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The map label for this gene is ribH

Identifier: 21674847

GI number: 21674847

Start: 1935749

End: 1936216

Strand: Reverse

Name: ribH

Synonym: CT2037

Alternate gene names: 21674847

Gene position: 1936216-1935749 (Counterclockwise)

Preceding gene: 21674848

Following gene: 21674843

Centisome position: 89.85

GC content: 56.62

Gene sequence:

>468_bases
ATGCAGGTACAAAATATTGAAGGCTCGTTGAATGCCTCCGGCTTGAAGTTCGCGCTCGTGGTTTCACGCTTCAACGATTT
TATCGGCCAGAAGCTGGTCGAGGGAGCCATTGACTGCATTGTGCGTCATGGCGGATCGGCTGACGAGATCACCGTTATTC
GTTGCCCCGGCGCTTTCGAGCTGCCGTCGGTTACGAGAAAGGCTATGTTGTCTGGCAAATACGATGCGATTGTGACGCTT
GGGGTTATCATCCGCGGCTCGACCCCGCACTTCGACGTGATTGCTGCCGAGGCGACCAAGGGGATCGCGCAGGTCGGCAT
GGAGGCCGCTATTCCCGTATCATTCGGTGTGCTGACCACCGAAAATCTGGAGCAGGCAATCGAGCGTGCCGGCACCAAGG
CTGGTAACAAAGGCTTCGACGCCGCCCTGGCCGCCATCGAAATGGCCAATCTTTACAAGCAGCTGTAA

Upstream 100 bases:

>100_bases
ATTGATGAGTGAAAATGCGGAGTAGCTCGTGGCGCGGCCTATAAAGCCCATTCCGTTCACTTTGTCCATTGTGGCATTGC
AAACCAAACAACAACTGACT

Downstream 100 bases:

>100_bases
GGTGAACGGGGGACTGTGCTTGCCTGAAATGATCTTGCAGGGGCGGTTCGCGAACCACCCTTGCTGATTCTGCTGTTGTT
TCGGAATTAAGGGCAGCGGG

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MQVQNIEGSLNASGLKFALVVSRFNDFIGQKLVEGAIDCIVRHGGSADEITVIRCPGAFELPSVTRKAMLSGKYDAIVTL
GVIIRGSTPHFDVIAAEATKGIAQVGMEAAIPVSFGVLTTENLEQAIERAGTKAGNKGFDAALAAIEMANLYKQL

Sequences:

>Translated_155_residues
MQVQNIEGSLNASGLKFALVVSRFNDFIGQKLVEGAIDCIVRHGGSADEITVIRCPGAFELPSVTRKAMLSGKYDAIVTL
GVIIRGSTPHFDVIAAEATKGIAQVGMEAAIPVSFGVLTTENLEQAIERAGTKAGNKGFDAALAAIEMANLYKQL
>Mature_155_residues
MQVQNIEGSLNASGLKFALVVSRFNDFIGQKLVEGAIDCIVRHGGSADEITVIRCPGAFELPSVTRKAMLSGKYDAIVTL
GVIIRGSTPHFDVIAAEATKGIAQVGMEAAIPVSFGVLTTENLEQAIERAGTKAGNKGFDAALAAIEMANLYKQL

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=151, Percent_Identity=51.6556291390728, Blast_Score=157, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324429, Length=148, Percent_Identity=34.4594594594595, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_CHLTE (Q8KAW4)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662912.1
- ProteinModelPortal:   Q8KAW4
- SMR:   Q8KAW4
- GeneID:   1007523
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT2037
- NMPDR:   fig|194439.1.peg.2006
- TIGR:   CT2037
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- ProtClustDB:   PRK00061
- BioCyc:   CTEP194439:CT_2037-MONOMER
- BRENDA:   2.5.1.9
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16308; Mature: 16308

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVQNIEGSLNASGLKFALVVSRFNDFIGQKLVEGAIDCIVRHGGSADEITVIRCPGAFE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
LPSVTRKAMLSGKYDAIVTLGVIIRGSTPHFDVIAAEATKGIAQVGMEAAIPVSFGVLTT
CHHHHHHHHHCCCCHHEEEEEEEEECCCCCEEEEEHHHHHHHHHHCCHHCCCEEECEEEH
ENLEQAIERAGTKAGNKGFDAALAAIEMANLYKQL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQVQNIEGSLNASGLKFALVVSRFNDFIGQKLVEGAIDCIVRHGGSADEITVIRCPGAFE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
LPSVTRKAMLSGKYDAIVTLGVIIRGSTPHFDVIAAEATKGIAQVGMEAAIPVSFGVLTT
CHHHHHHHHHCCCCHHEEEEEEEEECCCCCEEEEEHHHHHHHHHHCCHHCCCEEECEEEH
ENLEQAIERAGTKAGNKGFDAALAAIEMANLYKQL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901