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The map label for this gene is hemE [H]

Identifier: 21674849

GI number: 21674849

Start: 1937072

End: 1938127

Strand: Reverse

Name: hemE [H]

Synonym: CT2039

Alternate gene names: 21674849

Gene position: 1938127-1937072 (Counterclockwise)

Preceding gene: 21674850

Following gene: 21674848

Centisome position: 89.94

GC content: 56.82

Gene sequence:

>1056_bases
ATGCTCAAAAATGATCTTTTTATCAGGGCGTTGAAGAGGCAGGCTACCCCCCGTACTCCTATCTGGGTCATGCGTCAGGC
CGGTCGTTATCTGCCTGAATATCGCGCCGTCAGGGAGAAAACCGACTTTCTGACCCTCTGCAAAACCCCCGAGCTGGCTT
GTGAAGTCACCATCCAGCCGGTCGATCTGATGGGTGTGGACGCCGCGATCATTTTCTCCGACATCCTCGTCGTCAACGAA
GCGATGGGCATGAATGTCGAGATTATCGAGACCAAGGGCATCAAACTGACTCCGCCGATCCGTTCGCAGGCCGACATCGA
CAAACTGATCGATCCCGATATCGATGAGAAACTCGGCTACGTACTCGACGCAATCCGCCTCGCCAAAAAGGAACTCAACG
ACCGTGTGCCGCTCATCGGCTTCTCCGGCGCGGCATGGACGCTCTTCACCTATGCCGTCGAGGGGGGCGGTTCGAAGAAC
TACACCTGGGCCAAGAAGATGATGTACCGCGAGCCGAAGATGGCTCACCAGTTGCTCCAAAAGATCAGCGACTGCATTAG
CGCCTACCTCGTCAAGCAGGTAGAAGCTGGCGCCGACGCCATCCAGATTTTCGACTCCTGGGCCAGCGCGCTCTCCGAGG
ATGATTACCGCGAATTTGCCCTGCCGTACATCAAGCAGAACGTCGCTGCCGTGAAGGCCGCATATCCGGAAATTCCGGTC
ATCGCGTTTGCCAAGGATATGAACACTATTCTTTCCGACATCGCCGACTGCGGCGCCGATGCGGTTGGTCTCGGCTGGAA
CATCGATATCGCAAAGGCTCGCAAAGAGTTGAATGACCGCGTCTGCCTCCAGGGCAACATGGACCCGACGGTGCTCTACG
GCACGCCCGAGAAGATCAAGTCGGAAGCTGCCAAGGTGCTCAAGCAGTTCGGCCAGCACAACGACCACTCCGGTCACGTC
TTCAACCTCGGCCACGGCATTCTGCCCGACGTCGATCCTGCCAACCTGAAGTGCCTCGTTGAATTCGTCAAGGAAGAAAG
CGCCAAGTACCACTAA

Upstream 100 bases:

>100_bases
TGTACCTTTGCACCTGATTTATTTAATGTCTGCAAGGTTTCCGGTCTCGGTCCGGCCTTAAGCGCAGCTCTTTTCACAAC
ATCACTAATCATCGCATTCC

Downstream 100 bases:

>100_bases
GCGCGATTCCTCTTACTGAAAGCGTCACAGCCTGCCCGGCAAATACTTCGGGTAGGCTTTTTTTTTGATCAGCCCCATCT
GACCGATCATTTTTTATATT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MLKNDLFIRALKRQATPRTPIWVMRQAGRYLPEYRAVREKTDFLTLCKTPELACEVTIQPVDLMGVDAAIIFSDILVVNE
AMGMNVEIIETKGIKLTPPIRSQADIDKLIDPDIDEKLGYVLDAIRLAKKELNDRVPLIGFSGAAWTLFTYAVEGGGSKN
YTWAKKMMYREPKMAHQLLQKISDCISAYLVKQVEAGADAIQIFDSWASALSEDDYREFALPYIKQNVAAVKAAYPEIPV
IAFAKDMNTILSDIADCGADAVGLGWNIDIAKARKELNDRVCLQGNMDPTVLYGTPEKIKSEAAKVLKQFGQHNDHSGHV
FNLGHGILPDVDPANLKCLVEFVKEESAKYH

Sequences:

