Click here to switch to the map view.

The map label for this gene is menC [H]

Identifier: 21674660

GI number: 21674660

Start: 1746847

End: 1747938

Strand: Direct

Name: menC [H]

Synonym: CT1847

Alternate gene names: 21674660

Gene position: 1746847-1747938 (Clockwise)

Preceding gene: 21674659

Following gene: 21674661

Centisome position: 81.06

GC content: 64.74

Gene sequence:

>1092_bases
GTGAAGCCGCTTCATGCCGACATCTGCCGGTATGAAATGGATTTCACCGCGCCGGTCACCGTCCGAGGAGTGCTTCTCGC
CAGACGCCAGGGGTTGCTCCTGCGCCTGAAAAGTGAGGGGGTGACAGCGTATGGCGAAGTCGCCCCCCTCATCGGTCTGC
ACACGGAGTCACTCGACGAGGCCTTGCAGGCTCTTGCCACATTCATTCCCGAACTTTCACGACTCGACTGGAACGCATCC
GATGGTCGGCAACGCCTGCTCGACGAGGCAGCGCTGCCACCGTCGGTGACGACCGGTATCGAGATGGCGCTCATCAACCT
CGAAGCGACTGAGCGCAGCTCGCTTCCGTCTTTCACTGACGAATTCCCTCCAGCATCGAAAATCCCTGTCAACGCGCTGC
TAGCTGGGGATCCGCAAGCCGTGCTCAACCGCGCAGCGAAGCGCTACGCCGAGGGATTCCGCGCCTTCAAGCTGAAGGTG
CGCAAAGGAGAGCTCGACGGAGCCGTCGCCTGCATCCGCGCCCTGCACGAGGCTTTCGGCGACAAGGCGGAGCTGCGGCT
CGACGCCAACCAGTCGCTCGAATTCGACGAGGCGGTCGCGTTCGGCAAAGCCCTGCCGCCGGGTTGCGTCGCCTACATCG
AGGAGCCGCTGACCGATGCGGCGCTGATTTCCGACTTCCACGCCGCTACCGGTCTGCCGTCGGCGCTTGACGAGTCGCTC
TGGCAGCGCCCGGAGCTGCTCGACGAGATCGGCCCCGACCCACTCGGCGCGCTCGTGCTCAAGCCGAACTGCATCGGCGG
CATCGCGAAATCGCTCGACCTTGCGGCCAAAGCGCACCGGATGGGGTTGCAGGCGGTTTACAGCTCAGCTTTCGAGAGCA
GCGTCAGCCTCGGGCTCTACGCGCTCATGGCCGCCGTCTCGTCGCCAGCTCCGGCGGCATCAGGTCTCGACACGGCGAGC
TTTCTCGCCCGCGACCTCACCGCCACACCCTTCGCCACGCCGGACGGATTCGCCGATCCCGCAGCCGCATGGCGCGACAG
CTTGCGCGTGAGACCCGACATGATCGAAACCGTCAAGTCATGGAGCTTGTAA

Upstream 100 bases:

>100_bases
ACGCCACCCTGCTCTATTACATGAGCGAGGAGGGACAGGAGGGCCGCAACGCCTTCGTCGAGAAGCGCAAACCCGATTTC
AGCAAGTTCCCGAAACGCCC

Downstream 100 bases:

>100_bases
CCCAGGCCGCACAAACCTTCGGCGACCAACCCGCGCTCATCACCGACGAACGGCGCTGGAGCTTCGCCGACCTCGATGGC
GACACGGCTCGCATCGCCAC

Product: O-succinylbenzoate-CoA synthase

Products: NA

Alternate protein names: OSB synthase; OSBS; 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; o-succinylbenzoic acid synthase [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MKPLHADICRYEMDFTAPVTVRGVLLARRQGLLLRLKSEGVTAYGEVAPLIGLHTESLDEALQALATFIPELSRLDWNAS
DGRQRLLDEAALPPSVTTGIEMALINLEATERSSLPSFTDEFPPASKIPVNALLAGDPQAVLNRAAKRYAEGFRAFKLKV
RKGELDGAVACIRALHEAFGDKAELRLDANQSLEFDEAVAFGKALPPGCVAYIEEPLTDAALISDFHAATGLPSALDESL
WQRPELLDEIGPDPLGALVLKPNCIGGIAKSLDLAAKAHRMGLQAVYSSAFESSVSLGLYALMAAVSSPAPAASGLDTAS
FLARDLTATPFATPDGFADPAAAWRDSLRVRPDMIETVKSWSL

