Click here to switch to the map view.

The map label for this gene is lpcA

Identifier: 21674848

GI number: 21674848

Start: 1936312

End: 1936941

Strand: Reverse

Name: lpcA

Synonym: CT2038

Alternate gene names: 21674848

Gene position: 1936941-1936312 (Counterclockwise)

Preceding gene: 21674849

Following gene: 21674847

Centisome position: 89.88

GC content: 60.0

Gene sequence:

>630_bases
ATGACTCAGCAGTGTAACTGTTCGGAGGGAAGCTGTGGCGGCACCCGGTACGAAGAGCTGGTGCTCGAACGGATGCTCTA
CAGCGCGCGGCTTAAGGAGAGCGTGGCGCGGCGTGACAGCGACGTTATTGTAGCGATGGCATCGATGATCGCTGATACCT
TCAGGGAGGGGGGCAAAGTGCTCCTATGCGGCAATGGTGGAAGCGCCGCAGACGCGCAGCATCTGGCCGCAGAGTTCACC
ATCAGATACCGCAGCTCCGTGCATCGTCCGGCGCTTCCGGCCATCGCGCTTTCAACCGATACCTCGGCCCTGACGGCGGG
TGCAAACGACCTCGGTTTCGACGAGGTTTTCGTTCGGCTCACCGAAGCTTATGGTTGCCCTGGGGACATTCTGATCGGAC
TTTCAACCAGTGGCAATAGCGCCAGTGTGCTCAAGGCTCTCGAATTTGCCCGCAAGCGGGGGCTGAAAACACTCGCCCTG
CTTGGTGGTGATGGCGGTGCGATCAAGCCGCACGCTGACCTTGCGGTGGTGGTGCCCCATACCGGAAGCGCCGACAGAAT
CCAGGAGTGCCACATCGCTGTGGGGCACGTCATCGTGGAGCTCGTCGAAAAAATGATGGGCTATGATTGA

Upstream 100 bases:

>100_bases
CCTGCCCGGCAAATACTTCGGGTAGGCTTTTTTTTTGATCAGCCCCATCTGACCGATCATTTTTTATATTGCAGGAATTT
TTCAAAAAAGTAGTTAGGCC

Downstream 100 bases:

>100_bases
TGAGTGAAAATGCGGAGTAGCTCGTGGCGCGGCCTATAAAGCCCATTCCGTTCACTTTGTCCATTGTGGCATTGCAAACC
AAACAACAACTGACTATGCA

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MTQQCNCSEGSCGGTRYEELVLERMLYSARLKESVARRDSDVIVAMASMIADTFREGGKVLLCGNGGSAADAQHLAAEFT
IRYRSSVHRPALPAIALSTDTSALTAGANDLGFDEVFVRLTEAYGCPGDILIGLSTSGNSASVLKALEFARKRGLKTLAL
LGGDGGAIKPHADLAVVVPHTGSADRIQECHIAVGHVIVELVEKMMGYD

Sequences:

>Translated_209_residues
MTQQCNCSEGSCGGTRYEELVLERMLYSARLKESVARRDSDVIVAMASMIADTFREGGKVLLCGNGGSAADAQHLAAEFT
IRYRSSVHRPALPAIALSTDTSALTAGANDLGFDEVFVRLTEAYGCPGDILIGLSTSGNSASVLKALEFARKRGLKTLAL
LGGDGGAIKPHADLAVVVPHTGSADRIQECHIAVGHVIVELVEKMMGYD
>Mature_208_residues
TQQCNCSEGSCGGTRYEELVLERMLYSARLKESVARRDSDVIVAMASMIADTFREGGKVLLCGNGGSAADAQHLAAEFTI
RYRSSVHRPALPAIALSTDTSALTAGANDLGFDEVFVRLTEAYGCPGDILIGLSTSGNSASVLKALEFARKRGLKTLALL
GGDGGAIKPHADLAVVVPHTGSADRIQECHIAVGHVIVELVEKMMGYD

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1786416, Length=192, Percent_Identity=46.875, Blast_Score=176, Evalue=9e-46,
Organism=Escherichia coli, GI1789539, Length=170, Percent_Identity=41.1764705882353, Blast_Score=119, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_CHLTE (Q8KAW3)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662913.1
- ProteinModelPortal:   Q8KAW3
- SMR:   Q8KAW3
- GeneID:   1007522
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT2038
- NMPDR:   fig|194439.1.peg.2007
- TIGR:   CT2038
- HOGENOM:   HBG671955
- OMA:   ANDLGYD
- ProtClustDB:   CLSK638055
- BioCyc:   CTEP194439:CT_2038-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR004515
- InterPro:   IPR020620
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00441

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 22056; Mature: 21925

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS51464 SIS

Important sites: BINDING 78-78 BINDING 140-140 BINDING 188-188

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQCNCSEGSCGGTRYEELVLERMLYSARLKESVARRDSDVIVAMASMIADTFREGGKV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEE
LLCGNGGSAADAQHLAAEFTIRYRSSVHRPALPAIALSTDTSALTAGANDLGFDEVFVRL
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHCCCCCCCCHHHHHHHH
TEAYGCPGDILIGLSTSGNSASVLKALEFARKRGLKTLALLGGDGGAIKPHADLAVVVPH
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEEEEC
TGSADRIQECHIAVGHVIVELVEKMMGYD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQQCNCSEGSCGGTRYEELVLERMLYSARLKESVARRDSDVIVAMASMIADTFREGGKV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEE
LLCGNGGSAADAQHLAAEFTIRYRSSVHRPALPAIALSTDTSALTAGANDLGFDEVFVRL
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHCCCCCCCCHHHHHHHH
TEAYGCPGDILIGLSTSGNSASVLKALEFARKRGLKTLALLGGDGGAIKPHADLAVVVPH
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEEEEC
TGSADRIQECHIAVGHVIVELVEKMMGYD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901