>Translated_351_residues
MLKNDLFIRALKRQATPRTPIWVMRQAGRYLPEYRAVREKTDFLTLCKTPELACEVTIQPVDLMGVDAAIIFSDILVVNE
AMGMNVEIIETKGIKLTPPIRSQADIDKLIDPDIDEKLGYVLDAIRLAKKELNDRVPLIGFSGAAWTLFTYAVEGGGSKN
YTWAKKMMYREPKMAHQLLQKISDCISAYLVKQVEAGADAIQIFDSWASALSEDDYREFALPYIKQNVAAVKAAYPEIPV
IAFAKDMNTILSDIADCGADAVGLGWNIDIAKARKELNDRVCLQGNMDPTVLYGTPEKIKSEAAKVLKQFGQHNDHSGHV
FNLGHGILPDVDPANLKCLVEFVKEESAKYH
>Mature_351_residues
MLKNDLFIRALKRQATPRTPIWVMRQAGRYLPEYRAVREKTDFLTLCKTPELACEVTIQPVDLMGVDAAIIFSDILVVNE
AMGMNVEIIETKGIKLTPPIRSQADIDKLIDPDIDEKLGYVLDAIRLAKKELNDRVPLIGFSGAAWTLFTYAVEGGGSKN
YTWAKKMMYREPKMAHQLLQKISDCISAYLVKQVEAGADAIQIFDSWASALSEDDYREFALPYIKQNVAAVKAAYPEIPV
IAFAKDMNTILSDIADCGADAVGLGWNIDIAKARKELNDRVCLQGNMDPTVLYGTPEKIKSEAAKVLKQFGQHNDHSGHV
FNLGHGILPDVDPANLKCLVEFVKEESAKYH

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=352, Percent_Identity=45.7386363636364, Blast_Score=323, Evalue=1e-88,
Organism=Escherichia coli, GI2367337, Length=353, Percent_Identity=48.7252124645892, Blast_Score=346, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6320252, Length=349, Percent_Identity=42.4068767908309, Blast_Score=282, Evalue=6e-77,
Organism=Drosophila melanogaster, GI19921920, Length=350, Percent_Identity=40.5714285714286, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI221330099, Length=350, Percent_Identity=40.5714285714286, Blast_Score=279, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39105; Mature: 39105

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNDLFIRALKRQATPRTPIWVMRQAGRYLPEYRAVREKTDFLTLCKTPELACEVTIQP
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHEEECCCCCCEEEEEECC
VDLMGVDAAIIFSDILVVNEAMGMNVEIIETKGIKLTPPIRSQADIDKLIDPDIDEKLGY
CHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCCCHHHHHHHCCCCHHHHHHH
VLDAIRLAKKELNDRVPLIGFSGAAWTLFTYAVEGGGSKNYTWAKKMMYREPKMAHQLLQ
HHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHH
KISDCISAYLVKQVEAGADAIQIFDSWASALSEDDYREFALPYIKQNVAAVKAAYPEIPV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCE
IAFAKDMNTILSDIADCGADAVGLGWNIDIAKARKELNDRVCLQGNMDPTVLYGTPEKIK
EEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEECCHHHHH
SEAAKVLKQFGQHNDHSGHVFNLGHGILPDVDPANLKCLVEFVKEESAKYH
HHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLKNDLFIRALKRQATPRTPIWVMRQAGRYLPEYRAVREKTDFLTLCKTPELACEVTIQP
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHEEECCCCCCEEEEEECC
VDLMGVDAAIIFSDILVVNEAMGMNVEIIETKGIKLTPPIRSQADIDKLIDPDIDEKLGY
CHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCCCHHHHHHHCCCCHHHHHHH
VLDAIRLAKKELNDRVPLIGFSGAAWTLFTYAVEGGGSKNYTWAKKMMYREPKMAHQLLQ
HHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHH
KISDCISAYLVKQVEAGADAIQIFDSWASALSEDDYREFALPYIKQNVAAVKAAYPEIPV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCE
IAFAKDMNTILSDIADCGADAVGLGWNIDIAKARKELNDRVCLQGNMDPTVLYGTPEKIK
EEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEECCHHHHH
SEAAKVLKQFGQHNDHSGHVFNLGHGILPDVDPANLKCLVEFVKEESAKYH
HHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA