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The map label for this gene is menB [H]

Identifier: 21674659

GI number: 21674659

Start: 1745969

End: 1746850

Strand: Direct

Name: menB [H]

Synonym: CT1846

Alternate gene names: 21674659

Gene position: 1745969-1746850 (Clockwise)

Preceding gene: 21674658

Following gene: 21674660

Centisome position: 81.02

GC content: 61.0

Gene sequence:

>882_bases
TTGCCTGTAGAGCCGGGGCAACGCCGATTTTCATCAACTACCATCGAGATTTCAGATATGAGCACAGTCAACTGGATTAC
AGCCGGAGAGTACTCCGACATTCTCTACCACAAGACCGAAGAAGGGATCGCCAAAATCACCATCAACCGACCGGAGCGGC
GCAATGCGTTCCGCCCGCAGACGGTGGATCAGATGATCGAGGCGCTTCAGGATGCGCGTAACGACAGCCAGATCGGCGTC
ATCATCCTGACCGGTGCGGGCGACCTCGCGTTCTGCTCCGGCGGTGACCAAAAGATTCGCGGCAACGCAGGATACGCCGA
CGAAAAAGGCGTGAACAAGCTCAACGTGCTCGATTTCCAGCGCGACATCCGCACCTGCCCGAAGCCGATCATCGCAATGG
TGGCGGGCTACGCCATCGGCGGAGGCCACGTGCTGCACATGCTCTGCGACCTCACCATCGCGGCGGAAAACGCCCGTTTC
GGCCAGACCGGCCCACGCGTCGGCTCATTCGACGGCGGCTGGGGCGCGAGCTACATGGCGCGTCTGGTCGGTCAAAAAAA
GGCCCGCGAAATCTGGTACCTCTGCCGCCAGTACAACGCGCAAGAGGCGCTCGACATGGGCTTGGTCAACACCGTCGTGC
CACTCGAAAAGCTTGAAGAAGAGACCATCCAGTGGTGCCGCGAAATTCTCGCCAACTCGCCGCTCGCCATCCGCTGCCTC
AAGGCCGCGCTCAACGCCGACTGCGACGGTCAGGCTGGGTTGCAGGAGCTTGCGGGCAACGCCACCCTGCTCTATTACAT
GAGCGAGGAGGGACAGGAGGGCCGCAACGCCTTCGTCGAGAAGCGCAAACCCGATTTCAGCAAGTTCCCGAAACGCCCGT
GA

Upstream 100 bases:

>100_bases
GAAACGCATCCCCACAACAGCATTTCCCACGATGACCTGTAAGTCCCATTCCGCCGTCACGCCTCTCTAATCAACGGGGA
TTGTTTATATTTCAGCTCTT

Downstream 100 bases:

>100_bases
AGCCGCTTCATGCCGACATCTGCCGGTATGAAATGGATTTCACCGCGCCGGTCACCGTCCGAGGAGTGCTTCTCGCCAGA
CGCCAGGGGTTGCTCCTGCG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPVEPGQRRFSSTTIEISDMSTVNWITAGEYSDILYHKTEEGIAKITINRPERRNAFRPQTVDQMIEALQDARNDSQIGV
IILTGAGDLAFCSGGDQKIRGNAGYADEKGVNKLNVLDFQRDIRTCPKPIIAMVAGYAIGGGHVLHMLCDLTIAAENARF
GQTGPRVGSFDGGWGASYMARLVGQKKAREIWYLCRQYNAQEALDMGLVNTVVPLEKLEEETIQWCREILANSPLAIRCL
KAALNADCDGQAGLQELAGNATLLYYMSEEGQEGRNAFVEKRKPDFSKFPKRP

Sequences:

>Translated_293_residues
MPVEPGQRRFSSTTIEISDMSTVNWITAGEYSDILYHKTEEGIAKITINRPERRNAFRPQTVDQMIEALQDARNDSQIGV
IILTGAGDLAFCSGGDQKIRGNAGYADEKGVNKLNVLDFQRDIRTCPKPIIAMVAGYAIGGGHVLHMLCDLTIAAENARF
GQTGPRVGSFDGGWGASYMARLVGQKKAREIWYLCRQYNAQEALDMGLVNTVVPLEKLEEETIQWCREILANSPLAIRCL
KAALNADCDGQAGLQELAGNATLLYYMSEEGQEGRNAFVEKRKPDFSKFPKRP
>Mature_292_residues
PVEPGQRRFSSTTIEISDMSTVNWITAGEYSDILYHKTEEGIAKITINRPERRNAFRPQTVDQMIEALQDARNDSQIGVI
ILTGAGDLAFCSGGDQKIRGNAGYADEKGVNKLNVLDFQRDIRTCPKPIIAMVAGYAIGGGHVLHMLCDLTIAAENARFG
QTGPRVGSFDGGWGASYMARLVGQKKAREIWYLCRQYNAQEALDMGLVNTVVPLEKLEEETIQWCREILANSPLAIRCLK
AALNADCDGQAGLQELAGNATLLYYMSEEGQEGRNAFVEKRKPDFSKFPKRP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=244, Percent_Identity=35.655737704918, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI31542718, Length=251, Percent_Identity=30.6772908366534, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI45643119, Length=218, Percent_Identity=29.3577981651376, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI260275230, Length=218, Percent_Identity=29.3577981651376, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4502327, Length=261, Percent_Identity=29.8850574712644, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI260274832, Length=218, Percent_Identity=29.3577981651376, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI70995211, Length=232, Percent_Identity=28.0172413793103, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI25453481, Length=269, Percent_Identity=26.0223048327138, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI51538573, Length=269, Percent_Identity=26.0223048327138, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4757966, Length=222, Percent_Identity=27.4774774774775, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI51538581, Length=222, Percent_Identity=27.4774774774775, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI157694516, Length=226, Percent_Identity=24.3362831858407, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI213417737, Length=226, Percent_Identity=24.3362831858407, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4757968, Length=269, Percent_Identity=25.6505576208178, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI49355787, Length=269, Percent_Identity=25.6505576208178, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI37594471, Length=146, Percent_Identity=30.1369863013699, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI37594469, Length=146, Percent_Identity=30.1369863013699, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1788597, Length=275, Percent_Identity=76, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1787659, Length=251, Percent_Identity=33.4661354581673, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082183, Length=253, Percent_Identity=32.8063241106719, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI221142681, Length=260, Percent_Identity=31.9230769230769, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1787660, Length=270, Percent_Identity=31.1111111111111, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788682, Length=202, Percent_Identity=26.2376237623762, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790281, Length=227, Percent_Identity=29.5154185022026, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=289, Percent_Identity=31.4878892733564, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI25145438, Length=249, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17540714, Length=210, Percent_Identity=32.8571428571429, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17560910, Length=193, Percent_Identity=31.0880829015544, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17535521, Length=183, Percent_Identity=29.5081967213115, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17536985, Length=233, Percent_Identity=26.6094420600858, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=198, Percent_Identity=26.7676767676768, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=214, Percent_Identity=26.6355140186916, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20129971, Length=283, Percent_Identity=33.9222614840989, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24653477, Length=283, Percent_Identity=33.9222614840989, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24653139, Length=288, Percent_Identity=27.7777777777778, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21357171, Length=214, Percent_Identity=31.7757009345794, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922422, Length=293, Percent_Identity=26.6211604095563, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24654903, Length=184, Percent_Identity=29.8913043478261, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24650670, Length=176, Percent_Identity=30.6818181818182, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 32381; Mature: 32250

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVEPGQRRFSSTTIEISDMSTVNWITAGEYSDILYHKTEEGIAKITINRPERRNAFRPQ
CCCCCCCHHHCCCEEEEECCCEEEEEECCCCCHHHEEECCCCEEEEEECCCHHCCCCCCH
TVDQMIEALQDARNDSQIGVIILTGAGDLAFCSGGDQKIRGNAGYADEKGVNKLNVLDFQ
HHHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCEEECCCCCCCCCCCCCCHHHHHH
RDIRTCPKPIIAMVAGYAIGGGHVLHMLCDLTIAAENARFGQTGPRVGSFDGGWGASYMA
HHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHH
RLVGQKKAREIWYLCRQYNAQEALDMGLVNTVVPLEKLEEETIQWCREILANSPLAIRCL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
KAALNADCDGQAGLQELAGNATLLYYMSEEGQEGRNAFVEKRKPDFSKFPKRP
HHHHCCCCCCCHHHHHHCCCEEEEEEECCCCCCHHHHHHHCCCCCHHHCCCCC
>Mature Secondary Structure 
PVEPGQRRFSSTTIEISDMSTVNWITAGEYSDILYHKTEEGIAKITINRPERRNAFRPQ
CCCCCCHHHCCCEEEEECCCEEEEEECCCCCHHHEEECCCCEEEEEECCCHHCCCCCCH
TVDQMIEALQDARNDSQIGVIILTGAGDLAFCSGGDQKIRGNAGYADEKGVNKLNVLDFQ
HHHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCEEECCCCCCCCCCCCCCHHHHHH
RDIRTCPKPIIAMVAGYAIGGGHVLHMLCDLTIAAENARFGQTGPRVGSFDGGWGASYMA
HHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHH
RLVGQKKAREIWYLCRQYNAQEALDMGLVNTVVPLEKLEEETIQWCREILANSPLAIRCL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
KAALNADCDGQAGLQELAGNATLLYYMSEEGQEGRNAFVEKRKPDFSKFPKRP
HHHHCCCCCCCHHHHHHCCCEEEEEEECCCCCCHHHHHHHCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]