNTALANILPEKSGVAIGFYNLTINIGVPLGIAYTFKLMNLSIGTNAVIWI
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCHHHHHHHHHHEECCCCHHHHHH
LAAIAVVGAVMYFIADRALFSREKAAGIDSVANH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2109312 [H]