Sequences:

>Translated_363_residues
MKPLHADICRYEMDFTAPVTVRGVLLARRQGLLLRLKSEGVTAYGEVAPLIGLHTESLDEALQALATFIPELSRLDWNAS
DGRQRLLDEAALPPSVTTGIEMALINLEATERSSLPSFTDEFPPASKIPVNALLAGDPQAVLNRAAKRYAEGFRAFKLKV
RKGELDGAVACIRALHEAFGDKAELRLDANQSLEFDEAVAFGKALPPGCVAYIEEPLTDAALISDFHAATGLPSALDESL
WQRPELLDEIGPDPLGALVLKPNCIGGIAKSLDLAAKAHRMGLQAVYSSAFESSVSLGLYALMAAVSSPAPAASGLDTAS
FLARDLTATPFATPDGFADPAAAWRDSLRVRPDMIETVKSWSL
>Mature_363_residues
MKPLHADICRYEMDFTAPVTVRGVLLARRQGLLLRLKSEGVTAYGEVAPLIGLHTESLDEALQALATFIPELSRLDWNAS
DGRQRLLDEAALPPSVTTGIEMALINLEATERSSLPSFTDEFPPASKIPVNALLAGDPQAVLNRAAKRYAEGFRAFKLKV
RKGELDGAVACIRALHEAFGDKAELRLDANQSLEFDEAVAFGKALPPGCVAYIEEPLTDAALISDFHAATGLPSALDESL
WQRPELLDEIGPDPLGALVLKPNCIGGIAKSLDLAAKAHRMGLQAVYSSAFESSVSLGLYALMAAVSSPAPAASGLDTAS
FLARDLTATPFATPDGFADPAAAWRDSLRVRPDMIETVKSWSL

Specific function: Converts SHCHC to OSB [H]

COG id: COG1441

COG function: function code H; O-succinylbenzoate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788596, Length=320, Percent_Identity=30, Blast_Score=99, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013342
- InterPro:   IPR010196 [H]

Pfam domain/function: PF01188 MR_MLE [H]

EC number: =4.2.1.113 [H]

Molecular weight: Translated: 38777; Mature: 38777

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00909 MR_MLE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLHADICRYEMDFTAPVTVRGVLLARRQGLLLRLKSEGVTAYGEVAPLIGLHTESLDE
CCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHCCHHHHHH
ALQALATFIPELSRLDWNASDGRQRLLDEAALPPSVTTGIEMALINLEATERSSLPSFTD
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHCCCEEEEEEEEHHHCCCCCCCCC
EFPPASKIPVNALLAGDPQAVLNRAAKRYAEGFRAFKLKVRKGELDGAVACIRALHEAFG
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHC
DKAELRLDANQSLEFDEAVAFGKALPPGCVAYIEEPLTDAALISDFHAATGLPSALDESL
CCEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHH
WQRPELLDEIGPDPLGALVLKPNCIGGIAKSLDLAAKAHRMGLQAVYSSAFESSVSLGLY
HCCHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALMAAVSSPAPAASGLDTASFLARDLTATPFATPDGFADPAAAWRDSLRVRPDMIETVKS
HHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
WSL
CCC
>Mature Secondary Structure
MKPLHADICRYEMDFTAPVTVRGVLLARRQGLLLRLKSEGVTAYGEVAPLIGLHTESLDE
CCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHCCHHHHHH
ALQALATFIPELSRLDWNASDGRQRLLDEAALPPSVTTGIEMALINLEATERSSLPSFTD
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHCCCEEEEEEEEHHHCCCCCCCCC
EFPPASKIPVNALLAGDPQAVLNRAAKRYAEGFRAFKLKVRKGELDGAVACIRALHEAFG
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHC
DKAELRLDANQSLEFDEAVAFGKALPPGCVAYIEEPLTDAALISDFHAATGLPSALDESL
CCEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHH
WQRPELLDEIGPDPLGALVLKPNCIGGIAKSLDLAAKAHRMGLQAVYSSAFESSVSLGLY
HCCHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALMAAVSSPAPAASGLDTASFLARDLTATPFATPDGFADPAAAWRDSLRVRPDMIETVKS
HHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
WSL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA